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Volumn 387, Issue 6632, 1997, Pages 500-505

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN;

EID: 0030978998     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/387500a0     Document Type: Article
Times cited : (318)

References (30)
  • 1
    • 0026522375 scopus 로고
    • Potentially amyloidogenic carbon-terminal derivatives of the amyloid protein precursor
    • Estus, S. et al. Potentially amyloidogenic carbon-terminal derivatives of the amyloid protein precursor. Science 255, 726-728 (1992).
    • (1992) Science , vol.255 , pp. 726-728
    • Estus, S.1
  • 2
    • 0026735070 scopus 로고
    • Targeting of cell-surface β-amyloid precursor protein to lysosomes: Alternative processing into amyloid-bearing fragments
    • Haass, C,. Koo, E. H., Mellon, A., Hung, A. Y. & Selkoe, D. J. Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature 357, 500-502 (1992).
    • (1992) Nature , vol.357 , pp. 500-502
    • Haass, C.1    Koo, E.H.2    Mellon, A.3    Hung, A.Y.4    Selkoe, D.J.5
  • 3
    • 0026539090 scopus 로고
    • Processing of the amyloid protein precursor to potentially amyloidogenic derivatives
    • Golde, T. E., Estus, S., Younkin, L. H., Selkoe, D. J. & Younkin, S. G. Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science 255, 728-730 (1992).
    • (1992) Science , vol.255 , pp. 728-730
    • Golde, T.E.1    Estus, S.2    Younkin, L.H.3    Selkoe, D.J.4    Younkin, S.G.5
  • 4
    • 0026646604 scopus 로고
    • Amyloid β-peptide is produced by cultured cells during normal metabolism
    • Haass, C. et al. Amyloid β-peptide is produced by cultured cells during normal metabolism. Nature 359, 322-325 (1992).
    • (1992) Nature , vol.359 , pp. 322-325
    • Haass, C.1
  • 5
    • 0026760261 scopus 로고
    • Production of the Alzheimer β-protein by normal proteolytic processing
    • Shoji, M. et al. Production of the Alzheimer β-protein by normal proteolytic processing. Science 258, 126-129 (1992).
    • (1992) Science , vol.258 , pp. 126-129
    • Shoji, M.1
  • 6
    • 0026646605 scopus 로고
    • Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids
    • Seubert, P. et al. Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids. Nature 359, 325-327 (1992).
    • (1992) Nature , vol.359 , pp. 325-327
    • Seubert, P.1
  • 7
    • 0026632290 scopus 로고
    • Intragenic regulatory elements contribute to transcriptional control of the neurofilament light gene
    • Beaudet, L. et al. Intragenic regulatory elements contribute to transcriptional control of the neurofilament light gene. Gene 116, 205-214 (1992).
    • (1992) Gene , vol.116 , pp. 205-214
    • Beaudet, L.1
  • 8
    • 0029609021 scopus 로고
    • Increased production of 4kDa amyloid β-peptide in serum deprived human primary neuron cultures: Possible involvement of apoptosis
    • LeBlanc, A. Increased production of 4kDa amyloid β-peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis. J. Neurosci. 15, 7837-7846 (1995).
    • (1995) J. Neurosci. , vol.15 , pp. 7837-7846
    • LeBlanc, A.1
  • 9
    • 0023877370 scopus 로고
    • Effect of neonatal handling on age-related impairments associated with the hippocampus
    • Meaney, M. J., Aitken, D. H., van Berkel, C., Bhatnagar, S. & Sapolsky, R. M. Effect of neonatal handling on age-related impairments associated with the hippocampus. Science 239, 766-768 (1988).
    • (1988) Science , vol.239 , pp. 766-768
    • Meaney, M.J.1    Aitken, D.H.2    Van Berkel, C.3    Bhatnagar, S.4    Sapolsky, R.M.5
  • 10
    • 0021173996 scopus 로고
    • Development of a water-maze procedure for studying spatial learning in the rat
    • Morris, R. G. M. Development of a water-maze procedure for studying spatial learning in the rat J. Neurosci. Meth. 11, 47-60 (1984).
    • (1984) J. Neurosci. Meth. , vol.11 , pp. 47-60
    • Morris, R.G.M.1
  • 11
    • 0020579674 scopus 로고
    • A comparison of the contributions of the frontal and parietal association cortex to spatial localization in rats
    • Kolb, B., Sutherland, R. J. & Wishaw, I. Q. A comparison of the contributions of the frontal and parietal association cortex to spatial localization in rats. Behav. Neurosci. 97, 13-27 (1983).
    • (1983) Behav. Neurosci. , vol.97 , pp. 13-27
    • Kolb, B.1    Sutherland, R.J.2    Wishaw, I.Q.3
  • 12
    • 0026618354 scopus 로고
    • Bilateral knife cuts to the perforant path disrupt spatial learning in the Morris water maze
    • Skelton, R. W. & McNamara, R. K. Bilateral knife cuts to the perforant path disrupt spatial learning in the Morris water maze. Hippocampus 2, 73-80 (1992).
    • (1992) Hippocampus , vol.2 , pp. 73-80
    • Skelton, R.W.1    McNamara, R.K.2
  • 13
    • 0027476024 scopus 로고
    • A synaptic model of memory, long-term potentiation in the hippocampus
