메뉴 건너뛰기




Volumn 7, Issue , 2016, Pages

The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 21; G PROTEIN COUPLED RECEPTOR 120; LIPID; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; OMEGA 3 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; POLYUNSATURATED FATTY ACID; SIRTUIN 3; TRANSCRIPTOME; UNCOUPLING PROTEIN 1; FIBROBLAST GROWTH FACTOR; G PROTEIN COUPLED RECEPTOR; GW9508; ICOSAPENTAENOIC ACID; METHYLAMINE; O3FAR1 PROTEIN, MOUSE; PROPIONIC ACID DERIVATIVE;

EID: 84995578439     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms13479     Document Type: Article
Times cited : (187)

References (59)
  • 1
    • 0027731309 scopus 로고
    • Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
    • Lowell, B. B. et al. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 366, 740-742 (1993).
    • (1993) Nature , vol.366 , pp. 740-742
    • Lowell, B.B.1
  • 2
    • 58749091645 scopus 로고    scopus 로고
    • UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality
    • Feldmann, H. M., Golozoubova, V., Cannon, B., Nedergaard, J. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab. 9, 203-209 (2009).
    • (2009) Cell Metab. , vol.9 , pp. 203-209
    • Feldmann, H.M.1    Golozoubova, V.2    Cannon, B.3    Nedergaard, J.4
  • 3
    • 84946611387 scopus 로고    scopus 로고
    • Human brown adipose tissue: What we have learned so far
    • Betz, M. J., Enerbäck, S. Human brown adipose tissue: what we have learned so far. Diabetes 64, 2352-2412 (2015).
    • (2015) Diabetes , vol.64 , pp. 2352-2412
    • Betz, M.J.1    Enerbäck, S.2
  • 4
    • 84883145789 scopus 로고    scopus 로고
    • White brown beige/brite: Different adipose cells for different functions
    • Giralt, M., Villarroya, F. White, brown, beige/brite: different adipose cells for different functions? Endocrinology 154, 2992-3000 (2013).
    • (2013) Endocrinology , vol.154 , pp. 2992-3000
    • Giralt, M.1    Villarroya, F.2
  • 5
    • 84890234667 scopus 로고    scopus 로고
    • UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic
    • Shabalina, I. G. et al. UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic. Cell. Rep. 5, 1196-1399 (2013).
    • (2013) Cell. Rep. , vol.5 , pp. 1196-1399
    • Shabalina, I.G.1
  • 6
    • 84975757439 scopus 로고    scopus 로고
    • A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat
    • Kazak, L. et al. A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat. Cell 163, 643-698 (2015).
    • (2015) Cell , vol.163 , pp. 643-698
    • Kazak, L.1
  • 7
    • 84880554676 scopus 로고    scopus 로고
    • Zbtb16 has a role in brown adipocyte bioenergetics
    • Plaisier, C. L. et al. Zbtb16 has a role in brown adipocyte bioenergetics. Nutr. Diabetes 2, e46 (2012).
    • (2012) Nutr. Diabetes , vol.2 , pp. 46
    • Plaisier, C.L.1
  • 8
    • 84900554165 scopus 로고    scopus 로고
    • Brown and white adipose tissues: Intrinsic differences in gene expression and response to cold exposure in mice
    • Rosell, M. et al. Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice. Am. J. Physiol. Endocrinol. Metab. 306, E945-E964 (2014).
    • (2014) Am. J. Physiol. Endocrinol. Metab. , vol.306 , pp. E945-E964
    • Rosell, M.1
  • 9
    • 47649124124 scopus 로고    scopus 로고
    • A global view of gene activity and alternative splicing by deep sequencing of the human transcriptome
    • Sultan, M. et al. A global view of gene activity and alternative splicing by deep sequencing of the human transcriptome. Science 321, 956-1016 (2008).
