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Volumn 12, Issue 2, 2003, Pages 110-120

No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the β-cleaved C-terminal APP fragment

Author keywords

Immunohistochemistry; Intraneuronal A ; Neurodegeneration; SPA4CT; Stereology; Synaptophysin; Transgenic; Western blot

Indexed keywords

AMYLOID PRECURSOR PROTEIN; PRION PROTEIN; SIGNAL PEPTIDE;

EID: 0344405773     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-9961(02)00015-3     Document Type: Article
Times cited : (38)

References (50)
  • 2
    • 0035203662 scopus 로고    scopus 로고
    • Key factors in Alzheimer's disease: Β-Amyloid precursor protein processing, metabolism and intraneuronal transport
    • Bayer T.A., Wirths O., Majtenyi K., Hartmann T., Multhaup G., Beyreuther K., Czech C. Key factors in Alzheimer's disease β-Amyloid precursor protein processing, metabolism and intraneuronal transport . Brain Pathol. 11:2001;1-11.
    • (2001) Brain Pathol. , vol.11 , pp. 1-11
    • Bayer, T.A.1    Wirths, O.2    Majtenyi, K.3    Hartmann, T.4    Multhaup, G.5    Beyreuther, K.6    Czech, C.7
  • 3
    • 0033586449 scopus 로고    scopus 로고
    • Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein
    • Berger-Sweeney J., McPhie D.L., Arters J.A., Greenan J., Oster-Granite M.L., Neve R.L. Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein. Mol. Brain Res. 66:1999;150-162.
    • (1999) Mol. Brain Res. , vol.66 , pp. 150-162
    • Berger-Sweeney, J.1    McPhie, D.L.2    Arters, J.A.3    Greenan, J.4    Oster-Granite, M.L.5    Neve, R.L.6
  • 7
    • 0026725908 scopus 로고
    • Membrane inserted APP fragments containing the beta A4 sequence of Alzheimer's disease do not aggregate
    • Dyrks T., Dyrks E., Masters C., Beyreuther K. Membrane inserted APP fragments containing the beta A4 sequence of Alzheimer's disease do not aggregate. FEBS Lett. 309:1992;20-24.
    • (1992) FEBS Lett. , vol.309 , pp. 20-24
    • Dyrks, T.1    Dyrks, E.2    Masters, C.3    Beyreuther, K.4
  • 9
    • 0027300915 scopus 로고
    • Selective neurotoxicity of COOH-terminal fragments of the beta-amyloid precursor protein
    • Fukuchi K., Sopher B., Furlong C.E., Smith A.C., Dang N., Martin G.M. Selective neurotoxicity of COOH-terminal fragments of the beta-amyloid precursor protein. Neurosci. Lett. 154:1993;145-148.
    • (1993) Neurosci. Lett. , vol.154 , pp. 145-148
    • Fukuchi, K.1    Sopher, B.2    Furlong, C.E.3    Smith, A.C.4    Dang, N.5    Martin, G.M.6
  • 10
    • 0021256895 scopus 로고
    • Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • Glenner G.G., Wong C.W. Alzheimer's disease initial report of the purification and characterization of a novel cerebrovascular amyloid protein . Biochem. Biophys. Res. Commun. 120:1984;885-890.
    • (1984) Biochem. Biophys. Res. Commun. , vol.120 , pp. 885-890
    • Glenner, G.G.1    Wong, C.W.2
  • 12
    • 0034966874 scopus 로고    scopus 로고
    • Presenilins as therapeutic targets for the treatment of Alzheimer's disease
    • Golde T.E., Younkin S.G. Presenilins as therapeutic targets for the treatment of Alzheimer's disease. Trends Mol. Med. 7:2001;264-269.
    • (2001) Trends Mol. Med. , vol.7 , pp. 264-269
    • Golde, T.E.1    Younkin, S.G.2
  • 14
    • 84985280160 scopus 로고
    • The efficiency of systematic sampling in stereology and its prediction
    • Gundersen H.J.G., Jensen E.B. The efficiency of systematic sampling in stereology and its prediction. J. Microsc. 147:1987;229-263.
    • (1987) J. Microsc. , vol.147 , pp. 229-263
