메뉴 건너뛰기




Volumn 27, Issue 1, 2014, Pages 126-135

Novel insights into G protein and G protein-coupled receptor signaling in cancer

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; TARGET OF RAPAMYCIN KINASE; TUMOR SUPPRESSOR PROTEIN; VIRUS PROTEIN;

EID: 84893437204     PISSN: 09550674     EISSN: 18790410     Source Type: Journal    
DOI: 10.1016/j.ceb.2014.01.005     Document Type: Review
Times cited : (243)

References (91)
  • 1
    • 66249144426 scopus 로고    scopus 로고
    • The structure and function of G-protein-coupled receptors
    • Rosenbaum D.M., Rasmussen S.G., Kobilka B.K. The structure and function of G-protein-coupled receptors. Nature 2009, 459:356-363.
    • (2009) Nature , vol.459 , pp. 356-363
    • Rosenbaum, D.M.1    Rasmussen, S.G.2    Kobilka, B.K.3
  • 3
    • 77955058247 scopus 로고    scopus 로고
    • Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor
    • Nabhan J.F., Pan H., Lu Q. Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor. EMBO Rep 2010, 11:605-611.
    • (2010) EMBO Rep , vol.11 , pp. 605-611
    • Nabhan, J.F.1    Pan, H.2    Lu, Q.3
  • 4
    • 33846474121 scopus 로고    scopus 로고
    • G-protein-coupled receptors and cancer
    • Dorsam R.T., Gutkind J.S. G-protein-coupled receptors and cancer. Nat Rev Cancer 2007, 7:79-94.
    • (2007) Nat Rev Cancer , vol.7 , pp. 79-94
    • Dorsam, R.T.1    Gutkind, J.S.2
  • 5
    • 84857471063 scopus 로고    scopus 로고
    • Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins
    • Magalhaes A.C., Dunn H., Ferguson S.S. Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins. Br J Pharmacol 2012, 165:1717-1736.
    • (2012) Br J Pharmacol , vol.165 , pp. 1717-1736
    • Magalhaes, A.C.1    Dunn, H.2    Ferguson, S.S.3
  • 6
    • 78650845707 scopus 로고    scopus 로고
    • G protein-coupled receptors: novel targets for drug discovery in cancer
    • Lappano R., Maggiolini M. G protein-coupled receptors: novel targets for drug discovery in cancer. Nat Rev Drug Discov 2011, 10:47-60.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 47-60
    • Lappano, R.1    Maggiolini, M.2
  • 7
    • 0034789517 scopus 로고    scopus 로고
    • Receptor tyrosine kinase signalling as a target for cancer intervention strategies
    • Zwick E., Bange J., Ullrich A. Receptor tyrosine kinase signalling as a target for cancer intervention strategies. Endocr Relat Cancer 2001, 8:161-173.
    • (2001) Endocr Relat Cancer , vol.8 , pp. 161-173
    • Zwick, E.1    Bange, J.2    Ullrich, A.3
  • 9
    • 0023186924 scopus 로고
    • Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin
    • Chambard J.C., Paris S., Pouyssegur G.L.A.J. Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin. Nature 1987, 326:800-803.
    • (1987) Nature , vol.326 , pp. 800-803
    • Chambard, J.C.1    Paris, S.2    Pouyssegur, G.L.A.J.3
  • 11
    • 0024428410 scopus 로고
    • Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins
    • van Corven E.J., Groenink A., Jalink K., Eichholtz T., Moolenaar W.H. Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins. Cell 1989, 59:45-54.
    • (1989) Cell , vol.59 , pp. 45-54
    • van Corven, E.J.1    Groenink, A.2    Jalink, K.3    Eichholtz, T.4    Moolenaar, W.H.5
  • 12
    • 0026183605 scopus 로고
    • G-protein-coupled receptors, phosphoinositide hydrolysis, and cell proliferation
    • Moolenaar W.H. G-protein-coupled receptors, phosphoinositide hydrolysis, and cell proliferation. Cell Growth Differ 1991, 2:359-364.