    • (2008) Science , vol.321 , pp. 956-1016
    • Sultan, M.1
  • 10
    • 77749323185 scopus 로고    scopus 로고
    • RNA-Seq analysis to capture the transcriptome landscape of a single cell
    • Tang, F. et al. RNA-Seq analysis to capture the transcriptome landscape of a single cell. Nat. Protoc. 5, 516-551 (2010).
    • (2010) Nat. Protoc. , vol.5 , pp. 516-551
    • Tang, F.1
  • 11
    • 77952905505 scopus 로고    scopus 로고
    • Most 'dark matter' transcripts are associated with known genes
    • van Bakel, H., Nislow, C., Blencowe, B. J., Hughes, T. R. Most 'dark matter' transcripts are associated with known genes. PLoS Biol. 8, e1000371 (2010).
    • (2010) PLoS Biol. , vol.8 , pp. 1000371
    • Van Bakel, H.1    Nislow, C.2    Blencowe Hughes J B, T.R.3
  • 12
    • 84937576781 scopus 로고    scopus 로고
    • Dietary fatty acids and their potential for controlling metabolic diseases through activation of FFA4/GPR120
    • Ulven, T., Christiansen, E. Dietary fatty acids and their potential for controlling metabolic diseases through activation of FFA4/GPR120. Annu. Rev. Nutr. 35, 239-263 (2015).
    • (2015) Annu. Rev. Nutr. , vol.35 , pp. 239-263
    • Ulven, T.1    Christiansen, E.2
  • 13
    • 77956165390 scopus 로고    scopus 로고
    • GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects
    • Oh, D. Y. et al. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 142, 687-785 (2010).
    • (2010) Cell , vol.142 , pp. 687-785
    • Oh, D.Y.1
  • 14
    • 84858285593 scopus 로고    scopus 로고
    • Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human
    • Ichimura, A. et al. Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature 483, 350-354 (2012).
    • (2012) Nature , vol.483 , pp. 350-354
    • Ichimura, A.1
  • 15
    • 84923862308 scopus 로고    scopus 로고
    • Transcriptome profiling of brown adipose tissue during cold exposure reveals extensive regulation of glucose metabolism
    • Hao, Q. et al. Transcriptome profiling of brown adipose tissue during cold exposure reveals extensive regulation of glucose metabolism. Am. J. Physiol. Endocrinol. Metab. 308, E380-E392 (2015).
    • (2015) Am. J. Physiol. Endocrinol. Metab. , vol.308 , pp. E380-E392
    • Hao, Q.1
  • 16
    • 84923878835 scopus 로고    scopus 로고
    • Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion
    • Iwasaki, K. et al. Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion. Endocrinology 156, 837-883 (2015).
    • (2015) Endocrinology , vol.156 , pp. 837-883
    • Iwasaki, K.1
  • 17
    • 33846468320 scopus 로고    scopus 로고
    • The regulation of adipogenesis through GPR120
    • Gotoh, C. et al. The regulation of adipogenesis through GPR120. Biochem. Biophys. Res. Commun. 354, 591-597 (2007).
    • (2007) Biochem. Biophys. Res. Commun. , vol.354 , pp. 591-597
    • Gotoh, C.1
  • 18
    • 0035920122 scopus 로고    scopus 로고
    • Beta-Adrenergic activation of p38 MAP kinase in adipocytes: CAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase
    • Cao, W., Medvedev, A. V., Daniel, K. W., Collins, S. beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase. J. Biol. Chem. 276, 27077-27082 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 27077-27082
    • Cao, W.1    Medvedev, A.V.2    Daniel, K.W.3    Collins, S.4
  • 19
    • 79953886306 scopus 로고    scopus 로고
    • Thermogenic activation induces FGF21 expression and release in brown adipose tissue
    • Hondares, E. et al. Thermogenic activation induces FGF21 expression and release in brown adipose tissue. J. Biol. Chem. 286, 12983-12990 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 12983-12990
    • Hondares, E.1
  • 20
    • 84864287504 scopus 로고    scopus 로고
    • Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
    • Wu, J. et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150, 366-442 (2012).
