Catalytic site-directed γ-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and β-APP cleavages

Biochemistry

Volumn 42, Issue 24, 2003, Pages 7580-7586

  Lewis, Huw D ^a   Pérez Revuelta, Blanca I ^a,b   Nadin, Alan ^a   Neduvelil, Joe G ^a   Harrison, Timothy ^a   Pollack, Scott J ^a   Shearman, Mark S ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BRAIN; PATHOLOGY; PATIENT TREATMENT; TISSUE;

NOTCH INTRACELLULAR DOMAIN (NICD);

ENZYME INHIBITION;

AMYLOID BETA PROTEIN; ENZYME INHIBITOR; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; NOTCH RECEPTOR; PRESENILIN 1; PROTEIN NOTCH S3; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; BRAIN TISSUE; CATALYSIS; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME STABILITY; ENZYME STRUCTURE; HUMAN; HUMAN CELL; MOLECULAR STABILITY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS;

EID: 0038746673     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034310g     Document Type: Article

References (49)

1. Vassar, R. (2001) J. Mol. Neurosci. 17, 157-170.
2. De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J. S., Schroeter, E. H., Schrijvers, V., Wolfe, M. S., Ray, W. J., Goate, A., and Kopan, R. (1999) Nature 398, 518-522.
3. Li, Y. M., Xu, M., Lai, M. T., Huang, Q., Castro, J. L., DiMuzio-Mower, J., Harrison, T., Lellis, C., Nadin, A., Neduvelil, J. G., Register, R. B., Sardana, M. K., Shearman, M. S., Smith, A. L., Shi, X. P., Yin, K. C., Shafer, J. A., and Gardell, S. J. (2000) Nature 405, 689-694.
4. Yu, G., Nishimura, M., Arawaka, S., Levitan, D., Zhang, L., Tandon, A., Song, Y. Q., Rogaeva, E., Chen, F., Kawarai, T., Supala, A., Levesque, L., Yu, H., Yang, D. S., Holmes, E., Milman, P., Liang, Y., Zhang, D. M., Xu, D. H., Sato, C., Rogaev, E., Smith, M., Janus, C., Zhang, Y., Aebersold, R., Farrer, L. S., Sorbi, S., Bruni, A., Fraser, P., and George-Hyslop, P. (2000) Nature 407, 48-54.
5. Francis, R., McGrath, G., Zhang, J., Ruddy, D. A., Sym, M., Apfeld, J., Nicoll, M., Maxwell, M., Hai, B., Ellis, M. C., Parks, A. L., Xu, W., Li, J., Gurney, M., Myers, R. L., Himes, C. S., Hiebsch, R., Ruble, C., Nye, J. S., and Curtis, D. (2002) Dev. Cell 3, 85-97.
6. Josien, H. (2002) Curr. Opin. Drug Discov. Dev. 5, 513-525.
7. Mumm, J. S., and Kopan, R. (2000) Dev. Biol. 228, 151-165.
8. Ikeuchi, T., and Sisodia, S. S. (2003) J. Biol. Chem. (in press).
9. Lee, H. J., Jung, K. M., Huang, Y. Z., Bennett, L. B., Lee, J. S., Mei, L., and Kim, T. W. (2002) J. Biol. Chem. 277, 6318-6323.
10. May, P., Reddy, Y. K., and Herz, J. (2002) J. Biol. Chem. 277, 18736-18743.
11. Lammich, S., Okochi, M., Takeda, M., Kaether, C., Capell, A., Zimmer, A. K., Edbauer, D., Walter, J., Steiner, H., and Haass, C. (2002) J. Biol. Chem. 277, 44754-44759.
12. Marambaud, P., Shioi, J., Serban, G., Georgakopoulos, A., Sarner, S., Nagy, V., Baki, L., Wen, P., Efthimiopoulos, S., Shao, Z., Wisniewski, T., and Robakis, N. K. (2002) EMBO J. 21, 1948-1956.
13. Kim, D. Y., Ingano, L. A., and Kovacs, D. M. (2002) J. Biol. Chem. 277, 49976-49981.
