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Volumn 4, Issue 3, 2012, Pages 255-269

Modeling of mammalian olfactory receptors and docking of odorants

Author keywords

3D structure modeling; G protein coupled receptors; Homology modeling; Ligand docking; Virtual screening

Indexed keywords

MAMMALIA; RUMEX;

EID: 84873126314     PISSN: 18672450     EISSN: 18672469     Source Type: Journal    
DOI: 10.1007/s12551-012-0080-0     Document Type: Review
Times cited : (16)

References (116)
  • 1
    • 33847704180 scopus 로고    scopus 로고
    • The molecular basis for ligand specificity in a mouse olfactory receptor: a network of functionally important residues
    • Abaffy T, Malhotra A, Luetje C (2007) The molecular basis for ligand specificity in a mouse olfactory receptor: a network of functionally important residues. J Biol Chem 282: 1216-24.
    • (2007) J Biol Chem , vol.282 , pp. 1216-1224
    • Abaffy, T.1    Malhotra, A.2    Luetje, C.3
  • 2
    • 33847155026 scopus 로고    scopus 로고
    • Algorithms for incorporating prior topological information in hmms: application to transmembrane proteins
    • Bagos P, Liakopoulos T, Hamodrakas S (2006) Algorithms for incorporating prior topological information in hmms: application to transmembrane proteins. BMC Bioinformatics 7: 189.
    • (2006) BMC Bioinformatics , vol.7 , pp. 189
    • Bagos, P.1    Liakopoulos, T.2    Hamodrakas, S.3
  • 3
    • 0031565726 scopus 로고    scopus 로고
    • An alpha-carbon template for the trans-membrane helices in the rhodopsin family of G-protein-coupled receptors
    • Baldwin JM, Schertler GF, Unger VM (1997) An alpha-carbon template for the trans-membrane helices in the rhodopsin family of G-protein-coupled receptors. J Mol Biol 272: 144-164.
    • (1997) J Mol Biol , vol.272 , pp. 144-164
    • Baldwin, J.M.1    Schertler, G.F.2    Unger, V.M.3
  • 4
    • 77957055780 scopus 로고
    • Integrated methods and computational probing of structure-function relations in g protein-coupled receptors
    • Ballesteros JA, Weinstein H (1995) Integrated methods and computational probing of structure-function relations in g protein-coupled receptors. Methods Neurosci 25: 366-428.
    • (1995) Methods Neurosci , vol.25 , pp. 366-428
    • Ballesteros, J.A.1    Weinstein, H.2
  • 5
    • 79952084703 scopus 로고    scopus 로고
    • The mouse eugenol odorant receptor: structural and functional plasticity of a broadly tuned odorant binding pocket
    • Baud O, Etter S, Spreafico M, Bordoli L, Schwede T, Vogel H, Pick H (2010) The mouse eugenol odorant receptor: structural and functional plasticity of a broadly tuned odorant binding pocket. Biochemistry 50(5): 843-853.
    • (2010) Biochemistry , vol.50 , Issue.5 , pp. 843-853
    • Baud, O.1    Etter, S.2    Spreafico, M.3    Bordoli, L.4    Schwede, T.5    Vogel, H.6    Pick, H.7
  • 6
    • 34247631654 scopus 로고    scopus 로고
    • Enterochromaffin cells of the human gut: sensors for spices and odorants
    • Braun T, Voland P, Kunz L, Prinz C, Gratzl M (2007) Enterochromaffin cells of the human gut: sensors for spices and odorants. Gastroenterology 132(5): 1890-1901.
    • (2007) Gastroenterology , vol.132 , Issue.5 , pp. 1890-1901
    • Braun, T.1    Voland, P.2    Kunz, L.3    Prinz, C.4    Gratzl, M.5
  • 7
    • 20344370764 scopus 로고    scopus 로고
    • Allosteric mechanisms of signal transduction
    • Changeux JP, Edelstein SJ (2005) Allosteric mechanisms of signal transduction. Science 308(5727): 1424-1428.
    • (2005) Science , vol.308 , Issue.5727 , pp. 1424-1428
    • Changeux, J.P.1    Edelstein, S.J.2
  • 9
    • 79960176452 scopus 로고    scopus 로고
    • Progress in structure based drug design for g protein-coupled receptors
    • Congreve M, Langmead C, Mason J, Marshall F (2011) Progress in structure based drug design for g protein-coupled receptors. J Med Chem 54: 4283-311.