    • (2012) Cell , vol.150 , pp. 366-442
    • Wu, J.1
  • 21
    • 13444263540 scopus 로고    scopus 로고
    • Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120
    • Hirasawa, A. et al. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat. Med. 11, 90-94 (2005).
    • (2005) Nat. Med. , vol.11 , pp. 90-94
    • Hirasawa, A.1
  • 22
    • 57349141546 scopus 로고    scopus 로고
    • Linoleic acid stimulates gluconeogenesis via Ca2\+/PLC, cPLA2, PPAR pathways through GPR40 in primary cultured chicken hepatocytes
    • Suh, H. N., Huong, H. T., Song, C. H., Lee, J. H., Han, H. J. Linoleic acid stimulates gluconeogenesis via Ca2\+/PLC, cPLA2, PPAR pathways through GPR40 in primary cultured chicken hepatocytes. Am. J. Physiol. Cell Physiol. 295, 1518-1545 (2008).
    • (2008) Am. J. Physiol. Cell Physiol. , vol.295 , pp. 1518-1545
    • Suh, H.N.1    Huong, H.T.2    Song, C.H.3    Lee, J.H.4    Han, H.J.5
  • 23
    • 84940878202 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 in breast milk controls neonatal intestine function
    • Gavaldà-Navarro, A. et al. Fibroblast growth factor 21 in breast milk controls neonatal intestine function. Sci. Rep. 5, 13717 (2015).
    • (2015) Sci. Rep. , vol.5 , pp. 13717
    • Gavaldà-Navarro, A.1
  • 24
    • 84890548520 scopus 로고    scopus 로고
    • Identification of G-protein-coupled receptor 120 as a tumorpromoting receptor that induces angiogenesis and migration in human colorectal carcinoma
    • Wu, Q. et al. Identification of G-protein-coupled receptor 120 as a tumorpromoting receptor that induces angiogenesis and migration in human colorectal carcinoma. Oncogene 32, 5541-5550 (2013).
    • (2013) Oncogene , vol.32 , pp. 5541-5550
    • Wu, Q.1
  • 25
    • 0035847001 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell
    • Barbera, M. J. et al. Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell. J. Biol. Chem. 276, 1486-1579 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 1486-1579
    • Barbera, M.J.1
  • 26
    • 0037083983 scopus 로고    scopus 로고
    • Phytanic acid, a novel activator of uncoupling protein-1 gene transcription and brown adipocyte differentiation
    • Schlüter, A., Barberá, M. J., Iglesias, R., Giralt, M., Villarroya, F. Phytanic acid, a novel activator of uncoupling protein-1 gene transcription and brown adipocyte differentiation. Biochem. J. 362, 61-70 (2002).
    • (2002) Biochem. J. , vol.362 , pp. 61-70
    • Schlüter, A.1    Barberá, M.J.2    Iglesias, R.3    Giralt, M.4    Villarroya, F.5
  • 27
    • 84896710569 scopus 로고    scopus 로고
    • Functional thermogenic beige adipogenesis is inducible in human neck fat
    • Lee, P., Werner, C. D., Kebebew, E., Celi, F. S. Functional thermogenic beige adipogenesis is inducible in human neck fat. Int. J. Obes. (Lond) 38, 170-176 (2014).
    • (2014) Int. J. Obes. (Lond) , vol.38 , pp. 170-176
    • Lee, P.1    Werner, C.D.2    Kebebew, E.3    Celi, F.S.4
  • 28
    • 84893452569 scopus 로고    scopus 로고
    • Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans
    • Lee, P. et al. Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. Cell Metab. 19, 302-309 (2014).
