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1
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84960101628
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Unravelling the olfactory sense: from the gene to odor perception
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COI: 1:CAS:528:DC%2BC1cXitVGhu7c%3D, This is a comprehensive review of the role played by ORs and associated signalling pathways sensory olfactory neurons
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Silva Teixeira, C. S., Cerqueira, N. M. & Silva Ferreira, A. C. Unravelling the olfactory sense: from the gene to odor perception. Chem. Senses 41, 105–121 (2016). This is a comprehensive review of the role played by ORs and associated signalling pathways in sensory olfactory neurons.
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(2016)
Chem. Senses
, vol.41
, pp. 105-121
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Silva Teixeira, C.S.1
Cerqueira, N.M.2
Silva Ferreira, A.C.3
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2
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84979735722
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Olfactory sensitivity in mammalian species
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COI: 1:CAS:528:DC%2BC2sXhslWnsLjN
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Wackermannova, M., Pinc, L. & Jebavy, L. Olfactory sensitivity in mammalian species. Physiol. Res. 65, 369–390 (2016).
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(2016)
Physiol. Res.
, vol.65
, pp. 369-390
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Wackermannova, M.1
Pinc, L.2
Jebavy, L.3
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3
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84877287787
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An evolutionary perspective on food and human taste
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COI: 1:CAS:528:DC%2BC3sXnt1ajtb0%3D, PID: 3680351
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Breslin, P. A. S. An evolutionary perspective on food and human taste. Curr. Biol. 23, R409–R418 (2013).
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(2013)
Curr. Biol.
, vol.23
, pp. R409-R418
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Breslin, P.A.S.1
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4
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84937393107
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Chemosensory receptor specificity and regulation
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COI: 1:CAS:528:DC%2BC2MXhsVCjurfK, PID: 4882759
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Dalton, R. P. & Lomvardas, S. Chemosensory receptor specificity and regulation. Annu. Rev. Neurosci. 38, 331–349 (2015).
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(2015)
Annu. Rev. Neurosci.
, vol.38
, pp. 331-349
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Dalton, R.P.1
Lomvardas, S.2
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5
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84885460763
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Chemosensory signals and their receptors in the olfactory neural system
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COI: 1:CAS:528:DC%2BC3sXhslKnurbE
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Ihara, S., Yoshikawa, K. & Touhara, K. Chemosensory signals and their receptors in the olfactory neural system. Neuroscience 254, 45–60 (2013).
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(2013)
Neuroscience
, vol.254
, pp. 45-60
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Ihara, S.1
Yoshikawa, K.2
Touhara, K.3
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6
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33746092533
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Widespread ectopic expression of olfactory receptor genes
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PID: 1508154, This study systematically profiles OR gene expression different tissues, which express specific, relatively small OR gene subsets at particularly high levels, and suggests that such small OR subsets may play functional roles different tissues
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Feldmesser, E. et al. Widespread ectopic expression of olfactory receptor genes. BMC Genomics 7, 121 (2006). This study systematically profiles OR gene expression in different tissues, which express specific, relatively small OR gene subsets at particularly high levels, and suggests that such small OR subsets may play functional roles in different tissues.
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(2006)
BMC Genomics
, vol.7
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Feldmesser, E.1
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7
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84873563478
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Expression profile of ectopic olfactory receptors determined by deep sequencing
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COI: 1:CAS:528:DC%2BC3sXivFGqsbY%3D, PID: 3566163, This study uses next-generation sequencing to perform comprehensive RNA-seq experiments investigating the ectopic OR profiles of 16 human tissues. All tissues examined express at least some ORs, and several ORs such as OR2W3 and OR51E1 are widely distributed. OR4N4 is shown to be specifically expressed the testis
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Flegel, C., Manteniotis, S., Osthold, S., Hatt, H. & Gisselmann, G. Expression profile of ectopic olfactory receptors determined by deep sequencing. PLOS ONE 8, e55368 (2013). This study uses next-generation sequencing to perform comprehensive RNA-seq experiments investigating the ectopic OR profiles of 16 human tissues. All tissues examined express at least some ORs, and several ORs such as OR2W3 and OR51E1 are widely distributed. OR4N4 is shown to be specifically expressed in the testis.
