Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein

Molecular Brain Research

Volumn 66, Issue 1-2, 1999, Pages 150-162

  Berger Sweeney, Joanne ^a   McPhie, Donna L ^b   Arters, Jill A ^a   Greenan, Jane ^c   Oster Granite, Mary Lou ^c   Neve, Rachael L ^b  

^a WELLESLEY COLLEGE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer disease; Amyloid precursor protein; Cognition; Gene; Neurodegeneration; Neurotoxicity; Spatial learning; Transgenic mouse

Indexed keywords

AMYLOID PRECURSOR PROTEIN;

ALZHEIMER DISEASE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITION; CONTROLLED STUDY; DEGENERATIVE DISEASE; GENE EXPRESSION; LEARNING; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

AGE FACTORS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BEHAVIOR, ANIMAL; BRAIN CHEMISTRY; COGNITION; FEMALE; HETEROZYGOTE; HIPPOCAMPUS; HOMOZYGOTE; MALE; MAZE LEARNING; MEMORY; MICE; MICE, TRANSGENIC; MUTAGENESIS; NERVE DEGENERATION; SEX FACTORS; SPACE PERCEPTION; TRANSGENES;

EID: 0033586449     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(99)00014-5     Document Type: Article

References (41)

1. Bachman E.S., Berger-Sweeney J., Coyle J.T., Hohmann C.F. Developmental regulation of adult cortical morphology and behavior: an animal model for mental retardation. Int. J. Dev. Neurosci. 12:1994;239-253.
2. Benowitz L.I., Rodriguez W., Paskevich P., Mufson E.J., Schenk D., Neve R.L. The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects. Exp. Neurol. 106:1989;237-250.
3. Berger-Sweeney J., Arnold A., Gabeau D., Mills J. Sex differences in learning and memory in mice: effects of sequence of testing and cholinergic blockade. Behav. Neurosci. 109:1995;859-873.
4. Berger-Sweeney J., Heckers S., Mesulam M.M., Wiley R.G., Lappi D.A., Sharma M. Differential effects on spatial navigation of immunotoxin-induced cholinergic lesions of medial septal area and nucleus basalis magnocellularis. J. Neurosci. 14:1994;4507-4519.
5. Brenner D.E., Kukull W.A., Stergachis A., van Belle G., Bowen J.D., McCormick W.C., Teri L., Larson E.B. Postmenopausal estrogen replacement therapy and the risk of Alzheimer's disease: a population-based case-control study. Am. J. Epidemiol. 140:1994;262-267.
6. Buckwalter J.G., Sobel E., Dunn M.E., Diz M.M., Henderson V.W. Gender differences on a brief measure of cognitive functioning in Alzheimer's disease. Arch. Neurol. 50:1994;757-760.
7. Cummings B.J., Su J.H., Geddes J.W., Van Nostrand W.E., Wagner S.L., Cunningham D.D., Cotman C.W. Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in Alzheimer's disease. Neuroscience. 48:1992;763-777.
8. DeKosky S.T., Scheff S.W. Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann. Neurol. 27:1990;457-464.
9. Estus S., Golde T.E., Kunishita T., Blades D., Lowery D., Eisen M., Usiak M., Qu X., Tabira T., Greenberg B., Younkin S.G. Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor. Science. 255:1992;726-728.
10. Fratiglioni L. Epidemiology of Alzheimer's disease. Issues of etiology and validity. Acta Neurol. Scand. Suppl. 145:1993;1-70.
11. Fukuchi K., Sopher B., Furlong C.E., Smith A.C., Dang N.T., Martin G.M. Selective neurotoxicity of COOH-terminal fragments of the β-amyloid precursor protein. Neurosci. Lett. 154:1993;145-148.
12. Games D., Adams D., Alessandrini R., Barbour R., Berthelette P., Blackwell C., Carr T., Clemens J., Donaldson T., Gillespie F., Guido T., Hagopian S., Johnson-Wood K., Khan K., Lee M., Leibowitz P., Lieberburg I., Little S., Masliah E., McConlogue L., Montoya-Zavala M., Mucke L., Paganini L., Penniman E., Power M., Schenk D., Seubert P., Snyder B., Soriano F., Tan H., Vitale J., Wadsworth S., Wolozin B., Zhao J. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature. 373:1995;523-527.
13. Gorecki D.C., Monaco A.P., Derry J.M., Walker A.P., Barnard E.A., Barnard P.J. Expression of four alternative dystrophin transcripts in brain regions regulated by different promoters. Hum. Mol. Genet. 1:1992;505-510.
14. Hamos J.E., DeGennaro L.J., Drachman D.A. Synaptic loss in Alzheimer's disease and other dementias. Neurology. 39:1989;355-361.
15. E. Harlow, D. Lane (Eds.), Antibodies: A Laboratory Manual. Cold Spring Harbor Press, Cold Spring Harbor, 1988, 726 pp.
16. Henderson V.W., Paganini-Hill A., Emanuel C.K., Dunn M.E., Buckwalter J.G. Estrogen replacement therapy in older women. Comparisons between Alzheimer's disease cases and nondemented control subjects. Arch. Neurol. 51:1994;896-900.
17. Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., Yang, Cole G. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science. 274:1996;99-102.
18. Holcomb L., Gordon M.N., McGowan E., Yu X., Benkovic S., Jantzen P., Wright K., Saad I., Mueller R., Morgan D., Sanders S., Zehr C., O'Campo K., Hardy J., Prada C.-M., Eckman C., Younkin S., Hsiao K., Duff K. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nature Med. 4:1998;97-100.
