Adipsin, a Biomarker of Gastrointestinal Toxicity Mediated by a Functional γ-Secretase Inhibitor

Journal of Biological Chemistry

Volumn 278, Issue 46, 2003, Pages 46107-46116

  Searfoss, George H ^a   Jordan, William H ^a   Calligaro, David O ^a   Galbreath, Elizabeth J ^a   Schirtzinger, Linda M ^a   Berridge, Brian R ^a   Gao, Hong ^a   Higgins, Marnie A ^a   May, Patrick C ^a   Ryan, Timothy P ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMARKERS; CELL MEMBRANES; GENES; IMMUNOLOGY; POLYPEPTIDES; SIGNALING; TOXICITY;

GASTROINTESTINAL CONTENTS;

PROTEINS;

ADIPSIN; AMYLOID PRECURSOR PROTEIN; BIOLOGICAL MARKER; ENZYME INHIBITOR; GAMMA SECRETASE; MEMBRANE PROTEIN; NOTCH RECEPTOR; NOTCH1 RECEPTOR; REGULATOR PROTEIN; TRANSCRIPTION FACTOR HES 1; UNCLASSIFIED DRUG;

ADIPOCYTE; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL DIFFERENTIATION; CELL FATE; CELL POPULATION; CONTROLLED STUDY; CRYPT CELL; DNA MICROARRAY; DOWN REGULATION; FECES; GASTROINTESTINAL TOXICITY; GENE DISRUPTION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; ILEUM; IMMUNOHISTOCHEMISTRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN PROCESSING; RAT; SIGNAL TRANSDUCTION;

3T3-L1 CELLS; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BASE SEQUENCE; BINDING SITES; CELL DIFFERENTIATION; COMPLEMENT FACTOR D; DIGESTIVE SYSTEM; DOWN-REGULATION; ENDOPEPTIDASES; ENZYME INHIBITORS; ILEUM; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; MICE; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS (GENETICS); RATS; RECEPTORS, NOTCH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION, GENETIC; UP-REGULATION;

ANIMALIA;

EID: 0242412482     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M307757200     Document Type: Article

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