Opportunities for therapeutic antibodies directed at G-protein-coupled receptors

Nature Reviews Drug Discovery

Volumn 16, Issue 11, 2017, Pages 787-810

  Hutchings, Catherine J ^a   Koglin, Markus ^a   Olson, William C ^b   Marshall, Fiona H ^a  

^a Heptares Therapeutics Ltd   (United Kingdom)

^b REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR5; G PROTEIN COUPLED RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MOGAMULIZUMAB; MONOCLONAL ANTIBODY; PRO 140; WNT PROTEIN;

AMINO TERMINAL SEQUENCE; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; BLOOD BRAIN BARRIER; BRONCHIOLITIS; CELL COMMUNICATION; COMPLEMENT DEPENDENT CYTOTOXICITY; CUTANEOUS T CELL LYMPHOMA; CYTOMEGALOVIRUS INFECTION; DNA IMMUNIZATION; DRUG EFFICACY; DRUG SAFETY; DRUG TARGETING; DRUG TOLERABILITY; GRAFT VERSUS HOST REACTION; HEPATITIS B; HUMAN; IMMUNOGENICITY; INTRACELLULAR SIGNALING; LIGAND BINDING; LIPOPHILICITY; NONHUMAN; OUTCOME ASSESSMENT; PERIPHERAL T CELL LYMPHOMA; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PSORIASIS VULGARIS; REVIEW; STEVENS JOHNSON SYNDROME; T CELL LYMPHOMA; TUMOR ESCAPE; TUMOR MICROENVIRONMENT; VIRUS PARTICLE; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG DEVELOPMENT; MOLECULARLY TARGETED THERAPY; PHYSIOLOGY; PROCEDURES;

ANIMALS; ANTIBODIES, MONOCLONAL; DRUG DISCOVERY; HUMANS; MOLECULAR TARGETED THERAPY; RECEPTORS, G-PROTEIN-COUPLED;

EID: 85029667710     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd.2017.91     Document Type: Review

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