    • (2011) J Med Chem , vol.54 , pp. 4283-4311
    • Congreve, M.1    Langmead, C.2    Mason, J.3    Marshall, F.4
  • 10
    • 43949095157 scopus 로고    scopus 로고
    • On the applicability of GPCR homology models to computer-aided drug discovery: a comparison between in silico and crystal structures of the beta2-adrenergic receptor
    • Costanzi S (2008) On the applicability of GPCR homology models to computer-aided drug discovery: a comparison between in silico and crystal structures of the beta2-adrenergic receptor. J Med Chem 51(10): 2907-2914.
    • (2008) J Med Chem , vol.51 , Issue.10 , pp. 2907-2914
    • Costanzi, S.1
  • 11
    • 60149107539 scopus 로고    scopus 로고
    • A signature of evolutionary constraint on a subset of ectopically expressed olfactory receptor genes
    • De la Cruz O, Blekhman R, Zhang X, Nicolae D, Firestein S, Gilad Y (2009) A signature of evolutionary constraint on a subset of ectopically expressed olfactory receptor genes. Mol Biol Evol 26(3): 491-494.
    • (2009) Mol Biol Evol , vol.26 , Issue.3 , pp. 491-494
    • De la Cruz, O.1    Blekhman, R.2    Zhang, X.3    Nicolae, D.4    Firestein, S.5    Gilad, Y.6
  • 12
    • 44949158886 scopus 로고    scopus 로고
    • Comprehensive analysis of the helix-X-helix motif in soluble proteins
    • Deville J, Rey J, Chabbert M (2008) Comprehensive analysis of the helix-X-helix motif in soluble proteins. Proteins 72(1): 115-135.
    • (2008) Proteins , vol.72 , Issue.1 , pp. 115-135
    • Deville, J.1    Rey, J.2    Chabbert, M.3
  • 14
    • 0030767485 scopus 로고    scopus 로고
    • VERIFY3D: assessment of protein models with three-dimensional profiles
    • Eisenberg D, Luthy R, Bowie JU (1997) VERIFY3D: assessment of protein models with three-dimensional profiles. Methods Enzymol 277: 396-404.
    • (1997) Methods Enzymol , vol.277 , pp. 396-404
    • Eisenberg, D.1    Luthy, R.2    Bowie, J.U.3
  • 15
    • 0242301182 scopus 로고    scopus 로고
    • Ligand-supported homology modelling of protein binding-sites using knowledge-based potentials
    • Evers A, Gohlke H, Klebe G (2003) Ligand-supported homology modelling of protein binding-sites using knowledge-based potentials. J Mol Biol 334(2): 327-345.
    • (2003) J Mol Biol , vol.334 , Issue.2 , pp. 327-345
    • Evers, A.1    Gohlke, H.2    Klebe, G.3
  • 17
    • 0032011940 scopus 로고    scopus 로고
    • BUNDLE: a program for building the transmembrane domains of G-protein-coupled receptors
    • Filizola M, Perez JJ, Carteni-Farina M (1998) BUNDLE: a program for building the transmembrane domains of G-protein-coupled receptors. J Comput Aided Mol Des 12(2): 111-118.
    • (1998) J Comput Aided Mol Des , vol.12 , Issue.2 , pp. 111-118
    • Filizola, M.1    Perez, J.J.2    Carteni-Farina, M.3
  • 18
    • 4644273133 scopus 로고    scopus 로고
    • An automatic method for predicting transmembrane protein structures using cryo-EM and evolutionary data
    • Fleishman SJ, Harrington S, Friesner RA, Honig B, Ben-Tal N (2004) An automatic method for predicting transmembrane protein structures using cryo-EM and evolutionary data. Biophys J 87(5): 3448-3459.
    • (2004) Biophys J , vol.87 , Issue.5 , pp. 3448-3459
    • Fleishman, S.J.1    Harrington, S.2    Friesner, R.A.3    Honig, B.4    Ben-Tal, N.5
  • 19
    • 0034718560 scopus 로고    scopus 로고
    • Molecular mechanisms underlying differential odor responses of a mouse olfactory receptor
    • Floriano W, Vaidehi N, Goddard W III, Singer M, Shepherd G (2000) Molecular mechanisms underlying differential odor responses of a mouse olfactory receptor. Proc Natl Acad Sci USA 97(10): 712-10, 716.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.10 , pp. 712-716
    • Floriano, W.1    Vaidehi, N.2    Goddard III, W.3    Singer, M.4    Shepherd, G.5
  • 20
    • 16644373208 scopus 로고    scopus 로고
    • Making sense of olfaction through predictions of the 3-D structure and function of olfactory receptors
    • Floriano W, Vaidehi N, Goddard W III (2004) Making sense of olfaction through predictions of the 3-D structure and function of olfactory receptors. Chem Senses 29: 269-90.
