Denatonium induces secretion of glucagon-like peptide-1 through activation of bitter taste receptor pathways

Diabetologia

Volumn 57, Issue 10, 2014, Pages 2117-2125

  Kim, Ki Suk ^a   Egan, Josephine M ^b   Jang, Hyeung Jin ^a  

^a Kyung Hee University   (South Korea)

^b NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Bitter taste receptor; GLP 1; Incretin; PYY Type 2 diabetes mellitus; gustducin

Indexed keywords

CYCLIC AMP; DENATONIUM BENZOATE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN; MESSENGER RNA; PEPTIDE YY; PHOSPHOLIPASE C; G PROTEIN COUPLED RECEPTOR; QUATERNARY AMMONIUM DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BITTER TASTE; CALCIUM CELL LEVEL; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; ENHANCER REGION; ENTEROENDOCRINE CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR CALCIUM; GLUCOSE BLOOD LEVEL; HORMONE RELEASE; HUMAN; HUMAN CELL; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN LIKE ACTIVITY; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TASTE BUD; ANIMAL; CELL LINE; DRUG EFFECTS; GENETICS; METABOLISM; SECRETION (PROCESS);

ANIMALS; CELL LINE; CYCLIC AMP; GLUCAGON-LIKE PEPTIDE 1; HUMANS; MICE; PEPTIDE YY; QUATERNARY AMMONIUM COMPOUNDS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TYPE C PHOSPHOLIPASES;

EID: 84926611558     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3326-5     Document Type: Article

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