E-cadherin suppresses cellular transformation by inhibiting β-catenin signaling in an adhesion-independent manner

Journal of Cell Biology

Volumn 153, Issue 5, 2001, Pages 1049-1059

  Gottardi, Cara J ^a   Wong, Ellen ^a   Gumbiner, Barry M ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Box 564 ^*  (United States)

Author keywords

catenin; Adhesion; E cadherin; T cell factor; Tumor suppressor

Indexed keywords

BETA CATENIN; UVOMORULIN;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL ADHESION; CELL GROWTH; CELL TRANSFORMATION; COLON CARCINOMA; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE ACTIVATION; GENE ACTIVITY; GENE CONSTRUCT; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTO ONCOGENE; SIGNAL TRANSDUCTION;

BETA CATENIN; BINDING SITES; CADHERINS; CELL ADHESION; CELL DIVISION; CELL NUCLEUS; CELL TRANSFORMATION, NEOPLASTIC; CYTOPLASM; CYTOSKELETAL PROTEINS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; GENES, TUMOR SUPPRESSOR; HUMANS; LYMPHOID ENHANCER-BINDING FACTOR 1; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SEQUENCE DELETION; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0035947772     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.153.5.1049     Document Type: Article

References (68)

1. Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development
2. Dissecting tumor cell invasion: Epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion
3. Functional interaction of β-catenin with the transcription factor LEF-1
4. Functional interaction of an axin homolog, conductin, with β-catenin, APC, and GSK3β
5. Cadherin expression in carcinomas: Role in the formation of cell junctions and the prevention of invasiveness
6. Lateral dimerization is required for the homophilic binding activity of C-cadherin
7. Contribution of cadherins to directional cell migration and histogenesis in Xenopus embryos
8. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
9. Expression of cell adhesion molecule E-cadherin in Xenopus embryos begins at gastrulation and predominates in the ectoderm
10. Armadillo is required for adherens junction assembly, cell polarity, and morphogenesis during Drosophila embryogenesis
11. The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors
12. A comparative evaluation of various invasion assays testing colon carcinoma cell lines
13. Cell contact-dependent signaling
14. Binding to cadherins antagonizes the signaling activity of β-catenin during axis formation in Xenopus
15. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells
16. The adherens junction
17. The Wnt/Wg signal transducer β-catenin controls fibronectin expression
18. A mode of regulation of β-catenin signaling activity in Xenopus embryos independent of its levels
19. E-cadherin germline mutations in familial gastric cancer
20. The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex
21. Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3 β
22. Identification of c-MYC as a target of the APC pathway
23. Overexpression of cadherins and underexpression of β-catenin inhibit dorsal mesoderm induction in early Xenopus embryos
24. Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration and provides evidence for nonautonomous regulation of cell fate in a self-renewing system
25. Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with β-catenin
26. Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain
27. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/-colon carcinoma
28. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
29. Disruption of gastrulation movements in Xenopus by a dominant-negative mutant for C-cadherin
30. How and when do tumor cells metastasize?
31. Induction of a secondary body axis in Xenopus by antibodies to β-catenin
32. Increased cell-substratum adhesion, and decreased gelatinase secretion and cell growth, induced by E-cadherin transfection of human colon carcinoma cells
33. XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos
34. A β-catenin/engrailed chimera selectively suppresses Wnt signaling
35. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
36. Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines
37. The roles of catenins in the cadherin-mediated cell adhesion: Functional analysis of E-cadherin-α-catenin fusion molecules
38. A role for the E-cadherin cell-cell adhesion molecule during tumor progression of mouse epidermal carcinogenesis
39. Catenin-dependent and -independent functions of vascular endothelial cadherin
40. A cell-free assay system for β-catenin signaling that recapitulates direct inductive events in the early Xenopus laevis embryo
41. Exogenous expression of β-catenin regulates contact inhibition, anchorage-independent growth, anoikis, and radiation-induced cell cycle arrest
42. A causal role for E-cadherin in the transition from adenoma to carcinoma
43. The oncogenic activation of β-catenin
44. Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the -catenin destruction complex in polarized epithelial cells
45. Regulation of E-cadherin/catenin association by tyrosine phosphorylation
46. A novel β-catenin binding protein inhibits β-catenin-dependent Tcf activation and axis formation
47. Uncoupling cadherin-based adhesion from wingless signalling in Drosophila
48. Biochemical interactions in the Wnt pathway
49. E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1)
50. A short core region of E-cadherin is essential for catenin binding and is highly phosphorylated
51. Inhibition of Wnt signaling by ICAT, a novel β-catenin-interacting protein
52. Cadherins in cancer: Implications for invasion and metastasis
53. Morphogenetic roles of classical cadherins
54. β-catenin regulates expression of cyclin D1 in colon carcinoma cells
55. Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion
56. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
57. Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
58. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
59. The C-terminal transactivation domain of β-catenin is necessary and sufficient for signaling by the LEF-1/β-catenin complex in Xenopus laevis
60. TCF is the nuclear effector of the β-catenin signal that patterns the sea urchin animal-vegetal axis
61. E-cadherin inactivation in lobular carcinoma in situ of the breast: An early event in tumorigenesis
62. Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line
63. Tumor suppressors: Linking cell polarity and growth control
64. Mechanisms of Wnt signaling in development
65. The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions
66. The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn
67. Wnt-1 induces growth, cytosolic β-catenin, and Tcf/Lef transcriptional activation in Rat-1 fibroblasts
68. β-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion