PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: Effects of FAD mutations

EMBO Journal

Volumn 23, Issue 13, 2004, Pages 2586-2596

  Baki, Lia ^a   Shioi, Junichi ^a   Wen, Paul ^a   Shao, Zhiping ^a   Schwarzman, Alexander ^b   Gama Sosa, Miguel ^a   Neve, Rachael ^c   Robakis, Nikolaos K ^a,d  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d NEW YORK UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; Cadherin; PBK; Presenilin; Tau

Indexed keywords

GAMMA SECRETASE; GLYCOGEN SYNTHASE KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PRESENILIN 1; PROTEIN KINASE B; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; ENZYME ACTIVATION; GENE MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ALZHEIMER DISEASE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CADHERINS; CARBAMATES; CELL LINE, TRANSFORMED; CELL SURVIVAL; CELL TRANSFORMATION, VIRAL; DIPEPTIDES; ENZYME ACTIVATION; ENZYME INHIBITORS; FIBROBLASTS; FLOW CYTOMETRY; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MUTATION; PHOSPHORYLATION; PRECIPITIN TESTS; PRESENILIN-1; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIMPLEXVIRUS; TAU PROTEINS;

ANIMALIA;

EID: 3343005434     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600251     Document Type: Article

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