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(2013)
PLOS ONE
, vol.8
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Flegel, C.1
Manteniotis, S.2
Osthold, S.3
Hatt, H.4
Gisselmann, G.5
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8
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85041924326
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Chemoreceptors in the gut
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This is a comprehensive review of the role played by taste receptors enteroendocrine cells of the gut
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Steensels, S. & Depoortere, I. Chemoreceptors in the gut. Annu. Rev. Physiol. 80, 117–141 (2017). This is a comprehensive review of the role played by taste receptors in enteroendocrine cells of the gut.
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(2017)
Annu. Rev. Physiol.
, vol.80
, pp. 117-141
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Steensels, S.1
Depoortere, I.2
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9
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0037470996
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Identification of a testicular odorant receptor mediating human sperm chemotaxis
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COI: 1:CAS:528:DC%2BD3sXitlCis7k%3D, This is the first study to prove the functionality of an OR located outside the e. this study, OR1D2 is highly expressed human spermatozoa and is activated by the odorant bourgeonal, eliciting positive chemotactic and chemokinetic swimming behaviour by spermatozoa
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Spehr, M. et al. Identification of a testicular odorant receptor mediating human sperm chemotaxis. Science 299, 2054–2058 (2003). This is the first study to prove the functionality of an OR located outside the nose. In this study, OR1D2 is reported to be highly expressed in human spermatozoa and is activated by the odorant bourgeonal, eliciting positive chemotactic and chemokinetic swimming behaviour by spermatozoa.
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(2003)
Science
, vol.299
, pp. 2054-2058
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Spehr, M.1
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10
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84908567248
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A synthetic sandalwood odorant induces wound-healing processes in human keratinocytes via the olfactory receptor OR2AT4
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COI: 1:CAS:528:DC%2BC2cXht12msrzF, This study is the first to investigate the role of an OR skin keratinocytes. OR2AT4 activation by Sandalore is shown to induce wound healing by stimulating keratinocyte proliferation via activation of ERK1, ERK2 and p30 ex vivo human skin. Novel wound-healing therapeutics were developed on the basis of these findings
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Busse, D. et al. A synthetic sandalwood odorant induces wound-healing processes in human keratinocytes via the olfactory receptor OR2AT4. J. Invest. Dermatol. 134, 2823–2832 (2014). This study is the first to investigate the role of an OR in skin keratinocytes. OR2AT4 activation by Sandalore is shown to induce wound healing by stimulating keratinocyte proliferation via activation of ERK1, ERK2 and p30 in ex vivo human skin. Novel wound-healing therapeutics were developed on the basis of these findings.
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(2014)
J. Invest. Dermatol.
, vol.134
, pp. 2823-2832
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Busse, D.1
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11
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85007107570
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Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation
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COI: 1:CAS:528:DC%2BC2sXis1Kn
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Tsai, T. et al. Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation. Exp. Dermatol. 26, 58–65 (2017).
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(2017)
Exp. Dermatol.
, vol.26
, pp. 58-65
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Tsai, T.1
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12
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85053532868
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Hair follicles engage in chemosensation: olfactory receptor OR2AT4 regulates human hair growth
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PID: 6143528, This study demonstrates the functionality of OR2AT4 human hair growth. OR2AT4 is expressed the human hair follicles, and activation by Sandalore prolongs the active growth phase of hair by inducing the expression of IGF1. Results from the preliminary test on humans support the findings from ex vivo culture of human follicles
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Cheret, J. et al. Hair follicles engage in chemosensation: olfactory receptor OR2AT4 regulates human hair growth. Nat. Commun. 9, 3624 (2018). This study demonstrates the functionality of OR2AT4 in human hair growth. OR2AT4 is expressed in the human hair follicles, and activation by Sandalore prolongs the active growth phase of hair by inducing the expression of IGF1. Results from the preliminary test on humans support the findings from ex vivo culture of human follicles.
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(2018)
Nat. Commun.
