Neurodegeneration and gliosis in transgenic mice overexpressing a carboxy-terminal fragment of alzheimer amyloid-β protein precursor

Dementia and Geriatric Cognitive Disorders

Volumn 8, Issue 5, 1997, Pages 296-307

  Sato, Masahiro ^a,c   Kawarabayashi, Takeshi ^b   Shoji, Mikio ^b   Kobayashi, Takashi ^a   Tada, Norihiro ^a,d   Matsubara, Etsuro ^b   Hirai, Shunsaku ^b  

^a SANOFI   (France)

^b GUNMA UNIVERSITY   (Japan)

^c TOKAI UNIVERSITY   (Japan)

^d TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Alzheimer s disease; Gliosis; Neurodegeneration; Actin promoter

Indexed keywords

AMYLOID BETA PROTEIN; BETA ACTIN; MESSENGER RNA; PROTEIN PRECURSOR; SYNAPTOPHYSIN;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CARBOXY TERMINAL SEQUENCE; CHICKEN; CYTOMEGALOVIRUS; ENHANCER REGION; GLIOSIS; HIPPOCAMPUS; HYDROCEPHALUS; MOUSE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; BRAIN CHEMISTRY; FEMALE; FERTILIZATION IN VITRO; GENETIC VECTORS; GLIOSIS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, TRANSGENIC; NERVE DEGENERATION; PEPTIDE FRAGMENTS;

EID: 0030754865     PISSN: 14208008     EISSN: 14219824     Source Type: Journal    
DOI: 10.1159/000106647     Document Type: Article

References (44)