    • (2014) Cell Metab. , vol.19 , pp. 302-309
    • Lee, P.1
  • 29
    • 84886060164 scopus 로고    scopus 로고
    • The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism Mol
    • Hudson, B. D. et al. The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism Mol. Pharmacol. 84, 710-735 (2013).
    • (2013) Pharmacol. , vol.84 , pp. 710-735
    • Hudson, B.D.1
  • 30
    • 68349086914 scopus 로고    scopus 로고
    • Novel selective ligands for free fatty acid receptors GPR120 and GPR40
    • Hara, T. et al. Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch. Pharmacol. 380, 247-302 (2009).
    • (2009) Naunyn Schmiedebergs Arch. Pharmacol. , vol.380 , pp. 247-302
    • Hara, T.1
  • 31
    • 84875895887 scopus 로고    scopus 로고
    • Isolation and differentiation of stromal vascular cells to beige/brite cells
    • Aune, U. L., Ruiz, L., Kajimura, S. Isolation and differentiation of stromal vascular cells to beige/brite cells. J. Vis. Exp. 73, 50191 (2013).
    • (2013) J. Vis. Exp. , vol.73 , pp. 50191
    • Aune, U.L.1    Ruiz, L.2    Kajimura, S.3
  • 32
    • 34249711964 scopus 로고    scopus 로고
    • Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states
    • Badman, M. K. et al. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 5, 426-437 (2007).
    • (2007) Cell Metab. , vol.5 , pp. 426-437
    • Badman, M.K.1
  • 33
    • 34249686631 scopus 로고    scopus 로고
    • Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
    • Inagaki, T. et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab. 5, 415-425 (2007).
    • (2007) Cell Metab. , vol.5 , pp. 415-425
    • Inagaki, T.1
  • 34
    • 84902544474 scopus 로고    scopus 로고
    • Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120)
    • Sparks, S. M. et al. Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg. Med. Chem. Lett. 24, 3100-3103 (2014).
    • (2014) Bioorg. Med. Chem. Lett. , vol.24 , pp. 3100-3103
    • Sparks, S.M.1
  • 35
    • 0030051528 scopus 로고    scopus 로고
    • MKK3-and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
    • Raingeaud, J. et al. MKK3-and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol Cell Biol. 16, 1247-1255 (1996).
    • (1996) Mol Cell Biol. , vol.16 , pp. 1247-1255
    • Raingeaud, J.1
  • 36
    • 77249099832 scopus 로고    scopus 로고
    • Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat
    • Hondares, E. et al. Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat. Cell Metab. 11, 206-212 (2010).
    • (2010) Cell Metab. , vol.11 , pp. 206-212
    • Hondares, E.1
  • 37
    • 84863012022 scopus 로고    scopus 로고
    • FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis
    • Fisher, F. M. et al. FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 26, 271-281 (2012).
    • (2012) Genes Dev. , vol.26 , pp. 271-281
    • Fisher, F.M.1
  • 38
    • 84877585823 scopus 로고    scopus 로고
    • Beyond the sympathetic tone: The new brown fat activators
    • Villarroya, F., Vidal-Puig, A. Beyond the sympathetic tone: the new brown fat activators. Cell Metab. 17, 638-643 (2013).
    • (2013) Cell Metab. , vol.17 , pp. 638-643
    • Villarroya, F.1    Vidal-Puig, A.2
  • 39
    • 84907612482 scopus 로고    scopus 로고
    • A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice
    • Oh, D. L. et al. A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. Nat. Med. 20, 942-949 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 942-949
    • Oh, D.L.1
  • 40
    • 84902094655 scopus 로고    scopus 로고
    • Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat
    • Qiu, Y. et al. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell 157, 1292-1308 (2014).
    • (2014) Cell , vol.157 , pp. 1292-1308
    • Qiu, Y.1
  • 41
    • 84902097377 scopus 로고    scopus 로고
    • Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis
    • Rao, R. R. et al. Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell 157, 1279-1291 (2014).
