Decreased level of olfactory receptors in blood cells following traumatic brain injury and potential association with tauopathy

Journal of Alzheimer's Disease

Volumn 34, Issue 2, 2013, Pages 417-429

  Zhao, Wei ^a   Ho, Lap ^a   Varghese, Merina ^a   Yemul, Shrishailam ^a,b   Dams Oconnor, Kristen ^a   Gordon, Wayne ^a   Knable, Lindsay ^a   Freire, Daniel ^a   Haroutunian, Vahram ^a   Pasinetti, Giulio Maria ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Biomarker; olfactory receptor; peripheral blood mononuclear cell; tauopathy; traumatic brain injury

Indexed keywords

BIOLOGICAL MARKER; STRESS ACTIVATED PROTEIN KINASE; TAU PROTEIN;

ACCURACY; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN REGION; CLINICAL ARTICLE; CONSOLIDATION CHEMOTHERAPY; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; DOWN REGULATION; ENTORHINAL CORTEX; FEMALE; GENE; GENE EXPRESSION; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MALE; MEMORY; MOUSE; NEUROPATHOLOGY; NEUROPSYCHOLOGY; NONHUMAN; OLFACTORY BULB; OLFACTORY RECEPTOR; OR11H1 GENE; OR4M1 GENE; OR52N5 GENE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SENSITIVITY AND SPECIFICITY; TAUOPATHY; TRAUMATIC BRAIN INJURY;

EID: 84874289793     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-121894     Document Type: Article

References (50)

