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Volumn 11, Issue 10, 2016, Pages

Effectiveness of omega-3 polyunsaturated fatty acids in non-alcoholic fatty liver disease: A meta-analysis of randomized controlled trials

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OMEGA 3 FATTY ACID; TRIACYLGLYCEROL; GLUCOSE BLOOD LEVEL; LIPID;

EID: 84990988117     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0162368     Document Type: Article
Times cited : (96)

References (56)
  • 1
    • 84962307138 scopus 로고    scopus 로고
    • Obesity is an independent risk factor for non-alcoholic fatty liver disease: Evidence from a meta-analysis of 21 cohort studies
    • 27020692
    • Li L, Liu DW, Yan HY, Wang ZY, Zhao SH, Wang B. Obesity is an independent risk factor for non-alcoholic fatty liver disease: evidence from a meta-analysis of 21 cohort studies. Obes Rev. 2016; 17 (6):510-9 doi: 10.1111/obr.12407 PMID: 27020692
    • (2016) Obes Rev. , vol.17 , Issue.6 , pp. 510-519
    • Li, L.1    Liu, D.W.2    Yan, H.Y.3    Wang, Z.Y.4    Zhao, S.H.5    Wang, B.6
  • 2
    • 42249115056 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease and metabolic syndrome in Brazilian middle-aged and older adults
    • 18317603
    • Karnikowski M, Cordova C, Oliveira RJ, Karnikowski MG, Nobrega Ode T. Non-alcoholic fatty liver disease and metabolic syndrome in Brazilian middle-aged and older adults. Sao Paulo Med J. 2007; 125 (6):333-7. doi: 10.1590/s1516-31802007000600006 PMID: 18317603
    • (2007) Sao Paulo Med J. , vol.125 , Issue.6 , pp. 333-337
    • Karnikowski, M.1    Cordova, C.2    Oliveira, R.J.3    Karnikowski, M.G.4    Nobrega Ode, T.5
  • 3
    • 84866747705 scopus 로고    scopus 로고
    • Association of pro-inflammatory cytokines, adipokines & oxidative stress with insulin resistance & non-alcoholic fatty liver disease
    • 22960889
    • Kumar R, Prakash S, Chhabra S, Singla V, Madan K, Gupta SD, et al. Association of pro-inflammatory cytokines, adipokines & oxidative stress with insulin resistance & non-alcoholic fatty liver disease. Indian J Med Res. 2012; 136(2):229-36. PMID: 22960889
    • (2012) Indian J Med Res. , vol.136 , Issue.2 , pp. 229-236
    • Kumar, R.1    Prakash, S.2    Chhabra, S.3    Singla, V.4    Madan, K.5    Gupta, S.D.6
  • 4
    • 0034221273 scopus 로고    scopus 로고
    • Human requirement for N-3 polyunsaturated fatty acids
    • 10901194
    • Simopoulos AP. Human requirement for N-3 polyunsaturated fatty acids. Poult Sci. 2000; 79(7):961-70. doi: 10.1093/ps/79.7.961 PMID: 10901194
    • (2000) Poult Sci. , vol.79 , Issue.7 , pp. 961-970
    • Simopoulos, A.P.1
  • 5
    • 80052040620 scopus 로고    scopus 로고
    • Importance of the omega-6/omega-3 balance in health and disease: Evolutionary aspects of diet
    • 21865815
    • Simopoulos AP. Importance of the omega-6/omega-3 balance in health and disease: evolutionary aspects of diet. World Rev Nutr Diet. 2011; 102:10-21. doi: 10.1159/000327785 PMID: 21865815
    • (2011) World Rev Nutr Diet. , vol.102 , pp. 10-21
    • Simopoulos, A.P.1
  • 6
    • 0038341638 scopus 로고    scopus 로고
    • Role and importance of dietary polyunsaturated fatty acids in the prevention and therapy of atherosclerosis
    • 12793187
    • Ristic V, Ristic G. [Role and importance of dietary polyunsaturated fatty acids in the prevention and therapy of atherosclerosis]. Med Pregl. 2003; 56(1-2):50-3. PMID: 12793187
    • (2003) Med Pregl. , vol.56 , Issue.1-2 , pp. 50-53
    • Ristic, V.1    Ristic, G.2
  • 7
    • 2942706241 scopus 로고    scopus 로고
    • Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease
    • 14720121
    • Araya J, Rodrigo R, Videla LA, Thielemann L, Orellana M, Pettinelli P, et al. Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clinical science (London, England: 1979). 2004; 106(6):635-43. doi: 10.1042/ CS20030326 PMID: 14720121
    • (2004) Clinical Science (London, England: 1979) , vol.106 , Issue.6 , pp. 635-643
    • Araya, J.1    Rodrigo, R.2    Videla, L.A.3    Thielemann, L.4    Orellana, M.5    Pettinelli, P.6
  • 8
    • 84896770640 scopus 로고    scopus 로고
    • Design and rationale of the WELCOME trial: A randomised, placebo controlled study to test the efficacy of purified long chainomega-3 fatty acid treatment in non-alcoholic fatty liver disease [corrected]
    • 24556343
    • Scorletti E, Bhatia L, McCormick KG, Clough GF, Nash K, Calder PC, et al. Design and rationale of the WELCOME trial: A randomised, placebo controlled study to test the efficacy of purified long chainomega-3 fatty acid treatment in non-alcoholic fatty liver disease [corrected]. Contemp Clin Trials. 2014; 37(2):301-11. doi: 10.1016/j.cct.2014.02.002 PMID: 24556343
    • (2014) Contemp Clin Trials. , vol.37 , Issue.2 , pp. 301-311
    • Scorletti, E.1    Bhatia, L.2    McCormick, K.G.3    Clough, G.F.4    Nash, K.5    Calder, P.C.6
  • 9
    • 84878006961 scopus 로고    scopus 로고
    • Omega-3 fatty acids for treatment of non-alcoholic fatty liver disease: Design and rationale of randomized controlled trial
    • 23702094
    • Janczyk W, Socha P, Lebensztejn D, Wierzbicka A, Mazur A, Neuhoff-Murawska J, et al. Omega-3 fatty acids for treatment of non-alcoholic fatty liver disease: design and rationale of randomized controlled trial. BMC Pediatr. 2013; 13:85. doi: 10.1186/1471-2431-13-85 PMID: 23702094
    • (2013) BMC Pediatr. , vol.13 , pp. 85
    • Janczyk, W.1    Socha, P.2    Lebensztejn, D.3    Wierzbicka, A.4    Mazur, A.5    Neuhoff-Murawska, J.6
  • 10
    • 84921603820 scopus 로고    scopus 로고
    • Double-blind randomized placebo-controlled clinical trial of omega 3 fatty acids for the treatment of diabetic patients with nonalcoholic steatohepatitis
    • 24583757
    • Dasarathy S, Dasarathy J, Khiyami A, Yerian L, Hawkins C, Sargent R, et al. Double-blind randomized placebo-controlled clinical trial of omega 3 fatty acids for the treatment of diabetic patients with nonalcoholic steatohepatitis. J Clin Gastroenterol. 2015; 49(2):137-44. doi: 10.1097/MCG. 0000000000000099 PMID: 24583757
    • (2015) J Clin Gastroenterol. , vol.49 , Issue.2 , pp. 137-144
    • Dasarathy, S.1    Dasarathy, J.2    Khiyami, A.3    Yerian, L.4    Hawkins, C.5    Sargent, R.6
  • 11
  • 12
    • 84904661185 scopus 로고    scopus 로고
    • No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trial
    • 24818764
    • Sanyal AJ, Abdelmalek MF, Suzuki A, Cummings OW, Chojkier M. No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trial. Gastroenterology. 2014; 147(2):377-84.e1. doi: 10.1053/j.gastro.2014.04.046 PMID: 24818764
    • (2014) Gastroenterology. , vol.147 , Issue.2 , pp. 377-384
    • Sanyal, A.J.1    Abdelmalek, M.F.2    Suzuki, A.3    Cummings, O.W.4    Chojkier, M.5
  • 13
    • 84930268665 scopus 로고    scopus 로고
    • Omega-3 polyunsaturated fatty acids in treating non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled trial
    • 26047766
    • Nogueira MA, Oliveira CP, Ferreira Alves VA, Stefano JT, Rodrigues LS, Torrinhas RS, et al. Omega-3 polyunsaturated fatty acids in treating non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled trial. Clin Nutr. 2015. doi: 10.1016/j.clnu.2015.05.001 PMID: 26047766
    • (2015) Clin Nutr.