    • (2004) Chem Senses , vol.29 , pp. 269-290
    • Floriano, W.1    Vaidehi, N.2    Goddard III, W.3
  • 21
    • 17844400914 scopus 로고    scopus 로고
    • The repertoire of G-protein-coupled receptors in fully sequenced genomes
    • Fredriksson R, Schioth H (2005) The repertoire of G-protein-coupled receptors in fully sequenced genomes. Mol Pharmacol 67: 1414-25.
    • (2005) Mol Pharmacol , vol.67 , pp. 1414-1425
    • Fredriksson, R.1    Schioth, H.2
  • 22
    • 0038024615 scopus 로고    scopus 로고
    • The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints
    • Fredriksson R, Lagerstrom M, Lundin L, Schioth H (2003) The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol 63: 1256-72.
    • (2003) Mol Pharmacol , vol.63 , pp. 1256-1272
    • Fredriksson, R.1    Lagerstrom, M.2    Lundin, L.3    Schioth, H.4
  • 24
    • 33645888414 scopus 로고    scopus 로고
    • Developmental expression patterns of testicular olfactory receptor genes during mouse spermatogenesis
    • Fukuda N, Touhara K (2006) Developmental expression patterns of testicular olfactory receptor genes during mouse spermatogenesis. Genes Cells 11: 71-81.
    • (2006) Genes Cells , vol.11 , pp. 71-81
    • Fukuda, N.1    Touhara, K.2
  • 25
    • 84856156564 scopus 로고    scopus 로고
    • Prediction of a ligand-binding niche within a human olfactory receptor by combining site-directed mutagenesis with dynamic homology modeling
    • Gelis L, Wolf S, Hatt H, Neuhaus E, Gerwert K (2012) Prediction of a ligand-binding niche within a human olfactory receptor by combining site-directed mutagenesis with dynamic homology modeling. Angew Chem Int Ed 51(5): 1274-1278.
    • (2012) Angew Chem Int Ed , vol.51 , Issue.5 , pp. 1274-1278
    • Gelis, L.1    Wolf, S.2    Hatt, H.3    Neuhaus, E.4    Gerwert, K.5
  • 26
    • 79957756393 scopus 로고    scopus 로고
    • Successful prediction of the intra- and extracellular loops of four G-protein-coupled receptors
    • Goldfeld DA, Zhu K, Beuming T, Friesner RA (2011) Successful prediction of the intra- and extracellular loops of four G-protein-coupled receptors. Proc Natl Acad Sci USA 108(20): 8275-8280.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.20 , pp. 8275-8280
    • Goldfeld, D.A.1    Zhu, K.2    Beuming, T.3    Friesner, R.A.4
  • 28
    • 71549126815 scopus 로고    scopus 로고
    • MOR23 promotes muscle regeneration and regulates cell adhesion and migration
    • Griffin CA, Kafadar KA, Pavlath GK (2009) MOR23 promotes muscle regeneration and regulates cell adhesion and migration. Dev Cell 17(5): 649-661.
    • (2009) Dev Cell , vol.17 , Issue.5 , pp. 649-661
    • Griffin, C.A.1    Kafadar, K.A.2    Pavlath, G.K.3
  • 30
    • 14144249986 scopus 로고    scopus 로고
    • Predicted 3-D structures for mouse I7 and rat I7 olfactory receptors and comparison of predicted odor recognition profiles with experiment
    • Hall SE, Floriano WB, Vaidehi N, Goddard WA III (2004) Predicted 3-D structures for mouse I7 and rat I7 olfactory receptors and comparison of predicted odor recognition profiles with experiment. Chem Senses 29: 595-616.
    • (2004) Chem Senses , vol.29 , pp. 595-616
    • Hall, S.E.1    Floriano, W.B.2    Vaidehi, N.3    Goddard III, W.A.4
  • 31
    • 0031984517 scopus 로고    scopus 로고
    • The many faces of G protein signaling
    • Hamm HE (1998) The many faces of G protein signaling. J Biol Chem 273(2): 669-672.
    • (1998) J Biol Chem , vol.273 , Issue.2 , pp. 669-672
    • Hamm, H.E.1
  • 34
    • 0025292355 scopus 로고
    • Model for the structure of bacteriorhodopsin based on high-resolution electron cryomicroscopy
    • Henderson R, Baldwin JM, Ceska TA, Zemlin F, Beckmann E, Downing KH (1990) Model for the structure of bacteriorhodopsin based on high-resolution electron cryomicroscopy. J Mol Biol 213: 899-929.