    • (1991) Cell Growth Differ , vol.2 , pp. 359-364
    • Moolenaar, W.H.1
  • 14
    • 37049179817 scopus 로고
    • Early signals in the mitogenic response
    • Rozengurt E. Early signals in the mitogenic response. Science 1986, 234:161-166.
    • (1986) Science , vol.234 , pp. 161-166
    • Rozengurt, E.1
  • 15
    • 0027291886 scopus 로고
    • Inhibition of adenylyl cyclase by Gi alpha
    • Taussig R., Iniguez-Lluhi J.A., Gilman A.G. Inhibition of adenylyl cyclase by Gi alpha. Science 1993, 261:218-221.
    • (1993) Science , vol.261 , pp. 218-221
    • Taussig, R.1    Iniguez-Lluhi, J.A.2    Gilman, A.G.3
  • 16
    • 27444440633 scopus 로고    scopus 로고
    • Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins
    • Hubbard K.B., Hepler J.R. Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins. Cell Signal 2006, 18:135-150.
    • (2006) Cell Signal , vol.18 , pp. 135-150
    • Hubbard, K.B.1    Hepler, J.R.2
  • 18
    • 80053305618 scopus 로고    scopus 로고
    • Cross-talk between calcium and protein kinase A in the regulation of cell migration
    • Howe A.K. Cross-talk between calcium and protein kinase A in the regulation of cell migration. Curr Opin Cell Biol 2011, 23:554-561.
    • (2011) Curr Opin Cell Biol , vol.23 , pp. 554-561
    • Howe, A.K.1
  • 19
    • 79960759956 scopus 로고    scopus 로고
    • Calcium in tumour metastasis: new roles for known actors
    • Prevarskaya N., Skryma R., Shuba Y. Calcium in tumour metastasis: new roles for known actors. Nat Rev Cancer 2011, 11:609-618.
    • (2011) Nat Rev Cancer , vol.11 , pp. 609-618
    • Prevarskaya, N.1    Skryma, R.2    Shuba, Y.3
  • 20
    • 33947603008 scopus 로고    scopus 로고
    • Protein kinase C and other diacylglycerol effectors in cancer
    • Griner E.M., Kazanietz M.G. Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer 2007, 7:281-294.
    • (2007) Nat Rev Cancer , vol.7 , pp. 281-294
    • Griner, E.M.1    Kazanietz, M.G.2
  • 23
    • 0031893949 scopus 로고    scopus 로고
    • The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades
    • Gutkind J.S. The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades. J Biol Chem 1998, 273:1839-1842.
    • (1998) J Biol Chem , vol.273 , pp. 1839-1842
    • Gutkind, J.S.1
  • 24
    • 0029055812 scopus 로고
    • The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
    • Coso O.A., Chiariello M., Yu J.C., Teramoto H., Crespo P., Xu N., Miki T., Gutkind J.S. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 1995, 81:1137-1146.
    • (1995) Cell , vol.81 , pp. 1137-1146
    • Coso, O.A.1    Chiariello, M.2    Yu, J.C.3    Teramoto, H.4    Crespo, P.5    Xu, N.6    Miki, T.7    Gutkind, J.S.8
  • 25
    • 4143060469 scopus 로고    scopus 로고
    • P-REX2, a novel PI-3-kinase sensitive Rac exchange factor
    • Rosenfeldt H., Vazquez-Prado J., Gutkind J.S. P-REX2, a novel PI-3-kinase sensitive Rac exchange factor. FEBS Lett 2004, 572:167-171.
    • (2004) FEBS Lett , vol.572 , pp. 167-171
    • Rosenfeldt, H.1    Vazquez-Prado, J.2    Gutkind, J.S.3
  • 28
    • 84876927634 scopus 로고    scopus 로고
    • PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation
    • Mikelis C.M., Palmby T.R., Simaan M., Li W., Szabo R., Lyons R., Martin D., Yagi H., Fukuhara S., Chikumi H., et al. PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation. J Biol Chem 2013, 288:12232-12243.
