Yerba mate tea (Ilex paraguariensis): A comprehensive review on chemistry, health implications, and technological considerations

Journal of Food Science

Volumn 72, Issue 9, 2007, Pages

  Heck, C I ^a   De Mejia, E G ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Ilex paraguariensis; Mate tea; Nutraceutical industry; Tea; Yerba Mate

Indexed keywords

ANTIOXIDANT; MUTAGENIC AGENT; PLANT EXTRACT;

ANIMAL; BEVERAGE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; FOOD HANDLING; HUMAN; ILEX PARAGUARIENSIS; METHODOLOGY; NEOPLASM; OBESITY; ODOR; PLANT LEAF; REVIEW; TASTE;

ANIMALS; ANTIOXIDANTS; BEVERAGES; FOOD HANDLING; HUMANS; ILEX PARAGUARIENSIS; MUTAGENS; NEOPLASMS; OBESITY; ODORS; PLANT EXTRACTS; PLANT LEAVES; TASTE;

CROTON OVALIFOLIUS; ILEX PARAGUARIENSIS;

EID: 36349031175     PISSN: 00221147     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3841.2007.00535.x     Document Type: Review

References (116)

1. Alia M, Ramos S, Matcos R, Granado-Serrano AB, Bravo L, Goya L. 2006. Quercetin protects human hepatoma HepG2 against oxidative stress induced by tert-butyl hydroperoxide. Toxicol Appl Pharmacol. 212 : 110 8.
2. Amimoto K, Yoshikawa K, Arihara S. 1993. Triterpenes and triterpene glycosides from the leaves of Ilex rotunda. Phytochem 33 : 1475 80.
3. Andersen T, Fogh J. 2001. Weight loss and delayed gastric emptying following a South American herbal preparation in overweight patients. J Hum Nutr Diet 14 : 243 50.
4. Anesini C, Ferraro G, Filip R. 2006. Peroxidase-like activity of Ilex paraguariensis. Food Chem 97 : 459 64.
5. Arbiser JL, Li XC, Hossain CF, Nagle DG, Smith DM, Miller P, Govindarajan B, DiCarlo J, Landis-Piwowar KR, Dou QP. 2005. Naturally occurring proteasome inhibitors from Mate tea (Ilex paraguayensis) serve as models for topical proteasome inhibitors. J Invest Dermatol 125 : 207 12.
6. Athayde ML, Coelho GC, Schenkel EP. 2000. Caffeine and theobromine in epicuticular wax of Ilex paraguariensis A. St-Hil Phytochem 55 : 853 7.
7. Atoui AK, Mansouri A, Boskou G, Kefalas P. 2005. Tea and herbal infusions: their antioxidant activity ad phenolic profile. Food Chem 89 : 27 36.
8. Bastos DHM, Fornari AC, Queiroz YS, Torres EAFS. 2006a. Bioactive compounds content of Chimarrao infusions related to the moisture of Yerba Mate (Ilex paraguariensis) leaves. Braz Arch Bio Tech 49 : 399 404.
9. Bastos DHM, Ishimoto EY, Marques MOM, Ferri AF, Torres EAFS. 2006b. Essential oil and antioxidant activity of green Mate and Mate tea (Ilex paraguariensis) infusions. J Food Comp Anal 19 : 538 43.
10. Bastos DHM, Saldanha LA, Catharino RR, Sawaya ACHF, Cunha IBS, Carvalho PO, Eberlin MN. 2007. Phenolic antioxidants identified by ESI-MS from Yerba Mate (Ilex paraguariensis) and green tea (Camelia sinensis) extracts. Molecules 12 : 423 32.
11. Bates MN, Hopenhayn C, Rey OA, Moore LE. 2007. Bladder cancer and Mate consumption in Argentina: a case-control study. Cancer Lett 246 : 268 73.
12. Bixby M, Spieler L, Menini T, Gugliucci A. 2005. Ilex paraguariensis extracts are potent inhibitors of nitrosative stress: a comparative study with green tea and wines using a protein nitration model and mammalian cell cytotoxicity. Life Sci 77 : 345 58.
