Odorants could elicit repair processes in melanized neuronal and skin cells

Neural Regeneration Research

Volumn 12, Issue 9, 2017, Pages 1401-1404

  Pavan, Barbara ^a   Dalpiaz, Alessandro ^a  

^a UNIVERSITY OF FERRARA   (Italy)

Author keywords

Hedione; Melanoma; OR2AT4; OR51E2; Parkinson s disease; Sandalore; VN1R1; Ionone

Indexed keywords

ALPHA SYNUCLEIN; BETA IONONE; CARVONE; DOPAMINE; HEDIONE; JASMONIC ACID; MELANIN; MENTHONE; METHYL DIHYDROJASMONATE; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; NEUROMELANIN; UNCLASSIFIED DRUG;

CALCIUM SIGNALING; DOPAMINERGIC NERVE CELL; ENDOCRINE SYSTEM; HUMAN; MELANOGENESIS; MELANOMA; NERVE DEGENERATION; NERVE REGENERATION; OLFACTORY RECEPTOR; PARKINSON DISEASE; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; REVIEW; SKIN CELL; SKIN PIGMENTATION; SYNUCLEINOPATHY;

EID: 85032435839     PISSN: 16735374     EISSN: 18767958     Source Type: Journal    
DOI: 10.4103/1673-5374.215246     Document Type: Review

References (30)