    • (2013) J Biol Chem , vol.288 , pp. 12232-12243
    • Mikelis, C.M.1    Palmby, T.R.2    Simaan, M.3    Li, W.4    Szabo, R.5    Lyons, R.6    Martin, D.7    Yagi, H.8    Fukuhara, S.9    Chikumi, H.10
  • 31
    • 0031037296 scopus 로고    scopus 로고
    • Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma
    • Lopez-Ilasaca M., Crespo P., Pellici P.G., Gutkind J.S., Wetzker R. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma. Science 1997, 275:394-397.
    • (1997) Science , vol.275 , pp. 394-397
    • Lopez-Ilasaca, M.1    Crespo, P.2    Pellici, P.G.3    Gutkind, J.S.4    Wetzker, R.5
  • 32
    • 80052090231 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase p110gamma in immunity
    • Costa C., Martin-Conte E.L., Hirsch E. Phosphoinositide 3-kinase p110gamma in immunity. IUBMB Life 2011, 63:707-713.
    • (2011) IUBMB Life , vol.63 , pp. 707-713
    • Costa, C.1    Martin-Conte, E.L.2    Hirsch, E.3
  • 33
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • Engelman J.A., Luo J., Cantley L.C. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 2006, 7:606-619.
    • (2006) Nat Rev Genet , vol.7 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 36
    • 77957883342 scopus 로고    scopus 로고
    • The hippo signaling pathway in development and cancer
    • Pan D. The hippo signaling pathway in development and cancer. Dev Cell 2010, 19:491-505.
    • (2010) Dev Cell , vol.19 , pp. 491-505
    • Pan, D.1
  • 37
    • 84862764408 scopus 로고    scopus 로고
    • The Hippo signaling pathway and stem cell biology
    • Ramos A., Camargo F.D. The Hippo signaling pathway and stem cell biology. Trends Cell Biol 2012, 22:339-346.
    • (2012) Trends Cell Biol , vol.22 , pp. 339-346
    • Ramos, A.1    Camargo, F.D.2
  • 38
    • 77951837150 scopus 로고    scopus 로고
    • The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version
    • Zhao B., Li L., Lei Q., Guan K.L. The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. Genes Dev 2010, 24:862-874.
    • (2010) Genes Dev , vol.24 , pp. 862-874
    • Zhao, B.1    Li, L.2    Lei, Q.3    Guan, K.L.4
  • 39
    • 0028997651 scopus 로고
    • Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain
    • Sudol M., Bork P., Einbond A., Kastury K., Druck T., Negrini M., Huebner K., Lehman D. Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. J Biol Chem 1995, 270:14733-14741.
    • (1995) J Biol Chem , vol.270 , pp. 14733-14741
    • Sudol, M.1    Bork, P.2    Einbond, A.3    Kastury, K.4    Druck, T.5    Negrini, M.6    Huebner, K.7    Lehman, D.8
  • 40
    • 84874257648 scopus 로고    scopus 로고
    • The Hippo pathway: regulators and regulations
    • Yu F.X., Guan K.L. The Hippo pathway: regulators and regulations. Genes Dev 2013, 27:355-371.
    • (2013) Genes Dev , vol.27 , pp. 355-371
    • Yu, F.X.1    Guan, K.L.2
  • 42
    • 17644402459 scopus 로고    scopus 로고
    • Transduction of receptor signals by beta-arrestins
    • Lefkowitz R.J., Shenoy S.K. Transduction of receptor signals by beta-arrestins. Science 2005, 308:512-517.
    • (2005) Science , vol.308 , pp. 512-517
    • Lefkowitz, R.J.1    Shenoy, S.K.2
  • 43
    • 0036473397 scopus 로고    scopus 로고
    • The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals
    • Luttrell L.M., Lefkowitz R.J. The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. J Cell Sci 2002, 115:455-465.
    • (2002) J Cell Sci , vol.115 , pp. 455-465
    • Luttrell, L.M.1    Lefkowitz, R.J.2
  • 44
    • 77952415656 scopus 로고    scopus 로고
    • Beyond desensitization: physiological relevance of arrestin-dependent signaling
    • Luttrell L.M., Gesty-Palmer D. Beyond desensitization: physiological relevance of arrestin-dependent signaling. Pharmacol Rev 2010, 62:305-330.