13. Bracesco N, Dell M, Rocha A, Behtash S, Menini T, Gugliucci A, Nunes E. 2003. Antioxidant activity of a botanical extract preparation of Ilex paraguariensis: prevention of DNA double-strand breaks in Saccharomyces cerevisiae and human low-density lipoprotein oxidation. J Altern Complement Med 9 : 379 87.
14. Bravo L, Goya L, Lecumberri E. 2007. LC/MS characterization of phenolic constituents of Mate (Ilex paraguariensis, St. Hil.) and its antioxidant activity compared to commonly consumed beverages. Food Res Int 40 : 393 405.
15. Calvino A. 2005. Note. Caffeine content and dynamical bitterness of Yerba Mate Ilex paraguariensis infusions. Food Sci Tech Int 11 : 401 7.
16. Calvino A, Fraga SG, Garrido D. 2004. Effects of sampling conditions on temporal perception of bitterness in Yerba Mate (Ilex paraguariensis) infusions. J Sens Stud 19 : 193 210.
17. Carducci CN, Dabas PC, Muse JO. 2000. Determination of inorganic cations by capillary ion electrophoresis in Ilex paraguariensis (St. H.), a plant used to prepare tea in South America. J AOAC Int 83 : 1167 73.
18. Carini M, Facino RM, Aldini G, Calloni M, Colombo L. 1998. Characterization of phenolic antioxidants from Mate (Ilex paraguayensis) by liquid chromatography mass spectrometry and liquid chromatography tandem mass spectrometry. Rapid Commun in Mass Spec 12 : 1813 9.
19. Castellsague X, Munoz N, De Stefani E, Victora CG, Castelletto R, Rolon PA. 2000. Influence of Mate drinking, hot beverages and diet on esophageal cancer risk in South America. Int J Cancer 88 : 658 64.
20. Chandra S, De Mejia GE. 2004. Polyphenolic compounds, antioxidant capacity, and quinone reductase activity of an aqueous extract of Ardisia compressa in comparison to Mate (Ilex paraguariensis) and green (Camellia sinensis) teas. J Agric Food Chem 52 : 3583 90.
21. Choi YH, Sertic S, Kim HK, Wilson EG, Michopoulos F, Lefeber AWM, Erkelens C, PratKricun SD, Verpoorte R. 2005. Classification of Ilex species based on metabolomic fingerprinting using nuclear magnetic resonance and multivariate data analysis. J Agric Food Chem 53 : 1237 45.
22. Cruz MJS, Garitta LV, Hough G. 2003. Note: Relationships of consumer acceptability and sensory attributes of Yerba Mate (Ilex paraguariensis St. Hilarie) using preference mapping. Food Sci Tech Int 9 : 347 52.
23. Dall'Orto VC. 2005. Comparison of tyrosinase biosensor and colorimetric method for polyphenol analysis in different kinds of teas. Anal Lett 38 : 19 33.
24. De Stefani E, Correa P, Oreggia F, Deneo-Pellegrini H, Fernandez G, Zavala D, Carzoglio J, Leiva J, Fontham E, Rivero S. 1988. Black tobacco, wine and Mate in oropharyngeal cancer. A case-control study from Uruguay. Rev Epidemiol Sante Publique 36 : 389 94.
25. De Stefani E, Correa P, Fierro L, Fontham E, Chen V, Zavala D. 1991. Black tobacco, Mate, and bladder cancer. A case-control study from Uruguay. Cancer 67 : 536 40.
26. De Stefani E, Fierro L, Correa P, Fontham E, Ronco A, Larrinaga M, Balbi J, Mendilaharsu M. 1996. Mate drinking and risk of lung cancer in males: a case-control study from Uruguay. Cancer Epidemiol Biomarkers Prev 5 : 515 9.
27. De Stefani E, Fierro L, Mendilaharsu M, Ronco A, Larrinaga MT, Balbi JC, Alonso S, Deneo-Pellegrini H. 1998. Meat intake, 'Mate' drinking and renal cell cancer in Uruguay: a case-control study. Br J Cancer 78 : 1239 43.