1. Centers for Disease Control and Prevention (1999) Traumatic brain injury in the United States: A report to Congress. http://www.cdc.gov/ncipc/pub-res/tbi congress/TBI in the US.PDF
2. Elder GA, Cristian A (2009) Blast-related mild traumatic brain injury: Mechanisms of injury and impact on clinical care. Mt Sinai J Med 76, 111-118
3. Lezak M, Howieson DB, Loring DW (2004) Neuropsychological Assessment, Oxford University Press
4. Vasterling JJ, Proctor SP, Amoroso P, Kane R, Heeren T, White RF (2006) Neuropsychological outcomes of army personnel following deployment to the Iraq war. JAMA 296, 519-529 (Pubitemid 44157126)
5. Redell JB, Zhao J, Dash PK (2011) Altered expression of miRNA-21 and its targets in the hippocampus after traumatic brain injury. J Neurosci Res 89, 212-221
6. Reeves TM, Lyeth BG, Povlishock JT (1995) Long-term potentiation deficits and excitability changes following traumatic brain injury. Exp Brain Res 106, 248-256
7. Cohen AS, Pfister BJ, Schwarzbach E, Grady MS, Goforth PB, Satin LS (2007) Injury-induced alterations in CNS electrophysiology. Prog Brain Res 161, 143-169 (Pubitemid 47023092)
8. Gao X, Deng P, Xu ZC, Chen J (2011) Moderate traumatic brain injury causes acute dendritic and synaptic degeneration in the hippocampal dentate gyrus. PLoS One 6, e24566
9. Gobbel GT, Bonfield C, Carson-Walter EB, Adelson PD (2007) Diffuse alterations in synaptic protein expression following focal traumatic brain injury in the immature rat. Childs Nerv Syst 23, 1171-1179 (Pubitemid 47399550)
10. Witgen BM, Lifshitz J, Smith ML, Schwarzbach E, Liang SL, Grady MS, CohenAS(2005) Regional hippocampal alteration associated with cognitive deficit following experimental brain injury:Asystems, network and cellular evaluation. Neuroscience 133, 1-15 (Pubitemid 40694154)
11. Wu A, Molteni R, Ying Z, Gomez-Pinilla F (2003) A saturated-fat diet aggravates the outcome of traumatic brain injury on hippocampal plasticity and cognitive function by reducing brain-derived neurotrophic factor. Neuroscience 119, 365-375 (Pubitemid 36588816)
12. Patanella AK, Zinno M, Quaranta D, Nociti V, Frisullo G, Gainotti G, Tonali PA, Batocchi AP,Marra C (2010) Correlations between peripheral blood mononuclear cell production ofBDNF, TNF-alpha, IL-6, IL-10 and cognitive performances in multiple sclerosis patients. J Neurosci Res 88, 1106-1112
13. van Heerden JH, Conesa A, Stein DJ, Montaner D, Russell V, Illing N (2009) Parallel changes in gene expression in peripheral blood mononuclear cells and the brain after maternal separation in the mouse. BMC Res Notes 2, 195
14. Alberini CM (2009) Transcription factors in long-term memory and synaptic plasticity. Physiol Rev 89, 121-145
15. Gardiner E, Beveridge NJ, Wu JQ, Carr V, Scott RJ, Tooney PA, Cairns MJ (2011) Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells. Mol Psychiatry 17, 827-840
16. Maes OC, Schipper HM, Chertkow HM, Wang E (2009) Methodology for discovery of Alzheimer's disease bloodbased biomarkers. J Gerontol A Biol Sci Med Sci 64, 636-645
17. Speciale L, Calabrese E, Saresella M, Tinelli C, Mariani C, Sanvito L, Longhi R, Ferrante P (2007) Lymphocyte subset patterns and cytokine production in Alzheimer's disease patients. Neurobiol Aging 28, 1163-1169 (Pubitemid 46810052)
18. Archer T, Svensson K, Alricsson M (2012) Physical exercise ameliorates deficits induced by traumatic brain injury. Acta Neurol Scand 125, 293-302
19. Qu C, Mahmood A, Ning R, Xiong Y, Zhang L, Chen J, Jiang H, Chopp M (2010) The treatment of traumatic brain injury with velcade. J Neurotrauma 27, 1625-1634
20. Dams-O'Connor K, Gordon WA (2010) Role and impact of cognitive rehabilitation. Psychiatr Clin North Am 33, 893-904
21. Cantor JB, Gordon WA, Schwartz ME, Charatz HJ, Ashman TA, Abramowitz S (2004) Child and parent responses to a brain injury screening questionnaire. Arch Phys Med Rehabil 85, S54-S60 (Pubitemid 38857935)
22. GordonWA, Haddad L, Brown M, Hibbard MR, SliwinskiM (2000) The sensitivity and specificity of self-reported symptoms in individuals with traumatic brain injury. Brain Inj 14, 21-33 (Pubitemid 30040153)
23. Berg L (1988) Clinical dementia rating (CDR). Psychopharmacol Bull 24, 637-639 (Pubitemid 19054369)
24. Haroutunian V, Purohit DP, Perl DP,Marin D, Khan K, Lantz M, Davis KL, MohsRC(1999) Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease. Arch Neurol 56, 713-718 (Pubitemid 29266472)
25. Haroutunian V, Perl DP, Purohit DP,Marin D, Khan K, Lantz M, Davis KL, Mohs RC (1998) Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease. Arch Neurol 55, 1185-1191 (Pubitemid 28427489)
26. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25, 402-408 (Pubitemid 34164012)
27. Wang J, Ho L, Chen L, Zhao Z, Zhao W, Qian X, Humala N, Seror I, Bartholomew S, Rosendorff C, Pasinetti GM (2007) Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease. J Clin Invest 117, 3393-3402 (Pubitemid 350096995)
28. Zhao W, Varghese M, Yemul S, Pan Y, Cheng A, Marano P, Hassan S, Vempati P, Chen F, Qian X, Pasinetti GM (2011) Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1alpha) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis. Mol Neurodegener 6, 51
29. Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: A practical and powerful approach to multiple testing. J R Stat Soc Series B Stat Methodol 57, 289-300
30. Allen Human Cortex Study Internet]. Allen Institute for Brain Science ©2009, Seattle, WA. http://humancortex. alleninstitute.org
31. Reynolds CH, Betts JC, Blackstock WP, Nebreda AR, Anderton BH (2000) Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: Differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta. J Neurochem 74, 1587-1595 (Pubitemid 30163980)
32. DeMaria S, Ngai J (2010) The cell biology of smell. J Cell Biol 191, 443-452
33. Feldmesser E, Olender T, Khen M, Yanai I, Ophir R, Lancet D(2006)Widespread ectopic expression of olfactory receptor genes. BMC Genomic 7, 121
34. Lovell M, FranzenM(2012) Neuropsychological assessment. In Neuropsychiatry of Traumatic Brain Injury, Silver JM, Yudofsky SC, Hales RE, Eds. American Psychiatric Press, Inc, Washington, DC
35. Whyte J, Polansky M, Cavallucci C, Fleming M, Lhulier J, Coslett HB (1996) Inattentive behavior after traumatic brain injury. J Int Neuropsychol Soc2, 274-281 (Pubitemid 126449021)
36. Derdikman D, Moser EI (2010) A manifold of spatial maps in the brain. Trends Cogn Sci 14, 561-569
37. Eichenbaum H, Lipton PA (2008) Towards a functional organization of the medial temporal lobe memory system: Role of the parahippocampal and medial entorhinal cortical areas. Hippocampus 18, 1314-1324
38. Squire LR, Zola-Morgan S (1991) The medial temporal lobe memory system. Science 253, 1380-1386 (Pubitemid 21917285)
39. van Duijn CM, Tanja TA, Haaxma R, Schulte W, Saan RJ, Lameris AJ, ntonides-Hendriks G, Hofman A (1992) Head trauma and the risk of Alzheimer's disease. Am J Epidemiol 135, 775-782
40. Ikonomovic MD, Uryu K, Abrahamson EE, Ciallella JR, Trojanowski JQ, LeeVM,Clark RS, MarionDW,Wisniewski SR, DeKosky ST (2004) Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury. Exp Neurol 190, 192-203 (Pubitemid 39335718)
41. Marklund N, Blennow K, Zetterberg H, Ronne-Engstrom E, Enblad P, Hillered L (2009) Monitoring of brain interstitial total tau and beta amyloid proteins by microdialysis in patients with traumatic brain injury. J Neurosurg 110, 1227-1237
42. Olsson A, Csajbok L, Ost M, Hoglund K, Nylen K, Rosengren L, Nellgard B, Blennow K (2004) Marked increase of beta-amyloid(1-42) and amyloid precursor protein in ventricular cerebrospinal fluid after severe traumatic brain injury. J Neurol 251, 870-876 (Pubitemid 39005974)
43. Szczygielski J, Mautes A, Steudel WI, Falkai P, Bayer TA, Wirths O (2005) Traumatic brain injury: Cause or risk of Alzheimer's disease? A review of experimental studies. J Neural Transm 112, 1547-1564 (Pubitemid 41504269)
44. Liliang PC, Liang CL, Weng HC, Lu K, Wang KW, Chen HJ, Chuang JH (2010) Tau proteins in serum predict outcome after severe traumatic brain injury. J Surg Res 160, 302-307
45. Chen T, Zhang L, Qu Y, Huo K, Jiang X, Fei Z (2012) The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway. Int J Mol Med 29, 630-636
46. Dash PK, Johnson D, Clark J, Orsi SA, Zhang M, Zhao J, Grill RJ, Moore AN, Pati S (2011) Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcome. PLoS One 6, e24648
47. Oliva AA, Kang Y, Sanchez-Molano J, Furones C, Atkins CM (2012) STAT3 signaling after traumatic brain injury. J Neurochem 120, 710-720
48. Chen T, Cao L, Dong W, Luo P, Liu W, Qu Y, Fei Z (2012) Protective effects of mGluR5 positive modulators against traumatic neuronal injury through PKC-dependent activation of MEK/ERK Pathway. Neurochem Res 37, 983-990
49. Tran HT, Sanchez L, Brody DL (2012) Inhibition of JNK by a peptide inhibitor reduces traumatic brain injury-induced tauopathy in transgenic mice. J Neuropathol Exp Neurol 71, 116-129
50. Sjogren M, Davidsson P, Tullberg M, Minthon L, Wallin A, Wikkelso C, Granerus AK, Vanderstichele H, Vanmechelen E, Blennow K (2001) Both total and phosphorylated tau are increased in Alzheimer's disease. J Neurol Neurosurg Psychiatry 70, 624-630 (Pubitemid 32397998)