Bacterial D-amino acids suppress sinonasal innate immunity through sweet taste receptors in solitary chemosensory cells

Science Signaling

Volumn 10, Issue 495, 2017, Pages

  Lee, Robert J ^a   Hariri, Benjamin M ^a   McMahon, Derek B ^a   Chen, Bei ^a   Doghramji, Laurel ^a   Adappa, Nithin D ^a   Palmer, James N ^a   Kennedy, David W ^a   Jiang, Peihua ^b   Margolskee, Robert F ^b   Cohen, Noam A ^a,b,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MONELL CHEMICAL SENSES CENTER   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEFENSIN; DENATONIUM BENZOATE; DEXTRO AMINO ACID; RECEPTOR; T1R RECEPTOR; T1R2 RECEPTOR; T1R3 RECEPTOR; UNCLASSIFIED DRUG; AMINO ACID; G PROTEIN COUPLED RECEPTOR; TASTE RECEPTORS, TYPE 1; TASTE RECEPTORS, TYPE 2;

AIRWAY EPITHELIUM CELL; ARTICLE; BACTERIAL GROWTH; BACTERIUM; BACTERIUM ISOLATE; BIOFILM; CELL CULTURE; CELL DEATH; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; INNATE IMMUNITY; NONHUMAN; PARANASAL SINUS; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN SUBUNIT; QUORUM SENSING; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS; SWEETNESS; BIOSYNTHESIS; CHEMORECEPTOR CELL; DRUG EFFECT; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; NOSE MUCOSA; PHYSIOLOGY; PSEUDOMONAS AERUGINOSA; TASTE;

AMINO ACIDS; CELLS, CULTURED; CHEMORECEPTOR CELLS; HUMANS; IMMUNITY, INNATE; NASAL MUCOSA; PARANASAL SINUSES; PSEUDOMONAS AERUGINOSA; RECEPTORS, G-PROTEIN-COUPLED; STAPHYLOCOCCUS AUREUS; TASTE;

EID: 85028923546     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.aam7703     Document Type: Article

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