Berberine induces GLP-1 secretion through activation of bitter taste receptor pathways

Biochemical Pharmacology

Volumn 97, Issue 2, 2015, Pages 173-177

  Yu, Yunli ^a   Hao, Gang ^b   Zhang, Quanying ^a   Hua, Wenyan ^a   Wang, Meng ^a   Zhou, Wenjia ^a   Zong, Shunlin ^a   Huang, Ming ^a   Wen, Xiaozhou ^c  

^a THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b Suzhou Center for Disease Control   (China)

^c THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Berberine; Bitter taste receptor; Diabetes; Glucagon like peptide 1; PLC pathway

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; ANTIDIABETIC AGENT; BERBERINE; GLUCAGON LIKE PEPTIDE 1; PHENYLTHIOUREA; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE PHOSPHODIESTERASE; QUININE; SMALL INTERFERING RNA; TRANSIENT RECEPTOR POTENTIAL CHANNEL M5; G PROTEIN COUPLED RECEPTOR; TASTE RECEPTORS, TYPE 2;

ANTIDIABETIC ACTIVITY; ARTICLE; BITTER TASTE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; GENE SILENCING; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TASTE BUD; TASTE RECEPTOR 2 MEMBER 38; CELL LINE; DOSE RESPONSE; DRUG EFFECTS; ENTEROENDOCRINE CELL; METABOLISM; PHYSIOLOGY; SECRETION (PROCESS); TASTE;

BERBERINE; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENTEROENDOCRINE CELLS; GLUCAGON-LIKE PEPTIDE 1; HUMANS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TASTE; TASTE BUDS;

EID: 84940604280     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2015.07.012     Document Type: Article

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