메뉴 건너뛰기




Volumn 10, Issue 5, 2010, Pages 557-562

Development of aptamer therapeutics

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS ACTING ON THE EYE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIDIABETIC AGENT; ANTILEUKEMIC AGENT; ANTINEOPLASTIC AGENT; ANTITHROMBIN; APTAMER; ARC 1905; AS 1411; BIOTIN; CARDIOVASCULAR AGENT; CHOLESTEROL; E 10030; HEPARIN; MACROGOL; NOX A 12; NOX E 36; NU 172; NUCLEIC ACID; PEGAPTANIB; RANIBIZUMAB; RB 006; RB 007; RIBOSE; SINGLE STRANDED DNA; SMALL INTERFERING RNA; STREPTAVIDIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; URINARY TRACT AGENT; VASCULOTROPIN 165;

EID: 77956650825     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2010.06.009     Document Type: Review
Times cited : (130)

References (45)
  • 1
    • 0025332385 scopus 로고
    • Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA
    • Robertson D.L., Joyce G.F. Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA. Nature 1990, 344:467-468.
    • (1990) Nature , vol.344 , pp. 467-468
    • Robertson, D.L.1    Joyce, G.F.2
  • 2
    • 0025194307 scopus 로고
    • Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
    • Tuerk C., Gold L. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 1990, 249:505-510.
    • (1990) Science , vol.249 , pp. 505-510
    • Tuerk, C.1    Gold, L.2
  • 3
    • 0025074907 scopus 로고
    • In vitro selection of RNA molecules that bind specific ligands
    • Ellington A.D., Szostak J.W. In vitro selection of RNA molecules that bind specific ligands. Nature 1990, 346:818-822.
    • (1990) Nature , vol.346 , pp. 818-822
    • Ellington, A.D.1    Szostak, J.W.2
  • 4
    • 0025188193 scopus 로고
    • Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication
    • Sullenger B.A., Gallardo H.F., Ungers G.E., Gilboa E. Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication. Cell 1990, 63:601-608.
    • (1990) Cell , vol.63 , pp. 601-608
    • Sullenger, B.A.1    Gallardo, H.F.2    Ungers, G.E.3    Gilboa, E.4
  • 5
    • 68249092118 scopus 로고    scopus 로고
    • Aptamers as inhibitors of target proteins
    • Missailidis S., Hardy A. Aptamers as inhibitors of target proteins. Expert Opin Ther Pat 2009, 19:1073-1082.
    • (2009) Expert Opin Ther Pat , vol.19 , pp. 1073-1082
    • Missailidis, S.1    Hardy, A.2
  • 6
    • 33646948521 scopus 로고    scopus 로고
    • Pegaptanib sodium for neovascular age-related macular degeneration: two-year safety results of the two prospective, multicenter, controlled clinical trials
    • D'Amico D.J., Masonson H.N., Patel M., Adamis A.P., Cunningham E.T., Guyer D.R., Katz B. Pegaptanib sodium for neovascular age-related macular degeneration: two-year safety results of the two prospective, multicenter, controlled clinical trials. Ophthalmology 2006, 113:992-1001.
    • (2006) Ophthalmology , vol.113 , pp. 992-1001
    • D'Amico, D.J.1    Masonson, H.N.2    Patel, M.3    Adamis, A.P.4    Cunningham, E.T.5    Guyer, D.R.6    Katz, B.7
  • 9
    • 77956651955 scopus 로고    scopus 로고
    • Nucleic acid aptamers for diagnostics and therapeutics: global markets
    • (Report BIO071A)
    • Jackson G.W., Strych U. Nucleic acid aptamers for diagnostics and therapeutics: global markets. BCC Res 2010, (Report BIO071A).
    • (2010) BCC Res
    • Jackson, G.W.1    Strych, U.2
  • 10
    • 33845388596 scopus 로고    scopus 로고
    • First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: a phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity
    • Dyke C.K., Steinhubl S.R., Kleiman N.S., Cannon R.O., Aberle L.G., Lin M., Myles S.K., Melloni C., Harrington R.A., Alexander J.H., et al. First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: a phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity. Circulation 2006, 114:2490-2497.
