Wnt signaling and cancer

Genes and Development

Volumn 14, Issue 15, 2000, Pages 1837-1851

  Polakis, P ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AXIN; BETA CATENIN; PROTEIN SERINE THREONINE KINASE; TRANSCRIPTION FACTOR;

CARCINOGENESIS; CELL DIFFERENTIATION; CELL GROWTH; GENE ACTIVATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; PRIORITY JOURNAL; PROTO ONCOGENE; RECEPTOR DOWN REGULATION; REGULATOR GENE; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; BETA CATENIN; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CYTOSKELETAL PROTEINS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; NEOPLASMS; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEINS; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; WNT PROTEINS; ZEBRAFISH PROTEINS;

EID: 0033895709     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (176)

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5. Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein
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7. Functional interaction of an axin homolog, conductin, with β-catenin, APC, and GSK3β
8. A new member of the frizzled family from Drosophila functions as a wingless receptor
9. Alterations of the growth characteristics of the fibroblast cell line C3H 10T1/2 by members of the Wnt gene family
10. XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development
11. ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRα enhancer function
12. Pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila
13. Phenocopies induced with antisense RNA identify the wingless gene
14. Drosophila Tcf and Groucho interact to repress Wingless signalling activity
15. Hepatoblastoma and APC gene mutation in familial adenomatous polyposis
16. Germline mutations of the APC gene in patients with familial adenomatous polyposis-associated thyroid carcinoma: Results from a European cooperative study
17. A common human skin tumour is caused by activating mutations in β-catenin
18. Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas
19. A secreted frizzled related protein, FrzA, selectively associates with Wnt-1 protein and regulates wnt-1 signaling
20. Dominant negative effect of the APC1309 mutation: A possible explanation for genotype-phenotype correlations in familial adenomatous polyposis
21. Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos
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27. Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling
28. APC gene mutations and colorectal adenomatosis in familial adenomatous polyposis
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30. Beta-catenin mutation in carcinoma of the uterine endometrium
31. The C-terminal domain of armadillo binds to hypophosphorylated teashirt to modulate wingless signalling in Drosophila
32. Beta-catenin expression pattern in stage I and II ovarian carcinomas: Relationship with beta-catenin gene mutations, clinicopathological features, and clinical outcome
33. Frequent mutation and nuclear localization of beta-catenin in anaplastic thyroid carcinoma
34. De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin
35. Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response
36. Analysis of beta-catenin gene mutations in pancreatic tumors
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38. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
39. A screen for identifying genes interacting with armadillo, the Drosophila homolog of beta-catenin
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42. Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin
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44. The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell
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46. Identification of c-MYC as a target of the APC pathway
47. Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos
48. A member of the Frizzled protein family mediating axis induction by Wnt-5A
49. The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates
50. Xenopus axin interacts with glycogen synthase kinase-3 beta and is expressed in the anterior midbrain
51. Regulation of glycogen synthase kinase 3β and downstream Wnt signaling by axin
52. A new secreted protein that binds to Wnt proteins and inhibits their activities
53. Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain
54. Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection
55. Nuclear localization of beta-catenin by interaction with transcription factor LEF-1
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57. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3β and β-catenin and promotes GSK-3β-dependent phosphorylation of β-catenin
58. The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF
59. Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and beta-catenin
60. Activation of the beta-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations
61. Somatic mutations of beta-catenin play a crucial role in the tumorigenesis of sporadic hepatoblastoma
62. Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas
63. Overexpression of Frat1 in transgenic mice leads to glomerulosclerosis and nephrotic syndrome, and provides direct evidence for the involvement of Frat1 in lymphoma progression
64. Familial adenomatous polyposis associated with multiple adrenal adenomas in a patient with a rare 3' APC mutation
65. Down-regulation of beta-catenin by the colorectal tumor suppressor APC requires association with Axin and beta-catenin
66. Identification of FAP locus genes from chromosome 5q21
67. DIX domains of Dv1 and axin are necessary for protein interactions and their ability to regulate beta-catenin stability
68. Mutations in beta-catenin are uncommon in colorectal cancer occurring in occasional replication error-positive tumors
69. Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene
70. Mutational activation of the beta-catenin proto-oncogene is a common event in the development of Wilms' tumors
71. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
72. Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC
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74. Turcot's syndrome: Evidence for linkage to the adenomatous polyposis coli (APC) locus
75. SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm
76. Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice
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78. Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity
79. Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors
80. Frzβ1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer
81. Axin and Frat1 interact with dv1 and GSK, bridging Dv1 to GSK in Wnt- mediated regulation of LEF-1
82. Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells
83. The cysteine-rich frizzled domain of Frzβ-1 is required and sufficient for modulation of Wnt signaling
84. Direct regulation of the Xenopus engrailed-2 promoter by the Wnt signaling pathway, and a molecular screen for Wnt-responsive genes, confirm a role for Wnt signaling during neural patterning in Xenopus
85. Oncogenic homeodomain transcription factor E2A-Pbxl activates a novel WNT gene in pre-B acute lymphoblastoid leukemia
86. SARPs: A family of secreted apoptosis-related proteins
87. MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans
88. Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway
89. Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer
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92. XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos
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96. Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients
97. Axin, an inhibitor of the Wnt signalling pathway, interacts with beta- catenin, GSK-3beta and APC and reduces the beta-catenin level
98. The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway
99. Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma
100. Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer
101. Dishevelled and armadillo act in the wingless signalling pathway in Drosophila
102. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
103. Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene
104. Evidence against dominant negative mechanisms of intestinal polyp formation by APC gene mutations
105. Mutations in the beta-catenin gene (CTNNB1) in endometrioid ovarian carcinomas
106. Frequent somatic mutations of the beta-catenin gene in intestinal-type gastric cancer
107. Wnt signaling in oncogenesis and embryogenesis - A look outside the nucleus
108. Amplification of the c-myc gene in human hepatocellular carcinoma: Biologic significance
109. Casein kinase I transduces Wnt signals
110. The oncogenic activation of beta-catenin
111. Nuclear localization and formation of beta-catenin-lymphoid enhancer factor 1 complexes are not sufficient for activation of gene expression
112. LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic
113. The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless
114. Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma
115. Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos
116. Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain
117. TCF transcription factors: Molecular switches in carcinogenesis
118. Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1
119. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors
120. Association of the APC gene product with βcatenin
121. Binding of GSK3β to the APC-β-catenin complex and regulation of complex assembly
122. Stabilization of beta-catenin by genetic defects in melanoma cell lines
123. Bridging of β-catenin and glycogen synthase kinase-3β by axin and inhibition of beta-catenin-mediated transcription
124. Casein kinase-1 epsilon in the wnt pathway: Regulation of beta-catenin function
125. Control of beta-catenin stability: Reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts
126. Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas
127. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
128. Familial infiltrative fibromatosis (desmoid tumours) (MIM135290) caused by a recurrent 3' APC gene mutation
129. Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A
130. Casein kinase II alpha transgene-induced murine lymphoma: Relation to theileriosis in cattle
131. Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner
132. The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression
133. Transformation by Wnt family proteins correlates with regulation of beta-catenin
134. MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans
135. A novel case of a sporadic desmoid tumour with mutation of the beta catenin gene
136. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
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139. Endogenous protein kinase CK2 (casein kinase II) participates in Wnt signaling in mammary epithelial cells
140. Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer
141. Multiple intestinal neolasia caused by a mutation in the murine homolog of the APC gene
142. Association of the APC tumor suppressor protein with catenins
143. The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression
144. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals
145. Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor)
146. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
147. A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin
148. Beta-catenin mutations are absent in hepatocellular carcinomas of SV40 T-antigen transgenic mice
149. Secreted frizzled-related protein-1 binds directly to Wingless and is a biphasic modulator of Wnt signaling
150. Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
151. Germline mutations in the 3' part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli
152. Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice
153. Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation
154. Adenomatous polyposis coli tumor suppressor protein has signaling acitivity in Xenopus laevis embryos resulting in the induction of an ectopic dorsoanterior axis
155. Beta-catenin mutations in human prostate cancer
156. Novel germline mutations in the APC gene and their phenotypic spectrum in familial adenomatous polyposis kindreds
157. Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling
158. Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8
159. Alterations of the PPP2R1B gene in human lung and colon cancer
160. Activation of beta-catenin in epithelial and mesenchymal hepatoblastomas
161. Casein kinase 2 associates with and phosphorylates dishevelled
162. A Drosophila Axin homolog, Daxin, inhibits Wnt signaling
163. Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex
164. Mechanisms of Wnt signaling in development
165. Differential transformation of mammary epithelial cells by Wnt genes
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167. APC genotype, polyp number, and surgical options in familial adenomatous polyposis
168. WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene
169. Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction
170. Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3β regulates its stability
171. A frizzled homolog functions in a vertebrate Wnt signaling pathway
172. The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
173. GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis
174. The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation
175. Regulation of Wnt signaling by Sox proteins: XSoxl7 alpha/beta and XSox3 physically interact with beta-catenin
176. Sporadic medulloblastomas contain oncogenic beta-catenin mutations