    • (2010) Pharmacol Rev , vol.62 , pp. 305-330
    • Luttrell, L.M.1    Gesty-Palmer, D.2
  • 45
    • 77951844975 scopus 로고    scopus 로고
    • Teaching old receptors new tricks: biasing seven-transmembrane receptors
    • Rajagopal S., Rajagopal K., Lefkowitz R.J. Teaching old receptors new tricks: biasing seven-transmembrane receptors. Nat Rev Drug Discov 2010, 9:373-386.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 373-386
    • Rajagopal, S.1    Rajagopal, K.2    Lefkowitz, R.J.3
  • 46
    • 0033599039 scopus 로고    scopus 로고
    • EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
    • Prenzel N., Zwick E., Daub H., Leserer M., Abraham R., Wallasch C., Ullrich A. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 1999, 402:884-888.
    • (1999) Nature , vol.402 , pp. 884-888
    • Prenzel, N.1    Zwick, E.2    Daub, H.3    Leserer, M.4    Abraham, R.5    Wallasch, C.6    Ullrich, A.7
  • 47
    • 33747395791 scopus 로고    scopus 로고
    • Crosstalk coregulation mechanisms of G protein-coupled receptors and receptor tyrosine kinases
    • Natarajan K., Berk B.C. Crosstalk coregulation mechanisms of G protein-coupled receptors and receptor tyrosine kinases. Methods Mol Biol 2006, 332:51-77.
    • (2006) Methods Mol Biol , vol.332 , pp. 51-77
    • Natarajan, K.1    Berk, B.C.2
  • 48
    • 39749113080 scopus 로고    scopus 로고
    • Clonal integration of a polyomavirus in human Merkel cell carcinoma
    • Feng H., Shuda M., Chang Y., Moore P.S. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 2008, 319:1096-1100.
    • (2008) Science , vol.319 , pp. 1096-1100
    • Feng, H.1    Shuda, M.2    Chang, Y.3    Moore, P.S.4
  • 49
    • 72949087815 scopus 로고    scopus 로고
    • Human tumor-associated viruses and new insights into the molecular mechanisms of cancer
    • Martin D., Gutkind J.S. Human tumor-associated viruses and new insights into the molecular mechanisms of cancer. Oncogene 2008, 27(Suppl 2):S31-S42.
    • (2008) Oncogene , vol.27 , Issue.SUPPL. 2
    • Martin, D.1    Gutkind, J.S.2
  • 50
    • 84872238380 scopus 로고    scopus 로고
    • Molecular mechanisms deployed by virally encoded G protein-coupled receptors in human diseases
    • Montaner S., Kufareva I., Abagyan R., Gutkind J.S. Molecular mechanisms deployed by virally encoded G protein-coupled receptors in human diseases. Annu Rev Pharmacol Toxicol 2013, 53:331-354.
    • (2013) Annu Rev Pharmacol Toxicol , vol.53 , pp. 331-354
    • Montaner, S.1    Kufareva, I.2    Abagyan, R.3    Gutkind, J.S.4
  • 51
    • 0031032769 scopus 로고    scopus 로고
    • Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation [see comments]
    • Arvanitakis L., Geras-Raaka E., Varma A., Gershengorn M.C., Cesarman E. Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation [see comments]. Nature 1997, 385:347-350.
    • (1997) Nature , vol.385 , pp. 347-350
    • Arvanitakis, L.1    Geras-Raaka, E.2    Varma, A.3    Gershengorn, M.C.4    Cesarman, E.5
  • 52
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • Chambers A.F., Groom A.C., MacDonald I.C. Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2002, 2:563-572.
    • (2002) Nat Rev Cancer , vol.2 , pp. 563-572
    • Chambers, A.F.1    Groom, A.C.2    MacDonald, I.C.3
  • 54
    • 3042822267 scopus 로고    scopus 로고
    • Cancer and the chemokine network
    • Balkwill F. Cancer and the chemokine network. Nat Rev Cancer 2004, 4:540-550.
