Efficacy of omega-3 polyunsaturated fatty acids supplementation in managing overweight and obesity: A meta-analysis of randomized clinical trials

Journal of Nutrition, Health and Aging

Volumn 21, Issue 2, 2017, Pages 187-192

  Zhang, Y Y ^a   Liu, W ^a   Zhao, T Y ^a   Tian, H M ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

meta analysis; obesity; Omega 3 polyunsaturated fatty acids; overweight; randomized clinical trial

Indexed keywords

CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OMEGA 3 FATTY ACID; TRIACYLGLYCEROL;

ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CLINICAL EVALUATION; DIET RESTRICTION; DIET SUPPLEMENTATION; DRUG EFFICACY; GLUCOSE BLOOD LEVEL; HUMAN; META ANALYSIS; OBESITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SYSTEMATIC REVIEW; TREATMENT OUTCOME; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; WEIGHT REDUCTION; BLOOD; DIETARY SUPPLEMENT; FACTUAL DATABASE; OVERWEIGHT;

CHOLESTEROL, HDL; CHOLESTEROL, LDL; DATABASES, FACTUAL; DIETARY SUPPLEMENTS; FATTY ACIDS, OMEGA-3; HUMANS; OBESITY; OVERWEIGHT; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME; TRIGLYCERIDES;

EID: 84976330193     PISSN: 12797707     EISSN: 17604788     Source Type: Journal    
DOI: 10.1007/s12603-016-0755-5     Document Type: Article

References (30)