    • (1990) J Mol Biol , vol.213 , pp. 899-929
    • Henderson, R.1    Baldwin, J.M.2    Ceska, T.A.3    Zemlin, F.4    Beckmann, E.5    Downing, K.H.6
  • 35
    • 14144253386 scopus 로고    scopus 로고
    • Test of the binding threshold hypothesis for olfactory receptors: Explanation of the differential binding of ketones to the mouse and human orthologs of olfactory receptor 912-93
    • Hummel P, Vaidehi N, Floriano W, Hall S, Goddard W III (2005) Test of the binding threshold hypothesis for olfactory receptors: Explanation of the differential binding of ketones to the mouse and human orthologs of olfactory receptor 912-93. Protein Sci 14(3): 703-10.
    • (2005) Protein Sci , vol.14 , Issue.3 , pp. 703-710
    • Hummel, P.1    Vaidehi, N.2    Floriano, W.3    Hall, S.4    Goddard III, W.5
  • 37
    • 14044270215 scopus 로고    scopus 로고
    • Structural basis for a broad but selective ligand spectrum of a mouse olfactory receptor: mapping the odorant-binding site
    • Katada S, Hirokawa T, Oka Y, Suwa M, Touhara K (2005) Structural basis for a broad but selective ligand spectrum of a mouse olfactory receptor: mapping the odorant-binding site. J Neurosci 25: 1806-15.
    • (2005) J Neurosci , vol.25 , pp. 1806-1815
    • Katada, S.1    Hirokawa, T.2    Oka, Y.3    Suwa, M.4    Touhara, K.5
  • 38
    • 77649196223 scopus 로고    scopus 로고
    • GPCR 3D homology models for ligand screening: lessons learned from blind predictions of adenosine A2a receptor complex
    • Katritch V, Rueda M, Lam PC, Yeager M, Abagyan R (2010) GPCR 3D homology models for ligand screening: lessons learned from blind predictions of adenosine A2a receptor complex. Proteins 78(1): 197-211.
    • (2010) Proteins , vol.78 , Issue.1 , pp. 197-211
    • Katritch, V.1    Rueda, M.2    Lam, P.C.3    Yeager, M.4    Abagyan, R.5
  • 39
    • 84855799592 scopus 로고    scopus 로고
    • Diversity and modularity of G protein-coupled receptor structures
    • Katritch V, Cherezov V, Stevens RC (2012) Diversity and modularity of G protein-coupled receptor structures. Trends Pharmacol Sci 33(1): 17-27.
    • (2012) Trends Pharmacol Sci , vol.33 , Issue.1 , pp. 17-27
    • Katritch, V.1    Cherezov, V.2    Stevens, R.C.3
  • 41
    • 52449085809 scopus 로고    scopus 로고
    • Luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines, tastants, and olfactants
    • Kidd M, Modlin IM, Gustafsson BI, Drozdov I, Hauso O, Pfragner R (2008) Luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines, tastants, and olfactants. Am J Physiol Gastrointest Liver Physiol 295(2): G260-272.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.295 , Issue.2
    • Kidd, M.1    Modlin, I.M.2    Gustafsson, B.I.3    Drozdov, I.4    Hauso, O.5    Pfragner, R.6
  • 42
    • 16344382546 scopus 로고    scopus 로고
    • Solving and analyzing side-chain positioning problems using linear and integer programming
    • Kingsford CL, Chazelle B, Singh M (2005) Solving and analyzing side-chain positioning problems using linear and integer programming. Bioinformatics 21(7): 1028-1036.
    • (2005) Bioinformatics , vol.21 , Issue.7 , pp. 1028-1036
    • Kingsford, C.L.1    Chazelle, B.2    Singh, M.3
  • 45
    • 0038200571 scopus 로고    scopus 로고
    • Relationship between molecular structure, concentration and odor qualities of oxygenated aliphatic molecules
    • Laing DG, Legha PK, Jinks AL, Hutchinson I (2003) Relationship between molecular structure, concentration and odor qualities of oxygenated aliphatic molecules. Chem Senses 28(1): 57-69.
    • (2003) Chem Senses , vol.28 , Issue.1 , pp. 57-69
    • Laing, D.G.1    Legha, P.K.2    Jinks, A.L.3    Hutchinson, I.4
  • 46
    • 0030339738 scopus 로고    scopus 로고
    • AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR
    • Laskowski RA, Rullmannn JA, MacArthur MW, Kaptein R, Thornton JM (1996) AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR. J Biomol NMR 8(4): 477-486.
    • (1996) J Biomol NMR , vol.8 , Issue.4 , pp. 477-486
    • Laskowski, R.A.1    Rullmannn, J.A.2    MacArthur, M.W.3    Kaptein, R.4    Thornton, J.M.5
  • 47
  • 48
    • 79959564813 scopus 로고    scopus 로고
    • Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation
    • Lebon G, Warne T, Edwards PC, Bennett K, Langmead CJ, Leslie AG, Tate CG (2011) Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation. Nature 474(7352): 521-525.