    • (2006) Circulation , vol.114 , pp. 2490-2497
    • Dyke, C.K.1    Steinhubl, S.R.2    Kleiman, N.S.3    Cannon, R.O.4    Aberle, L.G.5    Lin, M.6    Myles, S.K.7    Melloni, C.8    Harrington, R.A.9    Alexander, J.H.10
  • 12
    • 0028100380 scopus 로고
    • Inhibition of receptor binding by high-affinity RNA ligands to vascular endothelial growth factor
    • Jellinek D., Green L.S., Bell C., Janjić N. Inhibition of receptor binding by high-affinity RNA ligands to vascular endothelial growth factor. Biochemistry 1994, 33:10450-10456.
    • (1994) Biochemistry , vol.33 , pp. 10450-10456
    • Jellinek, D.1    Green, L.S.2    Bell, C.3    Janjić, N.4
  • 13
    • 0025738773 scopus 로고
    • Association of antisense oligonucleotides with lipoproteins prolongs the plasma half-life and modifies the tissue distribution
    • de Smidt P.C., Le Doan T., de Falco S., van Berkel T.J. Association of antisense oligonucleotides with lipoproteins prolongs the plasma half-life and modifies the tissue distribution. Nucleic Acids Res 1991, 19:4695-4700.
    • (1991) Nucleic Acids Res , vol.19 , pp. 4695-4700
    • de Smidt, P.C.1    Le Doan, T.2    de Falco, S.3    van Berkel, T.J.4
  • 14
    • 70349786346 scopus 로고    scopus 로고
    • The chemical biology of aptamers
    • Mayer G. The chemical biology of aptamers. Angew Chem Int Ed Engl 2009, 48:2672-2689.
    • (2009) Angew Chem Int Ed Engl , vol.48 , pp. 2672-2689
    • Mayer, G.1
  • 15
    • 38949167600 scopus 로고    scopus 로고
    • Therapeutic applications of aptamers
    • Kaur G., Roy I. Therapeutic applications of aptamers. Expert Opin Investig Drugs 2008, 17:43-60.
    • (2008) Expert Opin Investig Drugs , vol.17 , pp. 43-60
    • Kaur, G.1    Roy, I.2
  • 16
    • 0029091457 scopus 로고
    • A mutant T7 RNA polymerase as a DNA polymerase
    • Sousa R., Padilla R. A mutant T7 RNA polymerase as a DNA polymerase. EMBO J 1995, 14:4609-4621.
    • (1995) EMBO J , vol.14 , pp. 4609-4621
    • Sousa, R.1    Padilla, R.2
  • 17
    • 4444326623 scopus 로고    scopus 로고
    • Evolution of a T7 RNA polymerase variant that transcribes 2'-O-methyl RNA
    • Chelliserrykattil J., Ellington A.D. Evolution of a T7 RNA polymerase variant that transcribes 2'-O-methyl RNA. Nat Biotechnol 2004, 22:1155-1160.
    • (2004) Nat Biotechnol , vol.22 , pp. 1155-1160
    • Chelliserrykattil, J.1    Ellington, A.D.2
  • 19
    • 0032493654 scopus 로고    scopus 로고
    • 2'-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain
    • Ruckman J., Green L.S., Beeson J., Waugh S., Gillette W.L., Henninger D.D., Claesson-Welsh L., Janjić N. 2'-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain. J Biol Chem 1998, 273:20556-20567.
    • (1998) J Biol Chem , vol.273 , pp. 20556-20567
    • Ruckman, J.1    Green, L.S.2    Beeson, J.3    Waugh, S.4    Gillette, W.L.5    Henninger, D.D.6    Claesson-Welsh, L.7    Janjić, N.8
  • 20
    • 25844498391 scopus 로고    scopus 로고
    • Conjugation to polyethylene glycol polymer promotes aptamer biodistribution to healthy and inflamed tissues
    • Boomer R.M., Lewis S.D., Healy J.M., Kurz M., Wilson C., McCauley T.G. Conjugation to polyethylene glycol polymer promotes aptamer biodistribution to healthy and inflamed tissues. Oligonucleotides 2005, 15:183-195.
