A γ-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

EMBO Reports

Volumn 3, Issue 7, 2002, Pages 688-694

  Geling, Andrea ^a   Steiner, Harald ^a   Willem, Michael ^a   Bally Cuif, Laure ^a   Haass, Christian ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,2-DILINOLENOYL-3-(4-AMINOBUTYRYL)PROPANE-1,2,3-TRIOL; 3 (4 AMINOBUTYRYL) 1,2 DILINOLENOYLGLYCEROL; 4 AMINOBUTYRIC ACID; AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; DRUG DERIVATIVE; ENZYME INHIBITOR; MEMBRANE PROTEIN; MESSENGER RNA; NOTCH RECEPTOR; PRESENILIN 1; PROTEINASE; PSEN1 PROTEIN, HUMAN; SECRETASE; TRIACYLGLYCEROL; ALPHA SECRETASE; AMYLOID BETA PROTEIN; PRESENILIN 2;

ALZHEIMER DISEASE; ANIMAL; ARTICLE; CELL LINE; CHEMISTRY; DRUG EFFECT; HUMAN; IN SITU HYBRIDIZATION; METABOLISM; MICROINJECTION; MORPHOGENESIS; PHENOTYPE; PHYSIOLOGY; PRENATAL DEVELOPMENT; SIGNAL TRANSDUCTION; ZEBRA FISH; ANIMAL CELL; ANIMAL TISSUE; BIOCHEMISTRY; CELL FATE; CELL STRUCTURE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN CELL; IN VIVO STUDY; INHIBITION KINETICS; MOLECULAR MECHANICS; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; VERTEBRATE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BODY PATTERNING; CELL LINE; ENDOPEPTIDASES; ENZYME INHIBITORS; GAMMA-AMINOBUTYRIC ACID; HUMANS; IN SITU HYBRIDIZATION; MEMBRANE PROTEINS; MICROINJECTIONS; PHENOTYPE; PRESENILIN-1; RECEPTORS, NOTCH; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRIGLYCERIDES; ZEBRAFISH; ANIMAL; HUMAN; SUPPORT, NON-U.S. GOV'T;

ANIMALIA; DANIO RERIO; VERTEBRATA;

EID: 0036023971     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kvf124     Document Type: Article

References (56)

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