28. De Stefani E, Boffetta P, Deneo-Pellegrini H, Correa P, Ronco A, Brennan P, Ferro G, Acosta G, Mendilaharsu M. 2007. Non-alcoholic beverages and risk of bladder cancer in Uruguay. BMC Cancer 7 : 57.
29. Dickel ML, Rates SM, Ritter MR. 2007. Plants popularly used for losing weight purposes in Porto Alegre, South Brazil. J Ethnopharmacol 109 : 60 71.
30. Drinkine J, Lopes P, Kennedy JA, Teissedre PL, Saucier C. 2007. Ethylidene-bridged flavan-3-ols in red wine and correlation with wine age. J Agric Food Chem 55 : 6292 9.
31. Duke JA. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, Fla. : CRC Press.
32. EPA National Primary Drinking Water Standards. June 2003. 816-F-03-016. Office of Water (4606M). Available from : http://www.epa.gov/safewater/ contaminats/index.html. Accessed July 10 2007.
33. Esmelindro AA, Girardi JDS, Mossi A, Jacques RA, Dariva C. 2004. Influence of agronomic variables on the composition of Mate tea leaves (Ilex paraguariensis) extracts obtained from CO2 extraction at 30 degrees C and 175 bar. J Agric Food Chem 52 : 1990 5.
34. Fagundes RB, Abnet CC, Strickland PT, Kamangar F, Roth MJ, Taylor PR, Dawsey SM. 2006. Higher urine 1-hydroxy pyrene glucuronide (1-OHPG) is associated with tobacco smoke exposure and drinking Mate in healthy subjects from Rio Grande do Sul, Brazil. BMC Cancer 6 : 139 45.
35. FAOSTAT. ©Food and Agricultural Organization (FAO) Statistics Division 2007. Available from : http://faostat.fao.org/site/408/DesktopDefault. aspx?PageID=408. Accessed Sept 12 2007.
36. Ferreira F. 1997. Inhibition of the passive diffusion of cholic acid by the Ilex paraguariensis St Hil saponins. Phytotherapy Res 11 : 79 81.
37. Filip R, Ferraro GE. 2003. Researching on new species of "Mate": Ilex brevicuspis: phytochemical and pharmacology study. Eur J Nutr 42 : 50 4.
38. Filip R, Lopez P, Coussio J, Ferraro G. 1998. Mate substitutes or adulterants: study of xanthine content. Phytotherapy Res 12 : 129 31.
39. Filip R, Lotito SB, Ferraro G, Fraga CG. 2000. Antioxidant activity of Ilex paraguariensis and related species. Nutr Res 20 : 1437 46.
40. Filip R, Lopez P, Giberti G, Coussio J, Ferraro G. 2001. Phenolic compounds in seven South American Ilex species. Fitoterapia 72 : 774 8.
41. Fonseca CA, Otto SS, Paumgartten FJ, Leitao AC. 2000. Nontoxic, mutagenic, and clastogenic activities of Mate-Chimarrao (Ilex paraguariensis). J Environ Pathol Toxicol Oncol 19 : 333 46.
42. Giberti GC. 1994. Mate (Ilex paraguariensis). In : Hernándo BJE, León J, editors. Neglected crops: 1492 from a different perspective. Plant Production and Protection Series No. 26 ed. Rome, Italy : FAO. p 252 4.
43. Giulian R, IochimsdosSantos CE, de Moraes Shubeita S, da Silva LM, Dias JF, Yoneama ML. 2007. Elemental characterization of commercial Mate tea leaves (Ilex paraguariensis A. St.-Hil.) before and after hot water infusion using ion beam techniques. J Agric Food Chem 55 : 741 6.
44. Gnoatto SCB, Schenkel EP, Bassani VL. 2005. HPLC method to assay total saponins in Ilex paraguariensis aqueous extract. J Braz Chem Soc 16 : 723 6.
45. Goldenberg D. 2002. Mate: a risk factor for oral and oropharyngeal cancer. Oral Oncol 38 : 646 9.
46. Goldenberg D, Golz A, Joachims HZ. 2003. The beverage Mate: a risk factor for cancer of the head and neck. Head Neck 25 : 595 601.