    • Bliss, T. V. P. & Collingridge, G. L. A synaptic model of memory, long-term potentiation in the hippocampus. Nature 361, 31-39 (1993).
    • (1993) Nature , vol.361 , pp. 31-39
    • Bliss, T.V.P.1    Collingridge, G.L.2
  • 15
    • 0024472693 scopus 로고
    • Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease
    • Yankner, B. A. et al. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science 245, 417-420 (1989).
    • (1989) Science , vol.245 , pp. 417-420
    • Yankner, B.A.1
  • 16
    • 0026779680 scopus 로고
    • Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor
    • Yoshikawa, K., Aizawa, T. & Hagashi, Y. Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor. Nature 359, 64-67 (1992).
    • (1992) Nature , vol.359 , pp. 64-67
    • Yoshikawa, K.1    Aizawa, T.2    Hagashi, Y.3
  • 17
    • 0026463326 scopus 로고
    • Down syndrome and Alzheimer disease
    • Hyman, B. T. Down syndrome and Alzheimer disease. Prog. Clin. Biol. Res. 379, 123-142 (1992).
    • (1992) Prog. Clin. Biol. Res. , vol.379 , pp. 123-142
    • Hyman, B.T.1
  • 18
    • 0024990330 scopus 로고
    • Neurotrophic and neurotoxic effects of amyloid β-protein: Reversal by tachykinin neuropeptides
    • Yankner, B. A., Duffy, L. K. & Kirschner, D. A. Neurotrophic and neurotoxic effects of amyloid β-protein: reversal by tachykinin neuropeptides. Science 250, 279-282 (1990).
    • (1990) Science , vol.250 , pp. 279-282
    • Yankner, B.A.1    Duffy, L.K.2    Kirschner, D.A.3
  • 19
    • 0026570528 scopus 로고
    • β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
    • Mattson, M. P. et al. β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12, 376-389 (1992).
    • (1992) J. Neurosci. , vol.12 , pp. 376-389
    • Mattson, M.P.1
  • 20
    • 0027257708 scopus 로고
    • Apoptosis is induced by β-amyloid in cultured central nervous system neurons
    • Loo, D. T. et al. Apoptosis is induced by β-amyloid in cultured central nervous system neurons. Proc. Natl Acad. Sci. USA 90, 7951-7955 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 7951-7955
    • Loo, D.T.1
  • 21
    • 0028233494 scopus 로고
    • Hydrogen peroxide mediates amyloid β-protein toxicity
    • Behl, C., Davis, J. B., Lesley, R. & Schubert, D. Hydrogen peroxide mediates amyloid β-protein toxicity. Cell 77, 817-822 (1994).
    • (1994) Cell , vol.77 , pp. 817-822
    • Behl, C.1    Davis, J.B.2    Lesley, R.3    Schubert, D.4
  • 23
    • 0027508926 scopus 로고
    • Alzheimer disease amyloid β protein forms calcium channels in bilayer membranes: Blockade by tromethamine and aluminum
    • Arispe, N., Rojas, J. & Pollard, H. B. Alzheimer disease amyloid β protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum. Proc. Natl Acad. Sci. USA 90, 567-571 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 567-571
    • Arispe, N.1    Rojas, J.2    Pollard, H.B.3
  • 24
    • 0028953529 scopus 로고
    • Activation of microglial cells by β-amyloid protein and interferon-γ
    • Meda, L. et al. Activation of microglial cells by β-amyloid protein and interferon-γ. Nature 374, 647-650 (1995).
    • (1995) Nature , vol.374 , pp. 647-650
    • Meda, L.1
  • 25
    • 0013615899 scopus 로고    scopus 로고
    • RAGE and amyloid β-peptide
    • Yan, S. D. et al. RAGE and amyloid β-peptide. Nature 382, 685-691 (1996).
    • (1996) Nature , vol.382 , pp. 685-691
    • Yan, S.D.1
  • 26
    • 1842270921 scopus 로고    scopus 로고
    • Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils
    • El Khoury, J. et al. Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils. Nature Science 274, 99-103 (1996).
    • (1996) Nature Science , vol.274 , pp. 99-103
    • El Khoury, J.1
  • 27
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Aβ elevation and amyloid plaques in transgenic mice
    • Hsiao, K. et al. Correlative memory deficits, Aβ elevation and amyloid plaques in transgenic mice. Science 274, 99-103 (1996).
    • (1996) Science , vol.274 , pp. 99-103
    • Hsiao, K.1
  • 28
    • 0028985574 scopus 로고
    • Alzheimer-type neuropathology in transgenic mice expressing V717F β-amyloid precursor
    • Games, D. et al. Alzheimer-type neuropathology in transgenic mice expressing V717F β-amyloid precursor. Nature 373, 523-526 (1995).
    • (1995) Nature , vol.373 , pp. 523-526
    • Games, D.1
  • 29
    • 0025743350 scopus 로고
    • Formation of β-amyloid protein deposits in brains of transgenic mice
    • Quon, D. et al. Formation of β-amyloid protein deposits in brains of transgenic mice. Nature 352, 239-241 (1991).
    • (1991) Nature , vol.352 , pp. 239-241
    • Quon, D.1
  • 30
    • 0023105114 scopus 로고
    • The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
    • Kang, J. et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325, 733-736 (1987).
    • (1987) Nature , vol.325 , pp. 733-736
    • Kang, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.