Intestinal bitter taste receptor activation alters hormone secretion and imparts metabolic benefits

Molecular Metabolism

Volumn 16, Issue , 2018, Pages 76-87

  Kok, Bernard P ^a   Galmozzi, Andrea ^a   Littlejohn, Nicole K ^a   Albert, Verena ^a   Godio, Cristina ^a   Kim, Woojoo ^a   Kim, Sean M ^a   Bland, Jeffrey S ^c   Grayson, Neile ^c   Fang, Mingliang ^b   Meyerhof, Wolfgang ^d   Siuzdak, Gary ^b   Srinivasan, Supriya ^a   Behrens, Maik ^d,e   Saez, Enrique ^a  

^a Department of Molecular Medicine ^*  (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c Kindex Pharmaceuticals   (United States)

^d GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^e DEUTSCHE FORSCHUNGSANSTALT FÜR LEBENSMITTELCHEMIE   (Germany)

Author keywords

Bitter taste receptor; Diabetes; Enteroendocrine hormones; GLP 1; Intestinal signaling; Isohumulone

Indexed keywords

ANTIDIABETIC AGENT; ANTIOBESITY AGENT; BILE ACID; BITTER TASTE RECEPTOR; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EMETINE; GLUCAGON LIKE PEPTIDE 1; INCRETIN; ISOHUMULONE; KDT 501; KR 62436; LIPID; RECEPTOR; ROSIGLITAZONE; SITAGLIPTIN; UNCLASSIFIED DRUG; CYCLOPENTANE DERIVATIVE; G PROTEIN COUPLED RECEPTOR; TAS2R108 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; BILE ACID METABOLISM; BITTER TASTE; BODY WEIGHT LOSS; CONTROLLED STUDY; DIABETES MELLITUS; DIET INDUCED OBESITY; DRUG DISTRIBUTION; DRUG POTENTIATION; DRUG SCREENING; ENERGY EXPENDITURE; ENTEROENDOCRINE CELL; FAT MASS; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HOPS; HORMONE BLOOD LEVEL; HORMONE RELEASE; HUMAN; INSULIN SENSITIVITY; INTESTINE; LIPID BLOOD LEVEL; LIVER TOXICITY; MALE; METABOLIC PARAMETERS; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; TREATMENT DURATION; ANIMAL; BODY WEIGHT; C57BL MOUSE; DISEASE MODEL; DRUG EFFECT; HUMULUS; INSULIN RESISTANCE; INTESTINE MUCOSA; METABOLISM; MOUSE MUTANT; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSIOLOGY;

ANIMALS; BODY WEIGHT; CYCLOPENTANES; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; ENTEROENDOCRINE CELLS; GLUCAGON-LIKE PEPTIDE 1; HUMULUS; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; INTESTINAL MUCOSA; INTESTINES; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 85051477974     PISSN: None     EISSN: 22128778     Source Type: Journal    
DOI: 10.1016/j.molmet.2018.07.013     Document Type: Article

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