47. Goldenberg D, Lee J, Koch WM, Kim MM, Trink B, Sidransky D, Moon CS. 2004. Habitual risk factors for head and neck cancer. Otolaryngol Head Neck Surg 131 : 986 93.
48. Gonzalez A, Ferreira F, Vazquez A, Moyna P, Paz EA. 1993. Biological screening of Uruguayan medicinal-plants. J Ethnopharmacol 39 : 217 20.
49. Gonzalez de Mejia E, Song YS, Ramirez-Mares MV, Kobayashi H. 2005. Effect of Yerba Mate (Ilex paraguariensis) tea on topoisomerase inhibition and oral carcinoma cell proliferation. J Agric Food Chem 53 : 1966 73.
50. Gorgen M, Turatti K, Medeiros AR, Buffon A, Bonan CD, Sarkis JJ, Pereira GS. 2005. Aqueous extract of Ilex paraguariensis decreases nucleotide hydrolysis in rat blood serum. J Ethnopharmacol 97 : 73 7.
51. Gorzalczany S, Filip R, Alonso MR, Mino J, Ferraro GE, Acevedo C. 2001. Choleretic effect and intestinal propulsion of 'Mate' (Ilex paraguariensis) and its substitutes or adulterants. J Ethnopharmacol 75 : 291 4.
52. Gosmann G, Guillaume D, Taketa AT, Schenkel EP. 1995. Triterpenoid saponins from Ilex paraguariensis. J Nat Prod 58 : 438 41.
53. Graham HN. 1992. Green tea composition, consumption, and polyphenol chemistry. Prev Med 21 : 334 50.
54. Grigioni G, Carduza F, Irurueta M, Pensel N. 2004. Flavour characteristics of Ilex paraguariensis infusion, a typical Argentine product, assessed by sensory evaluation and electronic nose. J Sci Food Agric 84 : 427 32.
55. Gugliucci A. 1996. Antioxidant effects of Ilex paraguariensis: induction of decreased oxidability of human LDL in vivo. Biochem Biophys Res Commun 224 : 338 44.
56. Gugliucci A, Menini T. 2002. The botanical extracts of Achyrocline satureoides and Ilex paraguariensis prevent methylglyoxal-induced inhibition of plasminogen and antithrombin III. Life Sci 72 : 279 92.
57. Gugliucci A, Stahl AJ. 1995. Low density lipoprotein oxidation is inhibited by extracts of Ilex paraguariensis. Biochem Mol Biol Int 35 : 47 56.
58. Hara Y. 2001. Green tea: health benefits and applications. New York : Marcel Dekker Inc. p 16 20.
59. Heck C, de Mejia E. 2007. Polyphenols in Mate tea depend on cultivation and preparation conditions. Symposium on functional plant phenolics: analysis and evaluation. Amer Chem Soc. AGFD 141.
60. Ito E, Crozier A, Ashihara H. 1997. Theophylline metabolism in higher plants. Biochim Biophys Acta 1336 : 323 30.
61. Jacques RA, dos Santos Freitas L, Perez VF, Dariva C, de Oliveira AP, de Oliveira JV, Caramao EB. 2007. The use of ultrasound in the extraction of Ilex paraguariensis leaves: a comparison with maceration. Ultrason Sonochem 14 : 6 12.
62. Kawakami M, Kobayashi A. 1991. Volatile constituents of green mate and roasted mate. J Agric Food Chem 39 : 1275 9.
63. Keast RS, Roper J. 2007. A complex relationship among chemical concentration, detection threshold, and suprathreshold intensity of bitter compounds. Chem Senses 32 : 245 53.
64. Kraemer KH, Taketa AT, Schenkel EP, Gosmann G, Guillaume D. 1996. Matesaponin 5, a highly polar saponin from Ilex paraguariensis. Phytochemistry 42 : 1119 22.
65. Leitao AC, Braga RS. 1994. Mutagenic and genotoxic effects of Mate (Ilex paraguariensis) in prokaryotic organisms. Braz J Med Biol Res 27 : 1517 25.
