Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

Science

Volumn 306, Issue 5694, 2004, Pages 269-271

  Weng, Andrew P ^a,c   Ferrando, Adolfo A ^b   Lee, Woojoong ^a   Morris IV, John P ^b   Silverman, Lewis B ^b   Sanchez Irizarry, Cheryll ^a   Blacklow, Stephen C ^a   Look, A Thomas ^b   Aster, Jon C ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; MEMBRANES; MOLECULES;

MUTATIONS; TRANSLOCATIONS; TRANSMEMBRANES;

CHROMOSOMES;

MEMBRANE RECEPTOR; NOTCH1 RECEPTOR;

BIOLOGY; GENETICS;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CARBOXY TERMINAL SEQUENCE; DIMERIZATION; GENE ACTIVATION; HUMAN; HUMAN CELL; MUTATION; MUTATION RATE; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL PROCESSING; SIGNAL TRANSDUCTION; T CELL LEUKEMIA;

ADOLESCENT; ALLELES; AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CELL CYCLE; CELL LINE, TUMOR; CHILD; DIMERIZATION; ENDOPEPTIDASES; FRAMESHIFT MUTATION; HUMANS; LEUKEMIA, T-CELL, ACUTE; MOLECULAR SEQUENCE DATA; MUTATION; MUTATION, MISSENSE; POINT MUTATION; PROTEASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, NOTCH1; RECEPTORS, CELL SURFACE; SEQUENCE DELETION; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 5044225888     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1102160     Document Type: Article

References (27)

1. A. A. Ferrando et al., Cancer Cell 1, 75 (2002).
2. L. W. Ellisen et al., Cell 66, 649 (1991).
3. F. Radtke et al., Immunity 10, 547 (1999).
4. A. Wolfer, A. Wilson, M. Nemir, H. R. MacDonald, F. Radtke, Immunity 16, 869 (2002).
5. F. Logeat et al., Proc. Natl. Acad. Sci. U.S.A. 95, 8108 (1998).
6. M. D. Rand et al., Mol. Cell. Biol. 20, 1825 (2000).
7. C. Sanchez-Irizarry et al., Mol. Cell. Biol. in press.
8. R. Francis et al., Dev. Cell. 3, 85 (2002).
9. W. T. Kimberly et al., Proc. Natl. Acad. Sci. U.S.A. 100, 6382 (2003).
10. A. E. Wallberg, K. Pedersen, U. Lendahl, R. G. Roeder, Mol. Cell. Biol. 22. 7812 (2002).
11. C. J. Fryer, E. Lamar, I. Turbachova, C. Kintner, K. A. Jones, Genes Dev. 16, 1397 (2002).
12. Y. Nam, A. P. Weng, J. C. Aster, S. C. Blacklow, J. Biol. Chem. 278, 21232 (2003).
13. J. C. Aster et al., Mol. Cell. Biol. 20, 7505 (2000).
14. C. D. Hoemann, N. Beaulieu, L. Girard, N. Rebai, P. Jolicoeur, Mol. Cell. Biol. 20, 3831 (2000).
15. B. J. Feldman, T. Hampton, M. L. Cleary, Blood 96, 1906 (2000).
16. A. P. Weng et al., Mol. Cell. Biol. 23, 655 (2003).
17. Materials and methods are available as supporting material on Science Online.
18. H. Kramer, Sci. STKE 2000, pe1 (2000).
19. N. Gupta-Rossi et al., J. Biol. Chem. 276, 34371 (2001).
20. J. C. Aster, A. A. Ferrando, A. P. Weng, unpublished data.
21. L. M. Calvi et al., Nature 425, 841 (2003).
22. D. Allman et al., J. Exp. Med. 194, 99 (2001).
23. L. W. Berry, B. Westlund, T. Schedl, Development 124, 925 (1997).
24. C. H. Pui, M. V. Relling, J. R. Downing, N. Engl. J. Med. 350, 1535 (2004).
25. M. S. Wolfe, Nature Rev. Drug Discov. 1, 859 (2002).
26. G. T. Wong et al., J. Biol. Chem. 279, 12876 (2004).
27. We thank M. Wolfe for compound E and J.-P. Hezel for expert technical assistance. Supported by NIH grants CA82308 (J.C.A.), CA68484 and CA109901 (A.T.L.), CA94233 (S.C.B.), CA98093 (A.P.W.), and CA21765 (St. Jude Cancer Center). A.A.F. is a fellow of the Leukemia and Lymphoma Society.