The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor

Journal of Cell Science

Volumn 117, Issue 19, 2004, Pages 4435-4448

  von Rotz, Ruth C ^a   Kohli, Bernhard M ^a   Bosset, Jérôme ^a   Meier, Michelle ^a   Suzuki, Toshiharu ^b   Nitsch, Roger M ^a   Konietzko, Uwe ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

secretase; AICD; Alzheimer's disease; Fe65; Tip60; Transcriptional regulation

Indexed keywords

ADAPTOR PROTEIN; ALPHA SECRETASE; AMYLOID BETA PROTEIN; DOCKING PROTEIN; ENZYME INHIBITOR; HYBRID PROTEIN; NOTCH RECEPTOR; NUCLEAR PROTEIN; PROTEIN FE65; PROTEIN JIP1B; PROTEIN PRECURSOR; PROTEIN TIP60; PROTEIN X11ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CHROMATIN; COMPLEX FORMATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSOL; GENE FUNCTION; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INTRACELLULAR TRANSPORT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ACETYLTRANSFERASES; ACTIVE TRANSPORT, CELL NUCLEUS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMYLOID BETA-PROTEIN PRECURSOR; ANTIGENS, CD; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL NUCLEUS; CELLS, CULTURED; FLUORESCENCE RESONANCE ENERGY TRANSFER; HISTONE ACETYLTRANSFERASES; HOMEODOMAIN PROTEINS; HUMANS; KANGAI-1 PROTEIN; MEMBRANE GLYCOPROTEINS; MULTIPROTEIN COMPLEXES; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; TRANSCRIPTION, GENETIC;

EID: 5444275067     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.01323     Document Type: Article

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