66. Ley JP, Blings M, Paetz S, Krammer GE, Bertram HJ. 2006. New bitter-masking compounds: hydroxylated benzoic acid amides of aromatic amines as structural analogues of homoeriodictyol. J Agric Food Chem 54 : 8574 9.
67. Lozano PR, Cadwallader KR, Gonzalez de Mejia E. 2007. Identification of characteristic aroma components of Mate (Ilex paraguariensis) Tea. In : Tunick MH, de Mejia EG, editors. Hispanic foods: chemistry and flavor. Washington, D.C. : Amer Chem Soc. p 143 50.
68. Lunceford N, Gugliucci A. 2005. Ilex paraguariensis extracts inhibit AGE formation more efficiently than green tea. Fitoterapia 76 : 419 27.
69. Ma WW, Heinstein PF, McLaughlin JL. 1989. Additional toxic, bitter saponins from the seeds of Chenopodium quinoa. J Nat Prod 52 : 1132 5.
70. Marchisio PF, Sales A, Cerutti S, Marchevski E, Martinez LD. 2005. On-line preconcentration/determination of lead in Ilex paraguariensis samples (Mate tea) using polyurethane foam as filter and USN-ICP-OES. J Hazard Mater 124 : 113 8.
71. Martinet A, Hostettmann K, Schutz Y. 1999. Thermogenic effects of commercially available plant preparations aimed at treating human obesity. Phytomedicine 6 : 231 8.
72. Martinet A, Ndjoko K, Terreaux C, Marston A, Hostettmann K, Schutz Y. 2001. NMR and LC-MSn characterisation of two minor saponins from Ilex paraguariensis. Phytochem Anal 12 : 48 52.
73. Mazzafera P. 1997. Mate drinking: caffeine and phenolic acid intake. Food Chem 60 : 67 71.
74. Mosimann AL, Wilhelm-Filho D, da Silva EL. 2006. Aqueous extract of Ilex paraguariensis attenuates the progression of atherosclerosis in cholesterol-fed rabbits. Biofactors 26 : 59 70.
75. Muccillo Baisch AL, Johnston KB, Paganini Stein FL. 1998. Endothelium-dependent vasorelaxing activity of aqueous extracts of Ilex paraguariensis on mesenteric arterial bed of rats. J Ethnopharmacol 60 : 133 9.
76. Newell AMB, Chandra S, Gonzalez de Mejia E. 2007. Ethnic teas and their bioactive components. In : Tunick MH, de Mejia EG, editors. Hispanic foods: chemistry and flavor. Washington, D.C. : Amer Chem Soc. p 127 31.
77. Opala T, Rzymskip P, Pischel I, Wilczak M, Wozniak J. 2006. Efficacy of 12 weeks supplementation of a botanical extract-based weight loss formula on body weight, body composition and blood chemistry in healthy, overweight subjects - a randomised double-blind placebo-controlled clinical trial. Eur J Med Res 11 : 343 50.
78. Osanai K, Landis-Piwowar KR, Dou QP, Chan TH. 2007. A para-amino substituent on the D-ring of green tea polyphenol epigallocatechin-3-gallate as a novel proteasome inhibitor and cancer cell apoptosis inducer. Bioorg Med Chem 15 : 5076 82.
79. Ouyang MA, Liu YQ, Wang HQ, Yang CR. 1998. Triterpenoid saponins from Ilex latifolia. Phytochem 49 : 2483 6.
80. Paganini Stein FL, Schmidt B, Furlong EB, Souza-Soares LA, Soares MC, Vaz MR, Muccillo Baisch AL. 2005. Vascular responses to extractable fractions of Ilex paraguariensis in rats fed standard and high-cholesterol diets. Biol Res Nurs 7 : 146 56.
81. Pavei C, Guzatto P, Petrovick P, Gosmann G, Gonzalez-Ortega G. 2007. Development and validation of an HPLC method for the characterization and assay of the saponins from Ilex paraguariensis A. St.-Hill (Mate) fruits. J Liquid Chromatogr Related Tech 30 : 87 95.