    • Gundersen, H.J.G.1    Jensen, E.B.2
  • 18
    • 0037013327 scopus 로고    scopus 로고
    • Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis
    • Kienlen-Campard P., Miolet S., Tasiaux B., Octave J.N. Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis. J. Biol. Chem. 277:2002;15666-15670.
    • (2002) J. Biol. Chem. , vol.277 , pp. 15666-15670
    • Kienlen-Campard, P.1    Miolet, S.2    Tasiaux, B.3    Octave, J.N.4
  • 19
    • 0035004122 scopus 로고    scopus 로고
    • Neuron loss during early adulthood following prenatal low-dose X-irradiation in the mouse brain
    • Korr H., Rohde H.T., Benders J., Dafotakis M., Grolms N., Schmitz C. Neuron loss during early adulthood following prenatal low-dose X-irradiation in the mouse brain. Int. J. Radiat. Biol. 77:2001;567-580.
    • (2001) Int. J. Radiat. Biol. , vol.77 , pp. 567-580
    • Korr, H.1    Rohde, H.T.2    Benders, J.3    Dafotakis, M.4    Grolms, N.5    Schmitz, C.6
  • 20
    • 0026608990 scopus 로고
    • The neurotoxic corboxy-terminal fragment of the Alzheimer amyloid precursor binds to a neuronal cell surface molecule: PH dependence of the neurotoxicity and the binding
    • Kozlowski M.R., Spanoyannis A., Manly S.P., Fidel S.A., Neve R.L. The neurotoxic corboxy-terminal fragment of the Alzheimer amyloid precursor binds to a neuronal cell surface molecule pH dependence of the neurotoxicity and the binding . J. Neurosci. 12:1992;1679-1687.
    • (1992) J. Neurosci. , vol.12 , pp. 1679-1687
    • Kozlowski, M.R.1    Spanoyannis, A.2    Manly, S.P.3    Fidel, S.A.4    Neve, R.L.5
  • 22
  • 23
    • 0032981558 scopus 로고    scopus 로고
    • Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein
    • Lichtenthaler S.F., Wang R., Grimm H., Uljon S.N., Masters C.L., Beyreuther K. Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein. Proc. Natl. Acad. Sci. USA. 96:1999;3053-3058.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 3053-3058
    • Lichtenthaler, S.F.1    Wang, R.2    Grimm, H.3    Uljon, S.N.4    Masters, C.L.5    Beyreuther, K.6
  • 25
    • 0032874960 scopus 로고    scopus 로고
    • PC12 cells transfected with a C-terminal fragment of the amyloid precursor protein (APP C-100), exhibit enhanced sensitivity to the calcium ionophore A23187, and diminished sensitivity to hydrogen peroxide
    • McKeon-O'Malley C., Wells J., Fine R., Ullman M.D., Volicer L. PC12 cells transfected with a C-terminal fragment of the amyloid precursor protein (APP C-100), exhibit enhanced sensitivity to the calcium ionophore A23187, and diminished sensitivity to hydrogen peroxide. Mol. Brain Res. 72:1999;103-107.
    • (1999) Mol. Brain Res. , vol.72 , pp. 103-107
    • McKeon-O'Malley, C.1    Wells, J.2    Fine, R.3    Ullman, M.D.4    Volicer, L.5
  • 26
    • 0035900875 scopus 로고    scopus 로고
    • Beta-secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations
    • McPhie D.L., Golde T., Eckman C.B., Yager D., Brant J.B., Neve R.L. Beta-secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations. Mol. Brain Res. 97:2001;103-113.
    • (2001) Mol. Brain Res. , vol.97 , pp. 103-113
    • McPhie, D.L.1    Golde, T.2    Eckman, C.B.3    Yager, D.4    Brant, J.B.5    Neve, R.L.6
  • 27
    • 0026907151 scopus 로고
    • A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid
    • Mullan M., Crawford F., Axelman K., Houlden H., Lilius L., Winblad B., Lannfelt L. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid. Nature Genet. 1:1992;345-347.
    • (1992) Nature Genet. , vol.1 , pp. 345-347