, vol.9
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Cheret, J.1
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13
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71549126815
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MOR23 promotes muscle regeneration and regulates cell adhesion and migration
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COI: 1:CAS:528:DC%2BD1MXhsFKltLfE, PID: 2780437, This study investigates the role played by the mouse OR OLFR16 (MOR23) skeletal muscle. this study, the receptor stimulates skeletal muscle regeneration by inducing myocyte migration and adhesion, thus contributing to tissue repair
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Griffin, C. A., Kafadar, K. A. & Pavlath, G. K. MOR23 promotes muscle regeneration and regulates cell adhesion and migration. Dev. Cell 17, 649–661 (2009). This study investigates the role played by the mouse OR OLFR16 (MOR23) in skeletal muscle. In this study, the receptor stimulates skeletal muscle regeneration by inducing myocyte migration and adhesion, thus contributing to tissue repair.
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(2009)
Dev. Cell
, vol.17
, pp. 649-661
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Griffin, C.A.1
Kafadar, K.A.2
Pavlath, G.K.3
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14
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85014701294
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Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis
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PID: 5342199
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Weber, L. et al. Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis. PLOS ONE 12, e0172491 (2017).
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(2017)
PLOS ONE
, vol.12
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Weber, L.1
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15
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85007578696
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Helional-induced activation of human olfactory receptor 2J3 promotes apoptosis and inhibits proliferation in a non-small-cell lung cancer cell line
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COI: 1:CAS:528:DC%2BC28XitVaqurnN
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Kalbe, B. et al. Helional-induced activation of human olfactory receptor 2J3 promotes apoptosis and inhibits proliferation in a non-small-cell lung cancer cell line. Eur. J. Cell Biol. 96, 34–46 (2017).
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(2017)
Eur. J. Cell Biol.
, vol.96
, pp. 34-46
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Kalbe, B.1
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16
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84982803598
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The activation of OR51E1 causes growth suppression of human prostate cancer cells
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PID: 5217014
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Massberg, D. et al. The activation of OR51E1 causes growth suppression of human prostate cancer cells. Oncotarget 7, 48231–48249 (2016).
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(2016)
Oncotarget
, vol.7
, pp. 48231-48249
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Massberg, D.1
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17
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67650233721
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Activation of an olfactory receptor inhibits proliferation of prostate cancer cells
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COI: 1:CAS:528:DC%2BD1MXmvFSjtr0%3D, PID: 2713531
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Neuhaus, E. M. et al. Activation of an olfactory receptor inhibits proliferation of prostate cancer cells. J. Biol. Chem. 284, 16218–16225 (2009).
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(2009)
J. Biol. Chem.
, vol.284
, pp. 16218-16225
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Neuhaus, E.M.1
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18
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84989287244
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Functional characterization of the ectopically expressed olfactory receptor 2AT4 in human myelogenous leukemia
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COI: 1:CAS:528:DC%2BC28Xht1ais73F, PID: 4979481, This study is the first to describe an OR-mediated pathway human myelogenous leukaemia cells; the pathway is shown to regulate cell proliferation, apoptosis and differentiation after stimulation of OR2AT4 with an odorant
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Manteniotis, S. et al. Functional characterization of the ectopically expressed olfactory receptor 2AT4 in human myelogenous leukemia. Cell Death Discov. 2, 15070 (2016). This study is the first to describe an OR-mediated pathway in human myelogenous leukaemia cells; the pathway is shown to regulate cell proliferation, apoptosis and differentiation after stimulation of OR2AT4 with an odorant.
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(2016)
Cell Death Discov.
, vol.2
, pp. 15070
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Manteniotis, S.1
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19
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85032986545
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Olfactory receptor 544 reduces adiposity by steering fuel preference toward fats
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PID: 5663348, This study is the first to investigate the role played by ectopic ORs obesity and energy metabolism vivo. this study, OLFR544 activation by azelaic acid reduces adiposity via induction of fatty acid oxidation, thermogenesis and lipolysis the liver, brown adipose tissue and white adipose tissue, respectively
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Wu, C. et al. Olfactory receptor 544 reduces adiposity by steering fuel preference toward fats. J. Clin. Invest. 127, 4118–4123 (2017). This study is the first to investigate the role played by ectopic ORs in obesity and energy metabolism in vivo. In this study, OLFR544 activation by azelaic acid reduces adiposity via induction of fatty acid oxidation, thermogenesis and lipolysis in the liver, brown adipose tissue and white adipose tissue, respectively.