    • (2005) Oligonucleotides , vol.15 , pp. 183-195
    • Boomer, R.M.1    Lewis, S.D.2    Healy, J.M.3    Kurz, M.4    Wilson, C.5    McCauley, T.G.6
  • 21
  • 23
    • 0032876515 scopus 로고    scopus 로고
    • Detection and plasma pharmacokinetics of an anti-vascular endothelial growth factor oligonucleotide-aptamer (NX1838) in rhesus monkeys
    • Tucker C.E., Chen L.S., Judkins M.B., Farmer J.A., Gill S.C., Drolet D.W. Detection and plasma pharmacokinetics of an anti-vascular endothelial growth factor oligonucleotide-aptamer (NX1838) in rhesus monkeys. J Chromatogr B Biomed Sci Appl 1999, 732:203-212.
    • (1999) J Chromatogr B Biomed Sci Appl , vol.732 , pp. 203-212
    • Tucker, C.E.1    Chen, L.S.2    Judkins, M.B.3    Farmer, J.A.4    Gill, S.C.5    Drolet, D.W.6
  • 24
    • 0034466813 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of an anti-vascular endothelial growth factor aptamer (NX1838) following injection into the vitreous humor of rhesus monkeys
    • Drolet D.W., Nelson J., Tucker C.E., Zack P.M., Nixon K., Bolin R., Judkins M.B., Farmer J.A., Wolf J.L., Gill S.C., Bendele R.A. Pharmacokinetics and safety of an anti-vascular endothelial growth factor aptamer (NX1838) following injection into the vitreous humor of rhesus monkeys. Pharm Res 2000, 17:1503-1510.
    • (2000) Pharm Res , vol.17 , pp. 1503-1510
    • Drolet, D.W.1    Nelson, J.2    Tucker, C.E.3    Zack, P.M.4    Nixon, K.5    Bolin, R.6    Judkins, M.B.7    Farmer, J.A.8    Wolf, J.L.9    Gill, S.C.10    Bendele, R.A.11
  • 25
    • 0037106622 scopus 로고    scopus 로고
    • Endogenous expression of a high-affinity pseudoknot RNA aptamer suppresses replication of HIV-1
    • Chaloin L., Lehmann M.J., Sczakiel G., Restle T. Endogenous expression of a high-affinity pseudoknot RNA aptamer suppresses replication of HIV-1. Nucleic Acids Res 2002, 30:4001-4008.
    • (2002) Nucleic Acids Res , vol.30 , pp. 4001-4008
    • Chaloin, L.1    Lehmann, M.J.2    Sczakiel, G.3    Restle, T.4
  • 27
    • 0037099536 scopus 로고    scopus 로고
    • Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostate-specific membrane antigen
    • Lupold S.E., Hicke B.J., Lin Y., Coffey D.S. Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostate-specific membrane antigen. Cancer Res 2002, 62:4029-4033.
    • (2002) Cancer Res , vol.62 , pp. 4029-4033
    • Lupold, S.E.1    Hicke, B.J.2    Lin, Y.3    Coffey, D.S.4
  • 29
    • 66249129385 scopus 로고    scopus 로고
    • Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells
    • Zhou J., Swiderski P., Li H., Zhang J., Neff C.P., Akkina R., Rossi J.J. Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells. Nucleic Acids Res 2009, 37:3094-3109.
    • (2009) Nucleic Acids Res , vol.37 , pp. 3094-3109
    • Zhou, J.1    Swiderski, P.2    Li, H.3    Zhang, J.4    Neff, C.P.5    Akkina, R.6    Rossi, J.J.7
  • 31
    • 72449209766 scopus 로고    scopus 로고
    • REG-1, a regimen comprising RB-006, a Factor IXa antagonist, and its oligonucleotide active control agent RB-007 for the potential treatment of arterial thrombosis
    • Becker R.C., Chan M.Y. REG-1, a regimen comprising RB-006, a Factor IXa antagonist, and its oligonucleotide active control agent RB-007 for the potential treatment of arterial thrombosis. Curr Opin Mol Ther 2009, 11:707-715.