1. Swinburn BA, Sacks G, Hall KD, McPherson K, Finegood DT, Moodie ML, at al. The global obesity pandemic: shaped by global drivers and local environments. Lancet 2011;378:804–814
2. de Luis DA, Aller R, Izaola O, Gonzalez Sagrado M, Bellioo D, Conde R. Effects of a low-fat versus a low-carbohydrate diet on adipocytokines in obese adults. Horm Res 2007;67:296–300
3. de Luis DA, Pacheco D, Izaola O, Terroba MC, Cuellar L, Martin T. Clinical results and nutritional consequences of biliopancreatic diversion: three years of follow-up. Ann Nutr Metab 2008;53:234–239
4. Van Gaal LF, Wauters MA, DeLeeuw IH. The beneficial effects of modest weight loss on cardiovascular risk factors. Int J Obes Relat Metab Disord 1997;21: S5–9
5. Kris-Etherton PM, Harris WS, Appel LJ. Omega-3 fatty acids and cardiovascular disease: new recommendations from the American Heart Association. Arterioscler Thromb Vasc Biol 2003;23:151–152
6. Pittaway JK, Chuang LT, Ahuja KD, Beckett JM, Glew RH, Ball MJ. Omega-3 dietary Fatty Acid status of healthy older adults in Tasmania, Australia: an observational study. J Nutr Health Aging 2015;19:505–510
7. Graham I, Atar D, Borch-Johnsen K, Boysen G, Burell G, Cifkova R, et al. European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). Eur J Cardiovasc Prev Rehabil 2007;14: S1–113
8. Lavie CJ, Milani RV, Mehra MR, Ventura HO. Omega-3 polyunsaturated fatty acids and cardiovascular diseases. J Am Coll Cardiol 2009;54:585–594
9. Flachs P, Horakova O, Brauner P, Rossmeisl M, Pecina P, Franssen-van Hal N, et al. Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce beta-oxidation in white fat. Diabetologia 2005;48:2365–2375
10. Ruzickova J, Rossmeisl M, Prazak T, Flachs P, Sponarova J, Veck M, et al. Omega-3 PUFA of marine origin limit diet-induced obesity in mice by reducing cellularity of adipose tissue. Lipids 2004;39:1177–1185
11. Minami A, Ishimura N, Sakamoto S, Takishita E, Mawatari K, Okada K, et al. Effect of eicosapentaenoic acid ethyl ester v. oleic acid-rich safflower oil on insulin resistance in type 2 diabetic model rats with hypertriacylglycerolaemia. Br J Nutr 2002;87:157–162
12. Raclot T, Groscolas R, Langin D, Ferré P. Site-specific regulation of gene expression by n-3 polyunsaturated fatty acids in rat white adipose tissues. J Lipid Res 1997;38:1963–1972
13. Buckley JD, Howe PR. Anti-obesity effects of long-chain omega-3 polyunsaturated fatty acids. Obes Rev 2009;10:648–659
14. Chan DC, Watts GF, Mori TA, Barrett PH, Redgrave TG, Beilin LJ. Randomized controlled trial of the effect of n-3 fatty acid supplementation on the metabolism of apolipoprotein B-100 and chylomicron remnants in men with visceral obesity. Am J Clin Nutr 2003;77:300–307
15. Krebs JD, Browning LM, McLean NK, Rothwell JL, Mishra GD, Moore CS, at al. Additive benefits of long-chain n-3 polyunsaturated fatty acids and weight-loss in the management of cardiovascular disease risk in overweight hyperinsulinaemic women. Int J Obes 2006;30:1535–1544
16. Kunesová M, Braunerová R, Hlavatý P, Tvrzická E, Stanková B, Skrha J, et al. The influence of n-3 polyunsaturated fatty acids and very low calorie diet during a shortterm weight reducing regimen on weight loss and serum fatty acid composition in severely obese women. Physiol Res 2006;55:63–72
17. Thorsdottir I, Tomasson H, Gunnarsdottir I, Gisladottir E, Kiely M, Parra MD, et al. Randomized trial of weight-loss-diets for young adults varying in fish and fish oil content. Int J Obes 2007;31:1560–1566
18. Hill AM, Buckley JD, Murphy KJ, Howe PR. Combining fish-oil supplements with regular aerobic exercise improves body composition and cardiovascular disease risk factors. Am J Clin Nutr 2007;85:1267–1274
19. DeFina LF, Marcoux LG, Devers SM, Cleaver JP, Willis BL. Effects of omega-3 supplementation in combination with diet and exercise on weight loss and body composition. Am J Clin Nutr 2011;93:455–462
20. Gammelmark A, Madsen T, Varming K, Lundbye-Christensen S, Schmidt EB. Low-dose fish oil supplementation increases serum adiponectin without affecting inflammatory markers in overweight subjects. Nutr Res 2012;32:15–23
21. Munro IA, Garg ML. Dietary supplementation with n-3 PUFA does not promote weight loss when combined with a very-low-energy diet. Br J Nutr 2012, 108, 1466–1474
22. Munro IA, Garg ML. Prior supplementation with long chain omega-3 polyunsaturated fatty acids promotes weight loss in obese adults: a double-blinded randomised controlled trial. Food Funct 2013;4:650–658
23. Munro IA, Garg ML. Dietary supplementation with long chain omega-3 polyunsaturated fatty acids and weight loss in obese adults. Obes Res Clin Pract 2013;7:173–181
24. Spencer M, Finlin BS, Unal R, Zhu B, Morris AJ, Shipp LR, et al. Omega-3 fatty acids reduce adipose tissue macrophages in human subjects with insulin resistance. Diabetes 2013;62:1709–1717
25. Buckley JD, Howe PR. Long-chain omega-3 polyunsaturated fatty acids may be beneficial for reducing obesity-a review. Nutrients 2010;2:1212–1230
26. Hajer GR, van Haeften TW, Visseren FL. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J 2008;29:2959–2971
27. Wadden TA, Butryn ML, Wilson C. Lifestyle modification for the management of obesity. Gastroenterology 2007;132:2226–2238
28. B. Vellas, I. Carrie, S. Gillette-Guyonnet, J. Touchon, T. Dantoine, J.F. Dartigues, et al. MAPT study: a multidomain approach for preventing Alzheimer’s disease: design and baseline data. J Prev Alz Dis 2014;1:13–22
29. Ioannidis JP, Evans SJ, Gøtzsche PC, O’Neill RT, Altman DG, Schulz K, Moher, D. Better reporting of harms in randomized trials: an extension of the CONSORT statement. Ann Intern Med 2004;141:781–788
30. Burdge GC, Wootton SA. Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br J Nutr 2002;88:411–420