Sulindac sulfide is a noncompetitive γ-secretase inhibitor that preferentially reduces Aβ42 generation

Journal of Biological Chemistry

Volumn 278, Issue 20, 2003, Pages 18664-18670

  Takahashi, Yasuko ^a   Hayashi, Ikuo ^a   Tominari, Yusuke ^a   Rikimaru, Kentaro ^a   Morohashi, Yuichi ^a   Kan, Toshiyuki ^a   Natsugari, Hideaki ^a   Fukuyama, Tohru ^a   Tomita, Taisuke ^a   Iwatsubo, Takeshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; CELL CULTURE; CELL MEMBRANES; DRUG PRODUCTS; FLAMMABILITY;

CELL INHIBITIONS;

BIOCHEMICAL ENGINEERING;

3 [(3 CHOLAMIDOPROPYL)DIMETHYLAMMONIO] 2 HYDROXY 1 PROPANESULFONIC ACID; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; NONSTEROID ANTIINFLAMMATORY AGENT; NOTCH RECEPTOR; SULINDAC SULFIDE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; COMPLEMENTARY DNA; DRUG DERIVATIVE; MEMBRANE PROTEIN; NAPROXEN; PEPTIDE; PEPTIDE FRAGMENT; PROTEINASE; SECRETASE; SULINDAC;

ALZHEIMER DISEASE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVITY; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; CELL CULTURE; CHEMISTRY; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; METABOLISM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE;

AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPARTIC ENDOPEPTIDASES; CELLS, CULTURED; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPEPTIDASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HELA CELLS; HUMANS; MEMBRANE PROTEINS; NAPROXEN; PEPTIDE FRAGMENTS; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, NOTCH; SULINDAC;

EID: 0038719688     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M301619200     Document Type: Article

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