The extracellular calcium-sensing receptor is required for cholecystokinin secretion in response to L-phenylalanine in acutely isolated intestinal I cells

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 300, Issue 4, 2011, Pages

  Liou, Alice P ^a,b   Sei, Yoshitatsu ^a   Zhao, Xilin ^a   Feng, Jianying ^a   Lu, Xinping ^a   Thomas, Craig ^c   Pechhold, Susanne ^a   Raybould, Helen E ^b   Wank, Stephen A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

Amino acid sensing; Enteroendocrine; Protein sensing

Indexed keywords

CALCIUM SENSING RECEPTOR; CHOLECYSTOKININ; CINACALCET; ENHANCED GREEN FLUORESCENT PROTEIN; PHENYLALANINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL ISOLATION; CELL POPULATION; CONTROLLED STUDY; DUODENUM; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; HORMONE RELEASE; IMMUNOHISTOCHEMISTRY; INTESTINE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEREOCHEMISTRY; TRANSGENIC MOUSE;

ANIMALS; CALCIUM; CELLS, CULTURED; CHOLECYSTOKININ; DUODENUM; FLUORESCENT ANTIBODY TECHNIQUE; MICE; MICE, TRANSGENIC; PHENYLALANINE; RECEPTORS, CALCIUM-SENSING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 79955069352     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00342.2010     Document Type: Article

References (47)

