APP on the move

Trends in Molecular Medicine

Volumn 8, Issue 4, 2002, Pages 152-155

  Müller, Ulrike ^a   Kins, Stefan ^b  

^a MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; KINESIN; KINESIN 1 CARGO RECEPTOR; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; CAENORHABDITIS ELEGANS; CELL VIABILITY; DROSOPHILA MELANOGASTER; FAMILIAL DISEASE; GENE OVEREXPRESSION; HUMAN; MOLECULAR MECHANICS; PATHOPHYSIOLOGY; PHENOTYPE; PROTEIN ANALYSIS; SHORT SURVEY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; AXONAL TRANSPORT; AXONS; HUMANS; KINESIN; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NEURONS; PRESENILIN-1;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 0036219610     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(02)02320-1     Document Type: Short Survey

References (29)

1. Presenilins: Molecular switches between proteolysis and signal transduction
2. Axonal membrane proteins are transported in distinct carriers: A two-color video microscopy study in cultured hippocampal neurons
3. β-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
4. Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells
5. Hypersensitivity to seizures in β-amyloid precursor protein deficient mice
6. The Drosophila β-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction
7. Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members
8. Abnormal brain development in mice deficient in all three APP/APLP-family members
9. Proteolytic processing and cell biological functions of the amyloid precursor protein
10. Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I
11. Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila
12. Kinesin-mediated axonal transport of a membrane compartment containing β-secrotase and presenilin-1 requires APP
13. The C. elegans amyloid protein precursor-related gene has an essential function
14. What the evolution of the amyloid protein precursor supergene family tells us about its function
15. Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene
16. Transgenic Drosophila expressing human amyloid precursor protein show γ-secretase activity and a blistered-wing phenotype
17. Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport
18. Kinesin·dependent axonal transport is mediated by the sunday driver (SYD) protein
19. Kinesin carries the signal
20. All kinesin superfamily protein, KIF, genes in mouse and human
21. Principles of cargo attachment to cytoplasmic motor proteins
22. The β-amyloid domain is essential for axonal sorting of amyloid precursor protein
23. Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice
24. The cell biology of Alzheimer's disease: Uncovering the secrets of secretases
25. A transcriptionally [correction of transcriptively] active complex of APP with FE65 and histone acetyltransferase Tip60
26. The intracellular domain of the β-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner
27. Regulation of Kinesin: Implications for neuronal development
28. Cell cycle regulation of myosin-V by calcium/calmodulin-dependent protein kinase II
29. Kinesin molecular motors: Transport pathways, receptors, and human disease