82. Pereira Jotz G, Sampaio Menezes H, Galleano Zetter C, Vargas Alves RJ, Chacur R, Buzzatti C, Dias de Oliveira M, Maeso Montes TH, Hübner M, Walker Zettler E. 2006. Mate (Ilex paraguariensis) as an etiological agent of neoplasia in the aerodigestive tract. An experimental study. Intl Arch Otorhinolaryngol São Paulo 10 : 306 11.
83. Pintos J, Franco EL, Oliveira BV, Kowalski LP, Curado MP, Dewar R. 1994. Mate, coffee, and tea consumption and risk of cancers of the upper aerodigestive tract in southern Brazil. Epidemiology 5 : 583 90.
84. Pires VS, Guillaume D, Gosmann G, Schenkel EP. 1997. Saponins from Ilex dumosa, an Erva-Mate (Ilex paraguariensis) adulterating plant. J Agric Food Chem 45 : 1027 31.
85. Pires VS, Gosmann G, Guillaume D, Schenkel EP. 2002. Triterpenes and saponins from Ilex psammophila. Nat Prod Lett 16 : 401 6.
86. Pittler MH, Ernst E. 2004. Dietary supplements for body-weight reduction: a systematic review. Am J Clin Nutr 79 : 529 36.
87. Pomilio AB, Trajtemberg S, Vitale AA. 2002. High-performance capillary electrophoresis analysis of Mate infusions prepared from stems and leaves of Ilex paraguariensis using automated micellar electrokinetic capillary chromatography. Phytochem Anal 13 : 235 41.
88. Ramirez-Mares MV, Chandra S, de Mejia EG. 2004. In vitro chemopreventive activity of Camellia sinensis, Ilex paraguariensis and Ardisia compressa tea extracts and selected polyphenols. Mutat Res 554 : 53 65.
89. Reginatto FH, Athayde ML, Gosmann G, Schenkel EP. 1999. Methylxanthines accumulation in Ilex species - Caffeine and theobromine in erva-Mate (Ilex paraguariensis) and other Ilex species. J Braz Chem Soc 10 : 443 6.
90. Rojo de Camargo, CM, Toledo MCF. 2002. Coffee and Mate tea as a dietary source of polycyclic aromatic hydrocarbon (PAHs) in Campinas. Food Sci Tech 22 : 49 53.
91. Rolon PA, Castellsague X, Benz M, Munoz N. 1995. Hot and cold Mate drinking and esophageal cancer in Paraguay. Cancer Epidemiol Biomarkers Prev 4 : 595 605.
92. 2. J Agric Food Chem 47 : 3804 8.
93. Saldana MD, Zetzl C, Mohamed RS, Brunner G. 2002. Extraction of methylxanthines from guarana seeds, Mate leaves, and cocoa beans using supercritical carbon dioxide and ethanol. J Agric Food Chem 50 : 4820 6.
94. Santa Cruz MJ. 2002. Sensory descriptive analysis of Yerba Mate (Ilex paraguariensis Saint Hilaire), a South American beverage. Food Sci Tech Int 8 : 25 31.
95. Schinella GR, Troiani G, Davila V, de Buschiazzo PM, Tournier HA. 2000. Antioxidant effects of an aqueous extract of Ilex paraguariensis. Biochem Biophys Res Commun 269 : 357 60.
96. Schinella G, Fantinelli JC, Mosca SM. 2005. Cardioprotective effects of Ilex paraguariensis extract: evidence for a nitric oxide-dependent mechanism. Clin Nutr 24 : 360 6.
97. Schmalko ME, Alzamora SM. 2001. Color, chlorophyll, caffeine, and water content variation during Yerba Mate processing. Drying Tech 19 (3&4 599 610.
98. Schmalko ME, Scipioni PG, Ferreyra DJ. 2005. Effect of water activity and temperature on color and chlorophylls changes in Yerba Mate leaves. Int J Food Prop 8 : 313 22.
99. Schneider E, Scherer RA, Janssens MJJ. 2006. Mate from Argentina - production, sensory analysis, use. Dtsch Lebensm -Rundsch 102 : 313 8.
