Substitution of a Glycogen Synthase Kinase-3β Phosphorylation Site in Presenilin 1 Separates Presenilin Function from β-Catenin Signaling

Journal of Biological Chemistry

Volumn 276, Issue 10, 2001, Pages 7366-7375

  Kirschenbaum, Ford ^b   Hsu, Shu Chi ^b   Cordell, Barbara ^a   McCarthy, Justin V ^b  

^a SCIOS INC   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; GENES; MOLECULAR WEIGHT; MUTAGENESIS;

PHSOPHORYLATION;

PROTEINS;

BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; PRESENILIN 1; SERINE; WNT PROTEIN; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA-PROTEIN (1-42); COMPLEMENTARY DNA; CTNNB1 PROTEIN, HUMAN; CYTOSKELETON PROTEIN; GLYCOGEN SYNTHASE KINASE; GLYCOGEN SYNTHASE KINASE 3; LUCIFERASE; MEMBRANE PROTEIN; PEPTIDE FRAGMENT; PROTEIN KINASE (CALCIUM,CALMODULIN); PSEN1 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOSOL; ENZYME ANALYSIS; FAMILIAL DISEASE; GENE MUTATION; HUMAN; HUMAN CELL; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; BINDING SITE; CELL DEATH; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; FLUORESCENCE MICROSCOPY; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; SERODIAGNOSIS; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; APOPTOSIS; BETA CATENIN; BINDING SITES; BLOTTING, WESTERN; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL DEATH; CELL LINE; CELL NUCLEUS; CYTOSKELETAL PROTEINS; CYTOSOL; DNA, COMPLEMENTARY; GENETIC VECTORS; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASES; HUMANS; LUCIFERASES; MEMBRANE PROTEINS; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PRECIPITIN TESTS; PRESENILIN-1; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSFECTION;

EID: 0035831453     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M004697200     Document Type: Article

References (30)

