Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein

Neuropharmacology

Volumn 38, Issue 3, 1999, Pages 349-359

  Seabrook, G R ^a   Smith, D W ^a   Bowery, B J ^a   Easter, A ^a   Reynolds, T ^a   Fitzjohn, S M ^b   Morton, R A ^c   Zheng, H ^d   Dawson, G R ^a   Sirinathsinghji, D J S ^a   Davies, C H ^c   Collingridge, G L ^b   Hilla, R G ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Alzheimer's disease; Amyloid precursor protein; Biocytin; GABA; Long term potentiation; Synaptic plasticity

Indexed keywords

4 AMINOBUTYRIC ACID; AMYLOID PRECURSOR PROTEIN; BIOCYTIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIAL; GENE DISRUPTION; HIPPOCAMPUS; MORPHOLOGY; MOUSE; MOUSE STRAIN; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; SYNAPTIC TRANSMISSION;

AGING; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; DENDRITES; ELECTRIC STIMULATION; EXCITATORY POSTSYNAPTIC POTENTIALS; GLIOSIS; HIPPOCAMPUS; LONG-TERM POTENTIATION; MICE; MICE, KNOCKOUT; MICROTUBULE-ASSOCIATED PROTEINS; NEURONAL PLASTICITY; NEURONS; SYNAPSES;

EID: 0033012737     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(98)00204-4     Document Type: Article

References (27)

