The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY)

Clinical Nutrition

Volumn 30, Issue 4, 2011, Pages 524-532

  Steinert, R E ^a,b   Gerspach, A C ^a,b   Gutmann, H ^a   Asarian, L ^c   Drewe, J ^a,b   Beglinger, C ^a,b  

^a Clinical Research Center   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c ETH ZURICH   (Switzerland)

Author keywords

Appetite; Gastrointestinal satiation peptides; Gut; Intestinal chemosensitivity; Nutrient sensing; Sweet taste receptors

Indexed keywords

ALPHA GUSTDUCIN; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN; LACTISOLE; MESSENGER RNA; PEPTIDE YY; PROTEIN INHIBITOR; PROTEIN T1R3; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; COLON; CONTROLLED STUDY; ENTEROENDOCRINE CELL; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; ILEUM; IMMUNOHISTOCHEMISTRY; INTESTINE EPITHELIUM; MALE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN SYNTHESIS INHIBITION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SWEETNESS; TASTE BUD;

ADULT; AGED; BENZENE DERIVATIVES; COLON; ENTEROENDOCRINE CELLS; FEMALE; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE; HUMANS; ILEUM; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PEPTIDE YY; RECEPTORS, G-PROTEIN-COUPLED; RNA, MESSENGER; TASTE; TRANSDUCIN;

EID: 79960687712     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2011.01.007     Document Type: Article

References (34)