    • (2009) Curr Opin Mol Ther , vol.11 , pp. 707-715
    • Becker, R.C.1    Chan, M.Y.2
  • 32
    • 76749169748 scopus 로고    scopus 로고
    • AS-1411, a guanosine-rich oligonucleotide aptamer targeting nucleolin for the potential treatment of cancer, including acute myeloid leukemia
    • Mongelard F., Bouvet P. AS-1411, a guanosine-rich oligonucleotide aptamer targeting nucleolin for the potential treatment of cancer, including acute myeloid leukemia. Curr Opin Mol Ther 2010, 12:107-114.
    • (2010) Curr Opin Mol Ther , vol.12 , pp. 107-114
    • Mongelard, F.1    Bouvet, P.2
  • 34
    • 77956647312 scopus 로고    scopus 로고
    • NOXXON website press release: NOXXON announces excellent preliminary phase I trial results for Spiegelmer NOX-E36. October 12, ().
    • NOXXON website press release: NOXXON announces excellent preliminary phase I trial results for Spiegelmer NOX-E36. October 12, 2009 (). http://www.noxxon.com/.
    • (2009)
  • 35
    • 77956649992 scopus 로고    scopus 로고
    • NOXXON website press release: NOXXON announces the completion of the first-in-human clinical trial with Spiegelmer® NOX-A12. May 3, ().
    • NOXXON website press release: NOXXON announces the completion of the first-in-human clinical trial with Spiegelmer® NOX-A12. May 3, 2010 (). http://www.noxxon.com/.
    • (2010)
  • 36
    • 21844443592 scopus 로고    scopus 로고
    • Structural characterization of an anti-gp120 RNA aptamer that neutralizes R5 strains of HIV-1
    • Dey A.K., Griffiths C., Lea S.M., James W. Structural characterization of an anti-gp120 RNA aptamer that neutralizes R5 strains of HIV-1. RNA 2005, 11:873-884.
    • (2005) RNA , vol.11 , pp. 873-884
    • Dey, A.K.1    Griffiths, C.2    Lea, S.M.3    James, W.4
  • 37
    • 27144483814 scopus 로고    scopus 로고
    • An aptamer that neutralizes R5 strains of human immunodeficiency virus type 1 blocks gp120-CCR5 interaction
    • Dey A.K., Khati M., Tang M., Wyatt R., Lea S.M., James W. An aptamer that neutralizes R5 strains of human immunodeficiency virus type 1 blocks gp120-CCR5 interaction. J Virol 2005, 79:13806-13810.
    • (2005) J Virol , vol.79 , pp. 13806-13810
    • Dey, A.K.1    Khati, M.2    Tang, M.3    Wyatt, R.4    Lea, S.M.5    James, W.6
  • 39
    • 0033543548 scopus 로고    scopus 로고
    • Antiproliferative activity of G-rich oligonucleotides correlates with protein binding
    • Bates P.J., Kahlon J.B., Thomas S.D., Trent J.O., Miller D.M. Antiproliferative activity of G-rich oligonucleotides correlates with protein binding. J Biol Chem 1999, 274:26369-26377.
    • (1999) J Biol Chem , vol.274 , pp. 26369-26377
    • Bates, P.J.1    Kahlon, J.B.2    Thomas, S.D.3    Trent, J.O.4    Miller, D.M.5
  • 41
    • 77956647718 scopus 로고    scopus 로고
    • Ophthotech website press release: Ophthotech enrolls its first patient in a randomized, controlled phase II study of E10030 in macular degeneration. April 26, ().
    • Ophthotech website press release: Ophthotech enrolls its first patient in a randomized, controlled phase II study of E10030 in macular degeneration. April 26, 2010 (). http://www.ophthotech.com/news.
    • (2010)
  • 42
    • 77954240065 scopus 로고    scopus 로고
    • Physicochemical stability of NOX-E36, a 40mer L-RNA (Spiegelmer) for therapeutic applications
    • Maasch C., Buchner K., Eulberg D., Vonhoff S., Klussmann S. Physicochemical stability of NOX-E36, a 40mer L-RNA (Spiegelmer) for therapeutic applications. Nucleic Acids Symp Ser 2008, 52:61-62.
    • (2008) Nucleic Acids Symp Ser , vol.52 , pp. 61-62
    • Maasch, C.1    Buchner, K.2    Eulberg, D.3    Vonhoff, S.4    Klussmann, S.5
  • 44


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.