    • (2004) Nat Rev Cancer , vol.4 , pp. 540-550
    • Balkwill, F.1
  • 55
    • 0038049137 scopus 로고    scopus 로고
    • Tumour-cell invasion and migration: diversity and escape mechanisms
    • Friedl P., Wolf K. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 2003, 3:362-374.
    • (2003) Nat Rev Cancer , vol.3 , pp. 362-374
    • Friedl, P.1    Wolf, K.2
  • 56
  • 57
    • 0141828145 scopus 로고    scopus 로고
    • Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
    • Staller P., Sulitkova J., Lisztwan J., Moch H., Oakeley E.J., Krek W. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 2003, 425:307-311.
    • (2003) Nature , vol.425 , pp. 307-311
    • Staller, P.1    Sulitkova, J.2    Lisztwan, J.3    Moch, H.4    Oakeley, E.J.5    Krek, W.6
  • 58
    • 33344464945 scopus 로고    scopus 로고
    • CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment
    • Burger J.A., Kipps T.J. CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood 2006, 107:1761-1767.
    • (2006) Blood , vol.107 , pp. 1761-1767
    • Burger, J.A.1    Kipps, T.J.2
  • 59
    • 0037237648 scopus 로고    scopus 로고
    • Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide
    • Levesque J.P., Hendy J., Takamatsu Y., Simmons P.J., Bendall L.J. Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide. J Clin Invest 2003, 111:187-196.
    • (2003) J Clin Invest , vol.111 , pp. 187-196
    • Levesque, J.P.1    Hendy, J.2    Takamatsu, Y.3    Simmons, P.J.4    Bendall, L.J.5
  • 62
    • 80052094283 scopus 로고    scopus 로고
    • Homeostatic chemokine receptors and organ-specific metastasis
    • Zlotnik A., Burkhardt A.M., Homey B. Homeostatic chemokine receptors and organ-specific metastasis. Nat Rev Immunol 2011, 11:597-606.
    • (2011) Nat Rev Immunol , vol.11 , pp. 597-606
    • Zlotnik, A.1    Burkhardt, A.M.2    Homey, B.3
  • 63
    • 38949205852 scopus 로고    scopus 로고
    • Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment
    • O'Hayre M., Salanga C.L., Handel T.M., Allen S.J. Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment. Biochem J 2008, 409:635-649.
    • (2008) Biochem J , vol.409 , pp. 635-649
    • O'Hayre, M.1    Salanga, C.L.2    Handel, T.M.3    Allen, S.J.4
  • 64
    • 84886066175 scopus 로고    scopus 로고
    • GPR116, an adhesion G-protein-coupled receptor, promotes breast cancer metastasis via the Galphaq-p63RhoGEF-Rho GTPase pathway
    • Tang X., Jin R., Qu G., Wang X., Li Z., Yuan Z., Zhao C., Siwko S., Shi T., Wang P., et al. GPR116, an adhesion G-protein-coupled receptor, promotes breast cancer metastasis via the Galphaq-p63RhoGEF-Rho GTPase pathway. Cancer Res 2013, 73:6206-6218.
    • (2013) Cancer Res , vol.73 , pp. 6206-6218
    • Tang, X.1    Jin, R.2    Qu, G.3    Wang, X.4    Li, Z.5    Yuan, Z.6    Zhao, C.7    Siwko, S.8    Shi, T.9    Wang, P.10
  • 65
    • 0032038939 scopus 로고    scopus 로고
    • CXC chemokine modulation of angiogenesis: the importance of balance between angiogenic and angiostatic members of the family
    • Moore B.B., Keane M.P., Addison C.L., Arenberg D.A., Strieter R.M. CXC chemokine modulation of angiogenesis: the importance of balance between angiogenic and angiostatic members of the family. J Investig Med 1998, 46:113-120.
    • (1998) J Investig Med , vol.46 , pp. 113-120
    • Moore, B.B.1    Keane, M.P.2    Addison, C.L.3    Arenberg, D.A.4    Strieter, R.M.5
  • 66
    • 0035952713 scopus 로고    scopus 로고
    • Angiogenesis and G-protein-coupled receptors: signals that bridge the gap
    • Richard D.E., Vouret-Craviari V., Pouyssegur J. Angiogenesis and G-protein-coupled receptors: signals that bridge the gap. Oncogene 2001, 20:1556-1562.