    • Nogueira, M.A.1    Oliveira, C.P.2    Ferreira Alves, V.A.3    Stefano, J.T.4    Rodrigues, L.S.5    Torrinhas, R.S.6
  • 14
    • 77649170234 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and metaanalyses: The PRISMA Statement
    • 21603045
    • Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and metaanalyses: the PRISMA Statement. Open Med. 2009; 3(3):e123-30. doi: 10.7326/0003-4819-151-4-200908180-00135 PMID: 21603045
    • (2009) Open Med. , vol.3 , Issue.3 , pp. e123-e130
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3    Altman, D.G.4
  • 15
    • 78649823911 scopus 로고    scopus 로고
    • Effects of a 1-year dietary intervention with n-3 polyunsaturated fatty acid-enriched olive oil on non-alcoholic fatty liver disease patients: A preliminary study
    • 20465434
    • Sofi F, Giangrandi I, Cesari F, Corsani I, Abbate R, Gensini GF, et al. Effects of a 1-year dietary intervention with n-3 polyunsaturated fatty acid-enriched olive oil on non-alcoholic fatty liver disease patients: a preliminary study. Int J Food Sci Nutr. 2010; 61(8):792-802. doi: 10.3109/09637486.2010. 487480 PMID: 20465434
    • (2010) Int J Food Sci Nutr. , vol.61 , Issue.8 , pp. 792-802
    • Sofi, F.1    Giangrandi, I.2    Cesari, F.3    Corsani, I.4    Abbate, R.5    Gensini, G.F.6
  • 16
    • 38749115791 scopus 로고    scopus 로고
    • Effects of n-3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease
    • 18054848
    • Spadaro L, Magliocco O, Spampinato D, Piro S, Oliveri C, Alagona C, et al. Effects of n-3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease. Dig Liver Dis. 2008; 40(3):194-9. doi: 10.1016/j.dld.2007.10.003 PMID: 18054848
    • (2008) Dig Liver Dis. , vol.40 , Issue.3 , pp. 194-199
    • Spadaro, L.1    Magliocco, O.2    Spampinato, D.3    Piro, S.4    Oliveri, C.5    Alagona, C.6
  • 17
    • 63449137594 scopus 로고    scopus 로고
    • Effects of n-3 polyunsaturated fatty acids from seal oils on nonalcoholic fatty liver disease associated with hyperlipidemia
    • 19009658
    • Zhu FS, Liu S, Chen XM, Huang ZG, Zhang DW. Effects of n-3 polyunsaturated fatty acids from seal oils on nonalcoholic fatty liver disease associated with hyperlipidemia. World J Gastroenterol. 2008; 14 (41):6395-400. doi: 10.3748/wjg.14.6395 PMID: 19009658
    • (2008) World J Gastroenterol. , vol.14 , Issue.41 , pp. 6395-6400
    • Zhu, F.S.1    Liu, S.2    Chen, X.M.3    Huang, Z.G.4    Zhang, D.W.5
  • 18
    • 50849124491 scopus 로고    scopus 로고
    • Therapeutic efficacy of (omega)-3 polyunsaturated fatty acid capsule in treatment of patients with non-alcoholic fatty liver disease
    • Chen R GQ, Zhu WJ, Xie Q, Wang H, Cai W. Therapeutic efficacy of (omega)-3 polyunsaturated fatty acid capsule in treatment of patients with non-alcoholic fatty liver disease. World Chin J Digestol. 2008; 16:2002-6. doi: 10.11569/wcjd.v16.i18.2002
    • (2008) World Chin J Digestol. , vol.16 , pp. 2002-2006
    • Chen, R.G.Q.1    Zhu, W.J.2    Xie, Q.3    Wang, H.4    Cai, W.5
  • 19
    • 84927776586 scopus 로고    scopus 로고
    • Effects of purified eicosapentaenoic and docosahexaenoic acids in nonalcoholic fatty liver disease: Results from the Welcome∗ study
    • 25043514
    • Scorletti E, Bhatia L, McCormick KG, Clough GF, Nash K, Hodson L, et al. Effects of purified eicosapentaenoic and docosahexaenoic acids in nonalcoholic fatty liver disease: results from the Welcome∗ study. Hepatology. 2014; 60(4):1211-21. doi: 10.1002/hep.27289 PMID: 25043514
    • (2014) Hepatology. , vol.60 , Issue.4 , pp. 1211-1221
    • Scorletti, E.1    Bhatia, L.2    McCormick, K.G.3    Clough, G.F.4    Nash, K.5    Hodson, L.6
  • 20
    • 84930851146 scopus 로고    scopus 로고
    • Efficacy of poly-unsaturated fatty acid therapy on patients with nonalcoholic steatohepatitis
    • 26078579
