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Volumn 130, Issue , 2015, Pages 1-36

Mammalian olfactory receptors: Molecular mechanisms of odorant detection, 3D-modeling, and structure-activity relationships

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; DIMER; G PROTEIN COUPLED RECEPTOR; LIGAND; OLFACTORY RECEPTOR;

EID: 84921808045     PISSN: 18771173     EISSN: 18780814     Source Type: Book Series    
DOI: 10.1016/bs.pmbts.2014.11.001     Document Type: Chapter
Times cited : (19)

References (253)
  • 2
    • 0842303304 scopus 로고    scopus 로고
    • After the holy grail: Establishing a molecular basis for mammalian olfaction
    • R. Reed After the holy grail: establishing a molecular basis for mammalian olfaction Cell 116 2004 329 336
    • (2004) Cell , vol.116 , pp. 329-336
    • Reed, R.1
  • 3
    • 14644399312 scopus 로고    scopus 로고
    • A comparison of the human and chimpanzee olfactory receptor gene repertoires
    • Y. Gilad, O. Man, and G. Glusman A comparison of the human and chimpanzee olfactory receptor gene repertoires Genome Res 15 2 2005 224 230
    • (2005) Genome Res , vol.15 , Issue.2 , pp. 224-230
    • Gilad, Y.1    Man, O.2    Glusman, G.3
  • 4
    • 0025825726 scopus 로고
    • A novel multigene family may encode odorant receptors: A molecular basis for odor recognition
    • L. Buck, and R. Axel A novel multigene family may encode odorant receptors: a molecular basis for odor recognition Cell 65 1991 175 187
    • (1991) Cell , vol.65 , pp. 175-187
    • Buck, L.1    Axel, R.2
  • 5
    • 0033525727 scopus 로고    scopus 로고
    • Combinatorial receptor codes for odors
    • B. Malnic, J. Hirono, T. Sato, and L. Buck Combinatorial receptor codes for odors Cell 96 5 1999 713 723
    • (1999) Cell , vol.96 , Issue.5 , pp. 713-723
    • Malnic, B.1    Hirono, J.2    Sato, T.3    Buck, L.4
  • 6
    • 36949011636 scopus 로고    scopus 로고
    • The G protein-coupled receptor subset of the rat genome
    • D. Gloriam, R. Fredriksson, and H. Schiöth The G protein-coupled receptor subset of the rat genome BMC Genomics 8 2007 338
    • (2007) BMC Genomics , vol.8 , pp. 338
    • Gloriam, D.1    Fredriksson, R.2    Schiöth, H.3
  • 7
    • 0031883174 scopus 로고    scopus 로고
    • Distribution of olfactory receptor genes in the human genome
    • S. Rouquier, S. Taviaux, and B. Trask Distribution of olfactory receptor genes in the human genome Nat Genet 18 1998 243 250
    • (1998) Nat Genet , vol.18 , pp. 243-250
    • Rouquier, S.1    Taviaux, S.2    Trask, B.3
  • 8
    • 0037092592 scopus 로고    scopus 로고
    • The sense of smell: Genomics of vertebrate odorant receptors
    • J.M. Young, and B.J. Trask The sense of smell: genomics of vertebrate odorant receptors Hum Mol Genet 11 10 2002 1153 1160
    • (2002) Hum Mol Genet , vol.11 , Issue.10 , pp. 1153-1160
    • Young, J.M.1    Trask, B.J.2
  • 9
    • 1542682074 scopus 로고    scopus 로고
    • Comparison of the canine and human olfactory receptor gene repertoires
    • P. Quignon, E. Kirkness, and E. Cadieu Comparison of the canine and human olfactory receptor gene repertoires Genome Biol 4 2003 R80.81 R80.89
    • (2003) Genome Biol , vol.4 , pp. R8081-R8089
    • Quignon, P.1    Kirkness, E.2    Cadieu, E.3
  • 10
    • 0035237870 scopus 로고    scopus 로고
    • The human olfactory receptor repertoire
    • S. Zozulya, F. Echeverri, and T. Nguyen The human olfactory receptor repertoire Genome Biol 2 6 2001 0018.0011 0018.0012
    • (2001) Genome Biol , vol.2 , Issue.6 , pp. 00180011-00180012
    • Zozulya, S.1    Echeverri, F.2    Nguyen, T.3
  • 11
    • 84860299628 scopus 로고    scopus 로고
    • Olfactory receptor multigene family in vertebrates: From the viewpoint of evolutionary genomics
    • Y. Niimura Olfactory receptor multigene family in vertebrates: from the viewpoint of evolutionary genomics Curr Genomics 13 2 2012 103 114
    • (2012) Curr Genomics , vol.13 , Issue.2 , pp. 103-114
    • Niimura, Y.1
  • 12
    • 84868674183 scopus 로고    scopus 로고
    • The complete swine olfactory subgenome: Expansion of the olfactory gene repertoire in the pig genome
    • D. Nguyen, K. Lee, and H. Choi The complete swine olfactory subgenome: expansion of the olfactory gene repertoire in the pig genome BMC Genomics 13 1 2012 584
    • (2012) BMC Genomics , vol.13 , Issue.1 , pp. 584
    • Nguyen, D.1    Lee, K.2    Choi, H.3
  • 13
    • 84907224951 scopus 로고    scopus 로고
    • Extreme expansion of the olfactory receptor gene repertoire in African elephants and evolutionary dynamics of orthologous gene groups in 13 placental mammals
    • Y. Niimura, A. Matsui, and K. Touhara Extreme expansion of the olfactory receptor gene repertoire in African elephants and evolutionary dynamics of orthologous gene groups in 13 placental mammals Genome Res 24 9 2014 1485 1496
    • (2014) Genome Res , vol.24 , Issue.9 , pp. 1485-1496
    • Niimura, Y.1    Matsui, A.2    Touhara, K.3
  • 14
    • 49749101118 scopus 로고    scopus 로고
    • Similar numbers but different repertoires of olfactory receptor genes in humans and chimpanzees
    • Y. Go, and Y. Niimura Similar numbers but different repertoires of olfactory receptor genes in humans and chimpanzees Mol Biol Evol 25 9 2008 1897 1907
    • (2008) Mol Biol Evol , vol.25 , Issue.9 , pp. 1897-1907
    • Go, Y.1    Niimura, Y.2
  • 15
    • 77951529170 scopus 로고    scopus 로고
    • Degeneration of olfactory receptor gene repertories in primates: No direct link to full trichromatic vision
    • A. Matsui, Y. Go, and Y. Niimura Degeneration of olfactory receptor gene repertories in primates: no direct link to full trichromatic vision Mol Biol Evol 27 5 2010 1192 1200
    • (2010) Mol Biol Evol , vol.27 , Issue.5 , pp. 1192-1200
    • Matsui, A.1    Go, Y.2    Niimura, Y.3
  • 16
    • 34548086194 scopus 로고    scopus 로고
    • The dog and rat olfactory receptor repertoires
    • P. Quignon, M. Giraud, and M. Rimbault The dog and rat olfactory receptor repertoires Genome Biol 6 10 2005 R83
    • (2005) Genome Biol , vol.6 , Issue.10 , pp. R83
    • Quignon, P.1    Giraud, M.2    Rimbault, M.3
  • 17
    • 33846691834 scopus 로고    scopus 로고
    • Olfactory receptor gene repertoires in mammals
    • S. Rouquier, and D. Giorgi Olfactory receptor gene repertoires in mammals Mutat Res 6 16 2007 95 102
    • (2007) Mutat Res , vol.6 , Issue.16 , pp. 95-102
    • Rouquier, S.1    Giorgi, D.2
  • 18
    • 19344370877 scopus 로고    scopus 로고
    • The human sense of smell: Are we better than we think?
    • 146
    • G. Shepherd The human sense of smell: are we better than we think? PLoS Biol 2 5 2004 e 146
    • (2004) PLoS Biol , vol.2 , Issue.5 , pp. e
    • Shepherd, G.1
  • 19
    • 0032965527 scopus 로고    scopus 로고
    • Molecular biology of odorant receptors in vertebrates
    • P. Mombaerts Molecular biology of odorant receptors in vertebrates Annu Rev Neurosci 22 1999 487 509
    • (1999) Annu Rev Neurosci , vol.22 , pp. 487-509
    • Mombaerts, P.1
  • 20
    • 0142091376 scopus 로고    scopus 로고
    • Evolution of olfactory receptor genes in the human genome
    • Y. Niimura, and M. Nei Evolution of olfactory receptor genes in the human genome Proc Natl Acad Sci 100 2003 12235 12240
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 12235-12240
    • Niimura, Y.1    Nei, M.2
  • 21
    • 7844234750 scopus 로고    scopus 로고
    • Large multi-chromosomal duplications encompass many members of the olfactory receptor gene family in the human genome
    • B. Trask, H. Massa, and V. Brand-Arpon Large multi-chromosomal duplications encompass many members of the olfactory receptor gene family in the human genome Hum Mol Genet 7 13 1998 2007 2020
    • (1998) Hum Mol Genet , vol.7 , Issue.13 , pp. 2007-2020
    • Trask, B.1    Massa, H.2    Brand-Arpon, V.3
  • 22
    • 0031033489 scopus 로고    scopus 로고
    • The evolution of mammalian olfactory receptor genes
    • L. Issel-Traver, and J. Rine The evolution of mammalian olfactory receptor genes Genetics 145 1 1997 185 195
    • (1997) Genetics , vol.145 , Issue.1 , pp. 185-195
    • Issel-Traver, L.1    Rine, J.2
  • 23
    • 0031659924 scopus 로고    scopus 로고
    • A gene recently inactivated in human defines a new olfactory receptor family in mammals
    • S. Rouquier, C. Friedman, and Delettre Cc A gene recently inactivated in human defines a new olfactory receptor family in mammals Hum Mol Genet 7 9 1998 1337 1345
    • (1998) Hum Mol Genet , vol.7 , Issue.9 , pp. 1337-1345
    • Rouquier, S.1    Friedman, C.2    Cc, D.3
  • 24
    • 0032862870 scopus 로고    scopus 로고
    • Primate evolution of an olfactory receptor cluster: Diversification by gene conversion and recent emergence of speudogenes
    • D. Sharon, G. Glusman, and Y. Pilpel Primate evolution of an olfactory receptor cluster: diversification by gene conversion and recent emergence of speudogenes Genomics 61 1 1999 24 36
    • (1999) Genomics , vol.61 , Issue.1 , pp. 24-36
    • Sharon, D.1    Glusman, G.2    Pilpel, Y.3
  • 25
    • 84864564596 scopus 로고    scopus 로고
    • Functional evolution of mammalian odorant receptors
    • K. Adipietro, J. Mainland, and H. Matsunami Functional evolution of mammalian odorant receptors PLoS Genet 8 7 2012 e1002821
    • (2012) PLoS Genet , vol.8 , Issue.7 , pp. e1002821
    • Adipietro, K.1    Mainland, J.2    Matsunami, H.3
  • 26
    • 0346102906 scopus 로고    scopus 로고
    • Prediction of the odorant binding site of olfactory receptor proteins by human-mouse comparisons
    • O. Man, Y. Gilad, and D. Lancet Prediction of the odorant binding site of olfactory receptor proteins by human-mouse comparisons Protein Sci 13 1 2004 240 254
    • (2004) Protein Sci , vol.13 , Issue.1 , pp. 240-254
    • Man, O.1    Gilad, Y.2    Lancet, D.3
  • 27
    • 17844373261 scopus 로고    scopus 로고
    • Evolutionary dynamics of olfactory receptor genes in fishes and tetrapods
    • Y. Niimura, and M. Nei Evolutionary dynamics of olfactory receptor genes in fishes and tetrapods Proc Natl Acad Sci 102 17 2005 6039 6044
    • (2005) Proc Natl Acad Sci , vol.102 , Issue.17 , pp. 6039-6044
    • Niimura, Y.1    Nei, M.2
  • 28
    • 14744284678 scopus 로고    scopus 로고
    • Comparative evolutionary analysis of olfactory receptor gene clusters between humans and mice
    • Y. Niimura, and M. Nei Comparative evolutionary analysis of olfactory receptor gene clusters between humans and mice Gene 346 2005 13 21
    • (2005) Gene , vol.346 , pp. 13-21
    • Niimura, Y.1    Nei, M.2
  • 29
    • 56549111367 scopus 로고    scopus 로고
    • The evolution of animal chemosensory receptor gene repertoires: Roles of chance and necessity
    • M. Nei, Y. Niimura, and M. Nozawa The evolution of animal chemosensory receptor gene repertoires: roles of chance and necessity Nat Rev Genet 9 12 2008 951 963
    • (2008) Nat Rev Genet , vol.9 , Issue.12 , pp. 951-963
    • Nei, M.1    Niimura, Y.2    Nozawa, M.3
  • 30
    • 1442281343 scopus 로고    scopus 로고
    • The human olfactory receptor gene family
    • B. Malnic, P. Godfrey, and L. Buck The human olfactory receptor gene family Proc Natl Acad Sci 101 8 2004 2584 2589
    • (2004) Proc Natl Acad Sci , vol.101 , Issue.8 , pp. 2584-2589
    • Malnic, B.1    Godfrey, P.2    Buck, L.3
  • 31
    • 0034672585 scopus 로고    scopus 로고
    • The genomic structure of human olfactory receptor genes
    • A. Sosinsky, G. Glusman, and D. Lancet The genomic structure of human olfactory receptor genes Genomics 70 1 2000 49 61
    • (2000) Genomics , vol.70 , Issue.1 , pp. 49-61
    • Sosinsky, A.1    Glusman, G.2    Lancet, D.3
  • 32
    • 0035912779 scopus 로고    scopus 로고
    • Genomic analysis of orthologous mouse and human olfactory receptor loci
    • R. Lane, T. Cutforth, and J. Young Genomic analysis of orthologous mouse and human olfactory receptor loci Proc Natl Acad Sci 98 13 2001 7390 7395
    • (2001) Proc Natl Acad Sci , vol.98 , Issue.13 , pp. 7390-7395
    • Lane, R.1    Cutforth, T.2    Young, J.3
  • 33
    • 0036143582 scopus 로고    scopus 로고
    • Genomic analysis of the olfactory receptor region of the mouse and human T-cell receptor alpha/delta loci
    • R. Lane, J. Roach, and I. Lee Genomic analysis of the olfactory receptor region of the mouse and human T-cell receptor alpha/delta loci Genome Res 12 1 2002 81 87