1. Sclkoc DJ: Normal and abnormal biology of the beta-amyloid precursor protein, Annu Rev Neurosci 1994;17:489-517.
2. Glenner GG, Wong CW: Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein, Biochem Biophys Res Commun 1984; 120:885-890.
3. Masters CL, Simms G, Weinman NA, Mul-thaup G, McDonald BL, Beyreuther K: Amyloid plaque core protein in Alzheimer’s disease and Down’s syndrome, Proc Natl Acad Sei USA 1985;82:4245-4249.
4. Kang J, Lemaire H-G, Unterbeck A, Salbaum JM, Masters CL, Grezeschik KH, Multhaup G, Beyreuther K, Müller-Hill B: The precursor of Alzheimer’s disease amyloid A4 protein resembles a ccll-surface receptor, Nature 1987;325: 733-736.
5. Selkoe DJ, Podlisny MB, Joachim CL, Vickers EA, Lee G, Fritz L, Oltcrsdorf T: P-Amyloid precursor protein occur as 110 to 135 kilodal-ton membrane-associated proteins in neural and nonneuronal tissues, Proc Natl Acad Sei USA 1988;85:7341-7345.
6. Saitoh T, Sundsmo M, Roch J-M, Kimura N, Cole G, Schubcr D, Oltcrsdorf T, Schenk D: Secreted form of amyloid p protein precursors is involved in the growth regulation of fibroblasts, Cell 1989;58:615-622.
7. Mihvard EA, Papadopoulos R, Fuller SJ, Moir RD, Small D, Beyreuther D, Masters CL: The amyloid protein precursor of Alzheimer’s disease is a mediator of the effects of nerve growth factor on neurite outgrowth, Neuron 1992;9: 129-137.
8. Schubert D, Jin L-W, Saitoh T, Cole G: The regulation of amyloid P protein precursor secretion and its modulatory role in cell adhesion, Neuron 1989;3:689-694.
9. Nishimoto I, Okamoto T, Matsuura Y, Taka-hashi S, Okamoto T, Maruyama Y, Ogata E: Alzheimer amyloid protein precursor complexes with brain GTP-binding protein Go- Nature 1993;362:75-79.
10. Zheng H, Jiang M, Trumbauer ME, Sirinath-singhji DJS, Hopkins R, Smith DW, Heavens RP, Dawson GR, Boyce S, Conner MW, Stevens KA, Slunt HH, Sisodia SS, Chen HY, Van dcr Plocg LHT: P-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity, Cell 1995:81:525-531.
11. Wolf D, Quon D, Wang Y, Cordell B: Identification and characterization of C-tcrminal fragments of the p-amyloid precursor produced in cell culture, EMBO J 1990;9:2079-2084
12. Fukuchi K, Sopher B, Furlong CE, Smith AC, DangN, Martin GM: Selective neurotoxicity of COOH-tcrminal fragments of the p-amyloid precursor protein, Neurosci Lett 1993; 154: 145-148.
13. Maruyama K, Terakado K, Usami M, Yoshi-kawa K: Formation of amyloid-like fibrils in COS cells overexprcssing part of the Alzheimer amyloid protein, Nature 1990;347:566-569
14. Yankner BA, Dawes LR, Fisher S, Villa-Koma-rolt L, Oster-Granite ML, Neve RL: Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer’s disease, Science 1989;245:417-420.
15. Yoshikawa K, Aizawa T, Hayashi Y: Degeneration in vitro of postmitotic neurons overexpressing the Alzheimer amyloid protein precursor, Nature 1992;359:64-67.
16. Price DL, Borchelt DR, Walker LC, Sisodia SS: Toxicity of synthetic Ap peptides and modelling of Alzheimer’s disease, Ncurobiol Aging 1992;13:623-625.
17. Niwa H, Yamamura K, Miyazaki J: Efficient selection for high-cxpression transfcctants with a novel eukaryotic vector, Gene 1991: 193-200.
18. Kawarabayashi T, Shoji M, Sato M, Sasaki A, Ho L, Eckman CB, Prada C-M, Younkin SG, Kobayashi T, Tada N, Matsubara E, Iizuka T, Harigaya Y, Kasai K, Hirai S: Accumulation of ß-amyloid fibrils in pancreas of transgenic mice, Neurobiol Aging 1996;17:215-222
19. Hogan B, Costantini F, Lacy E: Manipulating the Mouse Embryo - A Laboratory Manual, Cold Spring Harbor, Cold Spring Harbor Laboratory Press, 1986.
20. Toyoda Y, Yokoyama M, Hoslii T: Studies on the fertilization of mouse eggs in vitro, I, In vitro fertilization of eggs by fresh epididymal spermatozoa (in Japanese), Jpn J Anim Reprod 1971;16:147-151.
21. Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter WJ: Isolation of biologically active ribonucleic acid from sources enriched in ribonu-clease, Biochemistry 1979:18:5294-5299
22. Tezuka K, Takcshita S, Hakeda Y, Kumcgawa M, Kikuno R, Hashimolo-Gotoh T: Isolation of mouse and human cDNA clones encoding a protein expressed specifically in osteoblasts and brain tissues, Biochem Biophys Res Com-mun 1990:173:246-251.
23. Balcarek JM, Cowan NJ: Structure of the mouse glial fibrillary acidic protein gene: Implications for the evolution of the intermediate filament multigenc family, Nucleic Acids Res 1985:13:5527-5543.