    • Mullan, M.1    Crawford, F.2    Axelman, K.3    Houlden, H.4    Lilius, L.5    Winblad, B.6    Lannfelt, L.7
  • 28
    • 0029862137 scopus 로고    scopus 로고
    • Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein
    • Oster-Granite M.L., McPhie D.L., Greenan J., Neve R.L. Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein. J. Neurosci. 16:1996;6732-6741.
    • (1996) J. Neurosci. , vol.16 , pp. 6732-6741
    • Oster-Granite, M.L.1    McPhie, D.L.2    Greenan, J.3    Neve, R.L.4
  • 30
    • 0030754865 scopus 로고    scopus 로고
    • Neurodegeneration and gliosis in transgenic mice overexpressing a carboxy-terminal fragment of Alzheimer amyloid-beta protein precursor
    • Sato M., Kawarabayashi T., Shoji M., Kobayashi T., Tada N., Matsubara E., Hirai S. Neurodegeneration and gliosis in transgenic mice overexpressing a carboxy-terminal fragment of Alzheimer amyloid-beta protein precursor. Dement. Geriatr. Cogn. Disord. 8:1997;296-307.
    • (1997) Dement. Geriatr. Cogn. Disord. , vol.8 , pp. 296-307
    • Sato, M.1    Kawarabayashi, T.2    Shoji, M.3    Kobayashi, T.4    Tada, N.5    Matsubara, E.6    Hirai, S.7
  • 32
    • 0031671811 scopus 로고    scopus 로고
    • Variation of fractionator estimates and its prediction
    • Schmitz C. Variation of fractionator estimates and its prediction. Anat. Embryol. 198:1998;371-397.
    • (1998) Anat. Embryol. , vol.198 , pp. 371-397
    • Schmitz, C.1
  • 33
    • 0033042975 scopus 로고    scopus 로고
    • Age-related changes of DNA repair and mitochondrial DNA synthesis in the mouse brain
    • Schmitz C., Axmacher B., Zunker U., Korr H. Age-related changes of DNA repair and mitochondrial DNA synthesis in the mouse brain. Acta Neuropathol. 97:1999;71-81.
    • (1999) Acta Neuropathol. , vol.97 , pp. 71-81
    • Schmitz, C.1    Axmacher, B.2    Zunker, U.3    Korr, H.4
  • 34
    • 0344603638 scopus 로고    scopus 로고
    • Neuron loss in the mouse hippocampus following prenatal injection of tritiated thymidine or saline
    • Schmitz C., Bultmann E., Gube M., Korr H. Neuron loss in the mouse hippocampus following prenatal injection of tritiated thymidine or saline. Int. J. Dev. Neurosci. 17:1999;185-190.
    • (1999) Int. J. Dev. Neurosci. , vol.17 , pp. 185-190
    • Schmitz, C.1    Bultmann, E.2    Gube, M.3    Korr, H.4
  • 35
    • 0033295451 scopus 로고    scopus 로고
    • Cell-type-specific differences in age-related changes of DNA repair in the mouse brain - Molecular basis for a new approach to understand the selective neuronal vulnerability in Alzheimer's disease
    • Schmitz C., Materne S., Korr H. Cell-type-specific differences in age-related changes of DNA repair in the mouse brain - Molecular basis for a new approach to understand the selective neuronal vulnerability in Alzheimer's disease. J. Alzheimer's Dis. 1:1999;387-407.
    • (1999) J. Alzheimer's Dis. , vol.1 , pp. 387-407
    • Schmitz, C.1    Materne, S.2    Korr, H.3
  • 36
    • 0033789892 scopus 로고    scopus 로고
    • Recommendations for straightforward and rigorous methods of counting neurons based on a computer simulation approach
    • Schmitz C., Hof P.R. Recommendations for straightforward and rigorous methods of counting neurons based on a computer simulation approach. J. Chem. Neuroanat. 20:2000;93-114.
    • (2000) J. Chem. Neuroanat. , vol.20 , pp. 93-114
    • Schmitz, C.1    Hof, P.R.2
  • 37
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • Selkoe D.J. Alzheimer's disease genes, proteins, and therapy . Physiol. Rev. 81:2001;741-766.
    • (2001) Physiol. Rev. , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 39