    • (2001) Oncogene , vol.20 , pp. 1556-1562
    • Richard, D.E.1    Vouret-Craviari, V.2    Pouyssegur, J.3
  • 67
    • 29244449354 scopus 로고    scopus 로고
    • Prostaglandins and cancer
    • Wang D., Dubois R.N. Prostaglandins and cancer. Gut 2006, 55:115-122.
    • (2006) Gut , vol.55 , pp. 115-122
    • Wang, D.1    Dubois, R.N.2
  • 69
    • 18444408375 scopus 로고    scopus 로고
    • COX-2: a molecular target for colorectal cancer prevention
    • Brown J.R., DuBois R.N. COX-2: a molecular target for colorectal cancer prevention. J Clin Oncol 2005, 23:2840-2855.
    • (2005) J Clin Oncol , vol.23 , pp. 2840-2855
    • Brown, J.R.1    DuBois, R.N.2
  • 70
    • 0035496616 scopus 로고    scopus 로고
    • Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2
    • Gupta R.A., Dubois R.N. Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. Nat Rev Cancer 2001, 1:11-21.
    • (2001) Nat Rev Cancer , vol.1 , pp. 11-21
    • Gupta, R.A.1    Dubois, R.N.2
  • 71
    • 4444291042 scopus 로고    scopus 로고
    • Prostaglandin EP receptors: targets for treatment and prevention of colorectal cancer?
    • Hull M.A., Ko S.C., Hawcroft G. Prostaglandin EP receptors: targets for treatment and prevention of colorectal cancer?. Mol Cancer Ther 2004, 10:1-1039.
    • (2004) Mol Cancer Ther , vol.10 , pp. 1-1039
    • Hull, M.A.1    Ko, S.C.2    Hawcroft, G.3
  • 72
    • 0037081178 scopus 로고    scopus 로고
    • Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice
    • Hansen-Petrik M.B., McEntee M.F., Jull B., Shi H., Zemel M.B., Whelan J. Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice. Cancer Res 2002, 62:403-408.
    • (2002) Cancer Res , vol.62 , pp. 403-408
    • Hansen-Petrik, M.B.1    McEntee, M.F.2    Jull, B.3    Shi, H.4    Zemel, M.B.5    Whelan, J.6
  • 74
    • 28544444039 scopus 로고    scopus 로고
    • Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis
    • Castellone M.D., Teramoto H., Williams B.O., Druey K.M., Gutkind J.S. Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science 2005, 310:1504-1510.
    • (2005) Science , vol.310 , pp. 1504-1510
    • Castellone, M.D.1    Teramoto, H.2    Williams, B.O.3    Druey, K.M.4    Gutkind, J.S.5
  • 75
    • 22544475938 scopus 로고    scopus 로고
    • Prostaglandin E2 stimulates the beta-catenin/T cell factor-dependent transcription in colon cancer
    • Shao J., Jung C., Liu C., Sheng H. Prostaglandin E2 stimulates the beta-catenin/T cell factor-dependent transcription in colon cancer. J Biol Chem 2005, 280:26565-26572.
    • (2005) J Biol Chem , vol.280 , pp. 26565-26572
    • Shao, J.1    Jung, C.2    Liu, C.3    Sheng, H.4
  • 76
    • 33646485372 scopus 로고    scopus 로고
    • Inflammatory chemokines in cancer growth and progression
    • Rollins B.J. Inflammatory chemokines in cancer growth and progression. Eur J Cancer 2006, 42:760-767.
    • (2006) Eur J Cancer , vol.42 , pp. 760-767
    • Rollins, B.J.1
  • 78
    • 0024404145 scopus 로고
    • GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours
    • Landis C.A., Masters S.B., Spada A., Pace A.M., Bourne H.R., Vallar L. GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature 1989, 340:692-696.