    • (2002) Genome Res , vol.12 , Issue.1 , pp. 81-87
    • Lane, R.1    Roach, J.2    Lee, I.3
  • 34
    • 84897939199 scopus 로고    scopus 로고
    • Genetic basis of olfactory cognition: Extremely high level of DNA sequence polymorphism in promoter regions of the human olfactory receptor genes revealed using the 1000 Genomes Project dataset
    • Article
    • E. Ignatieva, V. Levitsky, N. Yudin, M. Moshkin, and N. Kolchanov Genetic basis of olfactory cognition: extremely high level of DNA sequence polymorphism in promoter regions of the human olfactory receptor genes revealed using the 1000 Genomes Project dataset Front Psychol 5 2014 247 Article
    • (2014) Front Psychol , vol.5 , pp. 247
    • Ignatieva, E.1    Levitsky, V.2    Yudin, N.3    Moshkin, M.4    Kolchanov, N.5
  • 35
    • 81055124162 scopus 로고    scopus 로고
    • Rigorous and thorough bioinformatic analyses of olfactory receptor promoters confirm enrichment of O/E and homeodomain binding sites but reveal no new common motifs
    • J. Young, R. Luche, and B. Trask Rigorous and thorough bioinformatic analyses of olfactory receptor promoters confirm enrichment of O/E and homeodomain binding sites but reveal no new common motifs BMC Genomics 12 2011 561
    • (2011) BMC Genomics , vol.12 , pp. 561
    • Young, J.1    Luche, R.2    Trask, B.3
  • 36
    • 0034687732 scopus 로고    scopus 로고
    • Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse b-globin gene clusters
    • M. Bulger, M. Bender, and J. van Doorminck Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse b-globin gene clusters Proc Natl Acad Sci 97 26 2000 14560 14565
    • (2000) Proc Natl Acad Sci , vol.97 , Issue.26 , pp. 14560-14565
    • Bulger, M.1    Bender, M.2    Van Doorminck, J.3
  • 37
    • 33748255705 scopus 로고    scopus 로고
    • Identification of potential regulatory motifs in odorant receptor genes by analysis of promoter sequences
    • J. Michaloski, P. Galande, and B. Malnic Identification of potential regulatory motifs in odorant receptor genes by analysis of promoter sequences Genome Res 16 2006 1091 1098
    • (2006) Genome Res , vol.16 , pp. 1091-1098
    • Michaloski, J.1    Galande, P.2    Malnic, B.3
  • 38
    • 84857857538 scopus 로고    scopus 로고
    • Promoter architecture of mouse olfactory receptor genes
    • C. Plessy, G. Pascarella, and N. Bertin Promoter architecture of mouse olfactory receptor genes Genome Res 22 3 2012 486 497
    • (2012) Genome Res , vol.22 , Issue.3 , pp. 486-497
    • Plessy, C.1    Pascarella, G.2    Bertin, N.3
  • 39
    • 33646845292 scopus 로고    scopus 로고
    • Promoter motifs of olfactory receptor genes expressed in distinct topographic patterns
    • R. Hoppe, H. Breer, and J. Strotmann Promoter motifs of olfactory receptor genes expressed in distinct topographic patterns Genomics 87 2006 711 723
    • (2006) Genomics , vol.87 , pp. 711-723
    • Hoppe, R.1    Breer, H.2    Strotmann, J.3
  • 40
    • 38049177062 scopus 로고    scopus 로고
    • Deletion of the core-H region in mice abolishes the expression of three proximal odorant receptor genes in cis
    • H. Nishizumi, K. Kumasaka, N. Inoue, A. Nakashima, and H. Sakano Deletion of the core-H region in mice abolishes the expression of three proximal odorant receptor genes in cis Proc Natl Acad Sci 104 50 2007 20067 20072
    • (2007) Proc Natl Acad Sci , vol.104 , Issue.50 , pp. 20067-20072
    • Nishizumi, H.1    Kumasaka, K.2    Inoue, N.3    Nakashima, A.4    Sakano, H.5
  • 41
    • 0038024615 scopus 로고    scopus 로고
    • The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints
    • R. Fredriksson, M.C. Lagerström, L.G. Lundin, and H.B. Schiöth The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints Mol Pharmacol 63 6 2003 1256 1272
    • (2003) Mol Pharmacol , vol.63 , Issue.6 , pp. 1256-1272
    • Fredriksson, R.1    Lagerström, M.C.2    Lundin, L.G.3    Schiöth, H.B.4
  • 42
    • 84869002200 scopus 로고    scopus 로고
    • Nuclear aggregation of olfactory receptor genes governs their monogenic expression
    • E. Clowney, M. LeGros, and C. Mosley Nuclear aggregation of olfactory receptor genes governs their monogenic expression Cell 151 4 2012 724 737
    • (2012) Cell , vol.151 , Issue.4 , pp. 724-737
    • Clowney, E.1    Legros, M.2    Mosley, C.3
  • 43
    • 84896703717 scopus 로고    scopus 로고
    • Silencing of odorant receptor genes by G protein beta-gamma signaling ensures the expression of one odorant receptor per olfactory sensory neuron
    • T. Ferreira, S. Wilson, and Y. Choi Silencing of odorant receptor genes by G protein beta-gamma signaling ensures the expression of one odorant receptor per olfactory sensory neuron Neuron 81 4 2014 847 859
    • (2014) Neuron , vol.81 , Issue.4 , pp. 847-859
    • Ferreira, T.1    Wilson, S.2    Choi, Y.3
  • 44
    • 84885656686 scopus 로고    scopus 로고
    • Singular expression of olfactory receptor genes
    • I. Rodriguez Singular expression of olfactory receptor genes Cell 155 2 2013 274 277
    • (2013) Cell , vol.155 , Issue.2 , pp. 274-277
    • Rodriguez, I.1
  • 45
    • 79955854161 scopus 로고    scopus 로고
    • An epigenetic signature for monoallelic olfactory receptor expression
    • A. Magklara, A. Yen, and B. Colquitt An epigenetic signature for monoallelic olfactory receptor expression Cell 145 4 2011 555 570
    • (2011) Cell , vol.145 , Issue.4 , pp. 555-570
    • Magklara, A.1    Yen, A.2    Colquitt, B.3
  • 47
    • 34447510932 scopus 로고    scopus 로고
    • Local and cis effects of the H element on expression of odorant receptor genes in mouse
    • S. Fuss, M. Omura, and P. Mombaerts Local and cis effects of the H element on expression of odorant receptor genes in mouse Cell 130 2 2007 373 384
    • (2007) Cell , vol.130 , Issue.2 , pp. 373-384
    • Fuss, S.1    Omura, M.2    Mombaerts, P.3
  • 48
    • 0033918082 scopus 로고    scopus 로고
    • Mutually exclusive expression of odorant receptor transgenes
    • S. Serizawa, T. Ishii, and H. Nakatani Mutually exclusive expression of odorant receptor transgenes Nat Neurosci 3 2000 687 693
    • (2000) Nat Neurosci , vol.3 , pp. 687-693
    • Serizawa, S.1    Ishii, T.2    Nakatani, H.3
  • 49
    • 77955933540 scopus 로고    scopus 로고
    • Neural map formation in the mouse olfactory system
    • H. Sakano Neural map formation in the mouse olfactory system Neuron 67 2010 530 542
    • (2010) Neuron , vol.67 , pp. 530-542
    • Sakano, H.1
  • 50
    • 84878267573 scopus 로고    scopus 로고
    • Functional interrogation of an odorant receptor locus reveals multiple axes of transcriptional regulation
    • A. Fleischmann, I. Abdus-Saboor, A. Sayed, and B. Shykind Functional interrogation of an odorant receptor locus reveals multiple axes of transcriptional regulation PLoS Biol 11 5 2013 e1001568
    • (2013) PLoS Biol , vol.11 , Issue.5 , pp. e1001568
    • Fleischmann, A.1    Abdus-Saboor, I.2    Sayed, A.3    Shykind, B.4
  • 51
    • 0346362447 scopus 로고    scopus 로고
    • Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse
    • S. Serizawa, K. Miyamichi, and H. Nakatani Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse Science 302 5653 2003 2088 2094
    • (2003) Science , vol.302 , Issue.5653 , pp. 2088-2094
    • Serizawa, S.1    Miyamichi, K.2    Nakatani, H.3
  • 52
    • 84891357984 scopus 로고    scopus 로고
    • Rare event of histone demethylation can initiate singular gene expression of olfactory receptors
    • L. Tan, C. Zong, and X. Xie Rare event of histone demethylation can initiate singular gene expression of olfactory receptors Proc Natl Acad Sci 110 52 2013 21148 21152
    • (2013) Proc Natl Acad Sci , vol.110 , Issue.52 , pp. 21148-21152
    • Tan, L.1    Zong, C.2    Xie, X.3
  • 53
    • 0034085533 scopus 로고    scopus 로고
    • Expression of mRNA encoding for two different olfactory receptors in a subset of olfactory receptor neurons
    • N. Rawson, J. Eberwine, R. Dotson, J. Jackson, P. Ulrich, and D. Restrepo Expression of mRNA encoding for two different olfactory receptors in a subset of olfactory receptor neurons J Neurochem 75 1 2000 185 195
    • (2000) J Neurochem , vol.75 , Issue.1 , pp. 185-195
    • Rawson, N.1    Eberwine, J.2    Dotson, R.3    Jackson, J.4    Ulrich, P.5    Restrepo, D.6
  • 54
    • 0036163689 scopus 로고    scopus 로고
    • The olfactory receptor gene superfamily of the mouse
    • X. Zhang, and S. Firestein The olfactory receptor gene superfamily of the mouse Nat Neurosci 5 2 2002 124 133
    • (2002) Nat Neurosci , vol.5 , Issue.2 , pp. 124-133
    • Zhang, X.1    Firestein, S.2
  • 55
    • 17044395103 scopus 로고    scopus 로고
    • Continuous and overlapping expression domains of odorant receptor genes in the olfactory epithelium determine the dorsal/ventral positioning of glomeruli in the olfactory bulb
    • S. Miyamichi, H. Serizawa, H. Kimura, and H. Sakano Continuous and overlapping expression domains of odorant receptor genes in the olfactory epithelium determine the dorsal/ventral positioning of glomeruli in the olfactory bulb J Neurosci 25 2005 3586 3592
    • (2005) J Neurosci , vol.25 , pp. 3586-3592
    • Miyamichi, S.1    Serizawa, H.2    Kimura, H.3    Sakano, H.4
  • 56
    • 84871439940 scopus 로고    scopus 로고
    • Olfactory receptors in non-chemosensory tissues
    • N. Kang, and J. Koo Olfactory receptors in non-chemosensory tissues BMB Rep 45 11 2012 612 622
    • (2012) BMB Rep , vol.45 , Issue.11 , pp. 612-622
    • Kang, N.1    Koo, J.2
  • 57
    • 84873563478 scopus 로고    scopus 로고
    • Expression profile of ectopic olfactory receptors determined by deep sequencing
    • C. Flegel, S. Manteniotis, S. Osthold, H. Hatt, and G. Gisselmann Expression profile of ectopic olfactory receptors determined by deep sequencing PLoS One 8 2 2013 e55368
    • (2013) PLoS One , vol.8 , Issue.2 , pp. e55368
    • Flegel, C.1    Manteniotis, S.2    Osthold, S.3    Hatt, H.4    Gisselmann, G.5
  • 58
    • 84896691815 scopus 로고    scopus 로고
    • Extrasensory perception: Odorant and taste receptors beyond the nose and mouth
    • S. Foster, E. Roura, and W. Thomas Extrasensory perception: odorant and taste receptors beyond the nose and mouth Pharmacol Ther 142 2014 41 61
    • (2014) Pharmacol Ther , vol.142 , pp. 41-61
    • Foster, S.1    Roura, E.2    Thomas, W.3
  • 59
    • 69049115153 scopus 로고    scopus 로고
    • Evidence for developmentally regulated local translation of odorant receptor mRNAs in the axons of olfactory sensory neurons
    • C. Dubacq, S. Jamet, and A. Trembleau Evidence for developmentally regulated local translation of odorant receptor mRNAs in the axons of olfactory sensory neurons J Neurosci 29 33 2009 10184 10190
    • (2009) J Neurosci , vol.29 , Issue.33 , pp. 10184-10190
    • Dubacq, C.1    Jamet, S.2    Trembleau, A.3
  • 60
    • 84891608241 scopus 로고    scopus 로고
    • Homotypic and heterotypic adhesion induced by odorant receptors and the beta2-adrenergic receptor
    • M. Richard, S. Jamet, and C. Fouquet Homotypic and heterotypic adhesion induced by odorant receptors and the beta2-adrenergic receptor PLoS One 8 12 2013 e80100
    • (2013) PLoS One , vol.8 , Issue.12 , pp. e80100
    • Richard, M.1    Jamet, S.2    Fouquet, C.3
  • 61
    • 84893770128 scopus 로고    scopus 로고
    • Making scent of the presence and local translation of odorant receptor mRNAs in olfactory axons
    • C. Dubacq, C. Fouquet, and A. Trembleau Making scent of the presence and local translation of odorant receptor mRNAs in olfactory axons Dev Neurobiol 74 3 2014 259 268
    • (2014) Dev Neurobiol , vol.74 , Issue.3 , pp. 259-268
    • Dubacq, C.1    Fouquet, C.2    Trembleau, A.3
  • 63
    • 33645888414 scopus 로고    scopus 로고
    • Developmental expression patterns of testicular olfactory receptor genes during mouse spermatogenesis
    • N. Fukuda, and K. Touhara Developmental expression patterns of testicular olfactory receptor genes during mouse spermatogenesis Genes Cells 11 1 2006 71 81
    • (2006) Genes Cells , vol.11 , Issue.1 , pp. 71-81
    • Fukuda, N.1    Touhara, K.2
  • 64
    • 0037470996 scopus 로고    scopus 로고
    • Identification of a testicular odorant receptor mediating human sperm chemotaxis
    • M. Spehr, G. Gisselmann, and A. Poplawski Identification of a testicular odorant receptor mediating human sperm chemotaxis Science 299 2003 2054 2058