    • (2011) Nature , vol.474 , Issue.7352 , pp. 521-525
    • Lebon, G.1    Warne, T.2    Edwards, P.C.3    Bennett, K.4    Langmead, C.J.5    Leslie, A.G.6    Tate, C.G.7
  • 50
    • 0026754015 scopus 로고
    • Accurate modeling of protein conformation by automatic segment matching
    • Levitt M (1992) Accurate modeling of protein conformation by automatic segment matching. J Mol Biol 226(2): 507-533.
    • (1992) J Mol Biol , vol.226 , Issue.2 , pp. 507-533
    • Levitt, M.1
  • 52
    • 0033525727 scopus 로고    scopus 로고
    • Combinatorial receptor codes for odors
    • Malnic B, Hirono J, Sato T, Buck LB (1999) Combinatorial receptor codes for odors. Cell 96(5): 713-723.
    • (1999) Cell , vol.96 , Issue.5 , pp. 713-723
    • Malnic, B.1    Hirono, J.2    Sato, T.3    Buck, L.B.4
  • 54
    • 1442310610 scopus 로고    scopus 로고
    • Loops In Proteins (LIP)-a comprehensive loop database for homology modelling
    • Michalsky E, Goede A, Preissner R (2003) Loops In Proteins (LIP)-a comprehensive loop database for homology modelling. Protein Eng 16(12): 979-985.
    • (2003) Protein Eng , vol.16 , Issue.12 , pp. 979-985
    • Michalsky, E.1    Goede, A.2    Preissner, R.3
  • 55
    • 67349088738 scopus 로고    scopus 로고
    • Community-wide assessment of GPCR structure modelling and ligand docking: GPCRDock 2008
    • GPCR Dock 2008 participants, Brooks III C, Dixon J, Moult J, Stevens R
    • Michino M, Abola E, GPCR Dock 2008 participants, Brooks III C, Dixon J, Moult J, Stevens R. (2009) Community-wide assessment of GPCR structure modelling and ligand docking: GPCRDock 2008. Proteins 8: 455-463.
    • (2009) Proteins , vol.8 , pp. 455-463
    • Michino, M.1    Abola, E.2
  • 57
    • 41149173662 scopus 로고    scopus 로고
    • Advances in the development and application of computational methodologies for structural modeling of G-protein coupled receptors
    • Mobarec JC, Filizola M (2008) Advances in the development and application of computational methodologies for structural modeling of G-protein coupled receptors. Expert Opin Drug Discov 3(3): 343-355.
    • (2008) Expert Opin Drug Discov , vol.3 , Issue.3 , pp. 343-355
    • Mobarec, J.C.1    Filizola, M.2
  • 58
    • 69049108756 scopus 로고    scopus 로고
    • Modern homology modeling of g-protein coupled receptors: which structural template to use?
    • Mobarec J, Sanchez R, Filizola M (2009) Modern homology modeling of g-protein coupled receptors: which structural template to use? J Med Chem 52: 5207-16.
    • (2009) J Med Chem , vol.52 , pp. 5207-5216
    • Mobarec, J.1    Sanchez, R.2    Filizola, M.3
  • 60
    • 43749109187 scopus 로고    scopus 로고
    • Crystal structure of squid rhodopsin
    • Murakami M, Kouyama T (2008) Crystal structure of squid rhodopsin. Nature 453: 363-367.
    • (2008) Nature , vol.453 , pp. 363-367
    • Murakami, M.1    Kouyama, T.2
  • 61
    • 33748079137 scopus 로고    scopus 로고
    • Local peptide movement in the photoreaction intermediate of rhodopsin
    • Nakamichi H, Okada T (2006) Local peptide movement in the photoreaction intermediate of rhodopsin. Proc Natl Acad Sci USA 103(34): 12, 729-12, 734.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.34 , pp. 729-734
    • Nakamichi, H.1    Okada, T.2
  • 62
    • 67650233721 scopus 로고    scopus 로고
    • Activation of an olfactory receptor inhibits proliferation of prostate cancer cells
    • Neuhaus EM, Zhang W, Gelis L, Deng Y, Noldus J, Hatt H (2009) Activation of an olfactory receptor inhibits proliferation of prostate cancer cells. J Biol Chem 284(24): 16, 218-16, 225.
    • (2009) J Biol Chem , vol.284 , Issue.24 , pp. 218-225
    • Neuhaus, E.M.1    Zhang, W.2    Gelis, L.3    Deng, Y.4    Noldus, J.5    Hatt, H.6
  • 65
    • 0842266021 scopus 로고    scopus 로고
    • Olfactory receptor antagonism between odorants
    • Oka Y, Omura M, Kataoka H, Touhara K (2004) Olfactory receptor antagonism between odorants. EMBO J 23(1): 120-126.
