Modulation of Notch processing by γ-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation

Toxicological Sciences

Volumn 82, Issue 1, 2004, Pages 341-358

  Milano, Joseph ^a   McKay, Jenny ^a   Dagenais, Claude ^a   Foster Brown, Linda ^a   Pognan, Francois ^a   Gadient, Reto ^a   Jacobs, Robert T ^a   Zacco, Anna ^a   Greenberg, Barry ^a   Ciaccio, Paul J ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Secretase; Adipsin; Atonal; Hes1; Intestinal goblet metaplasia; NICD; Notch intracellular domain; Notch receptor; Rath1

Indexed keywords

ADIPSIN; AMYLOID PRECURSOR PROTEIN; ARYLSULFONIC ACID DERIVATIVE; BENZODIAZEPINE; CHOLECYSTOKININ; CHROMOGRANIN A; CHROMOGRANIN B; DIBENZAZEPINE DERIVATIVE; GAMMA SECRETASE INHIBITOR; GASTRIN; GLYCOPROTEIN P; MESSENGER RNA; MUCIN; NOTCH RECEPTOR; SECRETIN; SOMATOSTATIN;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD SAMPLING; CELL CULTURE; CELL MEMBRANE PERMEABILITY; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE SEVERITY; GENE EXPRESSION PROFILING; GENE INDUCTION; GOBLET CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INTESTINE METAPLASIA; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; TRANSCRIPTION INITIATION; TRANSGENIC MOUSE; UNINDEXED SEQUENCE; WESTERN BLOTTING;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; APOPTOSIS; ASPARTIC ENDOPEPTIDASES; BENZODIAZEPINES; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL LINE, TUMOR; DIBENZAZEPINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPEPTIDASES; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GOBLET CELLS; HUMANS; MALE; METAPLASIA; RATS; RATS, WISTAR; RECEPTOR, NOTCH1; RECEPTORS, CELL SURFACE; RNA, MESSENGER; SIGNAL TRANSDUCTION; SULFONAMIDES; TRANSCRIPTION FACTORS;

ANIMALIA; RATTUS NORVEGICUS;

EID: 8444247084     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh254     Document Type: Article

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