    • Li YH, Yang LH, Sha KH, Liu TG, Zhang LG, Liu XX. Efficacy of poly-unsaturated fatty acid therapy on patients with nonalcoholic steatohepatitis. World J Gastroenterol. 2015; 21(22):7008-13. doi: 10.3748/ wjg.v21.i22.7008 PMID: 26078579
    • (2015) World J Gastroenterol. , vol.21 , Issue.22 , pp. 7008-7013
    • Li, Y.H.1    Yang, L.H.2    Sha, K.H.3    Liu, T.G.4    Zhang, L.G.5    Liu, X.X.6
  • 21
    • 84918554640 scopus 로고    scopus 로고
    • Effects of n-3 fish oil on metabolic and histological parameters in NASH: A double-blind, randomized, placebo-controlled trial
    • 25195547
    • Argo CK, Patrie JT, Lackner C, Henry TD, de Lange EE, Weltman AL, et al. Effects of n-3 fish oil on metabolic and histological parameters in NASH: a double-blind, randomized, placebo-controlled trial. J Hepatol. 2015; 62(1):190-7. doi: 10.1016/j.jhep.2014.08.036 PMID: 25195547
    • (2015) J Hepatol. , vol.62 , Issue.1 , pp. 190-197
    • Argo, C.K.1    Patrie, J.T.2    Lackner, C.3    Henry, T.D.4    De Lange, E.E.5    Weltman, A.L.6
  • 22
    • 84858703583 scopus 로고    scopus 로고
    • Omega-3 supplementation and non-alcoholic fatty liver disease: A systematic review and meta-analysis
    • 22023985
    • Parker HM, Johnson NA, Burdon CA, Cohn JS, O'Connor HT, George J. Omega-3 supplementation and non-alcoholic fatty liver disease: a systematic review and meta-analysis. J Hepatol. 2012; 56 (4):944-51. doi: 10.1016/j.jhep.2011.08.018 PMID: 22023985
    • (2012) J Hepatol. , vol.56 , Issue.4 , pp. 944-951
    • Parker, H.M.1    Johnson, N.A.2    Burdon, C.A.3    Cohn, J.S.4    O'Connor, H.T.5    George, J.6
  • 23
    • 77954239704 scopus 로고    scopus 로고
    • A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease
    • 20578268
    • Musso G, Gambino R, Cassader M, Pagano G. A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease. Hepatology. 2010; 52(1):79-104. doi: 10.1002/hep.23623 PMID: 20578268
    • (2010) Hepatology. , vol.52 , Issue.1 , pp. 79-104
    • Musso, G.1    Gambino, R.2    Cassader, M.3    Pagano, G.4
  • 24
    • 84870851072 scopus 로고    scopus 로고
    • Current limits and future challenges in the management of renal dysfunction in patients with cirrhosis: Report from the International Club of Ascites
    • 22507181
    • Angeli P, Sanyal A, Moller S, Alessandria C, Gadano A, Kim R, et al. Current limits and future challenges in the management of renal dysfunction in patients with cirrhosis: report from the International Club of Ascites. Liver Int. 2013; 33(1):16-23. doi: 10.1111/j.1478-3231.2012.02807.x PMID: 22507181
    • (2013) Liver Int. , vol.33 , Issue.1 , pp. 16-23
    • Angeli, P.1    Sanyal, A.2    Moller, S.3    Alessandria, C.4    Gadano, A.5    Kim, R.6
  • 25
    • 84931267166 scopus 로고    scopus 로고
    • Effect of caloric restriction with or without n-3 polyunsaturated fatty acids on insulin sensitivity in obese subjects: A randomized placebo controlled trial
    • 26925376
    • Razny U, Kiec-Wilk B, Polus A, Goralska J, Malczewska-Malec M, Wnek D, et al. Effect of caloric restriction with or without n-3 polyunsaturated fatty acids on insulin sensitivity in obese subjects: A randomized placebo controlled trial. BBA Clin. 2015; 4:7-13 doi: 10.1016/j.bbacli.2015.05.001 PMID: 26925376
    • (2015) BBA Clin. , vol.4 , pp. 7-13
    • Razny, U.1    Kiec-Wilk, B.2    Polus, A.3    Goralska, J.4    Malczewska-Malec, M.5    Wnek, D.6
  • 26
    • 30944455145 scopus 로고    scopus 로고
    • Insulin resistance: A metabolic pathway to chronic liver disease
    • 16250043
    • Bugianesi E, McCullough AJ, Marchesini G. Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology. 2005; 42(5):987-1000. doi: 10.1002/hep.20920 PMID: 16250043
    • (2005) Hepatology. , vol.42 , Issue.5 , pp. 987-1000
    • Bugianesi, E.1    McCullough, A.J.2    Marchesini, G.3
  • 27
    • 0141656292 scopus 로고    scopus 로고
