Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

Nature Medicine

Volumn 6, Issue 11, 2000, Pages 1278-1281

  Varnum Finney, Barbara ^a   Xu, Lanwei ^b   Brashem Stein, Carolyn ^a   Nourigat, Cynthia ^a   Flowers, David ^a   Bakkour, Sonia ^b   Pear, Warren S ^b   Bernstein, Irwin D ^a,c  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH RECEPTOR;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; BONE MARROW; CELL IMMORTALIZATION; CELL LINEAGE; CELL RENEWAL; CELL SUBPOPULATION; CONTROLLED STUDY; HEMATOPOIETIC STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALS; B-LYMPHOCYTES; BONE MARROW CELLS; CELL LINE, TRANSFORMED; CELLS, CULTURED; CYTOKINES; GAMMA RAYS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INTERLEUKIN-11; LEUKOPOIESIS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; RECEPTOR, NOTCH1; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; THYMUS GLAND; TRANSCRIPTION FACTORS; TRANSFECTION;

ANIMALIA; INVERTEBRATA; VERTEBRATA;

EID: 0033694305     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/81390     Document Type: Article

References (27)

1. Notch signaling: Cell fate control and signal integration in development
2. Introduction: Notch signalling and choice of cell fates in development
3. Xotch, the Xenopus homolog of Drosophila notch
4. A homolog of Drosophila Notch expressed during mammalian development
5. Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development
6. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
7. Notch2: A second mammalian Notch gene
8. A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors
9. Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1
10. The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells
11. The human homolog of rat Jagged 1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1
12. Stromal expression of Jagged 1 promotes colony formation by fetal hematopoietic progenitor cells
13. Notch1-induced delay of human hematopoietic progenitor cell differentiation is associated with altered cell cycle kinetics
14. A soluble form of human delta-like-1 inhibits differentiation of hematopoietic progenitor cells
15. The Notch/Jagged pathway inhibits proliferation of human hematopoietic progenitors in vitro
16. Deficient T cell fate specification in mice with an induced inactivation of Notch1
17. Notch1 expression in early lymphopoiesis influences B versus T lineage determination
18. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
19. The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate
20. Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes
21. Lymphohematopoietic progenitors immortalized by a retroviral vector harboring a dominant-negative retinoic acid receptor can recapitulate lymphoid, myeloid, and erythroid development
22. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
23. Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors
24. Neoplastic transformation b truncated alleles of human Notch1/Tan1 and Notch2
25. Improved gene transfer into baboon marrow repopulating cells using recombinant human fibronectin fragment CH-296 in combination with interleukin-6, stem cell factor, FLT-3 ligand, and megakaryocyte growth and development factor
26. Efficient and rapid induction of a CML-like myeloproliferative disease in mice receiving BCR/abl transduced bone marrow
27. Embryonic lethality in mice homozygous for a processing deficient Notch1 allele