Deorphanization and characterization of the ectopically expressed olfactory receptor OR51B5 in myelogenous leukemia cells

Cell Death Discovery

Volumn 2, Issue 1, 2016, Pages

  Manteniotis, S ^a   Wojcik, S ^a   Gothert J R ^b   Durig J ^b   Duhrsen U ^b   Gisselmann, G ^a   Hatt, H ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85009134358     PISSN: None     EISSN: 20587716     Source Type: Journal    
DOI: 10.1038/cddiscovery.2016.10     Document Type: Article

References (49)

1. Buck L, Axel R. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 1991; 65: 175–187.
2. Spehr M, Gisselmann G, Poplawski A, Riffell JA, Wetzel CH, Zimmer RK et al. Identification of a testicular odorant receptor mediating human sperm chemotaxis. Science 2003; 299: 2054–2058.
3. Braun T, Voland P, Kunz L, Prinz C, Gratzl M. Enterochromaffin cells of the human gut: sensors for spices and odorants. Gastroenterology 2007; 132: 1890–1901.
4. Weng J, Wang J, Hu X, Wang F, Ittmann M, Liu M. PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer. Int J Cancer 2006; 118: 1471–1480.
5. Xu L L, Stackhouse BG, Florence K, Zhang W, Shanmugam N, Sesterhenn IA et al. PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer. Cancer Res 2000; 60: 6568–6572.
6. Neuhaus EM, Zhang W, Gelis L, Deng Y, Noldus J, Hatt H et al. Activation of an olfactory receptor inhibits proliferation of prostate cancer cells. J Biol Chem 2009; 284: 16218–16225.
7. Maßberg D, Simon A, Häussinger D, Keitel V, Gisselmann G, Conrad H et al. Monoterpene (-)-citronellal affects hepatocarcinoma cell signaling via an olfactory receptor. Arch. Biochem Biophys 2014; 566: 100–109.
8. Zhang X, Bedigian AV, Wang W, Eggert US. G protein-coupled receptors participate in cytokinesis. Cytoskeleton (Hoboken) 2012; 69: 810–818.
9. Pluznick J L, Protzko RJ, Gevorgyan H, Peterlin Z, Sipos A, Han J et al. Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation. Proc Natl Acad Sci USA 2013; 110: 4410–4415.
10. Busse D, Kudella P, Grüning NM, Gisselmann G, Ständer S, Luger T et al. A synthetic sandalwood odorant induces wound-healing processes in human keratinocytes via the olfactory receptor OR2AT4. J Invest Dermatol 2014; 134: 2823–2832.
11. Manteniotis S, Wojcik S, Brauhoff P, Möllmann M, Petersen L, Göthert JR et al. Functional characterization of the ectopically expressed olfactory receptor 2AT4 in human myelogenous leukemia. Cell Death Discovery 2016; 2: 15070.
12. Veitinger T, Riffell JR, Veitinger S, Nascimento JM, Triller A, Chandsawangbhuwana C et al. Chemosensory Ca2+ dynamics correlate with diverse behavioral phenotypes in human sperm. J Biol Chem 2011; 286: 17311–17325.
13. Wang CL, Ng TB, Cao XH, Jiang Y, Liu ZK, Wen TY et al. CLP induces apoptosis in human leukemia K562 cells through Ca(2+) regulating extracellular-related protein kinase ERK activation. Cancer Lett 2009; 276: 221–227.
14. Sergeev IN. Calcium signaling in cancer and vitamin D. J Steroid Biochem Mol Biol 2005; 97: 145–151.
15. Lozzio CB, Lozzio BB. Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. Blood 1975; 45: 321–334.
16. Klein E, Ben-Bassat H, Neumann H, Ralph P, Zeuthen J, Polliack A et al. Properties of the K562 cell line, derived from a patient with chronic myeloid leukemia. Int J Cancer 1976; 18: 421–431.
17. Andersson LC, Nilsson K, Gahmberg CG. K562--a human erythroleukemic cell line. Int J Cancer 1979; 23: 143–147.
18. Forchap S L, Anandacoomarasamy A, Wicks J, Di Virgilio F, Baricordi OR, Rubbini M et al. P2X7 gene polymorphisms do not appear to be a susceptibility gene locus in sporadic cases of systemic lupus erythematosus. Tissue Antigens 2008; 72: 487–490.
19. Pastore S, Mascia F, Gulinelli S, Forchap S, Dattilo C, Adinolfi E et al. Stimulation of purinergic receptors modulates chemokine expression in human keratinocytes. J Invest Dermatol 2007; 127: 660–667.
20. Cabrini G, Falzoni S, Forchap SL, Pellegatti P, Balboni A, Agostini P et al. A His-155 to Tyr polymorphism confers gain-of-function to the human P2X7 receptor of human leukemic lymphocytes. J Immunol 2005; 175: 82–89.
21. Ferrari D, Pizzirani C, Adinolfi E, Forchap S, Sitta B, Turchet L et al. The antibiotic polymyxin B modulates P2X7 receptor function. J Immunol 2004; 173: 4652–4660.
22. Sweeney G et al. An inhibitor of p38 mitogen-activated protein kinase prevents insulin-stimulated glucose transport but not glucose transporter translocation in 3T3-L1 adipocytes and L6 myotubes. J Biol Chem 1999; 274: 10071–10078.