    • (2003) Science , vol.299 , pp. 2054-2058
    • Spehr, M.1    Gisselmann, G.2    Poplawski, A.3
  • 66
    • 67449152404 scopus 로고    scopus 로고
    • Behavioral response of human spermatozoa to a concentration jump of chemoattractants or intracellular cyclic nucleotides
    • A. Gakamsky, L. Armon, and M. Eisenbach Behavioral response of human spermatozoa to a concentration jump of chemoattractants or intracellular cyclic nucleotides Hum Reprod 24 5 2009 1152 1163
    • (2009) Hum Reprod , vol.24 , Issue.5 , pp. 1152-1163
    • Gakamsky, A.1    Armon, L.2    Eisenbach, M.3
  • 67
    • 71549126815 scopus 로고    scopus 로고
    • MOR23 promotes muscle regeneration and regulates cell adhesion and migration
    • C.A. Griffin, K.A. Kafadar, and G.K. Pavlath MOR23 promotes muscle regeneration and regulates cell adhesion and migration Dev Cell 17 2009 649 661
    • (2009) Dev Cell , vol.17 , pp. 649-661
    • Griffin, C.A.1    Kafadar, K.A.2    Pavlath, G.K.3
  • 68
    • 60549097679 scopus 로고    scopus 로고
    • Functional expression of the olfactory signaling system in the kidney
    • J.L. Pluznick, D.J. Zou, and X. Zhang Functional expression of the olfactory signaling system in the kidney Proc Natl Acad Sci USA 106 6 2009 2059 2064
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.6 , pp. 2059-2064
    • Pluznick, J.L.1    Zou, D.J.2    Zhang, X.3
  • 69
    • 84875047650 scopus 로고    scopus 로고
    • Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation
    • J.L. Pluznick, R.J. Protzko, and H. Gevorgyan Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation Proc Natl Acad Sci USA 110 11 2013 4410 4415
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.11 , pp. 4410-4415
    • Pluznick, J.L.1    Protzko, R.J.2    Gevorgyan, H.3
  • 70
    • 34247631654 scopus 로고    scopus 로고
    • Enterochromaffin cells of the human gut: Sensors for spices and odorants
    • T. Braun, P. Voland, L. Kunz, C. Prinz, and M. Gratzl Enterochromaffin cells of the human gut: sensors for spices and odorants Gastroenterology 132 5 2007 1890 1901
    • (2007) Gastroenterology , vol.132 , Issue.5 , pp. 1890-1901
    • Braun, T.1    Voland, P.2    Kunz, L.3    Prinz, C.4    Gratzl, M.5
  • 71
    • 52449085809 scopus 로고    scopus 로고
    • Luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines, tastants, and olfactants
    • M. Kidd, I.M. Modlin, B.I. Gustafsson, I. Drozdov, O. Hauso, and R. Pfragner Luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines, tastants, and olfactants Am J Physiol Gastrointest Liver Physiol 295 2 2008 G260 G272
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.295 , Issue.2 , pp. G260-G272
    • Kidd, M.1    Modlin, I.M.2    Gustafsson, B.I.3    Drozdov, I.4    Hauso, O.5    Pfragner, R.6
  • 72
    • 84873190680 scopus 로고    scopus 로고
    • High fat diet differentially regulates the expression of olfactory receptors in the duodenum of obesity-prone and obesity-resistant rats
    • S. Primeaux, H. Braymer, and G. Bray High fat diet differentially regulates the expression of olfactory receptors in the duodenum of obesity-prone and obesity-resistant rats Dig Dis Sci 58 1 2013 72 76
    • (2013) Dig Dis Sci , vol.58 , Issue.1 , pp. 72-76
    • Primeaux, S.1    Braymer, H.2    Bray, G.3
  • 73
    • 27944444047 scopus 로고    scopus 로고
    • Expression of Golf in the rat placenta: Possible implication of olfactory receptor transduction
    • S. Itakura, K. Ohno, T. Ueki, K. Sato, and N. Kanayama Expression of Golf in the rat placenta: possible implication of olfactory receptor transduction Placenta 27 1 2006 103 108
    • (2006) Placenta , vol.27 , Issue.1 , pp. 103-108
    • Itakura, S.1    Ohno, K.2    Ueki, T.3    Sato, K.4    Kanayama, N.5
  • 74
    • 84874519932 scopus 로고    scopus 로고
    • Olfactory receptor 51E1 protein as a potential novel tissue biomarker for small intestine neuroendocrine carcinomas
    • T. Cui, A. Tsolakis, and S. Li Olfactory receptor 51E1 protein as a potential novel tissue biomarker for small intestine neuroendocrine carcinomas Eur J Endocrinol 168 2 2013 253 261
    • (2013) Eur J Endocrinol , vol.168 , Issue.2 , pp. 253-261
    • Cui, T.1    Tsolakis, A.2    Li, S.3
  • 75
    • 33644500133 scopus 로고    scopus 로고
    • PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer
    • J. Weng, J. Wang, X. Hu, F. Wang, M. Ittman, and M. Liu PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer Int J Cancer 118 6 2006 1471 1480
    • (2006) Int J Cancer , vol.118 , Issue.6 , pp. 1471-1480
    • Weng, J.1    Wang, J.2    Hu, X.3    Wang, F.4    Ittman, M.5    Liu, M.6
  • 76
    • 59149090670 scopus 로고    scopus 로고
    • Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas
    • J. Leja, A. Essaghir, and M. Essand Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas Mod Pathol 22 2009 261 272
    • (2009) Mod Pathol , vol.22 , pp. 261-272
    • Leja, J.1    Essaghir, A.2    Essand, M.3
  • 77
    • 80054996659 scopus 로고    scopus 로고
    • Breast tumors from CHEK2 1100delC-mutation carriers: Genomic landscape and clinical implications
    • T.A. Muranen, D. Greco, and R. Fagerholm Breast tumors from CHEK2 1100delC-mutation carriers: genomic landscape and clinical implications Breast Cancer Res: BCR 13 5 2011 R90
    • (2011) Breast Cancer Res: BCR , vol.13 , Issue.5 , pp. R90
    • Muranen, T.A.1    Greco, D.2    Fagerholm, R.3
  • 78
    • 84897004342 scopus 로고    scopus 로고
    • Promotion of cancer cell invasiveness and metastasis emergence caused by olfactory receptor stimulation
    • G. Sanz, I. Leray, and A. Dewaele Promotion of cancer cell invasiveness and metastasis emergence caused by olfactory receptor stimulation PLoS One 9 1 2014 e85100
    • (2014) PLoS One , vol.9 , Issue.1 , pp. e85100
    • Sanz, G.1    Leray, I.2    Dewaele, A.3
  • 80
    • 84894061267 scopus 로고    scopus 로고
    • Activation of olfactory receptors on mouse pulmonary macrophages promotes monocyte chemotactic protein-1 production
    • J. Li, H. Tay, and M. Plank Activation of olfactory receptors on mouse pulmonary macrophages promotes monocyte chemotactic protein-1 production PLoS One 8 11 2013 e80148
    • (2013) PLoS One , vol.8 , Issue.11 , pp. e80148
    • Li, J.1    Tay, H.2    Plank, M.3
  • 82
    • 84892455634 scopus 로고    scopus 로고
    • The missense of smell: Functional variability in the human odorant receptor repertoire
    • J. Mainland, A. Keller, and Y. Li The missense of smell: functional variability in the human odorant receptor repertoire Nat Neurosci 17 1 2014 114 120
    • (2014) Nat Neurosci , vol.17 , Issue.1 , pp. 114-120
    • Mainland, J.1    Keller, A.2    Li, Y.3
  • 83
    • 84899514272 scopus 로고    scopus 로고
    • The state of the art of odorant receptor deorphanization: A report from the orphanage
    • Z. Peterlin, S. Firestein, and M. Rogers The state of the art of odorant receptor deorphanization: a report from the orphanage J Gen Physiol 143 5 2014 527 542
    • (2014) J Gen Physiol , vol.143 , Issue.5 , pp. 527-542
    • Peterlin, Z.1    Firestein, S.2    Rogers, M.3
  • 84
    • 34547129604 scopus 로고    scopus 로고
    • Specificity of olfactory receptor interaction with other G protein-coupled receptors
    • C. Bush, S. Jones, A. Lyle, K. Minneman, K. Ressler, and R. Hall Specificity of olfactory receptor interaction with other G protein-coupled receptors J Biol Chem 282 26 2007 19042 19051
    • (2007) J Biol Chem , vol.282 , Issue.26 , pp. 19042-19051
    • Bush, C.1    Jones, S.2    Lyle, A.3    Minneman, K.4    Ressler, K.5    Hall, R.6
  • 85
    • 4544226342 scopus 로고    scopus 로고
    • Olfactory receptor surface expression is driven by association with the beta2-adrenergic receptor
    • C. Hague, M. Uberti, and Z. Chen Olfactory receptor surface expression is driven by association with the beta2-adrenergic receptor Proc Natl Acad Sci 101 37 2004 13672 13676
    • (2004) Proc Natl Acad Sci , vol.101 , Issue.37 , pp. 13672-13676
    • Hague, C.1    Uberti, M.2    Chen, Z.3
  • 86
    • 8844270180 scopus 로고    scopus 로고
    • RTP family members induce functional expression of mammalian odorant receptors
    • H. Saito, M. Kubota, R. Roberts, Q. Chi, and H. Matsunami RTP family members induce functional expression of mammalian odorant receptors Cell 119 5 2004 679 691
    • (2004) Cell , vol.119 , Issue.5 , pp. 679-691
    • Saito, H.1    Kubota, M.2    Roberts, R.3    Chi, Q.4    Matsunami, H.5
  • 87
    • 77249084576 scopus 로고    scopus 로고
    • Olfactory signalling in vertebrates and insects: Differences and commonalities
    • U. Kaupp Olfactory signalling in vertebrates and insects: differences and commonalities Nat Rev Neurosci 11 3 2010 188 200
    • (2010) Nat Rev Neurosci , vol.11 , Issue.3 , pp. 188-200
    • Kaupp, U.1
  • 88
    • 56349169408 scopus 로고    scopus 로고
    • The electrochemical basis of odor transduction in vertebrate olfactory cilia
    • S. Kleene The electrochemical basis of odor transduction in vertebrate olfactory cilia Chem Senses 33 9 2008 839 859
    • (2008) Chem Senses , vol.33 , Issue.9 , pp. 839-859
    • Kleene, S.1
  • 89
    • 0031918820 scopus 로고    scopus 로고
    • Transduction mechanisms in vertebrate olfactory receptor cells
    • D. Schild, and D. Restrepo Transduction mechanisms in vertebrate olfactory receptor cells Physiol Rev 78 2 1998 429 465
    • (1998) Physiol Rev , vol.78 , Issue.2 , pp. 429-465
    • Schild, D.1    Restrepo, D.2
  • 90
    • 0030273253 scopus 로고    scopus 로고
    • General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel
    • L. Brunet, G. Gold, and J. Ngai General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel Neuron 17 4 1996 681 693
    • (1996) Neuron , vol.17 , Issue.4 , pp. 681-693
    • Brunet, L.1    Gold, G.2    Ngai, J.3
  • 91
    • 0031888199 scopus 로고    scopus 로고
    • Mice deficient in G(olf) are anosmic
    • L. Belluscio, G. Gold, A. Nemes, and R. Axel Mice deficient in G(olf) are anosmic Neuron 20 1 1998 69 81
    • (1998) Neuron , vol.20 , Issue.1 , pp. 69-81
    • Belluscio, L.1    Gold, G.2    Nemes, A.3    Axel, R.4
  • 92
    • 0024475378 scopus 로고
    • Golf: An olfactory neuron specific-G protein involved in odorant signal transduction
    • D. Jones, and R. Reed Golf: an olfactory neuron specific-G protein involved in odorant signal transduction Science 244 4906 1989 790 795
    • (1989) Science , vol.244 , Issue.4906 , pp. 790-795
    • Jones, D.1    Reed, R.2
  • 93
    • 84877152885 scopus 로고    scopus 로고
    • Heterotrimeric G protein subunit G gamma13 is critical to olfaction
    • F. Li, S. Ponissery-Saidu, and K. Yee Heterotrimeric G protein subunit G gamma13 is critical to olfaction J Neurosci 33 18 2013 7975 7984
    • (2013) J Neurosci , vol.33 , Issue.18 , pp. 7975-7984
    • Li, F.1    Ponissery-Saidu, S.2    Yee, K.3
  • 94
    • 0023111437 scopus 로고
    • A cyclic nucleotide-gated conductance in olfactory receptor cilia
    • T. Nakamura, and G. Gold A cyclic nucleotide-gated conductance in olfactory receptor cilia Nature 325 6103 1987 442 444
    • (1987) Nature , vol.325 , Issue.6103 , pp. 442-444
    • Nakamura, T.1    Gold, G.2
  • 95
    • 84903551274 scopus 로고    scopus 로고
    • Three structurally similar odorants trigger distinct signaling pathways in a mouse olfactory neuron
    • Y. Yu, N.P. Boyer, and C. Zhang Three structurally similar odorants trigger distinct signaling pathways in a mouse olfactory neuron Neuroscience 275 2014 194 210
    • (2014) Neuroscience , vol.275 , pp. 194-210
    • Yu, Y.1    Boyer, N.P.2    Zhang, C.3
  • 96
    • 33644787709 scopus 로고    scopus 로고
    • Odorant receptors directly activate phospholipase C/inositol-1,4,5-trisphosphate coupled to calcium influx in Odora cells
    • G. Liu, R.M. Badeau, A. Tanimura, and B.R. Talamo Odorant receptors directly activate phospholipase C/inositol-1,4,5-trisphosphate coupled to calcium influx in Odora cells J Neurochem 96 6 2006 1591 1605
    • (2006) J Neurochem , vol.96 , Issue.6 , pp. 1591-1605
    • Liu, G.1    Badeau, R.M.2    Tanimura, A.3    Talamo, B.R.4
  • 97
    • 0034743946 scopus 로고    scopus 로고
    • 3-gated channels and their occurrence relative to CNG channels in the soma and dendritic knob of rat olfactory receptor neurons