    • (2014) Cell , vol.157 , pp. 1279-1291
    • Rao, R.R.1
  • 42
    • 84897594241 scopus 로고    scopus 로고
    • The effect of n-3 fatty acids on glucose homeostasis and insulin sensitivity
    • Flachs, P., Rossmeisl, M., Kopecky, J. The effect of n-3 fatty acids on glucose homeostasis and insulin sensitivity. Physiol. Res. 63, S93-S118 (2014).
    • (2014) Physiol. Res. , vol.63 , pp. S93-S118
    • Flachs, P.1    Rossmeisl, M.2    Kopecky, J.3
  • 43
    • 0030782612 scopus 로고    scopus 로고
    • Brown fat thermogenesis in rats fed high-fat diets enriched with omega polyunsaturated fatty acids
    • Oudart, H. et al. Brown fat thermogenesis in rats fed high-fat diets enriched with omega polyunsaturated fatty acids. Int. J. Obes. Relat. Metab. Disord. 21, 955-1017 (1997).
    • (1997) Int. J. Obes. Relat. Metab. Disord. , vol.21 , pp. 955-1017
    • Oudart, H.1
  • 44
    • 0028893263 scopus 로고
    • Polyunsaturated fatty acids recruit brown adipose tissue: Increased UCP content and NST capacity
    • Sadurskis, A., Dicker, A., Cannon, B., Nedergaard, J. Polyunsaturated fatty acids recruit brown adipose tissue: increased UCP content and NST capacity. Am. J. Physiol. 269, e351-e411 (1995).
    • (1995) Am. J. Physiol. , vol.269 , pp. e351-e411
    • Sadurskis, A.1    Dicker, A.2    Cannon, B.3    Nedergaard, J.4
  • 45
    • 0033844398 scopus 로고    scopus 로고
    • Dietary omega fatty acids affect mRNA level of brown adipose tissue uncoupling protein 1, white adipose tissue leptin and glucose transporter 4 in the rat
    • Takahashi, Y., Ide, T. Dietary omega fatty acids affect mRNA level of brown adipose tissue uncoupling protein 1, white adipose tissue leptin and glucose transporter 4 in the rat. Br. J. Nutr. 84, 175-259 (2000).
    • (2000) Br. J. Nutr. , vol.84 , pp. 175-259
    • Takahashi, Y.1    Ide, T.2
  • 46
    • 80054122062 scopus 로고    scopus 로고
    • Synergistic induction of lipid catabolism and anti-inflammatory lipids in white at of dietary obese mice in response to calorie restriction and omega fatty acids
    • Flachs, P. et al. Synergistic induction of lipid catabolism and anti-inflammatory lipids in white at of dietary obese mice in response to calorie restriction and omega fatty acids. Diabetologia 54, 2626-2664 (2011).
    • (2011) Diabetologia , vol.54 , pp. 2626-2664
    • Flachs, P.1
  • 47
    • 84910643169 scopus 로고    scopus 로고
    • Fibroblast growth factor-21 and the beneficial effects of long-chain omega polyunsaturated fatty acids
    • Villarroya, J. et al. Fibroblast growth factor-21 and the beneficial effects of long-chain omega polyunsaturated fatty acids. Lipids 49, 1081-1090 (2014).
    • (2014) Lipids , vol.49 , pp. 1081-1090
    • Villarroya, J.1
  • 48
    • 85027925568 scopus 로고    scopus 로고
    • Eicosapentaenoic acid and arachidonic acid differentially regulate adipogenesis, acquisition of a brite phenotype and mitochondrial function in primary human adipocytes
    • Fleckenstein-Elsen, M. et al. Eicosapentaenoic acid and arachidonic acid differentially regulate adipogenesis, acquisition of a brite phenotype and mitochondrial function in primary human adipocytes. Mol. Nutr. Food Res. 60, 2065-2075 (2016).