    • Increased susceptibility to nonalcoholic fatty liver disease in heterozygotes for the mutation responsible for hereditary hemochromatosis
    • 12779071
    • Valenti L, Dongiovanni P, Fracanzani AL, Santorelli G, Fatta E, Bertelli C, et al. Increased susceptibility to nonalcoholic fatty liver disease in heterozygotes for the mutation responsible for hereditary hemochromatosis. Dig Liver Dis. 2003; 35(3):172-8. doi: 10.1016/s1590-8658(03)00025-2 PMID: 12779071
    • (2003) Dig Liver Dis. , vol.35 , Issue.3 , pp. 172-178
    • Valenti, L.1    Dongiovanni, P.2    Fracanzani, A.L.3    Santorelli, G.4    Fatta, E.5    Bertelli, C.6
  • 28
    • 84897348101 scopus 로고    scopus 로고
    • Identification and validation co-differentially expressed genes with NAFLD and insulin resistance
    • 24699882
    • Wang XC, Zhan XR, Li XY, Yu JJ, Liu XM. Identification and validation co-differentially expressed genes with NAFLD and insulin resistance. Endocrine. 2015; 48(1):143-51. doi: 10.1007/s12020-014-0247-5 PMID: 24699882
    • (2015) Endocrine. , vol.48 , Issue.1 , pp. 143-151
    • Wang, X.C.1    Zhan, X.R.2    Li, X.Y.3    Yu, J.J.4    Liu, X.M.5
  • 29
    • 84867792111 scopus 로고    scopus 로고
    • Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity
    • 22989629
    • Patel SA, Hoehn KL, Lawrence RT, Sawbridge L, Talbot NA, Tomsig JL, et al. Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity. Endocrinology. 2012; 153(11):5231-46. doi: 10.1210/en.2012-1368 PMID: 22989629
    • (2012) Endocrinology. , vol.153 , Issue.11 , pp. 5231-5246
    • Patel, S.A.1    Hoehn, K.L.2    Lawrence, R.T.3    Sawbridge, L.4    Talbot, N.A.5    Tomsig, J.L.6
  • 30
    • 84902544814 scopus 로고    scopus 로고
    • N-3 polyunsaturated fatty acids worsen inflammation and fibrosis in experimental nonalcoholic steatohepatitis
    • 24628836
    • Provenzano A, Milani S, Vizzutti F, Delogu W, Navari N, Novo E, et al. n-3 polyunsaturated fatty acids worsen inflammation and fibrosis in experimental nonalcoholic steatohepatitis. Liver Int. 2014; 34 (6):918-30. doi: 10.1111/liv.12500 PMID: 24628836
    • (2014) Liver Int. , vol.34 , Issue.6 , pp. 918-930
    • Provenzano, A.1    Milani, S.2    Vizzutti, F.3    Delogu, W.4    Navari, N.5    Novo, E.6
  • 31
    • 84878330831 scopus 로고    scopus 로고
    • Prospective histopathologic evaluation of lifestyle modification in nonalcoholic fatty liver disease: A randomized trial
    • 23814606
    • Eckard C, Cole R, Lockwood J, Torres DM, Williams CD, Shaw JC, et al. Prospective histopathologic evaluation of lifestyle modification in nonalcoholic fatty liver disease: a randomized trial. Therap Adv Gastroenterol. 2013; 6(4):249-59. doi: 10.1177/1756283X13484078 PMID: 23814606
    • (2013) Therap Adv Gastroenterol. , vol.6 , Issue.4 , pp. 249-259
    • Eckard, C.1    Cole, R.2    Lockwood, J.3    Torres, D.M.4    Williams, C.D.5    Shaw, J.C.6
  • 32
    • 84865507594 scopus 로고    scopus 로고
    • Improving dietary patterns in patients with nonalcoholic fatty liver disease
    • 22878240
    • Carvalhana S, Machado MV, Cortez-Pinto H. Improving dietary patterns in patients with nonalcoholic fatty liver disease. Curr Opin Clin Nutr Metab Care. 2012; 15(5):468-73. doi: 10.1097/MCO. 0b013e3283566614 PMID: 22878240
    • (2012) Curr Opin Clin Nutr Metab Care. , vol.15 , Issue.5 , pp. 468-473
    • Carvalhana, S.1    Machado, M.V.2    Cortez-Pinto, H.3
  • 33
    • 33751545838 scopus 로고    scopus 로고
    • A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
    • 17135584
    • Belfort R, Harrison SA, Brown K, Darland C, Finch J, Hardies J, et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med. 2006; 355(22):2297-307. doi: 10.1056/nejmoa060326 PMID: 17135584
    • (2006) N Engl J Med. , vol.355 , Issue.22 , pp. 2297-2307
    • Belfort, R.1    Harrison, S.A.2    Brown, K.3    Darland, C.4    Finch, J.5    Hardies, J.6
  • 34
