CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes

Neuron

Volumn 98, Issue 3, 2018, Pages 547-561.e10

  Ma, Zhongming ^a   Taruno, Akiyuki ^b   Ohmoto, Makoto ^c   Jyotaki, Masafumi ^c   Lim, Jason C ^d   Miyazaki, Hiroaki ^b   Niisato, Naomi ^b   Marunaka, Yoshinori ^b   Lee, Robert J ^a   Hoff, Henry ^a   Payne, Riley ^a   Demuro, Angelo ^e   Parker, Ian ^e   Mitchell, Claire H ^d   Henao Mejia, Jorge ^a   Tanis, Jessica E ^a,f   Matsumoto, Ichiro ^c   Tordoff, Michael G ^c   Foskett, J Kevin ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c MONELL CHEMICAL SENSES CENTER   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF DELAWARE   (United States)

Author keywords

ATP release; blue native page; concatemer; hexamer; knockout; mouse; patch clamp electrophysiology; single molecule photobleaching; taste bud; voltage gated

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM CHANNEL; CALCIUM HOMEOSTASIS MODULATOR 1; CALCIUM HOMEOSTASIS MODULATOR 3; G PROTEIN COUPLED RECEPTOR; ION CHANNEL; PURINERGIC RECEPTOR; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; CALHM1 PROTEIN, MOUSE;

ACTION POTENTIAL; ACTIVATION CONSTANT; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BITTER TASTE; CALCIUM HOMEOSTASIS; CALHM3 GENE; CELL ACTIVITY; CHANNEL GATING; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE EXPRESSION; GENE INTERACTION; GENE LOCATION; HEK293T CELL LINE; HELA CELL LINE; HUMAN; HUMAN CELL; IN VIVO STUDY; ION CURRENT; MALE; MOLECULAR INTERACTION; MOUSE; NEURO-2A CELL LINE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; SWEETNESS; TASTE; TASTE BUD CELL; UMAMI; ANIMAL; HEK293 CELL LINE; PHYSIOLOGY; SYNAPTIC TRANSMISSION; TRANSGENIC MOUSE; XENOPUS;

ANIMALS; CALCIUM CHANNELS; FEMALE; HEK293 CELLS; HELA CELLS; HUMANS; ION CHANNEL GATING; MICE; MICE, TRANSGENIC; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PURINERGIC; SYNAPTIC TRANSMISSION; TASTE; TASTE PERCEPTION; XENOPUS;

EID: 85045333802     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2018.03.043     Document Type: Article

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