    • 0027971254 scopus 로고
    • Cytotoxicity mediated by conditional expression of a carboxyl-terminal derivative of the beta-amyloid precursor protein
    • Sopher B.L., Fukuchi K., Smith A.C., Leppig K.A., Furlong C.E., Martin G.M. Cytotoxicity mediated by conditional expression of a carboxyl-terminal derivative of the beta-amyloid precursor protein. Mol. Brain Res. 26:1994;207-217.
    • (1994) Mol. Brain Res. , vol.26 , pp. 207-217
    • Sopher, B.L.1    Fukuchi, K.2    Smith, A.C.3    Leppig, K.A.4    Furlong, C.E.5    Martin, G.M.6
  • 40
    • 0030946552 scopus 로고    scopus 로고
    • An etiological role of amyloidogenic carboxyl-terminal fragments of the beta-amyloid precursor protein in Alzheimer's disease
    • Suh Y.H. An etiological role of amyloidogenic carboxyl-terminal fragments of the beta-amyloid precursor protein in Alzheimer's disease. J. Neurochem. 68:1997;1781-1791.
    • (1997) J. Neurochem. , vol.68 , pp. 1781-1791
    • Suh, Y.H.1
  • 41
    • 0033694131 scopus 로고    scopus 로고
    • Roles of A beta and carboxyl terminal peptide fragments of amyloid precursor protein in Alzheimer disease
    • Suh Y.H., Kim H.S., Lee J.P., Park C.H., Jeong S.J., Kim S.S., Rah J.C., Seo J.H., Kim S.S. Roles of A beta and carboxyl terminal peptide fragments of amyloid precursor protein in Alzheimer disease. J. Neural Transm. 58:(Suppl):2000;65-82.
    • (2000) J. Neural Transm , vol.58 , Issue.SUPPL. , pp. 65-82
    • Suh, Y.H.1    Kim, H.S.2    Lee, J.P.3    Park, C.H.4    Jeong, S.J.5    Kim, S.S.6    Rah, J.C.7    Seo, J.H.8    Kim, S.S.9
  • 43
    • 0033793772 scopus 로고    scopus 로고
    • Perinatal asphyxia results in changes in presynaptic bouton number in striatum and cerebral cortex - A stereological and behavioral analysis
    • Van de Berg W.D.J., Blokland A., Cuello A.C., Schmitz C., Vreuls W., Steinbusch H.W.M., Blanco C.E. Perinatal asphyxia results in changes in presynaptic bouton number in striatum and cerebral cortex - A stereological and behavioral analysis. J. Chem. Neuroanat. 20:2000;71-82.
    • (2000) J. Chem. Neuroanat. , vol.20 , pp. 71-82
    • Van de Berg, W.D.J.1    Blokland, A.2    Cuello, A.C.3    Schmitz, C.4    Vreuls, W.5    Steinbusch, H.W.M.6    Blanco, C.E.7
  • 44
    • 0033623415 scopus 로고    scopus 로고
    • Abeta-generating enzymes: Recent advances in beta- and gamma-secretase research
    • Vassar R., Citron M. Abeta-generating enzymes recent advances in beta- and gamma-secretase research . Neuron. 27:2000;419-422.
    • (2000) Neuron , vol.27 , pp. 419-422
    • Vassar, R.1    Citron, M.2
  • 46
    • 0024550204 scopus 로고
    • Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein
    • Weidemann A., Konig G., Bunke D., Fischer P., Salbaum J.M., Masters C.L., Beyreuther K. Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell. 57:1989;115-126.
    • (1989) Cell , vol.57 , pp. 115-126
    • Weidemann, A.1    Konig, G.2    Bunke, D.3    Fischer, P.4    Salbaum, J.M.5    Masters, C.L.6    Beyreuther, K.7
  • 49
    • 0031937121 scopus 로고    scopus 로고
    • Synaptic numbers across cortical laminae and cognitive performance of the rat during ageing
    • Wong T.P., Campbell P.M., Ribeiro-da-Silva A., Cuello A. Synaptic numbers across cortical laminae and cognitive performance of the rat during ageing. Neuroscience. 84:1998;403-412.
    • (1998) Neuroscience , vol.84 , pp. 403-412
    • Wong, T.P.1    Campbell, P.M.2    Ribeiro-da-Silva, A.3    Cuello, A.4


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