γ-Secretase inhibitors for Alzheimer's disease: Challenges of a promiscuous protease

Current Opinion in Investigational Drugs

Volumn 6, Issue 1, 2005, Pages 35-47

  Pollack, Scott J ^a   Lewis, Huw ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

amyloid precursor protein; secretase; Alzheimer's disease; Intracellular domain; Notch; Regulated intramembrane proteolysis

Indexed keywords

ALPHA SECRETASE; AMYLOID PRECURSOR PROTEIN; BETA CATENIN; CADHERIN; CELL ADHESION MOLECULE; COLONY STIMULATING FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 4; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; GROWTH FACTOR; HERMES ANTIGEN; LIGAND; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MATRIX PROTEIN; MEGALIN; NEU DIFFERENTIATION FACTOR; NEUROTROPHIC FACTOR; NONSTEROID ANTIINFLAMMATORY AGENT; NOTCH RECEPTOR; PROTEIN P75; SYNDECAN 3; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; PROTEINASE; PROTEINASE INHIBITOR; SECRETASE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ALZHEIMER DISEASE; BONE; BREAST CANCER; CARCINOGENESIS; CENTRAL NERVOUS SYSTEM; ENZYME INHIBITION; ENZYME SUBSTRATE; GASTROINTESTINAL TOXICITY; HAIR; HEMATOPOIETIC SYSTEM; HUMAN; IMMUNE SYSTEM; IN VITRO STUDY; IN VIVO STUDY; LEARNING DISORDER; LIGAND BINDING; MEMORY DISORDER; MUSCLE; NONHUMAN; PATHOPHYSIOLOGY; PHARMACOLOGICAL BLOCKING; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; RECEPTOR INTRINSIC ACTIVITY; REVIEW; SALIVARY GLAND CANCER; SIGNAL TRANSDUCTION; SKIN; ANIMAL; ENZYME SPECIFICITY; ENZYMOLOGY; METABOLISM;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; ENDOPEPTIDASES; HUMANS; LIGANDS; PROTEASE INHIBITORS; SUBSTRATE SPECIFICITY;

EID: 12544258201     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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