Widespread ectopic expression of olfactory receptor genes

BMC Genomics

Volumn 7, Issue , 2006, Pages

  Feldmesser, Ester ^a   Olender, Tsviya ^a   Khen, Miriam ^a   Yanai, Itai ^a,b   Ophir, Ron ^a   Lancet, Doron ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL TISSUE; ARTICLE; BODY DISTRIBUTION; CHEMOTAXIS; CONTROLLED STUDY; CORRELATION ANALYSIS; EXPRESSED SEQUENCE TAG; GENE EXPRESSION; GENE FUNCTION; GENE LOCUS; GENE NUMBER; GENETIC HETEROGENEITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; HUMAN VERSUS ANIMAL COMPARISON; MICROARRAY ANALYSIS; MOLECULAR EVOLUTION; MOUSE; MULTIGENE FAMILY; NONHUMAN; NORMAL HUMAN; OLFACTORY RECEPTOR; ORTHOLOGY; PSEUDOGENE; SPERMATOZOON MIGRATION; TESTIS; TRANSCRIPTION REGULATION;

ANIMALS; EXPRESSED SEQUENCE TAGS; GENE EXPRESSION PROFILING; GENOMICS; HUMANS; MALE; MICE; OLFACTORY MUCOSA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PSEUDOGENES; RECEPTORS, ODORANT; RNA, MESSENGER; SPERMATOZOA; TESTIS; TISSUE DISTRIBUTION; TRANSCRIPTION, GENETIC;

EID: 33746092533     PISSN: 14712164     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-7-121     Document Type: Article

References (79)

