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Variant exons v6 and v7 together expand the repertoire of glycosaminoglycans bound by CD44
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Sleeman, J., Kondo, K., Moll, J., Ponta, H. & Herrlich, P. Variant exons v6 and v7 together expand the repertoire of glycosaminoglycans bound by CD44. J. Biol. Chem. 272, 31837-31844 (1997).
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Skelton, T. P., Zeng, C., Nocks, A. & Stamenkovic, I. Glycosylation provides both stimulatory and inhibitory effects on cell surface and soluble CD44 binding to hyaluronan. J. Cell Biol. 140, 431-446 (1998). This study provides a detailed analysis of the effect of glycosylation on CD44 binding to hyaluronan.
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Antibody-induced activation of the hyaluronan receptor function of CD44 requires multivalent binding by antibody
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Lesley, J., Kincade, P. W. & Hyman, R. Antibody-induced activation of the hyaluronan receptor function of CD44 requires multivalent binding by antibody. Eur. J. Immunol. 23, 1902-1909 (1993).
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CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration
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König, H., Ponta, H. & Herrlich, P. Coupling of signal transduction to alternative pre-mRNA splicing by a composite splice regulator EMBO J. 10, 2904-2913 (1998). This paper presents the first evidence for Ras-dependent splice regulation and the cis-elements responsible.
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CD44 isoforms containing exon v3 are responsible for the presentation of heparin-binding growth factor
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Bennett, K. L. et al. CD44 isoforms containing exon v3 are responsible for the presentation of heparin-binding growth factor. J. Cell Biol. 128, 687-698 (1995). Reference 15 shows that heparan-sulphate modification on the CD44 exon v3 allows binding of heparin-binding growth factors.
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A splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb outgrowth
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Sherman, L., Wainwright, D., Ponta, H. & Herrlich, P. A splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb outgrowth. Genes Dev. 12, 1058-1071 (1998). This report shows that presentation of fibroblast growth factors by a heparan-sulphate-modified CD44 variant is required for limb development.
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CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling
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Yu, W. H., Woessner J. F. Jr, McNeish, J. D. & Stamenkovic, I. CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling. Genes Dev. 16, 307-323 (2002).
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Phorbol myristate acetate stimulates the dimenzation of CD44 involving a cysteine in the transmembrane domain
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Liu, D. & Sy, M. S. Phorbol myristate acetate stimulates the dimenzation of CD44 involving a cysteine in the transmembrane domain. J. Immunol. 159, 2702-2711 (1997).
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CD44 exhibits a cell type dependent interaction with triton X-100 insoluble, lipid rich, plasma membrane domains
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Neame, S. J., Uff, C. R., Sheikh, H., Wheatley, S. C. & Isacke, C. M. CD44 exhibits a cell type dependent interaction with triton X-100 insoluble, lipid rich, plasma membrane domains. J. Cell Sci. 108, 3127-3135 (1995).
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20
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Perschl, A., Lesley, J., English, N., Hyman, R. & Trowbridge, I. S. Transmembrane domain of CD44 is required for its detergent insolubility in fibroblasts. J. Cell Sci. 108, 1033-1041 (1995).
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ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons
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Tsukita, S., Oishi, K., Sato, N., Sagara, J. & Kawai, A. ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons. J. Cell Biol. 126, 391-401 (1994). This paper shows that ERM proteins link the cytoskeleton to the plasma membrane by binding to CD44.
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Legg, J. W. & Isacke, C. M. Identification and functional analysis of the ezrin-binding site in the hyaluronan receptor, CD44. Curr. Biol. 8, 705-708 (1998).
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Ezrin/redixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2
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Yonemura, S. et al. Ezrin/redixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. J. Cell. Biol. 140, 885-895 (1998).
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2- and calmodulin. Implications for modulation of CD44-ankyrin interaction. J. Biol. Chem. 272, 30322-30328 (1997).
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Legg, J. W., Lewis, C. A., Parsons, M., Ng, T. & Isacke, C. M. A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility. Nature Cell Biol. 4, 399-407 (2002). This study shows that site-specific serine phosphorylation of CD44 determines ezrin binding.
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Neame, S. J. & Isacke, C. M. Phosphorylation of CD44 in vivo requires both Ser323 and Ser325, but does not regulate membrane localization or cytoskeletal interaction in epithelial cells. EMBO J. 11, 4733-4738 (1992).
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Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells
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Bourguignon, L. Y., Zhu, H., Shao, L., Zhu, D. & Chen, Y. W. Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells. Cell. Motil. Cytoskeleton 43, 269-287 (1999).
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Schmits, R. et al. CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Blood 90, 2217-2233 (1997). This paper reports the disruption of the CD44 gene in the mouse.
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CD44-deficient mice develop normally with changes in subpopulations and recirculation of lymphocyte subsets
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Protin, U., Schweighoffer, T., Jochum, W. & Hilberg, F. CD44-deficient mice develop normally with changes in subpopulations and recirculation of lymphocyte subsets. J. Immunol. 163, 4917-4923 (1999).
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Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 vanant exon 7 (CD44v7)
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Wittig, B. M., Johansson, B., Zoller, M., Schwarzler, C. & Gunthert, U. Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 vanant exon 7 (CD44v7) J. Exp. Med. 191, 2053-2064 (2000).
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Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation
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Kaya, G., Rodriguez, I., Jorcano, J. L., Vassalli, P. & Stamenkovic, I. Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation Genes Dev. 11, 996-1007 (1997). So far, this is the only work to show the 'conditional' inactivation of CD44 (by CD44 antisense sequence expression in skin).
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41
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Cutaneous delayed-type hypersensitivity response is inhibited in transgenic mice with keratinocyte-specific CD44 expression defect
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Kaya, G., Rodriguez, I., Jorcano, J. L., Vassalli, P. & Stamenkovic, I. Cutaneous delayed-type hypersensitivity response is inhibited in transgenic mice with keratinocyte-specific CD44 expression defect. J. Invest. Dermatol. 113, 137-138 (1999).
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CD44-deficient mice exhibit enhanced hepatitis after concanavalin A injection: Evidence for involvement of CD44 in activation-induced cell death
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Chen, D. et al. CD44-deficient mice exhibit enhanced hepatitis after concanavalin A injection: evidence for involvement of CD44 in activation-induced cell death. J. Immunol. 166, 5889-5897 (2001).
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Chen, D.1
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CD44 is the physiological trigger of Fas up-regulation on rheumatoid synovial cells
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Fujii, K., Fujii, Y., Hubscher, S. & Tanaka, Y. CD44 is the physiological trigger of Fas up-regulation on rheumatoid synovial cells. J. Immunol. 167, 1198-1203 (2001).
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CD95 (Fas) may control the expansion of activated T cells after elimination of bacteria in murine listeriosis
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Fuse, Y., Nishimura, H., Maeda, K. & Yoshikai, Y. CD95 (Fas) may control the expansion of activated T cells after elimination of bacteria in murine listeriosis. Infect. Immun. 65, 1883-1891 (1997).
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Rafi-Janajreh, A. Q. et al. Evidence for the involvement of CD44 in endothelial cell injury and induction of vascular leak syndrome by IL-2. J. Immunol. 163, 1619-1627 (1999).
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Cuff, C. A. et al. The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation. J. Clin. Invest. 108, 1031-1040 (2001).
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