-
1
-
-
0030010183
-
Immunopharmacology of rapamycin
-
PMID: 8717522
-
Abraham R.T., Wiederrecht G.J. Immunopharmacology of rapamycin. Annu Rev Immunol 1996, 14:483-510. PMID: 8717522.
-
(1996)
Annu Rev Immunol
, vol.14
, pp. 483-510
-
-
Abraham, R.T.1
Wiederrecht, G.J.2
-
2
-
-
2342545519
-
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
-
PMID: 15094765
-
Fingar D.C., Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 2004, 23:3151-3171. PMID: 15094765.
-
(2004)
Oncogene
, vol.23
, pp. 3151-3171
-
-
Fingar, D.C.1
Blenis, J.2
-
3
-
-
0025776523
-
Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
-
PMID: 1715094
-
Heitman J., Movva N.R., Hall M.N. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 1991, 253:905-909. PMID: 1715094.
-
(1991)
Science
, vol.253
, pp. 905-909
-
-
Heitman, J.1
Movva, N.R.2
Hall, M.N.3
-
4
-
-
0029055145
-
Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue
-
PMID: 7539137
-
Chen J., Zheng X.F., Brown E.J., Schreiber S.L. Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Proc Natl Acad Sci U S A 1995, 92:4947-4951. PMID: 7539137.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 4947-4951
-
-
Chen, J.1
Zheng, X.F.2
Brown, E.J.3
Schreiber, S.L.4
-
5
-
-
77950900079
-
MTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action
-
PMID: 20022946
-
Soliman G.A., Acosta-Jaquez H.A., Dunlop E.A., Ekim B., Maj N.E., Tee A.R., et al. mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action. J Biol Chem 2010, 285:7866-7879. PMID: 20022946.
-
(2010)
J Biol Chem
, vol.285
, pp. 7866-7879
-
-
Soliman, G.A.1
Acosta-Jaquez, H.A.2
Dunlop, E.A.3
Ekim, B.4
Maj, N.E.5
Tee, A.R.6
-
6
-
-
84896692038
-
Rapamycin: one drug, many effects
-
PMID: 24508508
-
Li J., Kim S.G., Blenis J. Rapamycin: one drug, many effects. Cell Metab 2014, 19:373-379. PMID: 24508508.
-
(2014)
Cell Metab
, vol.19
, pp. 373-379
-
-
Li, J.1
Kim, S.G.2
Blenis, J.3
-
7
-
-
0028239893
-
RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
-
PMID: 7518356
-
Sabatini D.M., Erdjument-Bromage H., Lui M., Tempst P., Snyder S.H. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 1994, 78:35-43. PMID: 7518356.
-
(1994)
Cell
, vol.78
, pp. 35-43
-
-
Sabatini, D.M.1
Erdjument-Bromage, H.2
Lui, M.3
Tempst, P.4
Snyder, S.H.5
-
8
-
-
0028360374
-
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
-
PMID: 8008069
-
Brown E.J., Albers M.W., Shin T.B., Ichikawa K., Keith C.T., Lane W.S., et al. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 1994, 369:756-758. PMID: 8008069.
-
(1994)
Nature
, vol.369
, pp. 756-758
-
-
Brown, E.J.1
Albers, M.W.2
Shin, T.B.3
Ichikawa, K.4
Keith, C.T.5
Lane, W.S.6
-
9
-
-
0028950217
-
Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
-
PMID: 7822316
-
Sabers C.J., Martin M.M., Brunn G.J., Williams J.M., Dumont F.J., Wiederrecht G., et al. Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem 1995, 270:815-822. PMID: 7822316.
-
(1995)
J Biol Chem
, vol.270
, pp. 815-822
-
-
Sabers, C.J.1
Martin, M.M.2
Brunn, G.J.3
Williams, J.M.4
Dumont, F.J.5
Wiederrecht, G.6
-
10
-
-
84859778293
-
MTOR signaling in growth control and disease
-
PMID: 22500797
-
Laplante M., Sabatini D.M. mTOR signaling in growth control and disease. Cell 2012, 149:274-293. PMID: 22500797.
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
11
-
-
84877927481
-
MTOR in aging, metabolism, and cancer
-
PMID: 23317514
-
Cornu M., Albert V., Hall M.N. mTOR in aging, metabolism, and cancer. Curr Opin Genet Dev 2013, 23:53-62. PMID: 23317514.
-
(2013)
Curr Opin Genet Dev
, vol.23
, pp. 53-62
-
-
Cornu, M.1
Albert, V.2
Hall, M.N.3
-
12
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
PMID: 16603397
-
Sarbassov D.D., Ali S.M., Sengupta S., Sheen J.H., Hsu P.P., Bagley A.F., et al. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell 2006, 22:159-168. PMID: 16603397.