24. Yamaguchi H: Studies on the immunohisto-chentical localization of S-100 and glial fibrillary acidic proteins in the rat nervous system and in human brain tumors, Brain Nerve (Tokyo) 1980:32:1055-1064.
25. Beach TG, Walker R, McGeer EG: Patients of gliosis in Alzheimer's disease and aging cerebrum, Glia 1989:2:420-436.
26. Norton WT, Aquino DA, Hozumi I, Chiu F-C, Brosnan CF: Quantitative aspects of reactive gliosis: A review, Neurochem Res 1992:17: 877-885.
27. Masliah E, Terry RD, Alford M, DcTeresa R, Hansen LA: Cortical and subcortical patterns of svnaptophysinlikc immunoreactivity in Alzheimer's disease, Am J Pathol 1991:138:235-246.
28. Smeyne RJ, Vendrell M, Hayward M, Baker SJ, Miso GG, Schilling K, Robertson LM, Curran T, Morgan Jl: Continuous e-fos expression precedes programmed cell death in vivo, Nature 1993:363:166-169.
29. Buxbaum JD, Christensen JL, Rucfli AA, Grccngard P, Loring JF: Expression of APP in brains of transgenic mice containing the entire human APP gene, Biochem Biophys Res Com-mun 1993:197:639-645.
30. Kammcslieidt A, Boyce FM, Spanovannis AF, Cummings BJ, Ortegon M, Cotman C, Vaught JL, Neve RL: Deposition ofi/A4 imniunorcac-tivity and neuronal pathology in transgenic mice expressing the carboxy-tcrminal fragment of the Alzheimer amyloid precursor in the brain, Proc Natl Acad Sci USA 1992:89: 10857-10861.
31. Kawabata S, Higgins GA, Gordon JW: Amyloid plaque, neurofibrillary tangles and neuronal loss in brains of transgenic mice ovcrexprcss-ing a C-tcrminal fragment of human amyloid precursor protein, Nature 1991:354:476-478
32. Lamb BT, Sisodia SS, Lawler AM, Slum HH, Kitt CA, Kearns WG, Pearson PL, Price DL, Gcarheart JD: Introduction and expression of the 400 kilobasc precursor amyloid protein gene in transgenic mice, Nature Genet 1993:5: 22-30.
33. Pearson B, Choi T: Expression of the human p-amyloid precursor protein gene from a yeast artificial chromosome in transgenic mice, Proc Natl Acad Sci USA 1993:90:10578-10582
34. Quon D, Wang Y, Catalano R, Scardina JM, Murakami K, Cordell B: Formation of P-amyloid protein deposits in brains of transgenic mice, Nature 1991:352:239-241.
35. Sandhu FA, Salim M, Zain SB: Expression of the human P-amyloid protein of Alzheimer's disease specifically in the brains of transgenic mice, J Biol Chem 1991:266:21331-21334
36. Wirak DO, Bayncy R, Ramabhadran TV, Fra-casso RP, Hart JT, Hauer PE, Ilsiau P, Pckar SK, Scangos GA, Trapp BD, Untcrbeck AJ: Deposits of amyloid-p protein in the central nervous system of transgenic mice, Science 1991:253:323-325.
37. Yamaguchi F, Richards SJ, Beyreuiher K, Sal-baum M, Carlson GA, Dunnett SB: Transgenic mice for the amyloid precursor protein 695 iso-lorm have impaired spatial memory, Neuroreport 1991:2:781-784.
38. Kawabata S, Higgins GA, Gordon JW: Alzheimer's retraction, Nature 1992:356:23.
39. Wirak D, Bayncy R, Ramabhadran TV, Fra-casso RP, Hart JT, Hauer PF., Hsiau P, Pckar SK, Scangos GA, Trapp BD, Unterbcck AJ: Age-associated inclusions in normal and transgenic mouse brain, Science 1992:255:1443-1445.
40. Games D, Adams D, Alcssandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F, Guido T, Ilauo-pian S, Johnson-Wood K, Khan K, Lee M, Lei-bowitz P, Lieberburg I, Iitlle S, Masliah E, McConlogue L., Monloya-Zavala M, Mucke L, Paganini L, Pcnniman F., Power M, Schenk D, Seubert P, Snyder B, Soriano F, Tan H, Vitale J, Wadsworth S, Wolozin B, Zhao J: Alzheimer-type neuropathology in transgenic mice ovcrexprcssing V77F ß-amyloid precursor protein, Nature 1995:373:523-527.
41. LaFerla FM, Tinkle BT, Bieberich CJ, Hau-denschild CC, Jay CR, The Alzheimer's Aß peptide induces neurodegeneral ion and apoptotic cell death in transgenic mice, Nature Genet 1995:9:21-30.
42. Mucke L, Masliah E, Johnson WB, Ruppe MD, Alford M, Rockenslein EM, Forss-Pcttcr S, Pietropaolo M, Mallory M, Abraham CR: Sy-naptotropic effects of human amyloid ß protein precursors in the cortex of transgenic mice, Brain Res 1994:666:151-167.
43. Flsiao KK, Borchelt DR, Olson K, Johannsdot-tir R, Kitt C, Yunis W, Xu S, Eckman C, Younkin S, Price D, ladecola C, Clark HB, Carlson G: Age-related CNS disorder and early death in transgenic FVB/N mice ovcrexprcssing Alzheimer amyloid precursor proteins, Neuron 1995:15:1203-1218.
44. Wertkin A.M, Turner RS, Pleasure SJ, Golde TE, Younkin SG, Trojanowski JQ, Lee VM-Y; Human neurons derived from a tcralocarcino-ma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular ß-amyloid or A4 peptides, Proc Natl Acad Sci US A 1993:90:9513-9517.