1. Cruts, M., and Van Broeckhoeven, C. (1998) Hum. Mutat. 11, 183-190
2. Mattson, M. P., Guo, Q., Furukawa, K., and Pederson, W. A. (1998) J. Neurochem. 70, 1-14
3. Thinakaran, G. (1999) J. Clin. Invest. 104, 1321-1327
4. Price, D. L., and Sisodia, S. S. (1999) Annu. Rev. Neurosci. 21, 479-505
5. Zhou, J., Liyanage, U., Medina, M. Ho, C., Simmons, A. D., Lovett, M., and Kosik, K. S. (1997) Neuroreport 8, 1489-1494
6. Levesque, G., Yu, G., Nishimura, M., Zhang, D. M., Levesque, L., Yu, H., Xu, D., Liang, Y., Rogaeva, E., Ikeda, M., Duthie, M., Murgolo, N., Wang, L., VanderVere, P., Bayne, M. L., Strader, C. D., Rommens, J. M., Fraser, P. E., and St. George-Hyslop, P. (1999) J. Neurochem. 72, 999-1008
7. Murayama, M., Tanaka, S., Palacino, J., Murayama, O., Honda, T., Sun, X., Yasutake, K., Nihonmatsu, N., Wolozin, B., and Takashima, A. (1998) FEBS Lett. 433, 73-77
8. Yu, G., Chen, F., Levesque, G., Mishimura, M., Zhang, D.-M., Levesque, L., Rogaeva, E., Xu, D., Liang, Y., Duthie, M., St. George-Hyslop, P., and Fraser, P. E. (1998) J. Biol. Chem. 273, 16470-16475
9. Tesco, G., Kim, T. W., Diehlmann, A., Beyreuther, K., and Tanzi, R. E. (1998) J. Biol. Chem. 273, 33909-33914
10. Saura, C. A., Tomita, T., Soriano, S., Takahashi, M., Leem, J.-Y., Honda, T., Koo, E. H., Iwatsubo, T., and Thinakaran, G. (2000) J. Biol. Chem. 275, 17136-17142
11. Takashima, A., Murayama, M., Murayama, O., Kohno, T., Honda, T., Yasutake, K., Nihonmatsu, N., Mercken, M., Yanaguchi, H., Sugihara, S., and Wolozin, B. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 9637-9641
12. Peifer, M., and Polakis, P. (2000) Science 287, 1606-1609
13. Zhang, Z., Hartmann, H., Do, V. M., Abramowski, D., Sturchler-Pierrat, C., Staufenbiel, M., Sommer, B., van de Wetering, M., Clevers, H., Saftig, P., De Strooper, B., He, X., and Yankner, B. A. (1998) Nature 395, 698-702
14. Weil, C. C., Ghadge, G. D., Kennedy, S. G., Hay, N., Miller, R. J., and Roos, R. P. (1999) J. Neurosci. 19, 5360-5369
15. Kang, D. E., Soriano, S., Frosch, M. P., Collins, T., Naruse, S., Sisodia, S. S., Leibowitz, G., Levine, F., and Koo, E. H. (1999) J. Neurosci. 19, 4229-4237
16. Nishimura, M., Levesque, G., Zhang, D. M., Ruel, L., Chen, F., Milman, P., Holmes, E., Liang, Y., Kawarai, T., Jo, E., Supala, A., Rogaeva, E., Xu, D-M., Janus, C., Levesque, L., Bi, Q., Duthie, M., Rozmahel, R., Mattila, K., Lannfelt, L., Westaway, D., Mount, H. T. J., Woodgett, J., Fraser, P. E., and St. George-Hyslop, P. (1999) Nat. Med. 5, 164-169
17. Dong, L. Q., Zhang, R., Langlais, P., He, H., Clark, M., Zhu, L., and Liu, F. (1999) J. Biol. Chem. 274, 8117-1822
18. Thinakaran, G., Borchelt, D. R., Lee, M. K., Slunt, H. H., Spitzer, L., Kim, G., Ratovitsky, T., Davenport, F., Nordstedt, C., Seeger, M., Hardy, J., Levey, A. I., Gandy, S. E., Jenkins, N. A., Copeland, N. G., Price, D. L., and Sisodia, S. S. (1996) Neuron 17, 181-190
19. Mercken, M., Takahashi, H., Honda, t., Sato, K., Murayama, M., Nakazato, Y., Noguchi, K., Imahori, K., and Takashima, A. (1996) FEBS Lett. 389, 297-303
20. Tomita, T., Maruyama, K., Saido, T. C., Kume, H., Skinozaki, K., Tokuhiro, S., Capell, A., Walter, J., Grunberg, J., Haass, C., Iwatsubo, T., and Obata, K. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 2025-2030
21. Podlinsny, M. B., Citron, M., Amarante, P., Sherrington, R., Xia, W., Zhang, J., Dichl, T., Levesque, G., Fraser, P., Haass, C., Koo, E. H., Seubert, P., St. George-Hyslop, P., Teplow, D. B., and Selkoe, D. J. (1997) Neurobiol. Dis. 3, 325-337
22. De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., and Van Leuven, F. (1998) Nature 391, 387-390
23. Jho, E-H., Lomvardas, S., and Costantini, F. (1999) Biochem. Biophys. Res. Commun. 266, 28-35
24. Ikeda, S., Kishida, S., Yamamoto, H., Murai, H., Koyama, S., and Kikuchi, A. (1998) EMBO J. 17, 1371-1384
25. Sakanaka, C., Weiss, J. B., and Williams, L. T. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 3020-3023
26. Korinek, V., Barker, N., Morin, P. J., van Wichen, D., de Weger, R., Kinzler, K. W., Vogelstein, B., and Clevers, H. (1997) Science 275, 1784-1787
27. Morin, P. J., Sparks, A. B., Korinek, V., Barker, N., Clevers, H., Vogelstein, B., and Kinzler, K. W. (1997) Science 275, 1787-1790
28. Fiol, C. J., Wang, A., Roeske, R. W., and Roach, P. J. (1990) J. Biol. Chem. 265, 6061-6065
29. Seger, M., Nordstedt, C., Petanceska, S., Kovacs, D. M., Gouras, G. K., Hahne, S., Fraser, P., Levesque, G., Czernik, A. J., St. George-Hyslop, P., Sisodia, S. S., Thinakaran, G., Tanzi, R. E., Greengard, P., and Gandy, S. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 5090-5094
30. Walter, J., Grunberg, J., Capell, A., Pesold, B., Schindzielorz, A., Citron, M., Mendla, K., St. George-Hyslop, P., Multhaup, G., Selkoe, D., and Haass, C. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 5349-5354