    • (2004) EMBO J , vol.23 , Issue.1 , pp. 120-126
    • Oka, Y.1    Omura, M.2    Kataoka, H.3    Touhara, K.4
  • 66
    • 0001228323 scopus 로고
    • A common motif in g-protein-coupled seven transmembrane helix receptors
    • Oliveira L, Paiva ACM, Vriend G (1993) A common motif in g-protein-coupled seven transmembrane helix receptors. J Comput Aided Mol Des 7(6): 649-658.
    • (1993) J Comput Aided Mol Des , vol.7 , Issue.6 , pp. 649-658
    • Oliveira, L.1    Paiva, A.C.M.2    Vriend, G.3
  • 68
    • 0032900495 scopus 로고    scopus 로고
    • The variable and conserved interfaces of modeled olfactory receptor proteins
    • Pilpel Y, Lancet D (1999) The variable and conserved interfaces of modeled olfactory receptor proteins. Protein Sci 8(5): 969-977.
    • (1999) Protein Sci , vol.8 , Issue.5 , pp. 969-977
    • Pilpel, Y.1    Lancet, D.2
  • 69
    • 45749109114 scopus 로고    scopus 로고
    • Homology model-based virtual screening for gpcr ligands using docking and target-biased scoring
    • Radestock S, Weil T, Renner S (2008) Homology model-based virtual screening for gpcr ligands using docking and target-biased scoring. J Chem Inf Model 48: 1104-17.
    • (2008) J Chem Inf Model , vol.48 , pp. 1104-1117
    • Radestock, S.1    Weil, T.2    Renner, S.3
  • 70
    • 0033135619 scopus 로고    scopus 로고
    • Prediction of loop geometries using a generalized born model of solvation effects
    • Rapp CS, Friesner RA (1999) Prediction of loop geometries using a generalized born model of solvation effects. Proteins 35(2): 173-183.
    • (1999) Proteins , vol.35 , Issue.2 , pp. 173-183
    • Rapp, C.S.1    Friesner, R.A.2
  • 74
    • 69549096130 scopus 로고    scopus 로고
    • Molecular tuning of odorant receptors and its implication for odor signal processing
    • Reisert J, Restrepo D (2009) Molecular tuning of odorant receptors and its implication for odor signal processing. Chem Senses 34(7): 535-545.
    • (2009) Chem Senses , vol.34 , Issue.7 , pp. 535-545
    • Reisert, J.1    Restrepo, D.2
  • 75
    • 0036199224 scopus 로고    scopus 로고
    • G proteins and olfactory signal transduction
    • Ronnett G, Moon C (2002) G proteins and olfactory signal transduction. Annu Rev Physiol 64: 189-222.
    • (2002) Annu Rev Physiol , vol.64 , pp. 189-222
    • Ronnett, G.1    Moon, C.2
  • 77
    • 0027136282 scopus 로고
    • Comparative protein modelling by satisfaction of spatial restraints
    • Sali A, Blundell TL (1993) Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol 234(3): 779-815.
    • (1993) J Mol Biol , vol.234 , Issue.3 , pp. 779-815
    • Sali, A.1    Blundell, T.L.2
  • 78
    • 0033861004 scopus 로고    scopus 로고
    • Constructing side chains on near-native main chains for ab initio protein structure prediction
    • Samudrala R, Huang ES, Koehl P, Levitt M (2000) Constructing side chains on near-native main chains for ab initio protein structure prediction. Protein Eng 13(7): 453-457.
    • (2000) Protein Eng , vol.13 , Issue.7 , pp. 453-457
    • Samudrala, R.1    Huang, E.S.2    Koehl, P.3    Levitt, M.4
  • 79
    • 22344436740 scopus 로고    scopus 로고
    • Comparison of odorant specificity of two human olfactory receptors from different phylogenetic classes and evidence for antagonism
    • Sanz G, Schlegel C, Pernollet J, Briand L (2005) Comparison of odorant specificity of two human olfactory receptors from different phylogenetic classes and evidence for antagonism. Chem Senses 30: 69-80.
    • (2005) Chem Senses , vol.30 , pp. 69-80
    • Sanz, G.1    Schlegel, C.2    Pernollet, J.3    Briand, L.4
  • 81
    • 0029556994 scopus 로고
    • Projection structure of frog rhodopsin in two crystal forms
    • 578-11,582
    • Schertler GF, Hargrave PA (1995) Projection structure of frog rhodopsin in two crystal forms. Proc Natl Acad Sci USA 92(11): 578-11, 582.