100. Schubert A, Zanin FF, Pereira DF, Athayde ML. 2006. Annual variations of mehtylxanthines in Ilex paraguariensis A. St. Hil (Mate) samples in Ijui and Santa Maria, State of Rio Grande Do Sul. Quim Nova 29 : 1233 6.
101. Sewram V, De Stefani E, Brennan P, Boffetta P. 2003. Mate consumption and the risk of squamous cell esophageal cancer in Uruguay. Cancer Epidemiol Biomarkers Prev 12 : 508 13.
102. Small E, Catling PM. 2001. Blossoming treasures of biodiversity: 3. Mate (Ilex paraguariensis) - better than Viagra, marijuana, and coffee? Biodiversity 2 : 26 7.
103. Taketa AT. 2004. Triterpenes and triterpenoidal glycosides from the fruits of Ilex paraguariensis (Mate). J Braz Chem Soc 15 : 205 11.
104. Taketa AT, Schmittmann-Schlager T, Guillaume D, Gosmann G, Schenkel EP. 2000. Triterpenoid glycosides and a triterpene from Ilex brevicuspis. Phytochem 53 : 901 4.
105. Taketa AT, Gnoatto SC, Gosmann G, Pires VS, Schenkel EP, Guillaume D. 2004. Triterpenoids from Brazilian Ilex species and their in vitro antitrypanosomal activity. J Nat Prod 67 : 1697 700.
106. Tenorio Sanz MD, Torija Isasa ME. 1991. Mineral elements in Mate herb (Ilex paraguariensis St. H.). Arch Latinoam Nutr 41 : 441 54.
107. Turkmen N, Sari F, Velioglu YS. 2006. Effects of extraction solvents on concentration and antioxidant activity of black and black Mate tea polyphenols determined by ferrous tartrate and Folin-Ciocalteu methods. Food Chem 99 : 835 41.
108. USDA, ARS, National Genetic Resources Program. 2007. Germplasm Resources Information Network (GRIN) Online Database Beltsville, Maryland : Natl. Germplasm Resources Laboratory. Available from : http://www.ars-grin.gov/cgi- bin/npgs/html/taxon.pl?19756. Accessed Feb 16 2007.
109. VanderJagt TJ, Ghattas R, VanderJagt DJ, Crossey M, Glew RH. 2002. Comparison of the total antioxidant content of 30 widely used medicinal plants of New Mexico. Life Sci 70 : 1035 40.
110. Vassallo A, Correa P, De Stefani E, Cendan M, Zavala D, Chen V, Carzoglio J, Deneo-Pellegrini H. 1985. Esophageal cancer in Uruguay: a case-control study. J Natl Cancer Inst 75 : 1005 9.
111. Vera Garcia R, Basualdo I, Peralta I, de Herebia M, Caballero S. 1997. Minerals content of Paraguayan Yerba Mate (Ilex paraguariensis, S.H.). Arch Latinoam Nutr 47 : 77 80.
112. Wrobel K, Wrobel K, Urbina EM. 2000. Determination of total aluminum, chromium, copper, iron, manganese, and nickel and their fractions leached to the infusions of black tea, green tea, Hibiscus sabdariffa, and Ilex paraguariensis (Mate) by ETA-AAS. Biol Trace Elem Res 78 : 271 80.
113. Yamamoto T, Juneja LR, Chu DC, Kim M, editors. 1997. Chemistry and applications of green tea. New York : CRC Press. p 61 73.
114. Yano I, Nishiizumi C, Yochikawa K, Arihars S. 1993. Triterpenoid saponins from Ilex integra. Phytochem 32 : 417 20.
115. Zaporozhets OA, Krushynska OA, Lipkovska NA, Barvinchenk VN. 2004. A new test method for the evaluation of total antioxidant activity of herbal products. J Agric Food Chem 52 : 21 5.
116. Zuin VG, Montero L, Bauer C, Popp P. 2005. Stir bar sorptive extraction and high-performance liquid chromatography-fluorescence detection for the determination of polycyclic aromatic hydrocarbons in Mate teas. J Chromatogr A 1091 : 2 10.