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(2017)
J. Clin. Invest.
, vol.127
, pp. 4118-4123
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Wu, C.1
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20
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84925857433
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The endocrinology of taste receptors
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COI: 1:CAS:528:DC%2BC2MXjt1Snsro%3D
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Calvo, S. S. & Egan, J. M. The endocrinology of taste receptors. Nat. Rev. Endocrinol. 11, 213–227 (2015).
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(2015)
Nat. Rev. Endocrinol.
, vol.11
, pp. 213-227
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Calvo, S.S.1
Egan, J.M.2
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21
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84889637546
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Taste receptors of the gut: emerging roles in health and disease
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COI: 1:CAS:528:DC%2BC2cXit12htro%3D
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Depoortere, I. Taste receptors of the gut: emerging roles in health and disease. Gut 63, 179–190 (2014).
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(2014)
Gut
, vol.63
, pp. 179-190
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Depoortere, I.1
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22
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84945486808
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The pharmacology of bitter taste receptors and their role in human airways
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COI: 1:CAS:528:DC%2BC2MXhtlCqtrjM
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Devillier, P., Naline, E. & Grassin-Delyle, S. The pharmacology of bitter taste receptors and their role in human airways. Pharmacol. Ther. 155, 11–21 (2015).
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(2015)
Pharmacol. Ther.
, vol.155
, pp. 11-21
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Devillier, P.1
Naline, E.2
Grassin-Delyle, S.3
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23
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85014080866
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Key questions for translation of FFA receptors: from pharmacology to medicines
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Suckow, A. T. & Briscoe, C. P. Key questions for translation of FFA receptors: from pharmacology to medicines. Handb. Exp. Pharmacol. 236, 101–131 (2017).
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(2017)
Handb. Exp. Pharmacol.
, vol.236
, pp. 101-131
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Suckow, A.T.1
Briscoe, C.P.2
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24
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85029667710
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Opportunities for therapeutic antibodies directed at G-protein-coupled receptors
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COI: 1:CAS:528:DC%2BC2sXhtFOrsb%2FK
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Hutchings, C. J., Koglin, M., Olson, W. C. & Marshall, F. H. Opportunities for therapeutic antibodies directed at G-protein-coupled receptors. Nat. Rev. Drug Discov. 16, 787–810 (2017).
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(2017)
Nat. Rev. Drug Discov.
, vol.16
, pp. 787-810
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Hutchings, C.J.1
Koglin, M.2
Olson, W.C.3
Marshall, F.H.4
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25
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84984700600
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Functional characterization of the odorant receptor 51E2 in human melanocytes
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COI: 1:CAS:528:DC%2BC28Xhtlyjt7rI, PID: 5016170, This study examines the role played by OR51E2 melanogenesis. this study, activation of the receptor by β-ionone is shown to reduce melanogenesis and increase the levels of cAMP and intracellular calcium, and cell proliferation is inhibited by receptor activation
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Gelis, L. et al. Functional characterization of the odorant receptor 51E2 in human melanocytes. J. Biol. Chem. 291, 17772–17786 (2016). This study examines the role played by OR51E2 in melanogenesis. In this study, activation of the receptor by β-ionone is shown to reduce melanogenesis and increase the levels of cAMP and intracellular calcium, and cell proliferation is inhibited by receptor activation.
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(2016)
J. Biol. Chem.
, vol.291
, pp. 17772-17786
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Gelis, L.1
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26
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85047000322
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Characterization of the olfactory receptor OR10H1 in human urinary bladder cancer
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PID: 5964926
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Weber, L. et al. Characterization of the olfactory receptor OR10H1 in human urinary bladder cancer. Front. Physiol. 9, 456 (2018).
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(2018)
Front. Physiol.
, vol.9
, pp. 456
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Weber, L.1
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27
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0034547945
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PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer
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COI: 1:CAS:528:DC%2BD3cXosl2isLg%3D
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Xu, L. L. et al. PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer. Cancer Res. 60, 6568–6572 (2000).