    • 3-gated channels and their occurrence relative to CNG channels in the soma and dendritic knob of rat olfactory receptor neurons J Membr Biol 181 2001 91 105
    • (2001) J Membr Biol , vol.181 , pp. 91-105
    • Kaur, R.1    Zhu, X.2    Moorhouse, A.3    Barry, P.4
  • 98
    • 0025332773 scopus 로고
    • Rapid activation of alternative second messenger pathways on olfactory cilia from rats by different odorants
    • I. Boekhoff, E. Tareilus, J. Strotmann, and H. Breer Rapid activation of alternative second messenger pathways on olfactory cilia from rats by different odorants EMBO J 9 8 1990 2453 2458
    • (1990) EMBO J , vol.9 , Issue.8 , pp. 2453-2458
    • Boekhoff, I.1    Tareilus, E.2    Strotmann, J.3    Breer, H.4
  • 99
    • 0033021391 scopus 로고    scopus 로고
    • Characterization of inositol-1,4,5-triphosphate-gated channels in the plasma membrane of rat olfactory neurons
    • F. Lischka, M. Zviman, J. Teeter, and D. Restrepo Characterization of inositol-1,4,5-triphosphate-gated channels in the plasma membrane of rat olfactory neurons Biophys J 76 3 1999 1410 1422
    • (1999) Biophys J , vol.76 , Issue.3 , pp. 1410-1422
    • Lischka, F.1    Zviman, M.2    Teeter, J.3    Restrepo, D.4
  • 100
    • 0033911370 scopus 로고    scopus 로고
    • Cross-talk between olfactory second messenger pathways
    • A. Vogl, J. Noé, H. Breer, and I. Boekhoff Cross-talk between olfactory second messenger pathways Eur J Biochem 267 14 2000 4529 4535
    • (2000) Eur J Biochem , vol.267 , Issue.14 , pp. 4529-4535
    • Vogl, A.1    Noé, J.2    Breer, H.3    Boekhoff, I.4
  • 101
    • 0022455385 scopus 로고
    • Odorant- and guanine nucleotide-stimulated phosphoinositide turnover in olfactory cilia
    • T. Huque, and R. Bruch Odorant- and guanine nucleotide-stimulated phosphoinositide turnover in olfactory cilia Biochem Biophys Res Commun 137 1 1986 36 42
    • (1986) Biochem Biophys Res Commun , vol.137 , Issue.1 , pp. 36-42
    • Huque, T.1    Bruch, R.2
  • 102
    • 0025048403 scopus 로고
    • Odor stimuli trigger influx of calcium in olfactory neurons of the channel catfish
    • D. Restrepo, T. Miyamoto, B. Bryant, and J. Teeter Odor stimuli trigger influx of calcium in olfactory neurons of the channel catfish Science 249 4973 1990 1166 1168
    • (1990) Science , vol.249 , Issue.4973 , pp. 1166-1168
    • Restrepo, D.1    Miyamoto, T.2    Bryant, B.3    Teeter, J.4
  • 103
    • 0030583288 scopus 로고    scopus 로고
    • Dialysis of inositol 1,4,5-triphosphate induces inward currents and Ca2 + uptake in frog olfactory receptor cells
    • M. Kashiwayanagi Dialysis of inositol 1,4,5-triphosphate induces inward currents and Ca2 + uptake in frog olfactory receptor cells Biochem Biophys Res Commun 225 2 1996 666 671
    • (1996) Biochem Biophys Res Commun , vol.225 , Issue.2 , pp. 666-671
    • Kashiwayanagi, M.1
  • 104
    • 0028275013 scopus 로고
    • Cyclic nucleotide- and inositol phosphate-gated ion channels in lobster olfactory receptor neurons
    • H. Hatt, and B. Ache Cyclic nucleotide- and inositol phosphate-gated ion channels in lobster olfactory receptor neurons Proc Natl Acad Sci 91 14 1994 6264 6268
    • (1994) Proc Natl Acad Sci , vol.91 , Issue.14 , pp. 6264-6268
    • Hatt, H.1    Ache, B.2
  • 105
    • 0036798507 scopus 로고    scopus 로고
    • Two second messengers mediate amino acid responses in olfactory sensory neurons of the salamander, Necturus maculosus
    • R.J. Delay, and V.E. Dionne Two second messengers mediate amino acid responses in olfactory sensory neurons of the salamander, Necturus maculosus Chem Senses 27 2002 673 680
    • (2002) Chem Senses , vol.27 , pp. 673-680
    • Delay, R.J.1    Dionne, V.E.2
  • 106
    • 77955896060 scopus 로고    scopus 로고
    • Odorant-specific modes of signaling in mammalian olfaction
    • B.W. Ache Odorant-specific modes of signaling in mammalian olfaction Chem Senses 35 7 2010 533 539
    • (2010) Chem Senses , vol.35 , Issue.7 , pp. 533-539
    • Ache, B.W.1
  • 107
    • 40449142205 scopus 로고    scopus 로고
    • Competitive and non competitive odorant interactions in the early neural coding of odorant mixtures
    • J. Rospars, P. Lansky, M. Chaput, and P. Duchamp-Viret Competitive and non competitive odorant interactions in the early neural coding of odorant mixtures J Neurosci 28 10 2008 2659 2666
    • (2008) J Neurosci , vol.28 , Issue.10 , pp. 2659-2666
    • Rospars, J.1    Lansky, P.2    Chaput, M.3    Duchamp-Viret, P.4
  • 108
    • 78650917919 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase-dependent antagonism in Mammalian olfactory receptor neurons
    • K. Ukhanov, D. Brunert, E.A. Corey, and B.W. Ache Phosphoinositide 3-kinase-dependent antagonism in Mammalian olfactory receptor neurons J Neurosci 31 1 2011 273 280
    • (2011) J Neurosci , vol.31 , Issue.1 , pp. 273-280
    • Ukhanov, K.1    Brunert, D.2    Corey, E.A.3    Ache, B.W.4
  • 109
    • 84876025589 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase dependent inhibition as a broad basis for opponent coding in Mammalian olfactory receptor neurons
    • K. Ukhanov, E.A. Corey, and B.W. Ache Phosphoinositide 3-kinase dependent inhibition as a broad basis for opponent coding in Mammalian olfactory receptor neurons PLoS One 8 4 2013 e61553
    • (2013) PLoS One , vol.8 , Issue.4 , pp. e61553
    • Ukhanov, K.1    Corey, E.A.2    Ache, B.W.3
  • 110
    • 12544250956 scopus 로고    scopus 로고
    • Functional expression of olfactory receptors in yeast and development of a bioassay for odorant screening
    • J. Minic, M.A. Persuy, and E. Godel Functional expression of olfactory receptors in yeast and development of a bioassay for odorant screening FEBS J 272 2 2005 524 537
    • (2005) FEBS J , vol.272 , Issue.2 , pp. 524-537
    • Minic, J.1    Persuy, M.A.2    Godel, E.3
  • 111
    • 33746534801 scopus 로고    scopus 로고
    • Quantitative assessment of olfactory receptors activity in immobilized nanosomes: A novel concept for bioelectronic nose
    • J. Minic Vidic, J. Grosclaude, M.A. Persuy, J. Aioun, R. Salesse, and E. Pajot-Augy Quantitative assessment of olfactory receptors activity in immobilized nanosomes: a novel concept for bioelectronic nose Lab Chip 6 2006 1026 1032
    • (2006) Lab Chip , vol.6 , pp. 1026-1032
    • Minic Vidic, J.1    Grosclaude, J.2    Persuy, M.A.3    Aioun, J.4    Salesse, R.5    Pajot-Augy, E.6
  • 112
    • 0025309260 scopus 로고
    • Olfactory discrimination over a wide concentration range. Comparison of receptor cell and bulb neuron abilities
    • P. Duchamp-Viret, A. Duchamp, and G. Sicard Olfactory discrimination over a wide concentration range. Comparison of receptor cell and bulb neuron abilities Brain Res 517 1-2 1990 256 262
    • (1990) Brain Res , vol.517 , Issue.12 , pp. 256-262
    • Duchamp-Viret, P.1    Duchamp, A.2    Sicard, G.3
  • 113
    • 32444450878 scopus 로고    scopus 로고
    • Odorant responses of olfactory sensory neurons expressing the odorant receptor MOR23: A patch clamp analysis in gene-targeted mice
    • X. Grosmaitre, A. Vassalli, P. Mombaerts, G.M. Shepherd, and M. Ma Odorant responses of olfactory sensory neurons expressing the odorant receptor MOR23: a patch clamp analysis in gene-targeted mice Proc Natl Acad Sci USA 103 6 2006 1970 1975
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.6 , pp. 1970-1975
    • Grosmaitre, X.1    Vassalli, A.2    Mombaerts, P.3    Shepherd, G.M.4    Ma, M.5
  • 114
    • 42549149601 scopus 로고    scopus 로고
    • On a chip demonstration of a functional role for Odorant Binding Protein in the preservation of olfactory receptor activity at high odorant concentration
    • J. Vidic, J. Grosclaude, and R. Monnerie On a chip demonstration of a functional role for Odorant Binding Protein in the preservation of olfactory receptor activity at high odorant concentration Lab Chip 8 5 2008 678 688
    • (2008) Lab Chip , vol.8 , Issue.5 , pp. 678-688
    • Vidic, J.1    Grosclaude, J.2    Monnerie, R.3
  • 115
    • 79955460451 scopus 로고    scopus 로고
    • Relationship between homo-oligomerization of a mammalian olfactory receptor and its activation state demonstrated by bioluminescence resonance energy transfer
    • F. Wade, A. Espagne, and M.A. Persuy Relationship between homo-oligomerization of a mammalian olfactory receptor and its activation state demonstrated by bioluminescence resonance energy transfer J Biol Chem 286 17 2011 15252 15259
    • (2011) J Biol Chem , vol.286 , Issue.17 , pp. 15252-15259
    • Wade, F.1    Espagne, A.2    Persuy, M.A.3
  • 116
    • 0036797016 scopus 로고    scopus 로고
    • Porcine odorant-binding protein selectively binds to a human olfactory receptor
    • V. Matarazzo, N. Zsürger, and J.C. Guillemot Porcine odorant-binding protein selectively binds to a human olfactory receptor Chem Senses 27 2002 691 701
    • (2002) Chem Senses , vol.27 , pp. 691-701
    • Matarazzo, V.1    Zsürger, N.2    Guillemot, J.C.3
  • 117
    • 33745127060 scopus 로고    scopus 로고
    • The two-state dimer receptor model: A general model for receptor dimers
    • R. Franco, V. Casado, and J. Mallol The two-state dimer receptor model: a general model for receptor dimers Mol Pharmacol 69 6 2006 1905 1912
    • (2006) Mol Pharmacol , vol.69 , Issue.6 , pp. 1905-1912
    • Franco, R.1    Casado, V.2    Mallol, J.3
  • 118
    • 84895527785 scopus 로고    scopus 로고
    • Chemosensory functions for pulmonary neuroendocrine cells
    • X. Gu, P.H. Karp, and S.L. Brody Chemosensory functions for pulmonary neuroendocrine cells Am J Respir Cell Mol Biol 50 3 2013 637 646
    • (2013) Am J Respir Cell Mol Biol , vol.50 , Issue.3 , pp. 637-646
    • Gu, X.1    Karp, P.H.2    Brody, S.L.3
  • 119
    • 11944266934 scopus 로고    scopus 로고
    • Increased expression of prostate-specific G-protein-coupled receptor in human prostate intraepithelial neoplasia and prostate cancers
    • J. Weng, J. Wang, and Y. Cai Increased expression of prostate-specific G-protein-coupled receptor in human prostate intraepithelial neoplasia and prostate cancers Int J Cancer 113 5 2005 811 818
    • (2005) Int J Cancer , vol.113 , Issue.5 , pp. 811-818
    • Weng, J.1    Wang, J.2    Cai, Y.3
  • 120
    • 17844400914 scopus 로고    scopus 로고
    • The repertoire of G-protein-coupled receptors in fully sequenced genomes
    • R. Fredriksson, and H.B. Schioth The repertoire of G-protein-coupled receptors in fully sequenced genomes Mol Pharmacol 67 5 2005 1414 1425
    • (2005) Mol Pharmacol , vol.67 , Issue.5 , pp. 1414-1425
    • Fredriksson, R.1    Schioth, H.B.2
  • 122
    • 53149085926 scopus 로고    scopus 로고
    • Relationships between molecular structure and perceived odor quality of ligands for a human olfactory receptor
    • G. Sanz, T. Thomas-Danguin, and E.H. Hamdani Relationships between molecular structure and perceived odor quality of ligands for a human olfactory receptor Chem Senses 33 7 2008 639 653
    • (2008) Chem Senses , vol.33 , Issue.7 , pp. 639-653
    • Sanz, G.1    Thomas-Danguin, T.2    Hamdani, E.H.3
  • 123
    • 40349087133 scopus 로고    scopus 로고
    • Towards the development of universal, fast and highly accurate docking/scoring methods: A long way to go
    • S1
    • N. Moitessier, P. Englebienne, D. Lee, J. Lawandi, and C.R. Corbeil Towards the development of universal, fast and highly accurate docking/scoring methods: a long way to go Br J Pharmacol 153 S1 2008 S7 S26
    • (2008) Br J Pharmacol , vol.153 , pp. S7-S26
    • Moitessier, N.1    Englebienne, P.2    Lee, D.3    Lawandi, J.4    Corbeil, C.R.5
  • 124
    • 0034604451 scopus 로고    scopus 로고
    • Crystal structure of rhodopsin: A G protein-coupled receptor
    • K. Palczewski, T. Kumasaka, and T. Hori Crystal structure of rhodopsin: a G protein-coupled receptor Science 289 5480 2000 739 745
    • (2000) Science , vol.289 , Issue.5480 , pp. 739-745
    • Palczewski, K.1    Kumasaka, T.2    Hori, T.3
  • 125
    • 4344581120 scopus 로고    scopus 로고
    • The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure
    • T. Okada, M. Sugihara, A.N. Bondar, M. Elstner, P. Entel, and V. Buss The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure J Mol Biol 342 2 2004 571 583
    • (2004) J Mol Biol , vol.342 , Issue.2 , pp. 571-583
    • Okada, T.1    Sugihara, M.2    Bondar, A.N.3    Elstner, M.4    Entel, P.5    Buss, V.6