1. Bobela W, Aebischer P, Schneider BL (2015) Αlpha-synuclein as a mediator in the interplay between aging and Parkinson’s disease. Biomolecules 5:2675-2700.
2. Busse D, Kudella P, Grüning NM, Gisselmann G, Ständer S, Luger T, Jacobsen F, Steinsträßer L, Paus R, Gkogkolou P, Böhm M, Hatt H, Benecke H (2017) A synthetic sandalwood odorant induces wound-healing processes in human keratinocytes via the olfactory receptor OR2AT4. J Invest Dermatol 134:2823-2832.
3. Casettari L, Illum L (2014) Chitosan in nasal delivery systems for therapeutic drugs. J Control Release 190:189-200.
4. Cave JW, Fujiwara N, Weibman AR, Baker H (2016) Cytoarchitectural changes in the olfactory bulb of Parkinson’s disease patients. NPJ Parkinson’s disease 2:16011.
5. Dalpiaz A, Ferraro L, Perrone D, Leo E, Iannuccelli V, Pavan B, Paganetto G, Beggiato S, Scalia S (2014) Brain uptake of a Zidovudine prodrug after nasal administration of solid lipid microparticles. Mol Pharm 11:1550-1561.
6. Dalpiaz A, Fogagnolo M, Ferraro L, Capuzzo A, Pavan B, Rassu G, Salis A, Giunchedi P, Gavini E (2015) Nasal chitosan microparticles target a zidovudine prodrug to brain HIV sanctuaries. Antiviral Res 123:146-157.
7. Fedorow H, Tribl F, Halliday G, Gerlach M, Riederer P, Double KL (2005) Neuromelanin in human dopamine neurons: comparison with peripheral melanins and relevance to Parkinson’s disease. Prog Neurobiol 75:109-124.
8. Ferrer I, Garcia-Esparcia P, Carmona M, Carro E, Aronica E, Kovacs GG, Grison A, Gustincich S (2016) Olfactory receptors in non-chemosensory organs: the nervous system in health and disease. Front Aging Neurosci 8:163.
9. Gelis L, Jovancevic N, Bechara FG, Neuhaus EM, Hatt H (2017) Functional expression of olfactory receptors in human primary melanoma and melanoma metastasis. Exp Dermatol 26:569-576.
10. Gelis L, Jovancevic N, Veitinger S, Mandal B, Arndt HD, Neuhaus EM, Hatt H (2016) Functional characterization of the odorant receptor 51E2 in human melanocytes. J Biol Chem 291:17772-17786.
11. Grison A, Zucchelli S, Urzi A, Zamparo I, Lazarevic D, Pascarella G, Roncaglia P, Giorgetti A, Garcia-Esparcia P, Vlachouli C, Simone R, Persichetti F, Forrest AR, Hayashizaki Y, Carloni P, Ferrer I, Lodovichi C, Plessy C, Carninci P, Gustincich S (2014) Mesencephalic dopaminergic neurons express a repertoire of olfactory receptors and respond to odorant-like molecules. BMC Genomics 15:729.
12. Hanson LR, Frey WH, 2nd (2008) Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease. BMC Neurosci 9 Suppl 3:S5.
13. Hirobe T (2011) How are proliferation and differentiation of melanocytes regulated? Pigment Cell Melanoma Res 24:462-478.
14. Huang P, Yang XD, Chen SD, Xiao Q (2015) The association between Parkinson’s disease and melanoma: a systematic review and meta- analysis. Transl Neurodegener 4:21.
15. Ikemoto S (2007) Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex. Brain Res Rev 56:27-78.
16. Illum L (2003) Nasal drug delivery--possibilities, problems and solutions. J Control Release 87:187-198.
17. Khan W, Priyadarshini M, Zakai HA, Kamal MA, Alam Q (2012) A brief overview of tyrosine hydroxylase and α-synuclein in the Parkinsonian brain. CNS Neurol Disord Drug Targets 11:456-462.
18. Krautwurst D (2008) Human olfactory receptor families and their odorants. Chem Biodivers 5:842-852.
19. Magen I, Torres ER, Dinh D, Chung A, Masliah E, Chesselet MF (2015) Social cognition impairments in mice overexpressing alpha-synuclein under the thy1promoter, a model of pre-manifest Parkinson’s disease. J Parkinsons Dis 5:669-680.
20. Natale CA, Duperret EK, Zhang J, Sadeghi R, Dahal A, O’Brien KT, Cookson R, Winkler JD, Ridky TW (2016) Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors. Elife 5.
21. Neuhaus EM, Zhang W, Gelis L, Deng Y, Noldus J, Hatt H (2009) Activation of an olfactory receptor inhibits proliferation of prostate cancer cells. J Biol Chem 284:16218-16225.
22. Pan T, Zhu J, Hwu WJ, Jankovic J (2012) The role of alpha-synuclein in melanin synthesis in melanoma and dopaminergic neuronal cells. PLoS One 7:e45183.
23. Pavan B, Capuzzo A, Dalpiaz A (2017) Potential therapeutic effects of odorants through their ectopic receptors in pigmented cells. Drug Discov Today 22:1123-1130.
24. Pavan B, Paganetto G, Rossi D, Dalpiaz A (2014) Multidrug resistance in cancer or inefficacy of neuroactive agents: innovative strategies to inhibit or circumvent the active efflux transporters selectively. Drug Discov Today 19:1563-1571.
25. Pick H, Etter S, Baud O, Schmauder R, Bordoli L, Schwede T, Vogel H (2009) Dual activities of odorants on olfactory and nuclear hormone receptors. J Biol Chem 284:30547-30555.
26. Rashed HM, Shamma RN, Basalious EB (2016) Contribution of both olfactory and systemic pathways for brain targeting of nimodipine- loaded lipo-pluronics micelles: in vitro characterization and in vivo biodistribution study after intranasal and intravenous delivery. Drug Deliv 24:181-187.
27. Rassu G, Soddu E, Cossu M, Brundu A, Cerri G, Marchetti N, Ferraro L, Regan RF, Giunchedi P, Gavini E, Dalpiaz A (2015) Solid microparticles based on chitosan or methyl-beta-cyclodextrin: a first formulative approach to increase the nose-to-brain transport of deferoxamine mesylate. J Control Release 201:68-77.
28. Roh E, Yun CY, Young Yun J, Park D, Doo Kim N, Yeon Hwang B, Jung SH, Park SK, Kim YB, Han SB, Kim Y (2013) cAMP-binding site of PKA as a molecular target of bisabolangelone against melanocyte-specific hyperpigmented disorder. J Invest Dermatol 133:1072-1079.
29. Wallrabenstein I, Gerber J, Rasche S, Croy I, Kurtenbach S, Hummel T, Hatt H (2015) The smelling of Hedione results in sex-differentiated human brain activity. Neuroimage 113:365-373.
30. Xiao Q, Chen S, Le W (2014) Hyposmia: a possible biomarker of Parkinson’s disease. Neurosci Bull 30:134-140.