19. Kammesheidt A., Boyce F.M., Spanoyannis A.F., Cummings B.J., Ortegon M., Cotman C., Vaught J.L., Neve R.L. Amyloid deposition and neuronal pathology in transgenic mice expressing the carboxyterminal fragment of the Alzheimer amyloid precursor in the brain. Proc. Natl. Acad. Sci. U.S.A. 89:1992;10857-10861.
20. Kawas C., Resnick S., Morrison A., Brookmeyer R., Corrada M., Zonderman A., Bacal C., Lingle D.D., Metter E. A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: the Baltimore Longitudinal Study of Aging. Neurology. 48:1997;1517-1521.
21. Kozlowski M.R., Spanoyannis A.F., Manly S.P., Fidel S.A., Neve R.L. The neurotoxic carboxyterminal fragment of the Alzheimer amyloid precursor binds specifically to a neuronal cell surface molecule: pH dependence of the neurotoxicity and the binding. J. Neurosci. 12:1992;1679-1687.
22. LaFerla F.M., Tinkle B.T., Bieberich C.J., Haudenschild C.C., Jay G. The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nature Genet. 9:1995;21-30.
23. McPhie D.L., Lee R.K.K., Eckman C., Olstein D.H., Durham S.P., Yager D., Younkin S.G., Wurtman R.J., Neve R.L. Neuronal expression of amyloid precursor protein Alzheimer mutations causes intracellular accumulation of a carboxyl-terminal fragment containing both Aβ and cytoplasmic domains. J. Biol. Chem. 272:1997;24743-24746.
24. Nakanishi H., Amano T., Sastradipura D.F., Yoshimine Y., Tsukuba T., Tanabe K., Hirotsu I., Ohono R., Yamamoto K. Increased expression of cathepsins E and D in neurons of the aged rat brain and their colocalization with lipofuscin and carboxy-terminal fragments of Alzheimer amyloid precursor protein. J. Neurochem. 68:1997;739-749.
25. Nalbantoglu J., Tirado-Santiago G., Lahsaïni A., Poirier J., Goncalves O., Verge G., Momoli F., Welner S.A., Massicotte G., Julien J.P., Shapiro M.L. Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein. Nature. 387:1997;500-505.
26. Neve R.L., Valletta J.S., Li Y., Ventosa-Michelman M., Holtzman D.M., Mobley W.C. A comprehensive study of the spatiotemporal pattern of (amyloid protein precursor mRNA and protein in the rat brain: Lack of modulation by exogenously applied nerve growth factor. Mol. Brain Res. 39:1996;185-197.
27. Nudel U., Robzyk K., Yaffe D. Expression of the putative Duchenne muscular dystrophy gene in differentiated myogenic cell cultures and in the brain. Nature. 331:1988;635-638.
28. Oster-Granite M.L., Mcphie D.L., Greenan J., Neve R.L. Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein. J. Neurosci. 16:1996;6732-6741.
29. Paganini-Hill A., Henderson V.W. Estrogen deficiency and risk of Alzheimer's disease in women. Am. J. Epidemiol. 140:1994;256-261.
30. C.A. Paul, B. Beltz, J. Berger-Sweeney, Discovering Neurons: A Compilation of Classic and Novel Laboratory Exercises in Neuroscience, Cold Spring Harbor; Cold Spring Harbor Press, 1997, pp. 230-232.
31. Prickett K.S., Amberg D.C., Hopp T.P. A calcium-dependent antibody for identification and purification of recombinant proteins. Biotechniques. 7:1989;580-589.
32. Raghavan R., Khin-Nu C., Brown A.G., Day K.A., Tyrer S.P., Ince P.G., Perry E.K., Perry R.H. Gender differences in the phenotypic expression of Alzheimer's disease in Down's syndrome (trisomy 21). Neuroreport. 11:1994;1393-1396.
33. Ripich D.N., Petrill S.A., Whitehouse P.J., Ziol E.W. Gender differences in language of AD patients: a longitudinal study. Neurology. 45:1995;299-302.
34. Sato M., Kawarabayashi T., Shoji M., Kobayashi T., Tada N., Matsubara E., Hirai S. Neurodegeneration and gliosis in transgenic mice overexpressing a carboxy-terminal fragment of Alzheimer amyloid-beta protein precursor. Dementia and Geriatric Cognitive Disorders. 8:1997;296-307.
35. Scinto L.F., Daffner K.R., Castro L., Weintraub S., Vavrik M., Mesulam M.M. Impairment of spatially directed attention in patients with probable Alzheimer's disease as measured by eye movements. Arch. Neurol. 51:1994;682-688.
36. Selkoe D.J., Podlisny M.B., Joachim C.L., Vickers E.A., Lee G., Fritz L.C., Oltersdorf T. β-Amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues. Proc. Natl. Acad. Sci. U.S.A. 85:1988;7341-7345.
37. Sopher B.L., Fukuchi K., Smith A.C., Leppig K.A., Furlong C.E., Martin G.M. Cytotoxicity mediated by conditional expression of a carboxyl-terminal derivative of the β-amyloid precursor protein. Mol. Brain Res. 26:1994;207-217.
38. Terry R.C., Peck A., DeTeresa R., Horoupian D.S. Some morphometric aspects of the brain in senile dementia of the Alzheimer type. Ann. Neurol. 10:1981;184-192.
39. Terry R.D., Masliah E., Salmon D.B., Butters N., DeTeresa R., Hill R., Hansen L.A., Katzman R. Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 30:1990;572-580.
40. Wolfer D.P., Lipp H.P. A new computer program for detailed off-line analysis of swimming navigation in the Morris swim maze. J. Neurosci. 41:1992;65-74.
41. Yankner B.A., Dawes L.R., Fisher S., Villa-Komaroff L., Oster-Granite M.L., Neve R.L. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science. 245:1989;417-420.