  • 126
    • 79953234218 scopus 로고    scopus 로고
    • Crystal structure of metarhodopsin II
    • H.W. Choe, Y.J. Kim, and J.H. Park Crystal structure of metarhodopsin II Nature 471 7340 2011 651 655
    • (2011) Nature , vol.471 , Issue.7340 , pp. 651-655
    • Choe, H.W.1    Kim, Y.J.2    Park, J.H.3
  • 127
  • 128
    • 43749109187 scopus 로고    scopus 로고
    • Crystal structure of squid rhodopsin
    • M. Murakami, and T. Kouyama Crystal structure of squid rhodopsin Nature 453 7193 2008 363 367
    • (2008) Nature , vol.453 , Issue.7193 , pp. 363-367
    • Murakami, M.1    Kouyama, T.2
  • 129
    • 36248970132 scopus 로고    scopus 로고
    • Crystal structure of the human beta2 adrenergic G-protein-coupled receptor
    • S.G. Rasmussen, H.J. Choi, and D.M. Rosenbaum Crystal structure of the human beta2 adrenergic G-protein-coupled receptor Nature 450 7168 2007 383 387
    • (2007) Nature , vol.450 , Issue.7168 , pp. 383-387
    • Rasmussen, S.G.1    Choi, H.J.2    Rosenbaum, D.M.3
  • 130
    • 44649172481 scopus 로고    scopus 로고
    • A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor
    • M.A. Hanson, V. Cherezov, and M.T. Griffith A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor Structure 16 6 2008 897 905
    • (2008) Structure , vol.16 , Issue.6 , pp. 897-905
    • Hanson, M.A.1    Cherezov, V.2    Griffith, M.T.3
  • 131
    • 77955779227 scopus 로고    scopus 로고
    • Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography
    • D. Wacker, G. Fenalti, and M.A. Brown Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography J Am Chem Soc 132 33 2010 11443 11445
    • (2010) J Am Chem Soc , vol.132 , Issue.33 , pp. 11443-11445
    • Wacker, D.1    Fenalti, G.2    Brown, M.A.3
  • 132
    • 78651411166 scopus 로고    scopus 로고
    • Structure of a nanobody-stabilized active state of the beta(2) adrenoceptor
    • S.G. Rasmussen, H.J. Choi, and J.J. Fung Structure of a nanobody-stabilized active state of the beta(2) adrenoceptor Nature 469 7329 2011 175 180
    • (2011) Nature , vol.469 , Issue.7329 , pp. 175-180
    • Rasmussen, S.G.1    Choi, H.J.2    Fung, J.J.3
  • 133
    • 78651399683 scopus 로고    scopus 로고
    • Structure and function of an irreversible agonist-beta(2) adrenoceptor complex
    • D.M. Rosenbaum, C. Zhang, and J.A. Lyons Structure and function of an irreversible agonist-beta(2) adrenoceptor complex Nature 469 7329 2011 236 240
    • (2011) Nature , vol.469 , Issue.7329 , pp. 236-240
    • Rosenbaum, D.M.1    Zhang, C.2    Lyons, J.A.3
  • 134
    • 80051658642 scopus 로고    scopus 로고
    • Crystal structure of the beta2 adrenergic receptor-Gs protein complex
    • S.G. Rasmussen, B.T. DeVree, and Y. Zou Crystal structure of the beta2 adrenergic receptor-Gs protein complex Nature 477 7366 2011 549 555
    • (2011) Nature , vol.477 , Issue.7366 , pp. 549-555
    • Rasmussen, S.G.1    Devree, B.T.2    Zou, Y.3
  • 135
    • 84886947656 scopus 로고    scopus 로고
    • Adrenaline-activated structure of [bgr]2-adrenoceptor stabilized by an engineered nanobody
    • A.M. Ring, A. Manglik, and A.C. Kruse Adrenaline-activated structure of [bgr]2-adrenoceptor stabilized by an engineered nanobody Nature 502 7472 2013 575 579
    • (2013) Nature , vol.502 , Issue.7472 , pp. 575-579
    • Ring, A.M.1    Manglik, A.2    Kruse, A.C.3
  • 136
    • 47949129742 scopus 로고    scopus 로고
    • Structure of a beta1-adrenergic G-protein-coupled receptor
    • T. Warne, M.J. Serrano-Vega, and J.G. Baker Structure of a beta1-adrenergic G-protein-coupled receptor Nature 454 7203 2008 486 491
    • (2008) Nature , vol.454 , Issue.7203 , pp. 486-491
    • Warne, T.1    Serrano-Vega, M.J.2    Baker, J.G.3
  • 137
    • 78651405537 scopus 로고    scopus 로고
    • The structural basis for agonist and partial agonist action on a beta(1)-adrenergic receptor
    • T. Warne, R. Moukhametzianov, and J.G. Baker The structural basis for agonist and partial agonist action on a beta(1)-adrenergic receptor Nature 469 7329 2011 241 244
    • (2011) Nature , vol.469 , Issue.7329 , pp. 241-244
    • Warne, T.1    Moukhametzianov, R.2    Baker, J.G.3
  • 138
    • 79957707203 scopus 로고    scopus 로고
    • Two distinct conformations of helix 6 observed in antagonist-bound structures of a beta1-adrenergic receptor
    • R. Moukhametzianov, T. Warne, and P.C. Edwards Two distinct conformations of helix 6 observed in antagonist-bound structures of a beta1-adrenergic receptor Proc Natl Acad Sci USA 108 20 2011 8228 8232
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.20 , pp. 8228-8232
    • Moukhametzianov, R.1    Warne, T.2    Edwards, P.C.3
  • 139
    • 84861064804 scopus 로고    scopus 로고
    • Crystal structures of a stabilized beta1-adrenoceptor bound to the biased agonists bucindolol and carvedilol
    • T. Warne, P.C. Edwards, A.G. Leslie, and C.G. Tate Crystal structures of a stabilized beta1-adrenoceptor bound to the biased agonists bucindolol and carvedilol Structure 20 5 2012 841 849
    • (2012) Structure , vol.20 , Issue.5 , pp. 841-849
    • Warne, T.1    Edwards, P.C.2    Leslie, A.G.3    Tate, C.G.4
  • 140
    • 84877716938 scopus 로고    scopus 로고
    • Biophysical fragment screening of the beta-adrenergic receptor: Identification of high affinity arylpiperazine leads using structure-based drug design
    • J.A. Christopher, J. Brown, and A.S. Dore Biophysical fragment screening of the beta-adrenergic receptor: identification of high affinity arylpiperazine leads using structure-based drug design J Med Chem 56 9 2013 3446 3455
    • (2013) J Med Chem , vol.56 , Issue.9 , pp. 3446-3455
    • Christopher, J.A.1    Brown, J.2    Dore, A.S.3
  • 141
    • 56749103466 scopus 로고    scopus 로고
    • The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist
    • V.P. Jaakola, M.T. Griffith, and M.A. Hanson The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist Science 322 5905 2008 1211 1217
    • (2008) Science , vol.322 , Issue.5905 , pp. 1211-1217
    • Jaakola, V.P.1    Griffith, M.T.2    Hanson, M.A.3
  • 142
    • 79954782236 scopus 로고    scopus 로고
    • Structure of an agonist-bound human A2A adenosine receptor
    • F. Xu, H. Wu, and V. Katritch Structure of an agonist-bound human A2A adenosine receptor Science 332 6027 2011 322 327
    • (2011) Science , vol.332 , Issue.6027 , pp. 322-327
    • Xu, F.1    Wu, H.2    Katritch, V.3
  • 143
    • 79959564813 scopus 로고    scopus 로고
    • Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation
    • G. Lebon, T. Warne, and P.C. Edwards Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation Nature 474 7352 2011 521 525
    • (2011) Nature , vol.474 , Issue.7352 , pp. 521-525
    • Lebon, G.1    Warne, T.2    Edwards, P.C.3
  • 144
    • 79960181417 scopus 로고    scopus 로고
    • Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine
    • A.S. Dore, N. Robertson, and J.C. Errey Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine Structure 19 9 2011 1283 1293
    • (2011) Structure , vol.19 , Issue.9 , pp. 1283-1293
    • Dore, A.S.1    Robertson, N.2    Errey, J.C.3
  • 145
    • 85027927015 scopus 로고    scopus 로고
    • Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists
    • B. Wu, E.Y. Chien, and C.D. Mol Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists Science 330 6007 2010 1066 1071
    • (2010) Science , vol.330 , Issue.6007 , pp. 1066-1071
    • Wu, B.1    Chien, E.Y.2    Mol, C.D.3
  • 146
    • 78449305788 scopus 로고    scopus 로고
    • Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist
    • E.Y. Chien, W. Liu, and Q. Zhao Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist Science 330 6007 2010 1091 1095
    • (2010) Science , vol.330 , Issue.6007 , pp. 1091-1095
    • Chien, E.Y.1    Liu, W.2    Zhao, Q.3
  • 147
    • 79960070651 scopus 로고    scopus 로고
    • Structure of the human histamine H1 receptor complex with doxepin
    • T. Shimamura, M. Shiroishi, and S. Weyand Structure of the human histamine H1 receptor complex with doxepin Nature 475 7354 2011 65 70
    • (2011) Nature , vol.475 , Issue.7354 , pp. 65-70
    • Shimamura, T.1    Shiroishi, M.2    Weyand, S.3
  • 148
    • 84857254248 scopus 로고    scopus 로고
    • Crystal structure of a lipid G protein-coupled receptor
    • M.A. Hanson, C.B. Roth, and E. Jo Crystal structure of a lipid G protein-coupled receptor Science 335 6070 2012 851 855
    • (2012) Science , vol.335 , Issue.6070 , pp. 851-855
    • Hanson, M.A.1    Roth, C.B.2    Jo, E.3
  • 149
    • 84862777405 scopus 로고    scopus 로고
    • Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
    • K. Haga, A.C. Kruse, and H. Asada Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist Nature 482 7386 2012 547 551
    • (2012) Nature , vol.482 , Issue.7386 , pp. 547-551
    • Haga, K.1    Kruse, A.C.2    Asada, H.3
  • 150
    • 84889564886 scopus 로고    scopus 로고
    • Activation and allosteric modulation of a muscarinic acetylcholine receptor
    • A.C. Kruse, A.M. Ring, and A. Manglik Activation and allosteric modulation of a muscarinic acetylcholine receptor Nature 504 7478 2013 101 106
    • (2013) Nature , vol.504 , Issue.7478 , pp. 101-106
    • Kruse, A.C.1    Ring, A.M.2    Manglik, A.3
  • 151
    • 84863115467 scopus 로고    scopus 로고
    • Structure and dynamics of the M3 muscarinic acetylcholine receptor
    • A.C. Kruse, J. Hu, and A.C. Pan Structure and dynamics of the M3 muscarinic acetylcholine receptor Nature 482 7386 2012 552 556
    • (2012) Nature , vol.482 , Issue.7386 , pp. 552-556
    • Kruse, A.C.1    Hu, J.2    Pan, A.C.3
  • 152
    • 84861096654 scopus 로고    scopus 로고
    • Crystal structure of the micro-opioid receptor bound to a morphinan antagonist
    • A. Manglik, A.C. Kruse, and T.S. Kobilka Crystal structure of the micro-opioid receptor bound to a morphinan antagonist Nature 485 7398 2012 321 326
    • (2012) Nature , vol.485 , Issue.7398 , pp. 321-326
    • Manglik, A.1    Kruse, A.C.2    Kobilka, T.S.3
  • 153
    • 84862777742 scopus 로고    scopus 로고
    • Structure of the human kappa-opioid receptor in complex with JDTic
    • H. Wu, D. Wacker, and M. Mileni Structure of the human kappa-opioid receptor in complex with JDTic Nature 485 7398 2012 327 332
    • (2012) Nature , vol.485 , Issue.7398 , pp. 327-332
    • Wu, H.1    Wacker, D.2    Mileni, M.3
  • 154
    • 84861075468 scopus 로고    scopus 로고
    • Structure of the delta-opioid receptor bound to naltrindole
    • S. Granier, A. Manglik, and A.C. Kruse Structure of the delta-opioid receptor bound to naltrindole Nature 485 7398 2012 400 404
    • (2012) Nature , vol.485 , Issue.7398 , pp. 400-404
    • Granier, S.1    Manglik, A.2    Kruse, A.C.3
  • 155
    • 84861019261 scopus 로고    scopus 로고
    • Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic
    • A.A. Thompson, W. Liu, and E. Chun Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic Nature 485 7398 2012 395 399
    • (2012) Nature , vol.485 , Issue.7398 , pp. 395-399
    • Thompson, A.A.1    Liu, W.2    Chun, E.3
  • 156
    • 84867840947 scopus 로고    scopus 로고
    • Structure of the agonist-bound neurotensin receptor
    • J.F. White, N. Noinaj, and Y. Shibata Structure of the agonist-bound neurotensin receptor Nature 490 7421 2012 508 513
    • (2012) Nature , vol.490 , Issue.7421 , pp. 508-513
    • White, J.F.1    Noinaj, N.2    Shibata, Y.3
  • 157
    • 84871411930 scopus 로고    scopus 로고
    • High-resolution crystal structure of human protease-activated receptor 1
    • C. Zhang, Y. Srinivasan, and D.H. Arlow High-resolution crystal structure of human protease-activated receptor 1 Nature 492 7429 2012 387 392
    • (2012) Nature , vol.492 , Issue.7429 , pp. 387-392
    • Zhang, C.1    Srinivasan, Y.2    Arlow, D.H.3
  • 158
    • 84870290491 scopus 로고    scopus 로고
    • Structure of the chemokine receptor CXCR1 in phospholipid bilayers
    • S.H. Park, B.B. Das, and F. Casagrande Structure of the chemokine receptor CXCR1 in phospholipid bilayers Nature 491 7426 2012 779 783
    • (2012) Nature , vol.491 , Issue.7426 , pp. 779-783
    • Park, S.H.1    Das, B.B.2    Casagrande, F.3
  • 159
    • 84877631485 scopus 로고    scopus 로고
    • Structural features for functional selectivity at serotonin receptors