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.11
    • Schertler, G.F.1    Hargrave, P.A.2
  • 82
    • 0027190359 scopus 로고
    • Projection structure of rhodopsin
    • Schertler GF, Villa C, Henderson R (1993) Projection structure of rhodopsin. Nature 362(6422): 770-772.
    • (1993) Nature , vol.362 , Issue.6422 , pp. 770-772
    • Schertler, G.F.1    Villa, C.2    Henderson, R.3
  • 83
    • 33646526072 scopus 로고    scopus 로고
    • I want a new drug: G-protein-coupled receptors in drug development
    • Schlyer S, Horuk R (2006) I want a new drug: G-protein-coupled receptors in drug development. Drug Discov Today 11: 481-493.
    • (2006) Drug Discov Today , vol.11 , pp. 481-493
    • Schlyer, S.1    Horuk, R.2
  • 88
    • 0034042247 scopus 로고    scopus 로고
    • Analysis of the molecular basis for octanal interactions in the expressed rat 17 olfactory receptor
    • Singer M (2000) Analysis of the molecular basis for octanal interactions in the expressed rat 17 olfactory receptor. Chem Senses 25: 155-166.
    • (2000) Chem Senses , vol.25 , pp. 155-166
    • Singer, M.1
  • 89
    • 0028243376 scopus 로고
    • Molecular modeling of ligand-receptor interactions in the OR5 olfactory receptor
    • Singer MS, Shepherd GM (1994) Molecular modeling of ligand-receptor interactions in the OR5 olfactory receptor. Neuroreport 5(10): 1297-1300.
    • (1994) Neuroreport , vol.5 , Issue.10 , pp. 1297-1300
    • Singer, M.S.1    Shepherd, G.M.2
  • 92
    • 44349144497 scopus 로고    scopus 로고
    • Pharmacophore-based virtual screening
    • Sun H (2008) Pharmacophore-based virtual screening. Curr Med Chem 15: 1018-24.
    • (2008) Curr Med Chem , vol.15 , pp. 1018-1024
    • Sun, H.1
  • 93
    • 0001433241 scopus 로고
    • Knowledge based modelling of homologous proteins, Part I: Three-dimensional frameworks derived from the simultaneous superposition of multiple structures
    • Sutcliffe MJ, Haneef I, Carney D, Blundell TL (1987a) Knowledge based modelling of homologous proteins, Part I: Three-dimensional frameworks derived from the simultaneous superposition of multiple structures. Protein Eng 1(5): 377-384.
    • (1987) Protein Eng , vol.1 , Issue.5 , pp. 377-384
    • Sutcliffe, M.J.1    Haneef, I.2    Carney, D.3    Blundell, T.L.4
  • 94
    • 0000179199 scopus 로고
    • Knowledge based modelling of homologous proteins, Part II: rules for the conformations of substituted sidechains
    • Sutcliffe MJ, Hayes FR, Blundell TL (1987b) Knowledge based modelling of homologous proteins, Part II: rules for the conformations of substituted sidechains. Protein Eng 1(5): 385-392.
    • (1987) Protein Eng , vol.1 , Issue.5 , pp. 385-392
    • Sutcliffe, M.J.1    Hayes, F.R.2    Blundell, T.L.3
  • 96
    • 0000197372 scopus 로고    scopus 로고
    • Large amplitude elastic motions in proteins from a single-parameter, atomic analysis
    • Tirion MM (1996) Large amplitude elastic motions in proteins from a single-parameter, atomic analysis. Phys Rev Lett 77(9): 1905-1908.
    • (1996) Phys Rev Lett , vol.77 , Issue.9 , pp. 1905-1908
    • Tirion, M.M.1
  • 97
    • 0028962270 scopus 로고
    • Low resolution structure of bovine rhodopsin determined by electron cryo-microscopy
    • Unger VM, Schertler GF (1995) Low resolution structure of bovine rhodopsin determined by electron cryo-microscopy. Biophys J 68: 1776-1786.
    • (1995) Biophys J , vol.68 , pp. 1776-1786
    • Unger, V.M.1    Schertler, G.F.2
  • 100
    • 77955779227 scopus 로고    scopus 로고
    • Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography
    • Wacker D, Fenalti G, Brown MA, Katritch V, Abagyan R, Cherezov V, Stevens RC (2010) Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography. J Am Chem Soc 132(33): 11, 443-11, 445.