1. Ludwig J, Margalit T, Eismann E, Lancet D, Kaupp UB: Primary structure of cAMP-gated channel from bovine olfactory epithelium. FEBS Lett 1990, 270:24-29.
2. Lazard D, Zupko K, Poria Y, Nef P, Lazarovits J, Horn S, Khen M, Lancet D: Odorant signal termination by olfactory UDP glucuronosyl transferase. Nature 1991, 349:790-793.
3. Firestein S: How the olfactory system makes sense of scents. Nature 2001, 413:211-218.
4. Mombaerts P: The human repertoire of odorant receptor genes and pseudogenes. Annu Rev Genomics Hum Genet 2001, 2:493-510.
5. Feinstein P, Mombaerts P: A contextual model for axonal sorting into glomeruli in the mouse olfactory system. Cell 2004, 117:817-831.
6. Lewcock JW, Reed RR: A feedback mechanism regulates monoallelic odorant receptor expression. Proc Natl Acad Sci U S A 2004, 101:1069-1074.
7. Serizawa S, Miyamichi K, Nakatani H, Suzuki M, Saito M, Yoshihara Y, Sakano H: Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse. Science 2003, 302:2088-2094.
8. Olender T, Feldmesser E, Atarot T, Eisenstein M, Lancet D: The olfactory receptor universe-from whole genome analysis to structure and evolution. Genet Mol Res 2004, 3:545-553.
9. Young JM, Friedman C, Williams EM, Ross JA, Tonnes-Priddy L, Trask BJ: Different evolutionary processes shaped the mouse and human olfactory receptor gene families. Hum Mol Genet 2002, 11:1683.
10. Zhang X, Firestein S: The olfactory receptor gene superfamily of the mouse. Nature Neuroscience 2002, 5:124-133.
11. Quignon P, Giraud M, Rimbault M, Lavigne P, Tacher S, Morin E, Retout E, Valin AS, Lindblad-Toh K, Nicolas J, Galibert F: The dog and rat olfactory receptor repertoires. Genome Biol 2005, 6:R83.
12. Quignon P, Kirkness E, Cadieu E, Touleimat N, Guyon R, Renier C, Hitte C, Andre C, Fraser C, Galibert F: Comparison of the canine and human olfactory receptor gene repertoires. Genome Biol 2003, 4:R80.
13. Olender T, Fuchs T, Linhart C, Shamir R, Adams M, Kalush F, Khen M, Lancet D: The canine olfactory subgenome. Genomics 2004, 83:361-372.
14. Gilad Y, Man O, Glusman G: A comparison of the human and chimpanzee olfactory receptor gene repertoires. Genome Res 2005, 15:224-230.
15. Crasto C, Marenco L, Miller P, Shepherd G: Olfactory Receptor Database: a metadata-driven automated population from sources of gene and protein sequences. Nucleic Acids Res 2002, 30:354-360.
16. Young JM, Shykind BM, Lane RP, Tonnes-Priddy L, Ross JA, Walker M, Williams EM, Trask BJ: Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels. Genome Biol 2003, 4:R71.
17. Zhang X, Rogers M, Tian H, Zou DJ, Liu J, Ma M, Shepherd GM, Firestein SJ: High-throughput microarray detection of olfactory receptor gene expression in the mouse. Proc Natl Acad Sci U S A 2004, 101:14168-14173.
18. Sosinsky A, Glusman G, Lancet D: The variable structure of human olfactory receptor genes. Genomics 2000, 5:49-61.
19. Chess A, Simon I, Cedar H, Axel R: Allelic inactivation regulates olfactory receptor gene expression. Cell 1994, 78:823-834.
20. Malnic B, Hirono J, Sato T, Buck LB: Combinatorial receptor codes for odors. Cell 1999, 96:713-723.
21. Serizawa S, Ishii T, Nakatani H, Tsuboi A, Nagawa F, Asano M, Sudo K, Sakagami J, Sakano H, Ijiri T, Matsuda Y, Suzuki M, Yamamori T, Iwakura Y, Sakano H: Mutually exclusive expression of odorant receptor transgenes. Nat Neurosci 2000, 3:687-693.
22. Strotmann J, Levai O, Fleischer J, Schwarzenbacher K, Breer H: Olfactory receptor proteins in axonal processes of chemosensory neurons. J Neurosci 2004, 24:7754-7761.
23. Barnea G, O'Donnell S, Mancia F, Sun X, Nemes A, Mendelsohn M, Axel R: Odorant receptors on axon termini in the brain. Science 2004, 304:1468.
24. Life Science Dictionary [http://biotech.icmb.utexas.edu/search/dict-search.html]
25. Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J, Grootegoed A, Vassart G: Expression of members of the putative olfactory receptor gene family in mammalian germ cells. Nature 1992, 355:453-455.
26. Vanderhaeghen P, Schurmans S, Vassart G, Parmentier M: Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. Genomics 1997, 39:239-246.
27. Asai H, Kasai H, Matsuda Y, Yamazaki N, Nagawa F, Sakano H, Tsuboi A: Genomic structure and transcription of a murine odorant receptor gene: differential initiation of transcription in the olfactory and testicular cells. Biochem Biophys Res Commun 1996, 221:240-247.
