Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

Nature

Volumn 395, Issue 6703, 1998, Pages 698-702

  Zhang, Zhuohua ^a   Hartmann, Henrike ^a   Do, Viet Minh ^a   Abramowski, Dorothee ^b   Sturchler Pierrat, Christine ^b   Staufenbiel, Matthias ^b   Sommer, Bernd ^b   Van De Wetering, Marc ^c   Clevers, Hans ^c   Saftig, Paul ^d   De Strooper, Bart ^e   He, Xi ^a   Yankner, Bruce A ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d UNIVERSITY OF GÖTTINGEN   (Germany)

^e UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; PRESENILIN 1;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; DISEASE ASSOCIATION; GENE MUTATION; IMMUNOPRECIPITATION; MOUSE; NERVE CELL DEGENERATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; TRANSGENIC MOUSE;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; APOPTOSIS; BETA CATENIN; BRAIN; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL LINE; CYTOSKELETAL PROTEINS; ENDOPLASMIC RETICULUM; GLYCOGEN SYNTHASE KINASE 3; GOLGI APPARATUS; HUMANS; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; MUTATION; NEURONS; PRESENILIN-1; RATS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

ANIMALIA; MUS MUSCULUS;

EID: 0032531793     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/27208     Document Type: Article

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