1. Citron, M., Westway, D., Xia, W., et al., 1997. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice. Nat. Med. 3, 67-72.
2. Dawson, G.R., Seabrook, G.R., Zheng, H., Smith, D.W., Graham, S., O'Dowd, G., Bowery, B.J., Boyce, S., Trumbauer, M.E., Chen, H.Y., Van der Ploeg, L.H.T., Sirinathsinghji D.J.S., 1998. Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the β-amyloid precursor protein. Neuroscience, (Submitted).
3. Davies, C.H., Collingridge, G.L., 1996. Regulation of EPSPs by the synaptic activation of GABAB autoreceptors in rat hippocampus. J. Physiol (Lond) 496, 451-470.
4. De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., Van Leuven, F., 1998. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391, 387-390.
5. Freund, T.F., Buzsaki, G., 1996. Interneurons of the hippocampus. Hippocampus 6, 347-470.
6. Games, D., Adams, D., Alessandrini, R., et al., 1995. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 373, 523-527.
7. Goate, A., Chartier-Harlin, M-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., Mant, R., Newton, P., Rooke, K., Roques, P., Talbot, C., Periack-Vance, M., Roses, A., Williamson, R., Rossor, M., Owen, M., Hardy, J., 1991. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature, 349, 704-706.
8. Hardy, J., 1997. Amyloid, the presenilins and Alzheimer's disease. Trends in Neurosci. 20 (4), 154-159.
9. Harper, S.J., Bilsland, J.G., Shearman, M.S., Zheng, H., Van der Ploog, L., Sirinathsinghji, D.J.S., 1998. Cortical neurones lacking APP are not impaired in their neurite outgrowth or survival in response to amyloid-β in vitro. NeuroReport 9, 3053-3058.
10. Howard, C.V., Cruz-Orive, L.M., Yaegashi, H., 1992. Estimating neuron dendritic length in 3D from total vertical projections and from vertical slices. Acta Neurol. Scand. 137, 1419.
11. Hsiao, K., Borchelt, D.R., Olson, K., Johannsdottir, R., Kitt, C., Yunis, W., Xu, S., Eckman, C., Younkin, S., Price, D., Iadecola, C., Clark, H.B., Carlson, G., 1995. Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor protein. Neuron 15, 1203-1218.
12. Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., Cole, G., 1996. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science 274, 99-102.
13. Johnson-Wood, K., Lee, M., Motter, R., Hu, K., Gordon, G., Barbour, R., Khan, K., Gordon, M., Tan, H., Games, D., Lieberburg, I., Checnk, D., Seubert, P., McConlogue, L., 1997. Amyloid precursor protein processing and Aβ42 deposition in a transgenic mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 94, 1550-1555.
14. Kammesheidt, A., Boyce, F.M., Spanoyannis, A.F., Cummings, B.J., Ortegon, M., Cotrnan, C., Vaught, J.L., Neve, R.L., 1992. Deposition of p/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxy-terminal fragment of the Alzheimer amyloid precursor protein. Proc. Natl. Acad. Sci. USA 89, 10857-10861.
15. Masliah, E., Mallory, M., Ge, N., Saitoh, T., 1992. Amyloid precursor protein is localised in growing neuntes of neonatal rat brain. Brain Res. 593, 323-328.
16. Milward, E.A., Papadopoulos, R., Fuller, S.J., Moir, R.D., Small, D., Beyreuther, K., Masters, C.L., 1992. The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth. Neuron 9, 129-137.
17. Moran, P.M., Higgins, L.S., Cordell, B., Moser, P.C., 1995. Age-related learning deficits intransgenic mice expressing the 751-amino acid isoform of human β-amyloid precursor protein. Proc. Natl. Acad. Sci. USA 92, 5341-5345.
18. Nalbantoglu, J., Tirado-Santiago, G., Lahsaini, A., Poirer, J., Goncalves, O., Verge, G., Momoli, F., Weiner, S.A., Massicotte, G., Julien, J-P., Shapirro, M.L., 1997. Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein. Nature 387, 500-505.
19. Perez, R.G., Zheng, H., Van der Ploog, L.H.T., Koo, E.H., 1997. The,0-amyloid precursor protein of Alzheimer's disease enahuces neuron viability and modulates neuronal polarity. J. Neurosci. 17, 9407-9414.
20. Qui, W.Q., Ferreira, A., Miller, C., Koo, E.H., Selkoe, D.J., 1995. Cell surface β-amyloid precursor protein stimulates neunte outgrowth of hippocampal neurons in an isoform dependent manner. J. Neurosci. 15, 2157-2167.
21. Rogaev, E., Sherrington, R., Rogaev, E.A., Levesque, G., Ikeda, M., Liang, Y., Chi, H., Lin, C., Holman, K., Tsuda, T., Mar, L., Sorbi, S., Nacmias, B., Piacentini, S., Amaducci, L., Chumakov, Cohen, D., Lannfelt, L., Fraser, P.E., Rommens, J.M., St George-Hyslop, P.H., 1996. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376, 775-778.
22. Saitoh, T., Sundsmo, M., Roch, J-M., Kimura, N., Cole, G., Schenck, D., 1989. Secreted form of amyloid,8 protein precursor is involved in the growth regulation of fibroblasts. Cell 58, 615-622.
23. Schubert, D., Jin, L-W., Saitoh, T., Cole, G. 1989. The regulation of amyloid β protein precursor secretion and its modulatory role in cell adhesion. Neuron 3, 689-694.
24. A receptor benzodiazopine site ligands. Neuropharmacology 36, 823-830.
25. Seabrook, G.R., Rosahl, T.W., 1998. Transgenic animals relevant to Alzbeimer's disease. Neuropharmacology, (in press).
26. Sherrington R., Rogaev, E.I., Liang, Y., Rogaev, E.A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., Tsuda, T., Mar, L., Foncin, J-F., Bruni, A.C., Montesi, M.P., Sorbi, S., Rainero, I., Pinessi, L., Nee, L., Chumakov, I., Pollen, D., Brookes, A., Sanseau, P., Polinsky, R.J., Wasco, W., Da Sliva, H.A.R., Haines, J.L., Periack-Vance, M.A., Tanzi, R.E., Roses, A.D., Fraser, P.E., Rommens, J.M., St George-Hyslop, P.H., (1995). Cloning of a gene bearing missense mutations in early onset familial Alzheimer's disease. Nature 375: 754-760.
27. Zheng, H., Jiang, M., Trumbauer, M., Sirinathsinghji, D.J.S., Hopkins, R., Smith, D.W., Heavens, R.P., Dawson, G.R., Boyce, S., Conner, M.W., Stevens, K.A., Slunt, H.H., Sisodia, S.S., Chen, H.Y., Van der Ploeg, L.H.T., 1995. β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 81, 525-531.