28. Linardopoulou E, Mefford HC, Nguyen O, Friedman C, van den Engh G, Farwell DG, Coltrera M, Trask BJ: Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location. Hum Mol Genet 2001, 10:2373-2383.
29. Goto T, Salpekar A, Monk M: Expression of a testis-specific member of the olfactory receptor gene family in human primordial germ cells. Mol Hum Reprod 2001, 7:553-558.
30. Spehr M, Gisselmann G, Poplawski A, Riffell JA, Wetzel CH, Zimmer RK, Hatt H: Identification of a testicular odorant receptor mediating human sperm chemotaxis. Science 2003, 299:2054-2058.
31. Volz A, Ehlers A, Younger R, Forbes S, Trowsdale J, Schnorr D, Beck S, Ziegler A: Complex transcription and splicing of odorant receptor genes. J Biol Chem 2003, 278:19691-19701.
32. Vanderhaeghen P, Schurmans S, Vassart G, Parmentier M: Molecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: evidence for their wide distribution in the human genome. Biochem Biophys Res Commun 1997, 237:283-287.
33. Spehr M, Schwane K, Heilmann S, Gisselmann G, Hummel T, Hatt H: Dual capacity of a human olfactory receptor. Curr Biol 2004, 14:R832-3.
34. Fukuda N, Yomogida K, Okabe M, Touhara K: Functional characterization of a mouse testicular olfactory receptor and its role in chemosensing and in regulation of sperm motility. J Cell Sci 2004, 117:5835-5845.
35. Ziegler A, Dohr G, Uchanska-Ziegler B: Possible roles for products of polymorphic MHC and linked olfactory receptor genes during selection processes in reproduction. Am J Reprod Immunol 2002, 48:34-42.
36. Gaudin JC, Breuils L, Haertle T: New GPCRs from a human lingual cDNA library. Chem Senses 2001, 26:1157-1166.
37. Durzynski L, Gaudin JC, Myga M, Szydlowski J, Gozdzicka-Jozefiak A, Haertle T: Olfactory-like receptor cDNAs are present in human lingual cDNA libraries. Biochem Biophys Res Commun 2005, 333:264-272.
38. Feingold EA, Penny LA, Nienhuis AW, Forget BG: An olfactory receptor gene is located in the extended human beta-globin gene cluster and is expressed in erythroid cells. Genomics 1999, 61:15-23.
39. Xu LL, Stackhouse BG, Florence K, Zhang W, Shanmugam N, Sesterhenn IA, Zou Z, Srikantan V, Augustus M, Roschke V, Carter K, McLeod DG, Moul JW, Soppett D, Srivastava S: PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer. Cancer Res 2000, 60:6568-6572.
40. Xia C, Ma W, Wang F, Hua S, Liu M: Identification of a prostate-specific G-protein coupled receptor in prostate cancer. Oncogene 2001, 20:5903-5907.
41. Itakura S, K. Ohno K, Ueki T, Sato K, Kanayama N: Expression of Golf in the rat placenta: possible implication in olfactory receptor transduction. Placenta 2006, 27:103-108.
42. Conzelmann S, Levai O, Bode B, Eisel U, Raming K, al: A novel brain receptor is expressed in a distinct population of olfactory sensory neurons. Eur J Neurosci 2000, 12:3926-3934.
43. Yuan TT, Toy P, McClary JA, Lin RJ, Miyamoto NG, Kretschmer PJ: Cloning and genetic characterization of an evolutionarily conserved human olfactory receptor that is differentially expressed across species. Gene 2001, 278:41-51.
44. Weber M, Pehl U, Breer H, Strotmann J: Olfactory receptor expressed in ganglia of the autonomic nervous system. J Neurosci Res 2002, 68:176-184.
45. Otaki JM, Yamamoto H, Firestein S: Odorant receptor expression in the mouse cerebral cortex. J Neurobiol 2004, 58:315-327.
46. Dreyer WJ: The area code hypothesis revisited: olfactory receptors and other related transmembrane receptors may function as the last digits in a cell surface code for assembling embryos. Proc Natl Acad Sci U S A 1998, 95:9072-9077.
47. Su AI, Wiltshire T. Batalov S, Lapp H, Ching KA, Block D, Zhang J, Soden R, Hayakawa M, Kreiman G, Cooke MP, Walker JR, Hogenesch JB: A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A 2004, 101:6062-6067.
48. Human Olfactory Receptor Exploratorium Database (HORDE) [http://bip.weizmann.ac.il/HORDE]
49. Yanai I, Benjamin H, Shmoish M, Chalifa-Caspi V, Shklar M, Ophir R, Bar-Even A, Horn-Saban S, Safran M, Domany E, Lancet D, Shmueli O: Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification. Bioinformatics: 2004, 21:650-659.
50. Glusman G, Bahar A, Sharon D, Pilpel Y, White J, Lancet D: The Olfactory Receptor Gene Superfamily: Data Mining, Classification and Nomenclature. Mamm Genome 2000, 11:1016-1023.
51. Newman T, Trask BJ: Complex Evolution of 7E Olfactory Receptor Genes in Segmental Duplications. Genome Res 2003, 13:781-793.
