Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein

Journal of Neuroscience

Volumn 16, Issue 21, 1996, Pages 6732-6741

  Oster Granite, Mary Lou ^a   McPhie, Donna L ^b   Greenan, Jane ^a   Neve, Rachael L ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MCLEAN HOSPITAL   (United States)

Author keywords

aging; Alzheimer's disease; amyloid; Flag tag; hippocampus; neurodegeneration

Indexed keywords

AMYLOID PRECURSOR PROTEIN;

AGING; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DENDRITE; DENTATE GYRUS; HIPPOCAMPUS; MOUSE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SENILE PLAQUE; SYNAPSE; TRANSGENIC MOUSE;

EID: 0029862137     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-21-06732.1996     Document Type: Article

References (39)

1. Benowitz LI, Rodriguez W, Paskevich P, Mufson EJ, Schenk D, Neve RL (1989) The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects. Exp Neurol 106:237-250.
2. Buxbaum JD, Gandy SE, Cicchetti P, Ehrlich ME, Czernik AJ, Fracasso RP, Ramabhadran TV, Unterbeck AJ, Greengard P (1990) Processing of Alzheimer β/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. Proc Natl Acad Sci USA 87:6003-6006.
3. Carpenter AF, Carpenter PW, Markesbery WR (1993) Morphometric analysis of microglia in Alzheimer's disease. J Neuropathol Exp Neurol 52:601-608.
4. Cataldo AM, Hamilton DJ, Nixon RA (1994) Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease. Brain Res 640:68-80.
5. Cummings BJ, Su JH, Geddes JW, Van Nostrand WE, Wagner SL, Cunningham DD, Cotman CW (1992) Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in Alzheimer's disease. Neuroscience 48:763-777.
6. DeKosky ST, Scheff SW (1990) Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann Neurol 27:457-464.
7. De la Monte SM (1989) Quantitation of cerebral atrophy in preclinical and end-stage Alzheimer's disease. Ann Neurol 5:450-459.
8. Fukuchi K, Kamino K, Deeb SS, Smith AC, Dang T, Martin GM (1992) Overexpression of amyloid precursor protein alters its normal processing and is associated with neurotoxicity. Biochem Biophys Res Commun 182:165-173.
9. Fukuchi K, Sopher B, Furlong CE, Smith AC, Dang NT, Martin GM (1993) Selective neurotoxicity of COOH-terminal fragments of the β-amyloid precursor protein. Neurosci Lett 154:145-148.
10. Fukuchi K, Kunkel DD, Schwartzkroin PA, Kamino K, Ogburn CE, Furlong CE, Martin GM (1994) Overexpression of a C-terminal portion of the β-amyloid precursor protein in mouse brains by transplantation of transformed neuronal cells. Exp Neurol 127:253-264.
11. Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F, Guido T, Hagopian S, Johnson-Wood K, Khan K, Lee M, Leibowitz P, Lieberburg I, Little S, Masliah E, McConlogue L, Montoya-Zavala Mucke L, Paganini L, Penniman E, Power M, Schenk D, Seubert P, Snyder B, Soriano F, Tan H, Vitale J, Wadsworth S, Wolozin B, Zhao J (1995) Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 373:523-527.
12. Gorecki DC, Monaco AP, Derry JM, Walker AP, Barnard EA, Barnard PJ (1992) Expression of four alternative dystrophin transcripts in brain regions regulated by different promoters. Hum Mol Genet 1:505-510.
13. Hamos JE, DeGennaro LJ, Drachman DA (1989) Synaptic loss in Alzheimer's disease and other dementias. Neurology 39:355-361.
14. Ivins KJ, Neve KA, Feller DJ, Fidel SA, Neve RL (1993) Antisense GAP-43 inhibits the evoked release of dopamine from PC12 cells. J Neurochem 60:626-633.
15. Jucker M, Walker LC, Martin LJ, Kitt CA, Kleinman HK, Ingram DK, Price DL (1992) Age-associated inclusions in normal and transgenic mouse brain. Science 255:1443-1455.
16. Kalaria RN (1992) The blood-brain barrier and cerebral microcirculation in Alzheimer disease. Cerebrovasc Brain Metab Rev 4:226-260.
17. Kammesheidt A, Boyce FM, Spanoyannis AF, Cummings BJ, Ortegon M, Cotman CW, Vaught JL, Neve RL (1992) Amyloid deposition and neuronal pathology in transgenic mice expressing the carboxyterminal fragment of the Alzheimer amyloid precursor in the brain. Proc Natl Acad Sci USA 89:10857-10861.
18. Kozlowski MR, Spanoyannis A, Manly SP, Fidel SA, Neve RL (1992) The neurotoxic carboxy-terminal fragment of the Alzheimer amyloid precursor binds to a neuronal cell surface molecule: pH dependence of the neurotoxicity and the binding. J Neurosci 12:1679-1687.