    • 53049101877 scopus 로고    scopus 로고
    • Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis
    • 18718471
    • Aithal GP, Thomas JA, Kaye PV, Lawson A, Ryder SD, Spendlove I, et al. Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis. Gastroenterology. 2008; 135(4):1176-84. doi: 10.1053/j.gastro.2008.06.047 PMID: 18718471
    • (2008) Gastroenterology. , vol.135 , Issue.4 , pp. 1176-1184
    • Aithal, G.P.1    Thomas, J.A.2    Kaye, P.V.3    Lawson, A.4    Ryder, S.D.5    Spendlove, I.6
  • 37
    • 84990949990 scopus 로고    scopus 로고
    • The effect of Vitamin D supplementation on blood sugar and different indices of insulin resistance in patients with non-alcoholic fatty liver disease (NAFLD)
    • 26985230
    • Foroughi M, Maghsoudi Z, Askari G. The effect of vitamin D supplementation on blood sugar and different indices of insulin resistance in patients with non-alcoholic fatty liver disease (NAFLD). Iranian journal of nursing and midwifery research. 2016; 21(1):100-4. doi: 10.4103/1735-9066.174759 PMID: 26985230
    • (2016) Iranian Journal of Nursing and Midwifery Research. , vol.21 , Issue.1 , pp. 100-104
    • Foroughi, M.1    Maghsoudi, Z.2    Askari, G.3
  • 38
    • 0344742265 scopus 로고    scopus 로고
    • Vitamin E and Vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis
    • 14638353
    • Harrison SA, Torgerson S, Hayashi P, Ward J, Schenker S. Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis. Am J Gastroenterol. 2003; 98 (11):2485-90. doi: 10.1111/j.1572-0241.2003.08699.x PMID: 14638353
    • (2003) Am J Gastroenterol. , vol.98 , Issue.11 , pp. 2485-2490
    • Harrison, S.A.1    Torgerson, S.2    Hayashi, P.3    Ward, J.4    Schenker, S.5
  • 39
    • 84914698562 scopus 로고    scopus 로고
    • Treatment of nonalcoholic steatohepatitis with vitamins E and C: A pilot study
    • 24695939
    • Kawanaka M, Nishino K, Nakamura J, Suehiro M, Goto D, Urata N, et al. Treatment of nonalcoholic steatohepatitis with vitamins E and C: a pilot study. Hepat Med. 2013; 5:11-6. doi: 10.2147/HMER. S41258 PMID: 24695939
    • (2013) Hepat Med. , vol.5 , pp. 11-16
    • Kawanaka, M.1    Nishino, K.2    Nakamura, J.3    Suehiro, M.4    Goto, D.5    Urata, N.6
  • 40
    • 84869436442 scopus 로고    scopus 로고
    • Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review
    • 23041539 e2
    • White DL, Kanwal F, El-Serag HB. Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review. Clin Gastroenterol Hepatol. 2012; 10(12):1342-59.e2. doi: 10.1016/j.cgh.2012.10.001 PMID: 23041539
    • (2012) Clin Gastroenterol Hepatol. , vol.10 , Issue.12 , pp. 1342-1359
    • White, D.L.1    Kanwal, F.2    El-Serag, H.B.3
  • 41
    • 84955213803 scopus 로고    scopus 로고
    • Association of nonalcoholic fatty liver disease (NAFLD) with hepatocellular carcinoma (HCC) in the United States from 2004 to 2009
    • 26274335
    • Younossi ZM, Otgonsuren M, Henry L, Venkatesan C, Mishra A, Erario M, et al. Association of nonalcoholic fatty liver disease (NAFLD) with hepatocellular carcinoma (HCC) in the United States from 2004 to 2009. Hepatology. 2015; 62(6):1723-30. doi: 10.1002/hep.28123 PMID: 26274335
    • (2015) Hepatology. , vol.62 , Issue.6 , pp. 1723-1730
    • Younossi, Z.M.1    Otgonsuren, M.2    Henry, L.3    Venkatesan, C.4    Mishra, A.5    Erario, M.6
  • 42
    • 79953177813 scopus 로고    scopus 로고
    • Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: Double-blind randomised controlled clinical trial
    • 21233083
    • Nobili V, Bedogni G, Alisi A, Pietrobattista A, Rise P, Galli C, et al. Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trial. Arch Dis Child. 2011; 96(4):350-3 doi: 10.1136/adc.2010.192401 PMID: 21233083
    • (2011) Arch Dis Child. , vol.96 , Issue.4 , pp. 350-353
    • Nobili, V.1    Bedogni, G.2    Alisi, A.3    Pietrobattista, A.4    Rise, P.5    Galli, C.6
  • 43
