Bitter taste receptor (TAS2R) agonists inhibit IgE-dependent mast cell activation

Journal of Allergy and Clinical Immunology

Volumn 134, Issue 2, 2014, Pages 475-478

  Ekoff, Maria ^a   Choi, Jeong Hee ^a,b,c   James, Anna ^a   Dahlén, Barbro ^a,b   Nilsson, Gunnar ^a,b   Dahlén, Sven Erik ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c Hallym University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIMYCIN; CHLOROQUINE; COMPOUND 48-80; DENATONIUM BENZOATE; DEXTROMETHORPHAN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E RECEPTOR; NEDOCROMIL; NOSCAPINE; PROSTAGLANDIN D; DENATONIUM CHLORIDE; G PROTEIN COUPLED RECEPTOR; HISTAMINE; ISOPROTEIN; PROSTAGLANDIN D2; QUATERNARY AMMONIUM DERIVATIVE; TAS2R1 PROTEIN, HUMAN;

AIRWAY SMOOTH MUSCLE; BREATHING MUSCLE; CELL ACTIVATION; CONTROLLED STUDY; HISTAMINE RELEASE; HUMAN; HUMAN CELL; LETTER; MAST CELL; MEDIATOR RELEASE; PRIORITY JOURNAL; SMOOTH MUSCLE; TASTE BUD; AGONISTS; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CYTOLOGY; DRUG EFFECTS; FETUS BLOOD; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; SECRETION (PROCESS);

CHLOROQUINE; DEXTROMETHORPHAN; FETAL BLOOD; GENE EXPRESSION REGULATION; HISTAMINE; HUMANS; IMMUNOGLOBULIN E; MAST CELLS; NOSCAPINE; PROSTAGLANDIN D2; PROTEIN ISOFORMS; QUATERNARY AMMONIUM COMPOUNDS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, IGE;

EID: 84905571552     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.02.029     Document Type: Article

References (8)

1. D.A. Deshpande, W.C. Wang, E.L. McIlmoyle, K.S. Robinett, R.M. Schillinger, and S.S. An et al. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction Nat Med 16 2010 1299 1304
2. V. Pulkkinen, M.L. Manson, J. Safholm, M. Adner, and S.E. Dahlen The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea Am J Physiol Lung Cell Mol Physiol 303 2012 956 966
3. C. Orsmark-Pietras, A. James, J.R. Konradsen, B. Nordlund, C. Soderhall, and V. Pulkkinen et al. Transcriptome analysis reveals upregulation of bitter taste receptors in severe asthmatics Eur Respir J 42 2013 65 78
4. C.E. Brightling, P. Bradding, F.A. Symon, S.T. Holgate, A.J. Wardlaw, and I.D. Pavord Mast-cell infiltration of airway smooth muscle in asthma N Engl J Med 346 2002 1699 1705
5. K.B. Green, and H.W. Lim Effects of chloroquine on release of mediators from mast cells Skin Pharmacol 2 1989 77 85
6. R. Nosal, K. Drabikova, and J. Pecivova Effect of chloroquine on isolated mast cells Agents Actions 33 1991 37 40
7. W. Meyerhof, C. Batram, C. Kuhn, A. Brockhoff, E. Chudoba, and B. Bufe et al. The molecular receptive ranges of human TAS2R bitter taste receptors Chem Senses 35 2010 157 170
8. B.L. Charous, E.F. Halpern, and G.C. Steven Hydroxychloroquine improves airflow and lowers circulating IgE levels in subjects with moderate symptomatic asthma J Allergy Clin Immunol 102 1998 198 203