14. Scheinfeld, M. H., Ghersi, E., Laky, K., Fowlkes, B. J., and D'Adamio, L. (2002) J. Biol. Chem. 277, 44195-44201.
15. De Strooper presentation (no. 1043), 8th International Conference on Alzheimer's Disease and Related Disorders, July 2002.
16. Doerfler, P., Shearman, M. S., and Perlmutter, R. M. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 9312-9317.
17. Varnum-Finney, B., Purton, L. E., Yu, M., Brashem-Stein, C., Flowers, D., Staats, S., Moore, K. A., Le, R., I, Mann, R., Gray, G., Artavanis-Tsakonas, S., and Bernstein, I. D. (1998) Blood 91, 4084-4091.
18. Berezovska, O., McLean, P., Knowles, R., Frosh, M., Lu, F. M., Lux, S. E., and Hyman, B. T. (1999) Neuroscience 93, 433-439.
19. Beher, D., Wrigley, J. D., Nadin, A., Evin, G., Masters, C. L., Harrison, T., Castro, J. L., and Shearman, M. S. (2001) J. Biol. Chem. 276, 45394-45402.
20. Ida, N., Hartmann, T., Pantel, J., Schroder, J., Zerfass, R., Forstl, H., Sandbrink, R., Masters, C. L., and Beyreuther, K. (1996) J. Biol. Chem. 271, 22908-22914.
21. Kopan, R., Schroeter, E. H., Weintraub, H., and Nye, J. S. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 1683-1688.
22. Dovey, H. F., John, V., Anderson, J. P., Chen, L. Z., de Saint, A. P., Fang, L. Y., Freedman, S. B., Folmer, B., Goldbach, E., Holsztynska, E. J., Hu, K. L., Johnson-Wood, K. L., Kennedy, S. L., Kholodenko, D., Knops, J. E., Latimer, L. H., Lee, M., Liao, Z., Lieberburg, I. M., Motter, R. N., Mutter, L. C., Nietz, J., Quinn, K. P., Sacchi, K. L., Seubert, P. A., Shopp, G. M., Thorsett, E. D., Tung, J. S., Wu, J., Yang, S., Yin, C. T., Schenk, D. B., May, P. C., Altstiel, L. D., Bender, M. H., Boggs, L. N., Britton, T. C., Clemens, J. C., Czilli, D. L., Dieckman-McGinty, D. K., Droste, J. J., Fuson, K. S., Gitter, B. D., Hyslop, P. A., Johnstone, E. M., Li, W. Y., Little, S. P., Mabry, T. E., Miller, F. D., and Audia, J. E. (2001) J. Neurochem. 76, 173-181.
23. Lopes, U. G., Erhardt, P., Yao, R., and Cooper, G. M. (1997) J. Biol. Chem. 272, 12893-12896.
24. Meriin, A. B., Gabai, V. L., Yaglom, J., Shifrin, V. I., and Sherman, M. Y. (1998) J. Biol. Chem. 273, 6373-6379.
25. Rami, A., Ferger, D., and Krieglstein, J. (1997) Neurosci. Res. 27, 93-97.
26. Shearman, M. S., Beher, D., Clarke, E. E., Lewis, H. D., Harrison, T., Hunt, P., Nadin, A., Smith, A. L., Stevenson, G., and Castro, J. L. (2000) Biochemistry 39, 8698-8704.
27. Nadin, A., Owens, A. P., Castro, J. L., Harrison, T., and Shearman, M. S. (2003) Bioorg. Med. Chem. Lett. 13, 37-41.
28. Esler, W. P., Kimberly, W. T., Ostaszewski, B. L., Ye, W., Diehl, T. S., Selkoe, D. J., and Wolfe, M. S. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 2720-2725.
29. Skovronsky, D. M., Pijak, D. S., Doms, R. W., and Lee, V. M. (2000) Biochemistry 39, 810-817.
30. Weggen, S., Eriksen, J. L., Das, P., Sagi, S. A., Wang, R., Pietrzik, C. U., Findlay, K. A., Smith, T. E., Murphy, M. P., Bulter, T., Kang, D. E., Marquez-Sterling, N., Golde, T. E., and Koo, E. H. (2001) Nature 414, 212-216.