1. Anika SM, Houpt TR, Houpt KA. Satiety elicited by cholecystokinin in intact and vagotomized rats. Physiol Behav 19: 761-766, 1977.
2. Ballinger AB, Clark ML. L-Phenylalanine releases cholecystokinin (CCK) and is associated with reduced food intake in humans: evidence for a physiological role of CCK in control of eating. Metabolism 43: 735-738, 1994.
3. Bezencon C, le Coutre J, Damak S. Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells. Chem Senses 32: 41-49, 2007.
4. Bouras EP, Misukonis MA, Liddle RA. Role of calcium in monitor peptide-stimulated cholecystokinin release from perifused intestinal cells. Am J Physiol Gastrointest Liver Physiol 262: G791-G796, 1992.
5. Brown EM, Gamba G, Riccardi D, Lombardi M, Butters R, Kifor O, Sun A, Hediger MA, Lytton J, Hebert SC. Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid. Nature 366: 575-580, 1993.
6. Buchan AM, Squires PE, Ring M, Meloche RM. Mechanism of action of the calcium-sensing receptor in human antral gastrin cells. Gastroenterology 120: 1128-1139, 2001.
7. 2+-sensing receptor in rat intestine. Am J Physiol Gastrointest Liver Physiol 274: G122-G130, 1998.
8. Chattopadhyay N, Ye CP, Yamaguchi T, Vassilev PM, Brown EM. Evidence for extracellular calcium-sensing receptor mediated opening of an outward K+ channel in a human astrocytoma cell line (U87). Glia 26: 64-72, 1999.
9. Choi S, Lee M, Shiu AL, Yo SJ, Aponte GW. Identification of a protein hydrolysate responsive G protein-coupled receptor in enterocytes. Am J Physiol Gastrointest Liver Physiol 292: G98-G112, 2007.
10. Choi S, Lee M, Shiu AL, Yo SJ, Hallden G, Aponte GW. GPR93 activation by protein hydrolysate induces CCK transcription and secretion in STC-1 cells. Am J Physiol Gastrointest Liver Physiol 292: G1366-G1375, 2007.
11. Conigrave AD, Brown EM. Taste receptors in the gastrointestinal tract. II. L-Amino acid sensing by calcium-sensing receptors: implications for GI physiology. Am J Physiol Gastrointest Liver Physiol 291: G753-G761, 2006.
12. 2+-sensing receptor. Proc Natl Acad Sci U S A 97: 4814-4819, 2000.
13. Dyer J, Salmon KS, Zibrik L, Shirazi-Beechey SP. Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells. Biochem Soc Trans 33: 302-305, 2005.
14. Gibbs J, Falasco JD, McHugh PR. Cholecystokinin-decreased food intake in rhesus monkeys. Am J Physiol 230: 15-18, 1976.
15. Goebel SU, Peghini PL, Goldsmith PK, Spiegel AM, Gibril F, Raffeld M, Jensen RT, Serrano J. Expression of the calcium-sensing receptor in gastrinomas. J Clin Endocrinol Metab 85: 4131-4137, 2000.
16. Hira T, Nakajima S, Eto Y, Hara H. Calcium-sensing receptor mediates phenylalanine-induced cholecystokinin secretion in enteroendocrine STC-1 cells. FEBS J 275: 4620-4626, 2008.
17. Ho C, Conner DA, Pollak MR, Ladd DJ, Kifor O, Warren HB, Brown EM, Seidman JG, Seidman CE. A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Nat Genet 11: 389-394, 1995.
18. Huang C, Miller RT. The calcium-sensing receptor and its interacting proteins. J Cell Mol Med 11: 923-934, 2007.
19. Kos CH, Karaplis AC, Peng JB, Hediger MA, Goltzman D, Mohammad KS, Guise TA, Pollak MR. The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone. J Clin Invest 111: 1021-1028, 2003.
20. Mangel AW, Prpic V, Snow ND, Basavappa S, Hurst LJ, Sharara AI, Liddle RA. Regulation of cholecystokinin secretion by ATP-sensitive potassium channels. Am J Physiol Gastrointest Liver Physiol 267: G595-G600, 1994.
21. Mangel AW, Prpic V, Wong H, Basavappa S, Hurst LJ, Scott L, Garman RL, Hayes JS, Sharara AI, Snow ND, Walsh JH, Liddle RA. Phenylalanine-stimulated secretion of cholecystokinin is calcium dependent. Am J Physiol Gastrointest Liver Physiol 268: G90-G94, 1995.
22. Mangel AW, Scott L, Liddle RA. Depolarization-stimulated cholecystokinin secretion is mediated by L-type calcium channels in STC-1 cells. Am J Physiol Gastrointest Liver Physiol 270: G287-G290, 1996.
23. Mangel AW, Snow ND, Misukonis MA, Basavappa S, Middleton JP, Fitz JG, Liddle RA. Calcium-dependent regulation of cholecystokinin secretion and potassium currents in STC-1 cells. Am J Physiol Gastrointest Liver Physiol 264: G1031-G1036, 1993.