52. Yanai I, Graur D, Ophir R: Incongruent expression profiles between human and mouse orthologous genes suggest widespread neutral evolution of transcription control. Omics 2004, 8:15-24.
53. Jordan IK, Marino-Ramirez L, Wolf YI, Koonin EV: Conservation and coevolution in the scale-free human gene coexpression network. Mol Biol Evol 2004, 21:2058-2070.
54. Bammler T, Beyer RP, Bhattacharya S, Boorman GA, Boyles A, Bradford BU, Bumgarner RE, Bushel PR, Chaturvedi K, Choi D, Cunningham ML, Deng S, Dressman HK, Fannin RD, Farin FM, Freedman JH, Fry RC, Harper A, Humble MC, Hurban P, Kavanagh TJ, Kaufmann WK, Kerr KF, Jing L, Lapidus JA, Lasarev MR, Li J, Li YJ, Lobenhofer EK, Lu X, Malek RL, Milton S, Nagalla SR, O'Malley J P, Palmer VS, Pattee P, Paules RS, Perou CM, Phillips K, Qin LX, Qiu Y, Quigley SD, Rodland M, Rusyn I, Samson LD, Schwartz DA, Shi Y, Shin JL, Sieber SO, Slifer S, Speer MC, Spencer PS, Sproles DI, Swenberg JA, Suk WA, Sullivan RC, Tian R, Tennant RW, Todd SA, Tucker CJ, Van Houten B, Weis BK, Xuan S, Zarbl H: Standardizing global gene expression analysis between laboratories and across platforms. Nat Methods 2005, 2:351-356.
55. Vanderhaeghen P, Schurmans S, Vassart G, Parmentier M: Olfactory receptors are displayed on dog mature sperm cells. J Cell Biol 1993, 123:1441-1452.
56. Rodriguez-Trelles F, Tarrio R, Ayala FJ: Is ectopic expression caused by deregulatory mutations or due to gene-regulation leaks with evolutionary potential? Bioessays 2005, 27:592-601.
57. Strotmann J, Konzelmann S, Breer H: Laminar segregation of odorant receptor expression in the olfactory epithelium. Cell Tissue Res 1996, 284:347-354.
58. Iwema CL, Schwob JE: Odorant receptor expression as a function of neuronal maturity in the adult rodent olfactory system. J Comp Neurol 2003, 459:209-222.
59. Vosshall LB: Olfaction: attracting both sperm and the nose. Curr Biol 2004, 14:R918-20.
60. Khaitovich P, Weiss G, Lachmann M, Hellmann I, Enard W, Muetzel B. Wirkner U, Ansorge W, Paabo S: A neutral model of transcriptome evolution. PLoS Biol 2004, 2:E132.
61. Keightley PD, Lercher MJ, Eyre-Walker A: Evidence for widespread degradation of gene control regions in hominid genomes. PLoS Biol 2005, 3:e42.
62. Jordan IK, Marino-Ramirez L, Koonin EV: Evolutionary significance of gene expression divergence. Gene 2005, 345:119-126.
63. Gilad Y, Man O, Paabo S, Lancet D: Human specific loss of olfactory receptor genes. Proc Natl Acad Sci U S A 2003, 100:3324-3327.
64. Cohen BA, Mitra RD, Hughes JD, Church GM: A computational analysis of whole-genome expression data reveals chromosomal domains of gene expression. Nat Genet 2000, 26:183-186.
65. Lercher MJ, Urrutia, AO, Pavlicek A, Hurst LD: A unification of mosaic structures in the human genome. Hum Mol Genet 2003, 12:2411-2415.
66. Versteeg R, van Schaik BD, van Batenburg MF, Roos M, Monajemi R, Caron H, Bussemaker HJ, van Kampen AH: The human transcriptome map reveals extremes in gene density, intron length, GC content, and repeat pattern for domains of highly and weakly expressed genes. Genome Res 2003, 13:1998-2004.
67. Kalmykova AI, Nurminsky DI, Ryzhov DV, Shevelyov YY: Regulated chromatin domain comprising cluster of co-expressed genes in Drosophila melanogaster. Nucleic Acids Res 2005, 33:1435-1444.
68. UCSC genome browser annotation tables [http://hgdownload.cse.ucsc.edu/goldenPath]
69. Ensembl Mouse [http://www.ensembl.org/Mus_musculus]
70. Kent WJ: BLAT-the BLAST-like alignment tool. Genome Res 2002, 12:656-664.
71. Chalifa-Caspi V, Yanai I, Ophir R, Rosen N, Shmoish M, Benjamin-Rodrig H, Shklar M, Stein TI, Shmueli O, Safran M, Lancet D: Gene-Annot: comprehensive two-way linking between oligonucleotide array probesets and GeneCards genes. Bioinformatics 2004, 20:1457-1458.
72. GNF SymAtlas [http://symatlas.gnf.org]
73. Shannon CE: The mathematical theory of communication. The Bell system Technical Journal 1948, 27:379-423 & 623-656.
74. National center for Biotechnology information [http://www.ncbi.nlm.nih.gov/]
75. GNF Genome Informatics Applications & Datasets [http://wombat.gnf.org/index.html]
76. GeneCards http://genecards.weizmann.ac.il//index.shtml]
77. MEROPS http://merops.sanger.ac.uk]
78. Celera Genomics [http://www.celera.com]
79. KS-test Data Entry [http://www.physics.csbsju.edu/stats/KS-test.n.plot_form.html]