31. Kimberly, W. T., Esler, W. P., Ye, W., Ostaszewski, B. L., Gao, J., Diehl, T., Selkoe, D. J., and Wolfe, M. S. (2003) Biochemistry 42, 137-144.
32. Tian, G., Sobotka-Briner, C. D., Zysk, J., Liu, X., Birr, C., Sylvester, M. A., Edwards, P. D., Scott, C. D., and Greenberg, B. D. (2002) J. Biol. Chem. 277, 31499-31505.
33. Berezovska, O., Jack, C., Deng, A., Gastineau, N., Rebeck, G. W., and Hyman, B. T. (2001) J. Biol. Chem. 276, 30018-30023.
34. Petit, A., George-Hyslop, P., Fraser, P., and Checler, F. (2002) Biochem. Biophys. Res. Commun. 290, 1408-1410.
35. Ikeuchi, T., and Sisodia, S. S. (2002) Neuromol. Med. 1, 43-54.
36. Capell, A., Steiner, H., Romig, H., Keck, S., Baader, M., Grim, M. G., Baumeister, R., and Haass, C. (2000) Nat. Cell Biol. 2, 205-211.
37. Zhang, D. M., Levitan, D., Yu, G., Nishimura, M., Chen, F., Tandon, A., Kawarai, T., Arawaka, S., Supala, A., Song, Y. Q., Rogaeva, E., Liang, Y., Holmes, E., Milman, P., Sato, C., Zhang, L., and George-Hyslop, P. (2000) Neuroreport 11, 3227-3230.
38. Moehlmann, T., Winkler, E., Xia, X., Edbauer, D., Murrell, J., Capell, A., Kaether, C., Zheng, H., Ghetti, B., Haass, C., and Steiner, H. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 8025-8030.
39. Kulic, L., Walter, J., Multhaup, G., Teplow, D. B., Baumeister, R., Romig, H., Capell, A., Steiner, H., and Haass, C. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 5913-5918.
40. Rozmahel, R., Mount, H. T., Chen, F., Nguyen, V., Huang, J., Erdebil, S., Liauw, J., Yu, G., Hasegawa, H., Gu, Y., Song, Y. Q., Schmidt, S. D., Nixon. R. A., Mathews, P. M., Bergeron, C., Fraser, P., Westaway, D., and George-Hyslop, P. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 14452-14457.
41. Petit, A., Bihel, F., Alves, d. C., Pourquie, O., Checler, F., and Kraus, J. L. (2001) Nat. Cell Biol. 3, 507-511.
42. Esler, W. P., Das, C., Campbell, W. A., Kimberly, W. T., Kornilova, A. Y., Diehl, T. S., Ye, W., Ostaszewski, B. L., Xia, W., Selkoe, D. J., and Wolfe, M. S. (2002) Nat. Cell Biol. 4, E110-E111.
43. Fortini, M. E. (2002) Nat. Rev. Mol. Cell Biol. 3, 673-684.
44. Roncarati, R., Sestan, N., Scheinfeld, M. H., Berechid, B. E., Lopez, P. A., Meucci, O., McGlade, J. C., Rakic, P., and D'Adamio, L. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 7102-7107.
45. Okochi, M., Steiner, H., Fukumori, A., Tanii, H., Tomita, T., Tanaka, T., Iwatsubo, T., Kudo, T., Takeda, M., and Haass, C. (2002) EMBO J. 21, 5408-5416.
46. Berechid, B. E., Kitzmann, M., Foltz, D. R., Roach, A. H., Seiffert. D., Thompson, L. A., Olson, R. E., Bernstein, A., Donoviel, D. B., and Nye, J. S. (2002) J. Biol. Chem. 277, 8154-8165.
47. Taniguchi, Y., Karlstrom, H., Lundkvist, J., Mizutani, T., Otaka, A., Vestling, M., Bernstein, A., Donoviel, D., Lendahl, U., and Honjo, T. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 4014-4019.
48. Wilson, C. A., Doms, R. W., Zheng, H., and Lee, V. M. (2002) Nat. Neurosci. 5, 849-855.
49. Tian et al. (2003) J. Biol. Chem. (in press).