    • (2016) Mol. Nutr. Food Res. , vol.60 , pp. 2065-2075
    • Fleckenstein-Elsen, M.1
  • 49
    • 57749195712 scopus 로고    scopus 로고
    • RNA-Seq: A revolutionary tool for transcriptomics
    • Wang, Z., Gerstein, M., Snyder, M. RNA-Seq: a revolutionary tool for transcriptomics. Nat. Rev. Genet. 10, 57-63 (2009).
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 57-63
    • Wang, Z.1    Gerstein, M.2    Snyder, M.3
  • 50
    • 84859254586 scopus 로고    scopus 로고
    • The human pancreatic islet transcriptome: Expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines
    • Eizirik, D. L. et al. The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. PLoS Genet. 8, e1002552 (2012).
    • (2012) PLoS Genet. , vol.8 , pp. 1002552
    • Eizirik, D.L.1
  • 51
    • 84900334812 scopus 로고    scopus 로고
    • RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate
    • Cnop, M. et al. RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate. Diabetes 63, 1978-1993 (2014).
    • (2014) Diabetes , vol.63 , pp. 1978-1993
    • Cnop, M.1
  • 52
    • 77952123055 scopus 로고    scopus 로고
    • Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
    • Trapnell, C. et al. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat. Biotechnol. 28, 511-516 (2010).
    • (2010) Nat. Biotechnol. , vol.28 , pp. 511-516
    • Trapnell, C.1
  • 53
    • 77950458649 scopus 로고    scopus 로고
    • Transcriptome genetics using second generation sequencing in a Caucasian population
    • Montgomery, S. B. et al. Transcriptome genetics using second generation sequencing in a Caucasian population. Nature 464, 773-780 (2010).
    • (2010) Nature , vol.464 , pp. 773-780
    • Montgomery, S.B.1
  • 55
    • 84877272337 scopus 로고    scopus 로고
    • Multiple mechanisms of GW-9508, a selective G protein-coupled receptor 40 agonist, in the regulation of glucose homeostasis and insulin sensitivity
    • Ou, H. Y. et al. Multiple mechanisms of GW-9508, a selective G protein-coupled receptor 40 agonist, in the regulation of glucose homeostasis and insulin sensitivity. Am. J. Physiol. Endocrinol. Metab. 304, E668-E676 (2013).
    • (2013) Am. J. Physiol. Endocrinol. Metab. , vol.304 , pp. E668-E676
    • Ou, H.Y.1
  • 56
    • 0035432604 scopus 로고    scopus 로고
    • Bezafibrate reduces mRNA levels of adipocyte markers and increases fatty acid oxidation in primary culture of adipocytes
    • Cabrero, A. et al. Bezafibrate reduces mRNA levels of adipocyte markers and increases fatty acid oxidation in primary culture of adipocytes. Diabetes 50, 1883-1890 (2001).
    • (2001) Diabetes , vol.50 , pp. 1883-1890
    • Cabrero, A.1
  • 58
    • 34247607259 scopus 로고    scopus 로고
    • The relation between physical properties of the anterior eye and ocular surface temperature
    • Purslow, C., Wolffsohn, J. S. The relation between physical properties of the anterior eye and ocular surface temperature. Optom. Vis. Sci. 84, 197-201 (2007).
    • (2007) Optom. Vis. Sci. , vol.84 , pp. 197-201
    • Purslow, C.1    Wolffsohn, J.S.2
  • 59
    • 0031800882 scopus 로고    scopus 로고
    • Development of infrared imaging to measure thermogenesis in cell culture: Thermogenic effects of uncoupling protein-2, troglitazone, beta-adrenoceptor agonists
    • Paulik, M. A. et al. Development of infrared imaging to measure thermogenesis in cell culture: thermogenic effects of uncoupling protein-2, troglitazone, beta-adrenoceptor agonists. Pharm. Res. 15, 944-949 (1998).
    • (1998) Pharm. Res. , vol.15 , pp. 944-949
    • Paulik, M.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.