    • D. Wacker, C. Wang, and V. Katritch Structural features for functional selectivity at serotonin receptors Science 340 6132 2013 615 619
    • (2013) Science , vol.340 , Issue.6132 , pp. 615-619
    • Wacker, D.1    Wang, C.2    Katritch, V.3
  • 160
    • 84884673669 scopus 로고    scopus 로고
    • Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex
    • Q. Tan, Y. Zhu, and J. Li Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex Science 341 6152 2013 1387 1390
    • (2013) Science , vol.341 , Issue.6152 , pp. 1387-1390
    • Tan, Q.1    Zhu, Y.2    Li, J.3
  • 161
    • 84899751079 scopus 로고    scopus 로고
    • Agonist-bound structure of the human P2Y12 receptor
    • J. Zhang, K. Zhang, and Z.-G. Gao Agonist-bound structure of the human P2Y12 receptor Nature 509 7498 2014 119 122
    • (2014) Nature , vol.509 , Issue.7498 , pp. 119-122
    • Zhang, J.1    Zhang, K.2    Gao, Z.-G.3
  • 162
    • 84899755031 scopus 로고    scopus 로고
    • Structure of the human P2Y12 receptor in complex with an antithrombotic drug
    • K. Zhang, J. Zhang, and Z.-G. Gao Structure of the human P2Y12 receptor in complex with an antithrombotic drug Nature 509 7498 2014 115 118
    • (2014) Nature , vol.509 , Issue.7498 , pp. 115-118
    • Zhang, K.1    Zhang, J.2    Gao, Z.-G.3
  • 163
    • 84907221192 scopus 로고    scopus 로고
    • High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875
    • A. Srivastava, J. Yano, and Y. Hirozane High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875 Nature 513 7516 2014 124 127
    • (2014) Nature , vol.513 , Issue.7516 , pp. 124-127
    • Srivastava, A.1    Yano, J.2    Hirozane, Y.3
  • 164
    • 84873298278 scopus 로고    scopus 로고
    • The dynamic process of beta(2)-adrenergic receptor activation
    • R. Nygaard, Y. Zou, and R.O. Dror The dynamic process of beta(2)-adrenergic receptor activation Cell 152 3 2013 532 542
    • (2013) Cell , vol.152 , Issue.3 , pp. 532-542
    • Nygaard, R.1    Zou, Y.2    Dror, R.O.3
  • 165
    • 79953242234 scopus 로고    scopus 로고
    • The structural basis of agonist-induced activation in constitutively active rhodopsin
    • J. Standfuss, P.C. Edwards, and A. D'Antona The structural basis of agonist-induced activation in constitutively active rhodopsin Nature 471 7340 2011 656 660
    • (2011) Nature , vol.471 , Issue.7340 , pp. 656-660
    • Standfuss, J.1    Edwards, P.C.2    D'Antona, A.3
  • 166
    • 84862776738 scopus 로고    scopus 로고
    • Biased signaling pathways in beta2-adrenergic receptor characterized by 19F-NMR
    • J.J. Liu, R. Horst, V. Katritch, R.C. Stevens, and K. Wuthrich Biased signaling pathways in beta2-adrenergic receptor characterized by 19F-NMR Science 335 6072 2012 1106 1110
    • (2012) Science , vol.335 , Issue.6072 , pp. 1106-1110
    • Liu, J.J.1    Horst, R.2    Katritch, V.3    Stevens, R.C.4    Wuthrich, K.5
  • 168
    • 80052082999 scopus 로고    scopus 로고
    • Structural insights into agonist-induced activation of G-protein-coupled receptors
    • X. Deupi, and J. Standfuss Structural insights into agonist-induced activation of G-protein-coupled receptors Curr Opin Struct Biol 21 4 2011 541 551
    • (2011) Curr Opin Struct Biol , vol.21 , Issue.4 , pp. 541-551
    • Deupi, X.1    Standfuss, J.2
  • 169
    • 84881173408 scopus 로고    scopus 로고
    • Structure of class B GPCR corticotropin-releasing factor receptor 1
    • K. Hollenstein, J. Kean, and A. Bortolato Structure of class B GPCR corticotropin-releasing factor receptor 1 Nature 499 7459 2013 438 443
    • (2013) Nature , vol.499 , Issue.7459 , pp. 438-443
    • Hollenstein, K.1    Kean, J.2    Bortolato, A.3
  • 170
    • 84878112106 scopus 로고    scopus 로고
    • Structure of the human smoothened receptor bound to an antitumour agent
    • C. Wang, H. Wu, and V. Katritch Structure of the human smoothened receptor bound to an antitumour agent Nature 497 7449 2013 338 343
    • (2013) Nature , vol.497 , Issue.7449 , pp. 338-343
    • Wang, C.1    Wu, H.2    Katritch, V.3
  • 171
    • 84904994581 scopus 로고    scopus 로고
    • Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain
    • A.S. Dore, K. Okrasa, and J.C. Patel Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain Nature 511 7511 2014 557 562
    • (2014) Nature , vol.511 , Issue.7511 , pp. 557-562
    • Dore, A.S.1    Okrasa, K.2    Patel, J.C.3
  • 172
    • 84872221774 scopus 로고    scopus 로고
    • Structure-function of the G protein-coupled receptor superfamily
    • V. Katritch, V. Cherezov, and R.C. Stevens Structure-function of the G protein-coupled receptor superfamily Annu Rev Pharmacol Toxicol 53 1 2013 531 556
    • (2013) Annu Rev Pharmacol Toxicol , vol.53 , Issue.1 , pp. 531-556
    • Katritch, V.1    Cherezov, V.2    Stevens, R.C.3
  • 173
    • 84863247761 scopus 로고    scopus 로고
    • Structure-based design in the GPCR target space
    • M. Kontoyianni, and Z. Liu Structure-based design in the GPCR target space Curr Med Chem 19 4 2012 544 556
    • (2012) Curr Med Chem , vol.19 , Issue.4 , pp. 544-556
    • Kontoyianni, M.1    Liu, Z.2
  • 174
    • 84878543095 scopus 로고    scopus 로고
    • Modeling G, protein-coupled receptors and their interactions with ligands
    • S. Costanzi Modeling G, protein-coupled receptors and their interactions with ligands Curr Opin Struct Biol 23 2 2013 185 190
    • (2013) Curr Opin Struct Biol , vol.23 , Issue.2 , pp. 185-190
    • Costanzi, S.1
  • 175
    • 84873344962 scopus 로고    scopus 로고
    • From heptahelical bundle to hits from the Haystack: Structure-based virtual screening for GPCR ligands
    • A.J. Koolstra, L. Roumen, R. Leurs, I.J. de Esch, and C. de Graaf From heptahelical bundle to hits from the Haystack: structure-based virtual screening for GPCR ligands Methods Enzymol 522 2013 279 336
    • (2013) Methods Enzymol , vol.522 , pp. 279-336
    • Koolstra, A.J.1    Roumen, L.2    Leurs, R.3    De Esch, I.J.4    De Graaf, C.5
  • 176
    • 84906933886 scopus 로고    scopus 로고
    • GPCR structures in drug design, emerging opportunities with new structures
    • C.S. Tautermann GPCR structures in drug design, emerging opportunities with new structures Bioorg Med Chem Lett 24 17 2014 4073 4079
    • (2014) Bioorg Med Chem Lett , vol.24 , Issue.17 , pp. 4073-4079
    • Tautermann, C.S.1
  • 177
    • 33745076219 scopus 로고    scopus 로고
    • Advances in homology protein structure modeling
    • Z. Xiang Advances in homology protein structure modeling Curr Protein Pept Sci 7 3 2006 217 227
    • (2006) Curr Protein Pept Sci , vol.7 , Issue.3 , pp. 217-227
    • Xiang, Z.1
  • 178
    • 84873126314 scopus 로고    scopus 로고
    • Modeling of mammalian olfactory receptors and docking of odorants
    • G. Launay, G. Sanz, E. Pajot, and J.F. Gibrat Modeling of mammalian olfactory receptors and docking of odorants Biophys Rev 4 2012 255 269
    • (2012) Biophys Rev , vol.4 , pp. 255-269
    • Launay, G.1    Sanz, G.2    Pajot, E.3    Gibrat, J.F.4
  • 179
    • 77957055780 scopus 로고
    • Integrated methods and computational probing of structure-function relations in G protein-coupled receptors
    • J.A. Ballesteros, and H. Weinstein Integrated methods and computational probing of structure-function relations in G protein-coupled receptors Methods Neurosci 25 1995 366 428
    • (1995) Methods Neurosci , vol.25 , pp. 366-428
    • Ballesteros, J.A.1    Weinstein, H.2
  • 180
    • 1442310610 scopus 로고    scopus 로고
    • Loops in Proteins (LIP) - A comprehensive loop database for homology modelling
    • E. Michalsky, A. Goede, and R. Preissner Loops In Proteins (LIP) - a comprehensive loop database for homology modelling Protein Eng 16 12 2003 979 985
    • (2003) Protein Eng , vol.16 , Issue.12 , pp. 979-985
    • Michalsky, E.1    Goede, A.2    Preissner, R.3
  • 181
    • 79960176452 scopus 로고    scopus 로고
    • Progress in structure based drug design for G protein-coupled receptors
    • M. Congreve, C.J. Langmead, J.S. Mason, and F.H. Marshall Progress in structure based drug design for G protein-coupled receptors J Med Chem 54 13 2011 4283 4311
    • (2011) J Med Chem , vol.54 , Issue.13 , pp. 4283-4311
    • Congreve, M.1    Langmead, C.J.2    Mason, J.S.3    Marshall, F.H.4
  • 182
    • 74249090260 scopus 로고    scopus 로고
    • Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: Four approaches that performed well in CASP8
    • S9
    • E. Krieger, K. Joo, and J. Lee Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: Four approaches that performed well in CASP8 Proteins: Struct, Funct, Bioinform 77 S9 2009 114 122
    • (2009) Proteins: Struct, Funct, Bioinform , vol.77 , pp. 114-122
    • Krieger, E.1    Joo, K.2    Lee, J.3
  • 183
    • 79960156006 scopus 로고    scopus 로고
    • Biophysical mapping of the adenosine A2A receptor
    • A. Zhukov, S.P. Andrews, and J.C. Errey Biophysical mapping of the adenosine A2A receptor J Med Chem 54 13 2011 4312 4323
    • (2011) J Med Chem , vol.54 , Issue.13 , pp. 4312-4323
    • Zhukov, A.1    Andrews, S.P.2    Errey, J.C.3
  • 184
    • 84857451391 scopus 로고    scopus 로고
    • The errors of our ways: Taking account of error in computer-aided drug design to build confidence intervals for our next 25 years
    • T. Stouch The errors of our ways: taking account of error in computer-aided drug design to build confidence intervals for our next 25 years J Comput Aid Mol Des 26 1 2012 125 134
    • (2012) J Comput Aid Mol des , vol.26 , Issue.1 , pp. 125-134
    • Stouch, T.1
  • 185
    • 84871539979 scopus 로고    scopus 로고
    • Current assessment of docking into GPCR crystal structures and homology models: Successes, challenges, and guidelines
    • T. Beuming, and W. Sherman Current assessment of docking into GPCR crystal structures and homology models: successes, challenges, and guidelines J Chem Inf Model 52 12 2012 3263 3277
    • (2012) J Chem Inf Model , vol.52 , Issue.12 , pp. 3263-3277
    • Beuming, T.1    Sherman, W.2
  • 186
    • 80051521545 scopus 로고    scopus 로고
    • Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment
    • I. Kufareva, M. Rueda, V. Katritch, R.C. Stevens, and R. Abagyan Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment Structure 19 8 2011 1108 1126
    • (2011) Structure , vol.19 , Issue.8 , pp. 1108-1126
    • Kufareva, I.1    Rueda, M.2    Katritch, V.3    Stevens, R.C.4    Abagyan, R.5
  • 187
    • 84860513814 scopus 로고    scopus 로고
    • Structure-based drug screening for G-protein-coupled receptors
    • B.K. Shoichet, and B.K. Kobilka Structure-based drug screening for G-protein-coupled receptors Trends Pharmacol Sci 33 5 2012 268 272
    • (2012) Trends Pharmacol Sci , vol.33 , Issue.5 , pp. 268-272
    • Shoichet, B.K.1    Kobilka, B.K.2
  • 188
    • 79951521238 scopus 로고    scopus 로고
    • Chemogenomic analysis of G-protein coupled receptors and their ligands deciphers locks and keys governing diverse aspects of signalling
    • J.D. Wichard, A. Ter Laak, G. Krause, N. Heinrich, R. Kühne, and G. Kleinau Chemogenomic analysis of G-protein coupled receptors and their ligands deciphers locks and keys governing diverse aspects of signalling PLoS One 6 2 2011 e16811
    • (2011) PLoS One , vol.6 , Issue.2 , pp. e16811
    • Wichard, J.D.1    Ter Laak, A.2    Krause, G.3    Heinrich, N.4    Kühne, R.5    Kleinau, G.6
  • 189
    • 78751498756 scopus 로고    scopus 로고
    • Functional selectivity and biased receptor signaling
    • T. Kenakin Functional selectivity and biased receptor signaling J Pharmacol Exp Ther 336 2 2011 296 302
    • (2011) J Pharmacol Exp Ther , vol.336 , Issue.2 , pp. 296-302
    • Kenakin, T.1
  • 190
    • 84890917722 scopus 로고    scopus 로고
    • Cloud-based simulations on Google Exacycle reveal ligand-modulation of GPCR activation pathways
    • K.J. Kohlhoff, D. Shukla, and M. Lawrenz Cloud-based simulations on Google Exacycle reveal ligand-modulation of GPCR activation pathways Nat Chem 6 1 2014 15 21
    • (2014) Nat Chem , vol.6 , Issue.1 , pp. 15-21
    • Kohlhoff, K.J.1    Shukla, D.2    Lawrenz, M.3
  • 192
    • 1842653539 scopus 로고    scopus 로고
    • History of quantitative structure-activity relationships
    • D.J. Abraham, 6th ed. Drug Discovery John Wiley&Sons, Inc New-York
    • C.D. Selassie History of quantitative structure-activity relationships D.J. Abraham, Burger's medicinal chemistry and drug discovery 6th ed. Drug Discovery Vol. 1 2003 John Wiley&Sons, Inc New-York