    • (1989) Nature , vol.340 , pp. 692-696
    • Landis, C.A.1    Masters, S.B.2    Spada, A.3    Pace, A.M.4    Bourne, H.R.5    Vallar, L.6
  • 79
    • 0026003074 scopus 로고
    • Activating mutations of the stimulatory G protein in the McCune-Albright syndrome [see comments]
    • Weinstein L.S., Shenker A., Gejman P.V., Merino M.J., Friedman E., Spiegel A.M. Activating mutations of the stimulatory G protein in the McCune-Albright syndrome [see comments]. N Engl J Med 1991, 325:1688-1695.
    • (1991) N Engl J Med , vol.325 , pp. 1688-1695
    • Weinstein, L.S.1    Shenker, A.2    Gejman, P.V.3    Merino, M.J.4    Friedman, E.5    Spiegel, A.M.6
  • 80
    • 0026698944 scopus 로고
    • Identification of G protein alpha subunit mutations in human growth hormone (GH)- and GH/prolactin-secreting pituitary tumors by single-strand conformation polymorphism (SSCP) analysis
    • Drews R.T., Gravel R.A., Collu R. Identification of G protein alpha subunit mutations in human growth hormone (GH)- and GH/prolactin-secreting pituitary tumors by single-strand conformation polymorphism (SSCP) analysis. Mol Cell Endocrinol 1992, 87:125-129.
    • (1992) Mol Cell Endocrinol , vol.87 , pp. 125-129
    • Drews, R.T.1    Gravel, R.A.2    Collu, R.3
  • 81
    • 77955655753 scopus 로고    scopus 로고
    • The activating mutation R201C in GNAS promotes intestinal tumourigenesis in Apc(Min/+) mice through activation of Wnt and ERK1/2 MAPK pathways
    • Wilson C.H., McIntyre R.E., Arends M.J., Adams D.J. The activating mutation R201C in GNAS promotes intestinal tumourigenesis in Apc(Min/+) mice through activation of Wnt and ERK1/2 MAPK pathways. Oncogene 2010, 29:4567-4575.
    • (2010) Oncogene , vol.29 , pp. 4567-4575
    • Wilson, C.H.1    McIntyre, R.E.2    Arends, M.J.3    Adams, D.J.4
  • 83
    • 52649111039 scopus 로고    scopus 로고
    • Basal cell carcinomas: attack of the hedgehog
    • Epstein E.H. Basal cell carcinomas: attack of the hedgehog. Nat Rev Cancer 2008, 8:743-754.
    • (2008) Nat Rev Cancer , vol.8 , pp. 743-754
    • Epstein, E.H.1
  • 84
    • 33751549095 scopus 로고    scopus 로고
    • Targeting the Hedgehog pathway in cancer
    • Rubin L.L., de Sauvage F.J. Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov 2006, 5:1026-1033.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 1026-1033
    • Rubin, L.L.1    de Sauvage, F.J.2
  • 85
    • 2942738996 scopus 로고    scopus 로고
    • The Hedgehog response network: sensors, switches, and routers
    • Lum L., Beachy P.A. The Hedgehog response network: sensors, switches, and routers. Science 2004, 304:1755-1759.
    • (2004) Science , vol.304 , pp. 1755-1759
    • Lum, L.1    Beachy, P.A.2
  • 87
    • 84867772612 scopus 로고    scopus 로고
    • Adhesion G protein-coupled receptors: signaling, pharmacology, and mechanisms of activation
    • Paavola K.J., Hall R.A. Adhesion G protein-coupled receptors: signaling, pharmacology, and mechanisms of activation. Mol Pharmacol 2012, 82:777-783.
    • (2012) Mol Pharmacol , vol.82 , pp. 777-783
    • Paavola, K.J.1    Hall, R.A.2
  • 89
    • 84861530762 scopus 로고    scopus 로고
    • Towards the use of cannabinoids as antitumour agents
    • Velasco G., Sanchez C., Guzman M. Towards the use of cannabinoids as antitumour agents. Nat Rev Cancer 2012, 12:436-444.
    • (2012) Nat Rev Cancer , vol.12 , pp. 436-444
    • Velasco, G.1    Sanchez, C.2    Guzman, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.