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(2000)
Cancer Res.
, vol.60
, pp. 6568-6572
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Xu, L.L.1
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28
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33644920405
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Quantitative expression profile of PSGR in prostate cancer
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COI: 1:CAS:528:DC%2BD28XitFGiurk%3D
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Xu, L. L. et al. Quantitative expression profile of PSGR in prostate cancer. Prostate Cancer Prostat. Dis. 9, 56–61 (2006).
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(2006)
Prostate Cancer Prostat. Dis.
, vol.9
, pp. 56-61
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Xu, L.L.1
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29
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78349262391
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PSGR and PCA3 as biomarkers for the detection of prostate cancer in urine
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Rigau, M. et al. PSGR and PCA3 as biomarkers for the detection of prostate cancer in urine. Prostate 70, 1760–1767 (2010).
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(2010)
Prostate
, vol.70
, pp. 1760-1767
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Rigau, M.1
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30
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84897004342
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Promotion of cancer cell invasiveness and metastasis emergence caused by olfactory receptor stimulation
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PID: 3885679
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Sanz, G. et al. Promotion of cancer cell invasiveness and metastasis emergence caused by olfactory receptor stimulation. PLOS ONE 9, e85110 (2014).
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(2014)
PLOS ONE
, vol.9
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Sanz, G.1
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31
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84960433618
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Prostate specific G protein coupled receptor is associated with prostate cancer prognosis and affects cancer cell proliferation and invasion
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PID: 4652354
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Cao, W. Q., Li, F. Q., Yao, J. G. & Yu, J. Z. Prostate specific G protein coupled receptor is associated with prostate cancer prognosis and affects cancer cell proliferation and invasion. BMC Cancer 15, 915 (2015).
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(2015)
BMC Cancer
, vol.15
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Cao, W.Q.1
Li, F.Q.2
Yao, J.G.3
Yu, J.Z.4
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32
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33644500133
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PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer
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COI: 1:CAS:528:DC%2BD28XhslCqs7k%3D
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Weng, J. et al. PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer. Int. J. Cancer 118, 1471–1480 (2006).
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(2006)
Int. J. Cancer
, vol.118
, pp. 1471-1480
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Weng, J.1
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33
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0035855662
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Identification of a prostate-specific G-protein coupled receptor in prostate cancer
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COI: 1:CAS:528:DC%2BD3MXntlSgt7g%3D
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Xia, C., Ma, W., Wang, F., Hua, S. & Liu, M. Identification of a prostate-specific G-protein coupled receptor in prostate cancer. Oncogene 20, 5903–5907 (2001).
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(2001)
Oncogene
, vol.20
, pp. 5903-5907
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Xia, C.1
Ma, W.2
Wang, F.3
Hua, S.4
Liu, M.5
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34
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85042122817
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Olfactory receptors as biomarkers in human breast carcinoma tissues
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PID: 5818398
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Weber, L. et al. Olfactory receptors as biomarkers in human breast carcinoma tissues. Front. Oncol. 8, 33 (2018).
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(2018)
Front. Oncol.
, vol.8
, pp. 33
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Weber, L.1
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35
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85039152244
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Revisiting olfactory receptors as putative drivers of cancer
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PID: 5421569
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Ranzani, M. et al. Revisiting olfactory receptors as putative drivers of cancer. Wellcome Open Res. 2, 9 (2017).
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(2017)
Wellcome Open Res.
, vol.2
, pp. 9
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Ranzani, M.1
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36
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84956954404
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The gustatory signaling pathway and bitter taste receptors affect the development of obesity and adipocyte metabolism in mice
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PID: 4686985
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Avau, B. et al. The gustatory signaling pathway and bitter taste receptors affect the development of obesity and adipocyte metabolism in mice. PLOS ONE 10, e0145538 (2015).
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(2015)
PLOS ONE
, vol.10
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Avau, B.1
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37
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84926611558
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Denatonium induces secretion of glucagon-like peptide-1 through activation of bitter taste receptor pathways
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COI: 1:CAS:528:DC%2BC2cXhtFCqtLzN, PID: 5160131
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Kim, K. S., Egan, J. M. & Jang, H. J. Denatonium induces secretion of glucagon-like peptide-1 through activation of bitter taste receptor pathways. Diabetologia 57, 2117–2125 (2014).