    • 84885970553 scopus 로고    scopus 로고
    • The I148M variant of PNPLA3 reduces the response to docosahexaenoic acid in children with non-alcoholic fatty liver disease
    • 24074360
    • Nobili V, Bedogni G, Donati B, Alisi A, Valenti L. The I148M variant of PNPLA3 reduces the response to docosahexaenoic acid in children with non-alcoholic fatty liver disease. J Med Food. 2013; 16 (10):957-60 doi: 10.1089/jmf.2013.0043 PMID: 24074360
    • (2013) J Med Food. , vol.16 , Issue.10 , pp. 957-960
    • Nobili, V.1    Bedogni, G.2    Donati, B.3    Alisi, A.4    Valenti, L.5
  • 44
    • 84887609640 scopus 로고    scopus 로고
    • Docosahexaenoic acid for the treatment of fatty liver: Randomised controlled trial in children
    • 23220074
    • Nobili V, Alisi A, Della Corte C, Rise P, Galli C, Agostoni C, et al. Docosahexaenoic acid for the treatment of fatty liver: randomised controlled trial in children. Nutr Metab Cardiovasc Dis. 2013; 23 (11):1066-70 doi: 10.1016/j.numecd.2012.10.010 PMID: 23220074
    • (2013) Nutr Metab Cardiovasc Dis. , vol.23 , Issue.11 , pp. 1066-1070
    • Nobili, V.1    Alisi, A.2    Della Corte, C.3    Rise, P.4    Galli, C.5    Agostoni, C.6
  • 45
    • 84930180152 scopus 로고    scopus 로고
    • Omega-3 Fatty acids therapy in children with nonalcoholic Fatty liver disease: A randomized controlled trial
    • 25771388 e1-3
    • Janczyk W, Lebensztejn D, Wierzbicka-Rucinska A, Mazur A, Neuhoff-Murawska J, Matusik P, et al. Omega-3 Fatty acids therapy in children with nonalcoholic Fatty liver disease: a randomized controlled trial. J Pediatr. 2015; 166(6):1358-63.e1-3 doi: 10.1016/j.jpeds.2015.01.056 PMID: 25771388
    • (2015) J Pediatr. , vol.166 , Issue.6 , pp. 1358-1363
    • Janczyk, W.1    Lebensztejn, D.2    Wierzbicka-Rucinska, A.3    Mazur, A.4    Neuhoff-Murawska, J.5    Matusik, P.6
  • 46
    • 84955487817 scopus 로고    scopus 로고
    • Progression of carotid vascular damage and cardiovascular events in non-alcoholic fatty liver disease patients compared to the general population during 10 years of follow-up
    • 26803429
    • Fracanzani AL, Tiraboschi S, Pisano G, Consonni D, Baragetti A, Bertelli C, et al. Progression of carotid vascular damage and cardiovascular events in non-alcoholic fatty liver disease patients compared to the general population during 10 years of follow-up. Atherosclerosis. 2016; 246:208-13. doi: 10.1016/j.atherosclerosis.2016.01.016 PMID: 26803429
    • (2016) Atherosclerosis. , vol.246 , pp. 208-213
    • Fracanzani, A.L.1    Tiraboschi, S.2    Pisano, G.3    Consonni, D.4    Baragetti, A.5    Bertelli, C.6
  • 47
  • 48
    • 0348050063 scopus 로고    scopus 로고
    • Omega-3 polyunsaturated fatty acids and cardiovascular diseases
    • 14551524
    • Marchioli R. [Omega-3 polyunsaturated fatty acids and cardiovascular diseases]. Minerva Cardioangiol. 2003; 51(5):561-76. PMID: 14551524
    • (2003) Minerva Cardioangiol. , vol.51 , Issue.5 , pp. 561-576
    • Marchioli, R.1
  • 49
    • 84977123409 scopus 로고    scopus 로고
    • Different effects of eicosapentaenoic and docosahexaenoic acids on atherogenic high-fat diet-induced non-alcoholic fatty liver disease in mice
    • 27333187
    • Suzuki-Kemuriyama N, Matsuzaka T, Kuba M, Ohno H, Han SI, Takeuchi Y, et al. Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. PLoS One. 2016; 11(6):e0157580. doi: 10.1371/journal.pone.0157580 PMID: 27333187
    • (2016) PLoS One. , vol.11 , Issue.6
    • Suzuki-Kemuriyama, N.1    Matsuzaka, T.2    Kuba, M.3    Ohno, H.4    Han, S.I.5    Takeuchi, Y.6
  • 50
    • 84953278296 scopus 로고    scopus 로고
    • Potential for dietary omega-3 fatty acids to prevent nonalcoholic fatty liver disease and reduce the risk of primary liver cancer
    • 26567194