1. Sternini C., Anselmi L., Rozengurt E. Enteroendocrine cells: a site of 'taste' in gastrointestinal chemosensing. Curr Opin Endocrinol Diabetes Obes 2008, 15:73-78.
2. Rozengurt E., Sternini C. Taste receptor signaling in the mammalian gut. Curr Opin Pharmacol 2007, 7:557-562.
3. Raybould H. Gut chemosensing: interactions between gut endocrine cells and visceral afferents. Auton Neurosci 2009, 153(1-2):41-46.
4. Dockray G. Luminal sensing in the gut: an overview. J Physiol Pharmacol 2003, 54(Suppl. 4):9-17.
5. Fujita T. Concept of paraneurons. Arch Histol Jpn 1977, 40(Suppl. 1-12).
6. Newson B., Ahlman H., Dahlström A., Nyhus L. Ultrastructural observations in the rat ileal mucosa of possible epithelial "taste cells" and submucosal sensory neurons. Acta Physiol Scand 1982, 114:161-164.
7. Höfer D., Püschel B., Drenckhahn D. Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin. Proc Natl Acad Sci U S A 1996, 93:6631-6634.
8. Dyer J., Salmon K., Zibrik L., Shirazi-Beechey S. Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells. Biochem Soc Trans 2005, 33:302-305.
9. Wu S., Rozengurt N., Yang M., Young S., Sinnett-Smith J., Rozengurt E. Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells. Proc Natl Acad Sci U S A 2002, 99:2392-2397.
10. Rozengurt N., Wu S., Chen M., Huang C., Sternini C., Rozengurt E. Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon. Am J Physiol Gastrointest Liver Physiol 2006, 291:G792-G802.
11. Kokrashvili Z., Mosinger B., Margolskee R. Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones. Am J Clin Nutr 2009, 90:822S-825S.
12. Jang H., Kokrashvili Z., Theodorakis M., Carlson O., Kim B., Zhou J., et al. Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A 2007, 104:15069-15074.
13. Margolskee R., Dyer J., Kokrashvili Z., Salmon K., Ilegems E., Daly K., et al. T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1. Proc Natl Acad Sci U S A 2007, 104:15075-15080.
14. Schiffman S., Booth B., Sattely-Miller E., Graham B., Gibes K. Selective inhibition of sweetness by the sodium salt of +/-2-(4-methoxyphenoxy)propanoic acid. Chem Senses 1999, 24:439-447.
15. Flint A., Raben A., Blundell J.E., Astrup A. Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes Relat Metab Disord 2000, 24:38-48.
16. Steinert R.E., Poller B., Castelli M.C., Friedman K., Huber A.R., Drewe J., et al. Orally administered glucagon-like peptide-1 affects glucose homeostasis following an oral glucose tolerance test in healthy male subjects. Clin Pharmacol Ther 2009, 86:644-650.
17. Kokrashvili Z., Mosinger B., Margolskee R. T1r3 and alpha-gustducin in gut regulate secretion of glucagon-like peptide-1. Ann N Y Acad Sci 2009, 1170:91-94.
18. Fujita Y., Wideman R., Speck M., Asadi A., King D., Webber T., et al. Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo. Am J Physiol Endocrinol Metab 2009, 296:E473-E479.
19. Sutherland K., Young R., Cooper N., Horowitz M., Blackshaw L. Phenotypic characterization of taste cells of the mouse small intestine. Am J Physiol Gastrointest Liver Physiol 2007, 292:G1420-G1428.
20. Tolhurst G., Reimann F., Gribble F.M. Nutritional regulation of glucagon-like peptide-1 secretion. J Physiol 2009, 587:27-32.
21. Bezençon C., le Coutre J., Damak S. Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells. Chem Senses 2007, 32:41-49.
22. Young R., Sutherland K., Pezos N., Brierley S., Horowitz M., Rayner C., et al. Expression of taste molecules in the upper gastrointestinal tract in humans with and without type 2 diabetes. Gut 2009, 58:337-346.
23. Elliott R., Morgan L., Tredger J., Deacon S., Wright J., Marks V. Glucagon-like peptide-1 (7-36)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns. J Endocrinol 1993, 138:159-166.
24. Brubaker P., Anini Y. Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2. Can J Physiol Pharmacol 2003, 81:1005-1012.
25. Ferraris R., Yasharpour S., Lloyd K., Mirzayan R., Diamond J. Luminal glucose concentrations in the gut under normal conditions. Am J Physiol 1990, 259:G822-G837.
26. Schirra J., Katschinski M., Weidmann C., Schäfer T., Wank U., Arnold R., et al. Gastric emptying and release of incretin hormones after glucose ingestion in humans. J Clin Invest 1996, 97:92-103.
27. Eissele R., Göke R., Willemer S., Harthus H., Vermeer H., Arnold R., et al. Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man. Eur J Clin Invest 1992, 22:283-291.
28. Theodorakis M., Carlson O., Michopoulos S., Doyle M., Juhaszova M., Petraki K., et al. Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP. Am J Physiol Endocrinol Metab 2006, 290:E550-E559.
29. Fushiki T., Kojima A., Imoto T., Inoue K., Sugimoto E. An extract of Gymnema sylvestre leaves and purified gymnemic acid inhibits glucose-stimulated gastric inhibitory peptide secretion in rats. J Nutr 1992, 122:2367-2373.
30. Teff K.L., Engelman K. Oral sensory stimulation improves glucose tolerance in humans: effects on insulin, C-peptide, and glucagon. Am J Physiol 1996, 270:R1371-R1379.
31. De Jonge L., Agoues I., Garrel D.R. Decreased thermogenic response to food with intragastric vs. oral feeding. Am J Physiol 1991, 260:E238-E242.
32. Ma J., Bellon M., Wishart J., Young R., Blackshaw L., Jones K., et al. Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects. Am J Physiol Gastrointest Liver Physiol 2009, 296:G735-G739.
33. Little T., Gupta N., Case R., Thompson D., McLaughlin J. Sweetness and bitterness taste of meals per se does not mediate gastric emptying in humans. Am J Physiol Regul Integr Comp Physiol 2009, 297:R632-R639.
34. Steinert R.E., Frey F., Toepfer A., Drewe J., Beglinger C. Effects of carbohydrate sugars and artificial sweeteners on appetite and the secretion of gastrointestinal satiety peptides. Br J Nutr 2011, 24:1-9. [Epub ahead of print].