Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 8, 2012, Pages

  Kyriazis, George A ^a   Soundarapandian, Mangala M ^a   Tyrberg, Bjor̈n ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

G protein coupled receptor; Glucagon like peptide 1; MIN6; Saccharin; T1R3

Indexed keywords

CALCIUM ION; FRUCTOSE; GLUCOSE; INSULIN; PHOSPHOLIPASE C; TRANSIENT RECEPTOR POTENTIAL CHANNEL 5;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; ENZYME ACTIVATION; GLUCOSE METABOLISM; HUMAN; HUMAN TISSUE; INSULIN BLOOD LEVEL; INSULIN RELEASE; INTRACELLULAR SIGNALING; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; POSTPRANDIAL STATE; PRIORITY JOURNAL; REGULATORY MECHANISM; TASTE BUD;

ANIMALS; CALCIUM; ENZYME ACTIVATION; FRUCTOSE; GENE DELETION; GLUCOSE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; INTRACELLULAR SPACE; MALE; MICE; POSTPRANDIAL PERIOD; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TASTE; TRPM CATION CHANNELS; TYPE C PHOSPHOLIPASES;

EID: 84857426294     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1115183109     Document Type: Article

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