    • Jump DB, Depner CM, Tripathy S, Lytle KA. Potential for dietary omega-3 fatty acids to prevent nonalcoholic fatty liver disease and reduce the risk of primary liver cancer. Adv Nutr. 2015; 6(6):694-702. doi: 10.3945/an.115.009423 PMID: 26567194
    • (2015) Adv Nutr. , vol.6 , Issue.6 , pp. 694-702
    • Jump, D.B.1    Depner, C.M.2    Tripathy, S.3    Lytle, K.A.4
  • 51
    • 4344593276 scopus 로고    scopus 로고
    • Efficacy of omega-3 fatty acids, atorvastatin and orlistat in non-alcoholic fatty liver disease with dyslipidemia
    • 15333967
    • Hatzitolios A, Savopoulos C, Lazaraki G, Sidiropoulos I, Haritanti P, Lefkopoulos A, et al. Efficacy of omega-3 fatty acids, atorvastatin and orlistat in non-alcoholic fatty liver disease with dyslipidemia. Indian J Gastroenterol. 2004; 23(4):131-4. PMID: 15333967
    • (2004) Indian J Gastroenterol. , vol.23 , Issue.4 , pp. 131-134
    • Hatzitolios, A.1    Savopoulos, C.2    Lazaraki, G.3    Sidiropoulos, I.4    Haritanti, P.5    Lefkopoulos, A.6
  • 52
    • 41349102802 scopus 로고    scopus 로고
    • Highly purified eicosapentaenoic acid treatment improves nonalcoholic steatohepatitis
    • 18277895
    • Tanaka N, Sano K, Horiuchi A, Tanaka E, Kiyosawa K, Aoyama T. Highly purified eicosapentaenoic acid treatment improves nonalcoholic steatohepatitis. J Clin Gastroenterol. 2008; 42(4):413-8. doi: 10. 1097/MCG.0b013e31815591aa PMID: 18277895
    • (2008) J Clin Gastroenterol. , vol.42 , Issue.4 , pp. 413-418
    • Tanaka, N.1    Sano, K.2    Horiuchi, A.3    Tanaka, E.4    Kiyosawa, K.5    Aoyama, T.6
  • 53
    • 33646882162 scopus 로고    scopus 로고
    • Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: A pilot study
    • 16611275
    • Capanni M, Calella F, Biagini MR, Genise S, Raimondi L, Bedogni G, et al. Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: a pilot study. Aliment Pharmacol Ther. 2006; 23(8):1143-51. doi: 10.1111/j.1365-2036.2006. 02885.x PMID: 16611275
    • (2006) Aliment Pharmacol Ther. , vol.23 , Issue.8 , pp. 1143-1151
    • Capanni, M.1    Calella, F.2    Biagini, M.R.3    Genise, S.4    Raimondi, L.5    Bedogni, G.6
  • 54
    • 84902544814 scopus 로고    scopus 로고
    • N-3 polyunsaturated fatty acids worsen inflammation and fibrosis in experimental nonalcoholic steatohepatitis
    • 24628836
    • Provenzano A, Milani S, Vizzutti F, Delogu W, Navari N, Novo E, et al. n-3 polyunsaturated fatty acids worsen inflammation and fibrosis in experimental nonalcoholic steatohepatitis. Liver Int. 2014; 34 (6):918-30. doi: 10.1111/liv.12500 PMID: 24628836
    • (2014) Liver Int. , vol.34 , Issue.6 , pp. 918-930
    • Provenzano, A.1    Milani, S.2    Vizzutti, F.3    Delogu, W.4    Navari, N.5    Novo, E.6
  • 55
    • 84961245766 scopus 로고    scopus 로고
    • Expression and Sequence Variants of Inflammatory Genes; Effects on Plasma Inflammation Biomarkers Following a 6-Week Supplementation with Fish Oil
    • 26999109
    • Cormier H, Rudkowska I, Lemieux S, Couture P, Vohl MC. Expression and Sequence Variants of Inflammatory Genes; Effects on Plasma Inflammation Biomarkers Following a 6-Week Supplementation with Fish Oil. Int J Mol Sci. 2016; 17(3). doi: 10.3390/ijms17030375 PMID: 26999109
    • (2016) Int J Mol Sci. , vol.17 , Issue.3
    • Cormier, H.1    Rudkowska, I.2    Lemieux, S.3    Couture, P.4    Vohl, M.C.5
  • 56
    • 84958597386 scopus 로고    scopus 로고
    • Effects of dietary n-3 fatty acids on hepatic and peripheral insulin sensitivity in insulin-resistant humans
    • 25852206
    • Lalia AZ, Johnson ML, Jensen MD, Hames KC, Port JD, Lanza IR. Effects of Dietary n-3 Fatty Acids on Hepatic and Peripheral Insulin Sensitivity in Insulin-Resistant Humans. Diabetes Care. 2015; 38 (7):1228-37. doi: 10.2337/dc14-3101 PMID: 25852206
    • (2015) Diabetes Care. , vol.38 , Issue.7 , pp. 1228-1237
    • Lalia, A.Z.1    Johnson, M.L.2    Jensen, M.D.3    Hames, K.C.4    Port, J.D.5    Lanza, I.R.6


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