    • (2003) Burger's Medicinal Chemistry and Drug Discovery , vol.1
    • Selassie, C.D.1
  • 193
    • 33947547892 scopus 로고
    • Molecular architecture and biological reactions
    • L. Pauling Molecular architecture and biological reactions Chem Eng News 24 10 1946 1365 1377
    • (1946) Chem Eng News , vol.24 , Issue.10 , pp. 1365-1377
    • Pauling, L.1
  • 194
    • 0342861521 scopus 로고
    • The stereochemical specificities of human olfactory receptors
    • J.E. Amoore The stereochemical specificities of human olfactory receptors Perfum Essent Oil Rec 43 1952 321 330
    • (1952) Perfum Essent Oil Rec , vol.43 , pp. 321-330
    • Amoore, J.E.1
  • 195
    • 0003168596 scopus 로고
    • Stereochemical theory of olfaction
    • J.E. Amoore Stereochemical theory of olfaction Nature 198 1963 271 272
    • (1963) Nature , vol.198 , pp. 271-272
    • Amoore, J.E.1
  • 196
    • 0040914011 scopus 로고
    • P-σ-Π Analysis. A method for the correlation of biological activity and chemical structure
    • C. Hansch, and T. Fujita p-σ-Π Analysis. A method for the correlation of biological activity and chemical structure J Am Chem Soc 86 8 1964 1616 1626
    • (1964) J Am Chem Soc , vol.86 , Issue.8 , pp. 1616-1626
    • Hansch, C.1    Fujita, T.2
  • 197
    • 0000724210 scopus 로고    scopus 로고
    • Structure-odor relationships
    • K.J. Rossiter Structure-odor relationships Chem Rev 96 8 1996 3201 3240
    • (1996) Chem Rev , vol.96 , Issue.8 , pp. 3201-3240
    • Rossiter, K.J.1
  • 198
    • 0031296641 scopus 로고    scopus 로고
    • Trends in structure-odor relationships
    • M. Chastrette Trends in structure-odor relationships SAR QSAR Environ Res 6 3-4 1997 215 254
    • (1997) SAR QSAR Environ Res , vol.6 , Issue.34 , pp. 215-254
    • Chastrette, M.1
  • 200
    • 33749250384 scopus 로고    scopus 로고
    • On the unpredictability of odor
    • C.S. Sell On the unpredictability of odor Angew Chem Int Ed 45 38 2006 6254 6261
    • (2006) Angew Chem Int Ed , vol.45 , Issue.38 , pp. 6254-6261
    • Sell, C.S.1
  • 201
    • 0002702982 scopus 로고    scopus 로고
    • Quantitative structure-activity relationships (QSARs) for odor thresholds of volatile organic compounds (VOCs)
    • K.M. Hau, and D.W. Connell Quantitative structure-activity relationships (QSARs) for odor thresholds of volatile organic compounds (VOCs) Indoor Air 8 1 Mar 1998 23 33
    • (1998) Indoor Air , vol.8 , Issue.1 , pp. 23-33
    • Hau, K.M.1    Connell, D.W.2
  • 202
    • 84884936614 scopus 로고    scopus 로고
    • Odor qualities and thresholds of physiological metabolites of 1,8-cineole as an example for structure-activity relationships considering chirality aspects
    • F. Kirsch, and A. Buettner Odor qualities and thresholds of physiological metabolites of 1,8-cineole as an example for structure-activity relationships considering chirality aspects Chem Biodivers 10 9 2013 1683 1695
    • (2013) Chem Biodivers , vol.10 , Issue.9 , pp. 1683-1695
    • Kirsch, F.1    Buettner, A.2
  • 203
    • 84874021620 scopus 로고    scopus 로고
    • Predictive QSPR modelling for the olfactory threshold of a series of pyrazine derivatives
    • P. Pal, I. Mitra, and K. Roy Predictive QSPR modelling for the olfactory threshold of a series of pyrazine derivatives Flavour Frag J 28 2 2013 102 117
    • (2013) Flavour Frag J , vol.28 , Issue.2 , pp. 102-117
    • Pal, P.1    Mitra, I.2    Roy, K.3
  • 204
    • 80054920613 scopus 로고    scopus 로고
    • Prediction of odour detection thresholds using partition coefficients
    • O. Rodriguez, M.A. Teixeira, and A.E. Rodrigues Prediction of odour detection thresholds using partition coefficients Flavour Frag J 26 6 2011 421 428
    • (2011) Flavour Frag J , vol.26 , Issue.6 , pp. 421-428
    • Rodriguez, O.1    Teixeira, M.A.2    Rodrigues, A.E.3
  • 205
    • 2442447372 scopus 로고    scopus 로고
    • Quantitative structure-activity relationship modeling of alcohol, ester, aldehyde, and ketone flavor thresholds in beer from molecular features
    • Y.X. Tan, and K.J. Siebert Quantitative structure-activity relationship modeling of alcohol, ester, aldehyde, and ketone flavor thresholds in beer from molecular features J Agric Food Chem 52 10 2004 3057 3064
    • (2004) J Agric Food Chem , vol.52 , Issue.10 , pp. 3057-3064
    • Tan, Y.X.1    Siebert, K.J.2
  • 206
    • 0026785439 scopus 로고
    • A quantitative structure activity relationship (QSAR) study of alkylpyrazine odor modalities
    • A. Tsantili-Kakoulidou, and L.B. Kier A quantitative structure activity relationship (QSAR) study of alkylpyrazine odor modalities Pharm Res 9 10 1992 1321 1323
    • (1992) Pharm Res , vol.9 , Issue.10 , pp. 1321-1323
    • Tsantili-Kakoulidou, A.1    Kier, L.B.2
  • 207
    • 0033795503 scopus 로고    scopus 로고
    • Threshold-based structure-activity relationships of pyrazines with bell-pepper flavor
    • G. Buchbauer, C.T. Klein, B. Wailzer, and P. Wolschann Threshold-based structure-activity relationships of pyrazines with bell-pepper flavor J Agric Food Chem 48 9 2000 4273 4278
    • (2000) J Agric Food Chem , vol.48 , Issue.9 , pp. 4273-4278
    • Buchbauer, G.1    Klein, C.T.2    Wailzer, B.3    Wolschann, P.4
  • 208
    • 0029685059 scopus 로고    scopus 로고
    • Structure-odor relationships: Using neural networks in the estimation of camphoraceous or fruity odors and olfactory thresholds of aliphatic alcohols
    • M. Chastrette, D. Cretin, and C. ElAidi Structure-odor relationships: using neural networks in the estimation of camphoraceous or fruity odors and olfactory thresholds of aliphatic alcohols J Chem Inf Comput Sci 36 1 1996 108 113
    • (1996) J Chem Inf Comput Sci , vol.36 , Issue.1 , pp. 108-113
    • Chastrette, M.1    Cretin, D.2    Elaidi, C.3
  • 209
    • 0027689276 scopus 로고
    • Quantitative structure-retention and structure-odor intensity relationships for a diverse group of odor-active compounds
    • L.M. Egolf, and P.C. Jurs Quantitative structure-retention and structure-odor intensity relationships for a diverse group of odor-active compounds Anal Chem 65 21 1993 3119 3126
    • (1993) Anal Chem , vol.65 , Issue.21 , pp. 3119-3126
    • Egolf, L.M.1    Jurs, P.C.2
  • 210
    • 84897915988 scopus 로고    scopus 로고
    • A quantitative structure-property relationship approach to determine the essential molecular functionalities of potent odorants
    • P. Pal, I. Mitra, and K. Roy A quantitative structure-property relationship approach to determine the essential molecular functionalities of potent odorants Flavour Frag J 29 3 2014 157 165
    • (2014) Flavour Frag J , vol.29 , Issue.3 , pp. 157-165
    • Pal, P.1    Mitra, I.2    Roy, K.3
  • 211
    • 0035899178 scopus 로고    scopus 로고
    • Prediction of the aroma quality and the threshold values of some pyrazines using artificial neural networks
    • B. Wailzer, J. Klocker, G. Buchbauer, G. Ecker, and P. Wolschann Prediction of the aroma quality and the threshold values of some pyrazines using artificial neural networks J Med Chem 44 17 2001 2805 2813
    • (2001) J Med Chem , vol.44 , Issue.17 , pp. 2805-2813
    • Wailzer, B.1    Klocker, J.2    Buchbauer, G.3    Ecker, G.4    Wolschann, P.5
  • 212
    • 33749258254 scopus 로고    scopus 로고
    • Structure-olfactive threshold relationships for pyrazine derivatives
    • D. Zakarya, L. Farhaoui, M. Hamidi, and M. Bouachrine Structure-olfactive threshold relationships for pyrazine derivatives J Mol Model 12 6 2006 985 989
    • (2006) J Mol Model , vol.12 , Issue.6 , pp. 985-989
    • Zakarya, D.1    Farhaoui, L.2    Hamidi, M.3    Bouachrine, M.4
  • 214
    • 84874069923 scopus 로고    scopus 로고
    • Odor classification: A review of factors influencing perception-based odor arrangements
    • K. Kaeppler, and F. Mueller Odor classification: a review of factors influencing perception-based odor arrangements Chem Senses 38 3 2013 189 209
    • (2013) Chem Senses , vol.38 , Issue.3 , pp. 189-209
    • Kaeppler, K.1    Mueller, F.2
  • 215
    • 34247093419 scopus 로고    scopus 로고
    • Chemical indices and methods of multivariate statistics as a tool for odor classification
    • I.T. Mahlke, P.H. Thiesen, and B. Niemeyer Chemical indices and methods of multivariate statistics as a tool for odor classification Environ Sci Technol 41 7 2007 2414 2421
    • (2007) Environ Sci Technol , vol.41 , Issue.7 , pp. 2414-2421
    • Mahlke, I.T.1    Thiesen, P.H.2    Niemeyer, B.3
  • 217
    • 84864324393 scopus 로고    scopus 로고
    • Mixed odor classification for QCM sensor data by neural networks
    • S. Omatu, J.F.D. Santana, S.R. Gonzalez, J.M. Molina, A.M. Bernardos, J.M.C. Rodriguez, Springer-Verlag Berlin, Germany
    • S. Omatu, H. Araki, T. Fujinaka, M. Yoshioka, and H. Nakazumi Mixed odor classification for QCM sensor data by neural networks S. Omatu, J.F.D. Santana, S.R. Gonzalez, J.M. Molina, A.M. Bernardos, J.M.C. Rodriguez, Distributed Computing and Artificial Intelligence Vol. 151 2012 Springer-Verlag Berlin, Germany 1 8
    • (2012) Distributed Computing and Artificial Intelligence , vol.151 , pp. 1-8
    • Omatu, S.1    Araki, H.2    Fujinaka, T.3    Yoshioka, M.4    Nakazumi, H.5
  • 218
    • 0033648307 scopus 로고    scopus 로고
    • Hybrid systems for virtual screening: Interest of fuzzy clustering applied to olfaction
    • F. Ros, K. Audouze, M. Pintore, and J.R. Chretien Hybrid systems for virtual screening: interest of fuzzy clustering applied to olfaction SAR QSAR Environ Res 11 3-4 2000 281 300
    • (2000) SAR QSAR Environ Res , vol.11 , Issue.34 , pp. 281-300
    • Ros, F.1    Audouze, K.2    Pintore, M.3    Chretien, J.R.4
  • 220
    • 0025997147 scopus 로고
    • Structure-odor relationships using neural networks
    • M. Chastrette, and J. de Saint Laumer Structure-odor relationships using neural networks Eur J Med Chem 26 8 1991 829 833
    • (1991) Eur J Med Chem , vol.26 , Issue.8 , pp. 829-833
    • Chastrette, M.1    De Saint Laumer, J.2
  • 221
    • 0028200748 scopus 로고
    • Structure-musk odor relationships for tetralins and indans using neural networks (on the contribution of descriptors to the classification)
    • M. Chastrette, D. Zakarya, and J. Peyraud Structure-musk odor relationships for tetralins and indans using neural networks (on the contribution of descriptors to the classification) Eur J Med Chem 29 5 1994 343 348
    • (1994) Eur J Med Chem , vol.29 , Issue.5 , pp. 343-348
    • Chastrette, M.1    Zakarya, D.2    Peyraud, J.3
  • 222
    • 0037014313 scopus 로고    scopus 로고
    • Aroma quality differentiation of pyrazine derivatives using self-organizing molecular field analysis and artificial neural network
    • J. Klocker, B. Wailzer, G. Buchbauer, and P. Wolschann Aroma quality differentiation of pyrazine derivatives using self-organizing molecular field analysis and artificial neural network J Agric Food Chem 50 14 2002 4069 4075
    • (2002) J Agric Food Chem , vol.50 , Issue.14 , pp. 4069-4075
    • Klocker, J.1    Wailzer, B.2    Buchbauer, G.3    Wolschann, P.4
  • 223
    • 0034270282 scopus 로고    scopus 로고
    • Prediction of odours of aliphatic alcohols and carbonylated compounds using fuzzy partition and self organising maps (SOM)
    • K. Audouze, F. Ros, M. Pintore, and J.R. Chretien Prediction of odours of aliphatic alcohols and carbonylated compounds using fuzzy partition and self organising maps (SOM) Analusis 28 7 2000 625 632
    • (2000) Analusis , vol.28 , Issue.7 , pp. 625-632
    • Audouze, K.1    Ros, F.2    Pintore, M.3    Chretien, J.R.4
  • 224
    • 10244276964 scopus 로고    scopus 로고
    • A structure-odour relationship study using EVA descriptors and hierarchical clustering
    • S.Y. Takane, and J.B.O. Mitchell A structure-odour relationship study using EVA descriptors and hierarchical clustering Org Biomol Chem 2 22 2004 3250 3255
    • (2004) Org Biomol Chem , vol.2 , Issue.22 , pp. 3250-3255
    • Takane, S.Y.1    Mitchell, J.B.O.2
  • 225
    • 34548610239 scopus 로고    scopus 로고
    • Predicting odor pleasantness from odorant structure: Pleasantness as a reflection of the physical world
    • R.M. Khan, C.H. Luk, and A. Flinker Predicting odor pleasantness from odorant structure: pleasantness as a reflection of the physical world J Neurosci 27 37 2007 10015 10023
