Discovery of novel ligands for mouse olfactory receptor MOR42-3 using an in silico screening approach and in vitro validation

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Bavan, Selvan ^a   Sherman, Benjamin ^a   Luetje, Charles W ^a   Abaffy, Tatjana ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIETHYL BUTANEDIOATE; 3 [4 (2 CARBOXYETHYL)PHENYL]PROPANOIC ACID; 4 (7,9 DIOXABICYCLO[4.3.0]NONA 1,3,5 TRIEN 3 YL)BUTAN 2 ONE; 8 METHOXY 8 OXO OCTANOIC ACID; 9 METHOXY 9 OXO NONANOIC ACID; ADIPIC ACID; ALPHA HEXYL CINNAMALDEHYDE; AZELAIC ACID; BUTYRIC ACID; DODECANEDIOIC ACID; GLUTARIC ACID; LIGAND; MALONIC ACID; NONANEDIOYL CHLORIDE; NONANOIC ACID; OCTANEDIOYL CHLORIDE; OXALIC ACID; PIMELIC ACID; RHODOPSIN; SUBERIC ACID; SUCCINIC ACID; UNCLASSIFIED DRUG; UNDECANEDIOIC ACID;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ELECTROPHYSIOLOGY; FEMALE; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; NONHUMAN; ODOR; OLFACTORY RECEPTOR; OLFACTORY RECEPTOR MOR42 3; OOCYTE; PREDICTIVE VALUE; PROTEIN EXPRESSION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; VALIDATION PROCESS;

ANIMALS; BINDING SITES; CLUSTER ANALYSIS; COMPUTER SIMULATION; DRUG EVALUATION, PRECLINICAL; FEMALE; LIGANDS; MICE; MODELS, MOLECULAR; RECEPTORS, ODORANT; REPRODUCIBILITY OF RESULTS; SMALL MOLECULE LIBRARIES; XENOPUS LAEVIS;

EID: 84898623330     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092064     Document Type: Article

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