    • (2010) J Am Chem Soc , vol.132 , Issue.33 , pp. 443-445
    • Wacker, D.1    Fenalti, G.2    Brown, M.A.3    Katritch, V.4    Abagyan, R.5    Cherezov, V.6    Stevens, R.C.7
  • 101
    • 79955460451 scopus 로고    scopus 로고
    • Relationship between homo-oligomerization of a mammalian olfactory receptor and its activation state demonstrated by bioluminescence resonance energy transfer
    • Wade F, Espagne A, Persuy MA, Vidic J, Monnerie R, Merola F, Pajot-Augy E, Sanz G (2011) Relationship between homo-oligomerization of a mammalian olfactory receptor and its activation state demonstrated by bioluminescence resonance energy transfer. J Biol Chem 286(17): 15, 252-15, 259.
    • (2011) J Biol Chem , vol.286 , Issue.17 , pp. 252-259
    • Wade, F.1    Espagne, A.2    Persuy, M.A.3    Vidic, J.4    Monnerie, R.5    Merola, F.6    Pajot-Augy, E.7    Sanz, G.8
  • 106
    • 11944266934 scopus 로고    scopus 로고
    • Increased expression of prostate-specific G-protein-coupled receptor in human prostate intraepithelial neoplasia and prostate cancers
    • Weng J, Wang J, Cai Y, Stafford LJ, Mitchell D, Ittmann M, Liu M (2005) Increased expression of prostate-specific G-protein-coupled receptor in human prostate intraepithelial neoplasia and prostate cancers. Int J Cancer 113(5): 811-818.
    • (2005) Int J Cancer , vol.113 , Issue.5 , pp. 811-818
    • Weng, J.1    Wang, J.2    Cai, Y.3    Stafford, L.J.4    Mitchell, D.5    Ittmann, M.6    Liu, M.7
  • 107
    • 70349513038 scopus 로고    scopus 로고
    • Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models
    • e7011
    • Worth C, Kleinau G, Krause G (2009) Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models. PLoS One 4(9): e7011.
    • (2009) PLoS One , vol.4 , Issue.9
    • Worth, C.1    Kleinau, G.2    Krause, G.3
  • 110
    • 33745076219 scopus 로고    scopus 로고
    • Advances in homology protein structure modeling
    • Xiang Z (2006) Advances in homology protein structure modeling. Curr Protein Pept Sci 7: 217-27.
    • (2006) Curr Protein Pept Sci , vol.7 , pp. 217-227
    • Xiang, Z.1
  • 112
    • 77954052042 scopus 로고    scopus 로고
    • Homology modeling of g-protein-coupled receptors with x-ray structures on the rise
    • Yarnitzky T, Levit A, Niv M (2010) Homology modeling of g-protein-coupled receptors with x-ray structures on the rise. Curr Opin Drug Discov Devel 13: 317-25.
    • (2010) Curr Opin Drug Discov Devel , vol.13 , pp. 317-325
    • Yarnitzky, T.1    Levit, A.2    Niv, M.3
  • 113
    • 33644842630 scopus 로고    scopus 로고
    • Multipass membrane protein structure prediction using Rosetta
    • Yarov-Yarovoy V, Schonbrun J, Baker D (2006) Multipass membrane protein structure prediction using Rosetta. Proteins 62(4): 1010-1025.
    • (2006) Proteins , vol.62 , Issue.4 , pp. 1010-1025
    • Yarov-Yarovoy, V.1    Schonbrun, J.2    Baker, D.3
  • 114
    • 1642534609 scopus 로고    scopus 로고
    • An accurate, residue-level, pair potential of mean force for folding and binding based on the distance-scaled, ideal-gas reference state
    • Zhang C, Liu S, Zhou H, Zhou Y (2004) An accurate, residue-level, pair potential of mean force for folding and binding based on the distance-scaled, ideal-gas reference state. Protein Sci 13: 400-11.
    • (2004) Protein Sci , vol.13 , pp. 400-411
    • Zhang, C.1    Liu, S.2    Zhou, H.3    Zhou, Y.4
  • 115
    • 33645793799 scopus 로고    scopus 로고
    • Structure modeling of all identified G protein-coupled receptors in the human genome
    • Zhang Y, Devries ME, Skolnick J (2006) Structure modeling of all identified G protein-coupled receptors in the human genome. PLoS Comput Biol 2(2): e13.
    • (2006) PLoS Comput Biol , vol.2 , Issue.2
    • Zhang, Y.1    Devries, M.E.2    Skolnick, J.3
  • 116
    • 34548851759 scopus 로고    scopus 로고
    • Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarray
    • Zhang X, De la Cruz O, Pinto JM, Nicolae D, Firestein S, Gilad Y (2007) Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarray. Genome Biol 8(5): R86.
    • (2007) Genome Biol , vol.8 , Issue.5
    • Zhang, X.1    De la Cruz, O.2    Pinto, J.M.3    Nicolae, D.4    Firestein, S.5    Gilad, Y.6


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