    • (2007) J Neurosci , vol.27 , Issue.37 , pp. 10015-10023
    • Khan, R.M.1    Luk, C.H.2    Flinker, A.3
  • 226
    • 0034283584 scopus 로고    scopus 로고
    • Odds and trends: Recent developments in the chemistry of odorants
    • P. Kraft, J.A. Bajgrowicz, C. Denis, and G. Frater Odds and trends: recent developments in the chemistry of odorants Angew Chem Int Ed 39 17 2000 2981 3010
    • (2000) Angew Chem Int Ed , vol.39 , Issue.17 , pp. 2981-3010
    • Kraft, P.1    Bajgrowicz, J.A.2    Denis, C.3    Frater, G.4
  • 227
    • 0344686491 scopus 로고    scopus 로고
    • Electronic van der Waals surface property descriptors and genetic algorithms for developing structure-activity correlations in olfactory databases
    • B.K. Lavine, C.E. Davidson, C. Breneman, and W. Katt Electronic van der Waals surface property descriptors and genetic algorithms for developing structure-activity correlations in olfactory databases J Chem Inf Comput Sci 43 6 2003 1890 1905
    • (2003) J Chem Inf Comput Sci , vol.43 , Issue.6 , pp. 1890-1905
    • Lavine, B.K.1    Davidson, C.E.2    Breneman, C.3    Katt, W.4
  • 228
    • 0033863294 scopus 로고    scopus 로고
    • Quantitative structure-odor relationships of aliphatic esters using topological indices
    • R. Amboni, Junkes B. da Silva, R.A. Yunes, and V.E. Fonseca Heinzen Quantitative structure-odor relationships of aliphatic esters using topological indices J Agric Food Chem 48 8 2000 3517 3521
    • (2000) J Agric Food Chem , vol.48 , Issue.8 , pp. 3517-3521
    • Amboni, R.1    Da Silva, J.B.2    Yunes, R.A.3    Fonseca Heinzen, V.E.4
  • 229
    • 0033553898 scopus 로고    scopus 로고
    • Structure-camphor odour relationships using the Generation and Selection of Pertinent Descriptors approach
    • D. Zakarya, M. Chastrette, M. Tollabi, and S. Fkih-Tetouani Structure-camphor odour relationships using the Generation and Selection of Pertinent Descriptors approach Chemometr Intell Lab Syst 48 1 1999 35 46
    • (1999) Chemometr Intell Lab Syst , vol.48 , Issue.1 , pp. 35-46
    • Zakarya, D.1    Chastrette, M.2    Tollabi, M.3    Fkih-Tetouani, S.4
  • 230
    • 0031934435 scopus 로고    scopus 로고
    • Structure-minty odour relationships: Suggestion of an interaction pattern
    • M. Chastrette, and E. Rallet Structure-minty odour relationships: suggestion of an interaction pattern Flavour Frag J 13 1 1998 5 18
    • (1998) Flavour Frag J , vol.13 , Issue.1 , pp. 5-18
    • Chastrette, M.1    Rallet, E.2
  • 231
    • 0029050990 scopus 로고
    • Tetralin, indan and nitrobenzene compound structure-musk odor relationship using neural networks
    • M. Chastrette, C.E. AIdi, and J. Peyraud Tetralin, indan and nitrobenzene compound structure-musk odor relationship using neural networks Eur J Med Chem 30 9 1995 679 686
    • (1995) Eur J Med Chem , vol.30 , Issue.9 , pp. 679-686
    • Chastrette, M.1    Aidi, C.E.2    Peyraud, J.3
  • 232
    • 9644268879 scopus 로고    scopus 로고
    • Structure-activity relationships of sandalwood odorants: Synthesis and odor of tricyclo beta-santalol
    • G. Buchbauer, I. Stappen, C. Pretterklieber, and A. Wolschann Structure-activity relationships of sandalwood odorants: synthesis and odor of tricyclo beta-santalol Eur J Med Chem 39 12 2004 1039 1046
    • (2004) Eur J Med Chem , vol.39 , Issue.12 , pp. 1039-1046
    • Buchbauer, G.1    Stappen, I.2    Pretterklieber, C.3    Wolschann, A.4
  • 233
    • 56949098994 scopus 로고    scopus 로고
    • Study of structural and electronic origin of ambergris odor of some compounds
    • L.P. Cheng, L. Xu, H.F. Mao, and G.L. Wang Study of structural and electronic origin of ambergris odor of some compounds J Mol Model 15 1 2009 1 8
    • (2009) J Mol Model , vol.15 , Issue.1 , pp. 1-8
    • Cheng, L.P.1    Xu, L.2    Mao, H.F.3    Wang, G.L.4
  • 234
    • 78651112946 scopus 로고    scopus 로고
    • QSAR of alpha-campholenic derivatives with sandalwood odor, and molecular design
    • L. Cheng, Y. Gu, and Q.A. Jin QSAR of alpha-campholenic derivatives with sandalwood odor, and molecular design Mon Chem 141 9 2010 953 959
    • (2010) Mon Chem , vol.141 , Issue.9 , pp. 953-959
    • Cheng, L.1    Gu, Y.2    Jin, Q.A.3
  • 235
    • 0032838032 scopus 로고    scopus 로고
    • QSAR for cycloaliphatic alcohols with qualitatively defined sandalwood odour characteristics
    • D.I. Hadaruga, S. Muresan, and C. Bologa QSAR for cycloaliphatic alcohols with qualitatively defined sandalwood odour characteristics Quant Struct-Act Relat 18 3 1999 253 261
    • (1999) Quant Struct-Act Relat , vol.18 , Issue.3 , pp. 253-261
    • Hadaruga, D.I.1    Muresan, S.2    Bologa, C.3
  • 237
    • 18244388238 scopus 로고    scopus 로고
    • QSAR modeling of datasets with enantioselective compounds using chirality sensitive molecular descriptors
    • A. Kovatcheva, A. Golbraikh, S. Oloff, J. Feng, W. Zheng, and A. Tropsha QSAR modeling of datasets with enantioselective compounds using chirality sensitive molecular descriptors SAR QSAR Environ Res 16 1-2 2005 93 102
    • (2005) SAR QSAR Environ Res , vol.16 , Issue.12 , pp. 93-102
    • Kovatcheva, A.1    Golbraikh, A.2    Oloff, S.3    Feng, J.4    Zheng, W.5    Tropsha, A.6
  • 238
    • 1842640098 scopus 로고    scopus 로고
    • Structure-odour relationships: Results of an applied electron-topological approach
    • N.M. Shvets, and A.S. Dimoglo Structure-odour relationships: results of an applied electron-topological approach Nahrung 42 6 1998 364 370
    • (1998) Nahrung , vol.42 , Issue.6 , pp. 364-370
    • Shvets, N.M.1    Dimoglo, A.S.2
  • 239
    • 45849094083 scopus 로고    scopus 로고
    • Structure-activity relationships of sandalwood odorants: Total synthesis and fragrance properties of cyclopropano-beta-santalol
    • I. Stappen, J. Hofinghoff, S. Friedl, C. Pammer, P. Wolschann, and G. Buchbauer Structure-activity relationships of sandalwood odorants: total synthesis and fragrance properties of cyclopropano-beta-santalol Eur J Med Chem 43 7 2008 1525 1529
    • (2008) Eur J Med Chem , vol.43 , Issue.7 , pp. 1525-1529
    • Stappen, I.1    Hofinghoff, J.2    Friedl, S.3    Pammer, C.4    Wolschann, P.5    Buchbauer, G.6
  • 240
    • 0032890696 scopus 로고    scopus 로고
    • A new electronic-topological investigation of the relationship between chemical structure and ambergris odour
    • M.Y. Gorbachov, and K.J. Rossiter A new electronic-topological investigation of the relationship between chemical structure and ambergris odour Chem Senses 24 2 1999 171 178
    • (1999) Chem Senses , vol.24 , Issue.2 , pp. 171-178
    • Gorbachov, M.Y.1    Rossiter, K.J.2
  • 241
    • 1842740111 scopus 로고    scopus 로고
    • Combinatorial QSAR of ambergris fragrance compounds
    • A. Kovatcheva, A. Golbraikh, and S. Oloff Combinatorial QSAR of ambergris fragrance compounds J Chem Inf Comput Sci 44 2 2004 582 595
    • (2004) J Chem Inf Comput Sci , vol.44 , Issue.2 , pp. 582-595
    • Kovatcheva, A.1    Golbraikh, A.2    Oloff, S.3
  • 242
    • 0025285379 scopus 로고
    • Relations structure-odeur de bois de santal: Recherche d'un modele d'interaction fonde sur le concept d'hypermotif santalophore
    • M. Chastrette, D. Zakarya, and C. Pierre Relations structure-odeur de bois de santal: recherche d'un modele d'interaction fonde sur le concept d'hypermotif santalophore Eur J Med Chem 25 5 1990 433 440
    • (1990) Eur J Med Chem , vol.25 , Issue.5 , pp. 433-440
    • Chastrette, M.1    Zakarya, D.2    Pierre, C.3
  • 243
    • 0028049535 scopus 로고
    • Structure-odor relationships: A highly predictive tridimensional interaction model for the bell-pepper note
    • C. Rognon, and M. Chastrette Structure-odor relationships: a highly predictive tridimensional interaction model for the bell-pepper note Eur J Med Chem 29 7-8 1994 595 609
    • (1994) Eur J Med Chem , vol.29 , Issue.78 , pp. 595-609
    • Rognon, C.1    Chastrette, M.2
  • 244
    • 77249106566 scopus 로고    scopus 로고
    • Three-dimensional pharmacophore methods in drug discovery
    • A.R. Leach, V.J. Gillet, R.A. Lewis, and R. Taylor Three-dimensional pharmacophore methods in drug discovery J Med Chem 53 2 2010 539 558
    • (2010) J Med Chem , vol.53 , Issue.2 , pp. 539-558
    • Leach, A.R.1    Gillet, V.J.2    Lewis, R.A.3    Taylor, R.4
  • 245
    • 0033645953 scopus 로고    scopus 로고
    • Chiral recognition of sandalwood odorants
    • J.A. Bajgrowicz, and G. Frater Chiral recognition of sandalwood odorants Enantiomer 5 2000 225 234
    • (2000) Enantiomer , vol.5 , pp. 225-234
    • Bajgrowicz, J.A.1    Frater, G.2
  • 246
    • 0038547948 scopus 로고    scopus 로고
    • Substituted hepta-1,6-dien-3-ones with green/fruity odours green/galbanum olfactophore model
    • J.A. Bajgrowicz, K. Berg-Schultz, and G. Brunner Substituted hepta-1,6-dien-3-ones with green/fruity odours green/galbanum olfactophore model Bioorg Med Chem 11 13 2003 2931 2946
    • (2003) Bioorg Med Chem , vol.11 , Issue.13 , pp. 2931-2946
    • Bajgrowicz, J.A.1    Berg-Schultz, K.2    Brunner, G.3
  • 247
    • 80051713465 scopus 로고    scopus 로고
    • New developments in the chemistry of cooling compounds
    • S.M. Furrer, J.P. Slack, and S.T. McCluskey New developments in the chemistry of cooling compounds Chemosens Percept 1 2 2008 119 126
    • (2008) Chemosens Percept , vol.1 , Issue.2 , pp. 119-126
    • Furrer, S.M.1    Slack, J.P.2    McCluskey, S.T.3
  • 248
    • 34047097447 scopus 로고    scopus 로고
    • QSAR modeling on the basis of 3D descriptors representing the electrostatic molecular surface (ambergris fragrances)
    • I.V. Svitanko, D.A. Devetyarov, and D.E. Tcheboukov QSAR modeling on the basis of 3D descriptors representing the electrostatic molecular surface (ambergris fragrances) Mendeleev Commun 17 2 2007 90 91
    • (2007) Mendeleev Commun , vol.17 , Issue.2 , pp. 90-91
    • Svitanko, I.V.1    Devetyarov, D.A.2    Tcheboukov, D.E.3
  • 249
    • 0029989174 scopus 로고    scopus 로고
    • Construction of a quantitative three-dimensional model for odor quality using comparative molecular field analysis (CoMFA)
    • F. Yoshii, and S. Hirono Construction of a quantitative three-dimensional model for odor quality using comparative molecular field analysis (CoMFA) Chem Senses 21 2 1996 201 210
    • (1996) Chem Senses , vol.21 , Issue.2 , pp. 201-210
    • Yoshii, F.1    Hirono, S.2
  • 250
    • 84898870890 scopus 로고    scopus 로고
    • Identification of odorant-receptor interactions by global mapping of the human odorome
    • K. Audouze, A. Tromelin, and A.M. Le Bon Identification of odorant-receptor interactions by global mapping of the human odorome PLoS One 9 4 2014 e93037
    • (2014) PLoS One , vol.9 , Issue.4 , pp. e93037
    • Audouze, K.1    Tromelin, A.2    Le Bon, A.M.3
  • 251
    • 84870663645 scopus 로고    scopus 로고
    • Chemoinformatic analysis of GRAS (generally recognized as safe) flavor chemicals and natural products
    • J.L. Medina-Franco, K. Martinez-Mayorga, T.L. Peppard, and A. Del Rio Chemoinformatic analysis of GRAS (generally recognized as safe) flavor chemicals and natural products PLoS One 7 11 2012 e50798
    • (2012) PLoS One , vol.7 , Issue.11 , pp. e50798
    • Medina-Franco, J.L.1    Martinez-Mayorga, K.2    Peppard, T.L.3    Del Rio, A.4
  • 252
    • 84866882901 scopus 로고    scopus 로고
    • Chemoinformatics and chemical genomics: Potential utility of in silico methods
    • L.G. Valerio, and S. Choudhuri Chemoinformatics and chemical genomics: potential utility of in silico methods J Appl Toxicol 32 11 2012 880 889
    • (2012) J Appl Toxicol , vol.32 , Issue.11 , pp. 880-889
    • Valerio, L.G.1    Choudhuri, S.2
  • 253
    • 84877823346 scopus 로고    scopus 로고
    • Stochastic voyages into uncharted chemical space produce a representative library of all possible drug-like compounds
    • A.M. Virshup, J. Contreras-Garcia, P. Wipf, W.T. Yang, and D.N. Beratan Stochastic voyages into uncharted chemical space produce a representative library of all possible drug-like compounds J Am Chem Soc 135 19 2013 7296 7303
    • (2013) J Am Chem Soc , vol.135 , Issue.19 , pp. 7296-7303
    • Virshup, A.M.1    Contreras-Garcia, J.2    Wipf, P.3    Yang, W.T.4    Beratan, D.N.5


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