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(2014)
Diabetologia
, vol.57
, pp. 2117-2125
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Kim, K.S.1
Egan, J.M.2
Jang, H.J.3
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38
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77954134133
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Taste preference for fatty acids is mediated by GPR40 and GPR120
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COI: 1:CAS:528:DC%2BC3cXos1KntLo%3D
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Cartoni, C. et al. Taste preference for fatty acids is mediated by GPR40 and GPR120. J. Neurosci. 30, 8376–8382 (2010).
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(2010)
J. Neurosci.
, vol.30
, pp. 8376-8382
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Cartoni, C.1
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39
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79960397923
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Accumulating evidence supports a taste component for free fatty acids in humans
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COI: 1:CAS:528:DC%2BC3MXptVSquro%3D, PID: 3139746
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Mattes, R. D. Accumulating evidence supports a taste component for free fatty acids in humans. Physiol. Behav. 104, 624–631 (2011).
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(2011)
Physiol. Behav.
, vol.104
, pp. 624-631
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Mattes, R.D.1
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40
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84976330193
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Efficacy of omega-3 polyunsaturated fatty acids supplementation in managing overweight and obesity: a meta-analysis of randomized clinical trials
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COI: 1:CAS:528:DC%2BC28XpsF2qsr8%3D
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Zhang, Y. Y., Liu, W., Zhao, T. Y. & Tian, H. M. Efficacy of omega-3 polyunsaturated fatty acids supplementation in managing overweight and obesity: a meta-analysis of randomized clinical trials. J. Nutr. Health Aging 21, 187–192 (2017).
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(2017)
J. Nutr. Health Aging
, vol.21
, pp. 187-192
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Zhang, Y.Y.1
Liu, W.2
Zhao, T.Y.3
Tian, H.M.4
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41
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78149355561
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Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction
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COI: 1:CAS:528:DC%2BC3cXhtlahu7rF, PID: 3066567, This study shows that aerosol administration of bitter substances may induce bronchodilation patients with asthma by activating bitter taste receptors human airway smooth muscles
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Deshpande, D. A. et al. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nat. Med. 16, 1299–1304 (2010). This study shows that aerosol administration of bitter substances may induce bronchodilation in patients with asthma by activating bitter taste receptors in human airway smooth muscles.
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(2010)
Nat. Med.
, vol.16
, pp. 1299-1304
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Deshpande, D.A.1
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42
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84896770768
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Bitter and sweet taste receptors regulate human upper respiratory innate immunity
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COI: 1:CAS:528:DC%2BC2cXkt1Wrurs%3D, PID: 3934184, this study, targeting of a sweet taste receptor is shown to inhibit bitter taste receptor-induced antimicrobial peptide production the upper airway and may aid the treatment of upper respiratory tract infections
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Lee, R. J. et al. Bitter and sweet taste receptors regulate human upper respiratory innate immunity. J. Clin. Invest. 124, 1393–1405 (2014). In this study, targeting of a sweet taste receptor is shown to inhibit bitter taste receptor-induced antimicrobial peptide production in the upper airway and may aid in the treatment of upper respiratory tract infections.
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(2014)
J. Clin. Invest.
, vol.124
, pp. 1393-1405
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Lee, R.J.1
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43
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84868610108
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T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection
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COI: 1:CAS:528:DC%2BC38Xhs1CisL%2FL, PID: 3484455, this study, genetic variation of the bitter taste receptor TAS2R38 is shown to regulate the innate defence mechanism against quorum-sensing molecules secreted by Gram-negative bacteria the epithelia of the human upper airway
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Lee, R. J. et al. T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J. Clin. Invest. 122, 4145–4159 (2012). In this study, genetic variation of the bitter taste receptor TAS2R38 is shown to regulate the innate defence mechanism against quorum-sensing molecules secreted by Gram-negative bacteria in the epithelia of the human upper airway.
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(2012)
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