23. Heidenreich KA, Kummer JL. Inhibition of p38 mitogen-activated protein kinase by insulin in cultured fetal neurons. J Biol Chem 1996; 271: 9891–9894.
24. Dorsey JF, Cunnick JM, Lanehart R, Huang M, Kraker AJ, Bhalla KN et al. Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors. Leukemia 2002; 16: 1589–1595.
25. Satheesh NJ, Büsselberg D. The role of intracellular calcium for the development and treatment of neuroblastoma. Cancers 2015; 7: 823–848.
26. Forchap SL, Pirmohamed M, Clark RE. Release of intracellular calcium primes chronic myeloid leukaemia cells for tyrosine kinase inhibitor-induced apoptosis. Leukemia 2012; 26: 490–498.
27. Lemoli RM, Ferrari D, Fogli M, Rossi L, Pizzirani C, Forchap S et al. Extracellular nucleotides are potent stimulators of human hematopoietic stem cells in vitro and in vivo. Blood 2004; 104: 1662–1670.
28. Wang CL, Ng TB, Yuan F, Liu ZK, Liu F. Induction of apoptosis in human leukemia K562 cells by cyclic lipopeptide from Bacillus subtilis natto T-2. Peptides 2007; 28: 1344–1350.
29. Demes B, Forchap E, Herwig H. They seem to glide. Are there aerodynamic effects in leaping prosimian primates? Z Morphol Anthropol 1991; 78: 373–385.
30. Bedi A, Zehnbauer BA, Barber JP, Sharkis SJ, Jones RJ. Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia. Blood 1994; 83: 2038–2044.
31. Apáti A, Jánossy J, Brózik A, Bauer PI, Magócsi M. Calcium induces cell survival and proliferation through the activation of the MAPK pathway in a human hormone-dependent leukemia cell line, TF-1. J Biol Chem 2003; 278: 9235–9243.
32. Boekhoff I, Breer H. Differential stimulation of second messenger pathways by distinct classes of odorants. Neurochem Int 1990; 17: 553–557.
33. Boekhoff I, Tareilus E, Strotmann J, Breer H. Rapid activation of alternative second messenger pathways in olfactory cilia from rats by different odorants. EMBO J 1990; 9: 2453–2458.
34. Spehr J, Gelis L, Osterloh M, Oberland S, Hatt H, Spehr M et al. G protein-coupled receptor signaling via Src kinase induces endogenous human transient receptor potential vanilloid type 6 (TRPV6) channel activation. J Biol Chem 2011; 286: 13184–13192.
35. Zhang H, Tan S, Wang J, Chen S, Quan J, Xian J et al. Musashi2 modulates K562 leukemic cell proliferation and apoptosis involving the MAPK pathway. Exp Cell Res 2014; 320: 119–127.
36. Paz-Elizur T, Sevilya Z, Leitner-Dagan Y, Elinger D, Roisman LC, Livneh Z. DNA repair of oxidative DNA damage in human carcinogenesis: potential application for cancer risk assessment and prevention. Cancer Lett 2008; 266: 60–72.
37. Lampronti I, Saab A M, Gambari R. Antiproliferative activity of essential oils derived from plants belonging to the Magnoliophyta division. Int J Oncol 2006; 29: 989–995.
38. Jaganathan SK, Mazumdar A, Mondhe D, Mandal M. Apoptotic effect of eugenol in human colon cancer cell lines. Cell Biol Int 2011; 35: 607–615.
39. Jaganathan SK, Supriyanto E. Antiproliferative and molecular mechanism of eugenol-induced apoptosis in cancer cells. Molecules 2012; 17: 6290–6304.
40. Xiao Y, Yang FQ, Li SP, Hu G, Lee SM, Wang YT. Essential oil of Curcuma wenyujin induces apoptosis in human hepatoma cells. World J Gastroenterol 2008; 14: 4309–4318.
41. Sylvestre M, Legault J, Dufour D, Pichette A. Chemical composition and anticancer activity of leaf essential oil of Myrica gale L. Phytomedicine 2005; 12: 299–304.
42. Cragg GM, Newman DJ, Weiss RB. Coral reefs, forests, and thermal vents: the worldwide exploration of nature for novel antitumor agents. Semin Oncol 1997; 24: 156–163.
43. Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat Prod 2007; 70: 461–477.
44. Estey E, Döhner H. Acute myeloid leukaemia. Lancet 2006; 368: 1894–1907.
45. Burnett AK. New induction and postinduction strategies in acute myeloid leukemia. Curr Opin Hematol 2012; 19: 76–81.
46. Murgo AJ, Sistare FD. K562 leukemia cells express P2T (adenosine diphosphate) purinergic receptors. J Pharmacol Exp Ther 1992; 261: 580–585.
47. Palme D, Misovic M, Schmid E, Klumpp D, Salih HR, Rudner J et al. Kv3.4 potassium channel-mediated electrosignaling controls cell cycle and survival of irradiated leukemia cells. Pflugers Arch 2013; 465: 1209–1221.
48. Schneider CA, Rasband WS, Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis. Nat Methods 2012; 9: 671–675.
49. Okazaki K, Ishikawa T, Inui M, Tada M, Goshima K, Okamoto T et al. KN-62, a specific Ca++/calmodulin-dependent protein kinase inhibitor, reversibly depresses the rate of beating of cultured fetal mouse cardiac myocytes. J Pharmacol Exp Ther 1994; 270: 1319–1324.