19. LaFerla FM, Tinkle BT, Bieberich CJ, Haudenschild CC, Jay G (1995) The Alzheimer's Aβ peptide induces neurodegeneration and apoptic cell death in transgenic mice. Nature Genet 9:21-30.
20. Mantione JR, Kleppner SF, Miyazono M, Wertkin AM, Lee VM-Y, Trojanowski JQ (1995) Human neurons that constitutively secrete Aβ do not induce Alzheimer's disease pathology following transplantation and long-term survival in the rodent brain. Brain Res 671:333-337.
21. Masliah E, Mallory M, Deerinck T, DeTeresa R, Lamont S, Miller A, Terry RD, Carragher B, Ellisman M (1993) Re-evaluation of the structural organization of neuritic plaques in Alzheimer's disease. J Neuropathol Exp Neurol 52:619-632.
22. Masliah E, Honer WG, Mallory M, Voigt M, Kushner P, Hansen L, Terry R (1994) Topographical distribution of synaptic-associated proteins in the neuritic plaques of Alzheimer's disease hippocampus. Acta Neuropathol (Berl) 87:135-142.
23. Neve RL, Boyce FM (1996) Construction and analysis of transgenic mice expressing amyloidogenic fragments of the Alzheimer amyloid protein precursor. In: Paradigms of neural injury, methods in neurosciences, Vol 30 (Perez-Polo JR, eds), pp 298-314. San Diego: Academic.
24. Neve RL, Harris P, Kosik KS, Kurnit DM, Donlon TA (1986) Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2. Mol Brain Res 1:271-280.
25. Neve RL, Perrone-Bizzozero NI, Finklestein S, Zwiers H, Bird E, Kurnit DM, Benowitz LI (1987) The neuronal growth-associated protein GAP-43 (B-50, F1): neuronal specificity, developmental regulation and regional expression of the human and rat cDNAs. Mol Brain Res 2:177-183.
26. Neve RL, Kammesheidt A, Hohmann CF (1992) Brain transplants of cells expressing the carboxyterminal fragment of the Alzheimer amyloid protein precursor cause specific neuropathology in vivo. Proc Natl Acad Sci USA 89:3448-3452.
27. Oster-Granite ML, Herndon RM (1976) The development of the cerebellar cortex of the Syrian hamster, Mesocricetus auratus. Foliation, cytoarchitectonic, Golgi, and electron microscopic studies. J Comp Neurol 169:443-479.
28. Perlmutter LS, Myers MA, Barrón E (1994) Vascular basement membrane components and the lesions of Alzheimer's disease: light and electron microscopic analyses. Microsc Res Tech 28:204-215.
29. Prickett KS, Amberg DC, Hopp TP (1989) A calcium-dependent antibody for identification and purification of recombinant proteins. Biotechniques 7:580-589.
30. Quon D, Wang Y, Catalano R, Scardina JM, Murakami K, Cordell B (1991) Formation of β-amyloid protein deposits in brains of transgenic mice. Nature 352:239-241.
31. Selkoe DJ, Podlisney MB, Joachim CL, Vickers EA, Lee G, Fritz LC, Oltersdorf T (1988) β-Amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues. Proc Natl Acad Sci USA 85:7341-7345.
32. Sopher BL, Fukuchi K, Smith AC, Leppig KA, Furlong CE, Martin GM (1994) Cytotoxicity mediated by conditional expression of a carboxyl-terminal derivative of the β-amyloid precursor protein. MoI Brain Res 26:207-217.
33. Terry RC, Peck A, DeTeresa R, Horoupian DS (1981) Some morphometric aspects of the brain in senile dementia of the Alzheimer type. Ann Neurol 10:184-192.
34. Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R (1990) Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30:572-580.
35. Vickers JC, Riederer BM, Marugg RA, Buee-Scherrer V, Buee L, Delacourte A, Morrison JH (1994) Alterations in neurofilament protein immunoreactivity in human hippocampal neurons related to normal aging and Alzheimer's disease. Neuroscience 62:1-13.
36. Wirak DO, Bayney R, Ramabhadran TV, Fracasso RP, Hart JT, Hauer PE, Hsiau P, Pekar SI, Scangos GA, Trapp BD, Unterbeck AJ (1991) Deposits of amyloid β protein in the central nervous system of transgenic mice. Science 253:323-325.
37. Wolozin BL, Pruchnicki A, Dickson DW, Davies P (1986) A neuronal antigen in the brains of Alzheimer patients. Science 232:648-650.
38. Yankner BA, Dawes LR, Fisher S, Villa-Komaroff L Oster-Granite ML, Neve RL (1989) Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science 245:417-420.
39. Yoshikawa K, Aizawa T, Hayashi Y (1992) Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor. Nature 359:64-67.