24. Matsumura K, Miki T, Jhomori T, Gonoi T, Seino S. Possible role of PEPT1 in gastrointestinal hormone secretion. Biochem Biophys Res Commun 336: 1028-1032, 2005.
25. 2+-dependent mechanism in the enteroendocrine cell line STC-1. J Physiol 513: 11-18, 1998.
26. Miedlich SU, Gama L, Seuwen K, Wolf RM, Breitwieser GE. Homology modeling of the transmembrane domain of the human calcium sensing receptor and localization of an allosteric binding site. J Biol Chem 279: 7254-7263, 2004.
27. 2+-sensing receptor is required for L-amino acid sensing. J Biol Chem 279: 51739-51744, 2004.
28. Nelson G, Chandrashekar J, Hoon MA, Feng L, Zhao G, Ryba NJ, Zuker CS. An amino-acid taste receptor. Nature 416: 199-202, 2002.
29. Nemeth EF, Heaton WH, Miller M, Fox J, Balandrin MF, Van Wagenen BC, Colloton M, Karbon W, Scherrer J, Shatzen E, Rishton G, Scully S, Qi M, Harris R, Lacey D, Martin D. Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl. J Pharmacol Exp Ther 308: 627-635, 2004.
30. Nemoz-Gaillard E, Bernard C, Abello J, Cordier-Bussat M, Chayvialle JA, Cuber JC. Regulation of cholecystokinin secretion by peptones and peptidomimetic antibiotics in STC-1 cells. Endocrinology 139: 932-938, 1998.
31. Oda Y, Tu CL, Chang W, Crumrine D, Komuves L, Mauro T, Elias PM, Bikle DD. The calcium sensing receptor and its alternatively spliced form in murine epidermal differentiation. J Biol Chem 275: 1183-1190, 2000.
32. Oda Y, Tu CL, Pillai S, Bikle DD. The calcium sensing receptor and its alternatively spliced form in keratinocyte differentiation. J Biol Chem 273: 23344-23352, 1998.
33. Rasschaert J, Malaisse WJ. Expression of the calcium-sensing receptor in pancreatic islet B-cells. Biochem Biophys Res Commun 264: 615-618, 1999.
34. Ray JM, Squires PE, Curtis SB, Meloche MR, Buchan AM. Expression of the calcium-sensing receptor on human antral gastrin cells in culture. J Clin Invest 99: 2328-2333, 1997.
35. 2+ oscillations by the calcium-sensing receptor. J Biol Chem 281: 38730-38737, 2006.
36. 2+-sensing receptor are mediated by a phospholipase C/inositol 1,4,5-trisphosphate-independent pathway that requires G12, Rho, filamin-A, and the actin cytoskeleton. J Biol Chem 280: 22875-22882, 2005.
37. Sai Y, Tamai I, Sumikawa H, Hayashi K, Nakanishi T, Amano O, Numata M, Iseki S, Tsuji A. Immunolocalization and pharmacological relevance of oligopeptide transporter PepT1 in intestinal absorption of beta-lactam antibiotics. FEBS Lett 392: 25-29, 1996.
38. Sharara AI, Bouras EP, Misukonis MA, Liddle RA. Evidence for indirect dietary regulation of cholecystokinin release in rats. Am J Physiol Gastrointest Liver Physiol 265: G107-G112, 1993.
39. Sheinin Y, Kallay E, Wrba F, Kriwanek S, Peterlik M, Cross HS. Immunocytochemical localization of the extracellular calcium-sensing receptor in normal and malignant human large intestinal mucosa. J Histochem Cytochem 48: 595-602, 2000.
40. Snow ND, Prpic V, Mangel AW, Sharara AI, McVey DC, Hurst LJ, Vigna SR, Liddle RA. Regulation of cholecystokinin secretion by bomb-esin in STC-1 cells. Am J Physiol Gastrointest Liver Physiol 267: G859-G865, 1994.
41. Squires PE, Harris TE, Persaud SJ, Curtis SB, Buchan AM, Jones PM. The extracellular calcium-sensing receptor on human beta-cells negatively modulates insulin secretion. Diabetes 49: 409-417, 2000.
42. Straub SG, Kornreich B, Oswald RE, Nemeth EF, Sharp GW. The calcimimetic R-467 potentiates insulin secretion in pancreatic beta cells by activation of a nonspecific cation channel. J Biol Chem 275: 18777-18784, 2000.
43. + channels is blunted in CaR gene-deficient mouse neurons. Neuroreport 8: 1411-1416, 1997.
44. 2+-sensing receptor gene. Brain Res Bull 44: 75-84, 1997.
45. 2+-sensing receptor agonists of nonselective cation channels in rat hippocampal neurons. Biochem Biophys Res Commun 224: 271-280, 1996.
46. Zhang Z, Jiang Y, Quinn SJ, Krapcho K, Nemeth EF, Bai M. L-Phenylalanine and NPS R-467 synergistically potentiate the function of the extracellular calcium-sensing receptor through distinct sites. J Biol Chem 277: 33736-33741, 2002.
47. Zhang Z, Qiu W, Quinn SJ, Conigrave AD, Brown EM, Bai M. Three adjacent serines in the extracellular domains of the CaR are required for L-amino acid-mediated potentiation of receptor function. J Biol Chem 277: 33727-33735, 2002.