Cancer chemoprevention and therapy by monoterpenes

Environmental Health Perspectives

Volumn 105, Issue SUPPL. 4, 1997, Pages 977-979

  Gould, Michael N ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Breast cancer; Cancer prevention; Cancer therapy; Limonene; Monoterpene; Perillyl alcohol

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; ESSENTIAL OIL; GUANINE NUCLEOTIDE BINDING PROTEIN; LIMONENE; LIVER ENZYME; MANNOSE 6 PHOSPHATE; PERILLA OIL; PERILLYL ALCOHOL; POLYCYCLIC HYDROCARBON; SOMATOMEDIN B RECEPTOR; TERPENE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ADVANCED CANCER; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; BREAST CANCER; CANCER; CANCER PREVENTION; CANCER THERAPY; CARCINOGENESIS; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CLINICAL TRIAL; CONFERENCE PAPER; EARLY CANCER; FRUIT; GENE EXPRESSION; HERB; HUMAN; ISOPRENYLATION; LEUKEMIA; LIVER CANCER; LUNG CANCER; MOUSE; NEUROBLASTOMA; NONHUMAN; PANCREAS CARCINOMA; PARENCHYMA; PHASE 1 CLINICAL TRIAL; PLANT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TUMOR REGRESSION; VEGETABLE;

ANIMALIA; PERILLA; RODENTIA;

EID: 0030867207     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.97105s4977     Document Type: Conference Paper

References (15)

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2. Elegbede JA, Elson CE, Qureshi A, Tanner MA, Gould MN. Inhibition of DMBA-induced mammary cancer by the monoterpene d-limonene. Carcinogenesis 5:661-664 (1984).
3. Wattenberg LW. Inhibition of neoplasia by minor dietary constituents. Cancer Res 43:2448-2453 (1983).
4. Elson CE, Maltzman TH, Boston JL, Tanner MA, Gould MN. Anti-carcinogenic activity of d-limonene during the initiation and promotion/progression stages of DMBA-induced rat mammary carcinogenesis. Carcinogenesis 9:331-332 (1988).
5. Haag JD, Lindstrom MJ, Gould MN. Limonene-induced regression of mammary carcinomas. Cancer Res 52:4021-4026 (1992).
6. Haag JD, Gould MN. Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene. Cancer Chemother Pharmacol 34:477-483 (1994).
7. Stark MJ, Burke YD, McKinzie JH, Ayoubi AS, Crowell PL. Chemotherapy of pancreatic cancer with the monoterpene perillyl alcohol. Cancer Lett 9:15-21 (1995).
8. Gould MN, Moore CJ, Zhang R, Wang B, Kennan WS, Haag JD. Limonene chemoprevention of mammary carcinoma induction following direct in situ transfer of v-Ha-ras into rat mammary epithelial cells using replication-defective retroviral vectors. Cancer Res 54:3540-3543 (1994).
9. Crowell PL, Ren Z, Lin S, Vedejs E, Gould MN. Structure-activity relationships among monoterpene inhibitors of protein isoprenylation and cell proliferation. Biochem Pharmacol 47:1405-1415 (1994).
10. Crowell PL, Chang RR, Ren Z, Elson CE, Gould MN. Selective inhibition of isoprenylation of 21-26 kDa proteins by the anticarcinogen d-limonene and its metabolites. J Biol Chem 266:17679-17685 (1991).
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14. Kornfeld S. Structure and function of the mannose 6-phosphate/insulin-like growth factor II receptors. Annu Rev Biochem 61:307-330 (1992).
15. McNamee D. Limonene trial in cancer. Lancet 342:801 (1993).