-
(2006)
Mol Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
Bagley, A.F.6
-
13
-
-
61449235398
-
Not all substrates are treated equally: implications for mTOR, rapamycin-resistance and cancer therapy
-
PMID: 19197153
-
Choo A.Y., Blenis J. Not all substrates are treated equally: implications for mTOR, rapamycin-resistance and cancer therapy. Cell Cycle 2009, 8:567-572. PMID: 19197153.
-
(2009)
Cell Cycle
, vol.8
, pp. 567-572
-
-
Choo, A.Y.1
Blenis, J.2
-
14
-
-
56249147509
-
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
-
PMID: 18955708
-
Choo A.Y., Yoon S.O., Kim S.G., Roux P.P., Blenis J. Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proc Natl Acad Sci U S A 2008, 105:17414-17419. PMID: 18955708.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 17414-17419
-
-
Choo, A.Y.1
Yoon, S.O.2
Kim, S.G.3
Roux, P.P.4
Blenis, J.5
-
15
-
-
68149096799
-
The pharmacology of mTOR inhibition
-
PMID: 19383975
-
Guertin D.A., Sabatini D.M. The pharmacology of mTOR inhibition. Sci Signal 2009, 2:pe24. PMID: 19383975.
-
(2009)
Sci Signal
, vol.2
, pp. pe24
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
16
-
-
65549145048
-
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
-
PMID: 19150980
-
Thoreen C.C., Kang S.A., Chang J.W., Liu Q., Zhang J., Gao Y., et al. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem 2009, 284:8023-8032. PMID: 19150980.
-
(2009)
J Biol Chem
, vol.284
, pp. 8023-8032
-
-
Thoreen, C.C.1
Kang, S.A.2
Chang, J.W.3
Liu, Q.4
Zhang, J.5
Gao, Y.6
-
17
-
-
67650228579
-
Rapamycin inhibits mTORC1, but not completely
-
PMID: 19395872
-
Thoreen C.C., Sabatini D.M. Rapamycin inhibits mTORC1, but not completely. Autophagy 2009, 5:725-726. PMID: 19395872.
-
(2009)
Autophagy
, vol.5
, pp. 725-726
-
-
Thoreen, C.C.1
Sabatini, D.M.2
-
18
-
-
67650312583
-
Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)
-
PMID: 19402821
-
Garcia-Martinez J.M., Moran J., Clarke R.G., Gray A., Cosulich S.C., Chresta C.M., et al. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). Biochem J 2009, 421:29-42. PMID: 19402821.
-
(2009)
Biochem J
, vol.421
, pp. 29-42
-
-
Garcia-Martinez, J.M.1
Moran, J.2
Clarke, R.G.3
Gray, A.4
Cosulich, S.C.5
Chresta, C.M.6
-
19
-
-
84877761058
-
MTOR kinase structure, mechanism and regulation
-
PMID: 23636326
-
Yang H., Rudge D.G., Koos J.D., Vaidialingam B., Yang H.J., Pavletich N.P. mTOR kinase structure, mechanism and regulation. Nature 2013, 497:217-223. PMID: 23636326.
-
(2013)
Nature
, vol.497
, pp. 217-223
-
-
Yang, H.1
Rudge, D.G.2
Koos, J.D.3
Vaidialingam, B.4
Yang, H.J.5
Pavletich, N.P.6
-
20
-
-
84880709668
-
MTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin
-
PMID: 23888043
-
Kang S.A., Pacold M.E., Cervantes C.L., Lim D., Lou H.J., Ottina K., et al. mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin. Science 2013, 341:1236566. PMID: 23888043.
-
(2013)
Science
, vol.341
, pp. 1236566
-
-
Kang, S.A.1
Pacold, M.E.2
Cervantes, C.L.3
Lim, D.4
Lou, H.J.5
Ottina, K.6
-
21
-
-
84885206511
-
Rapamycin resistance: mTORC1 substrates hold some of the answers
-
PMID: 24112984
-
Yoon S.O., Roux P.P. Rapamycin resistance: mTORC1 substrates hold some of the answers. Curr Biol 2013, 23:R880-R883. PMID: 24112984.
-
(2013)
Curr Biol
, vol.23
, pp. R880-R883
-
-
Yoon, S.O.1
Roux, P.P.2
-
22
-
-
0037178786
-
MTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
PMID: 12150925
-
Kim D.H., Sarbassov D.D., Ali S.M., King J.E., Latek R.R., Erdjument-Bromage H., et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002, 110:163-175. PMID: 12150925.
-
(2002)
Cell
, vol.110
, pp. 163-175
-
-
Kim, D.H.1
Sarbassov, D.D.2
Ali, S.M.3
King, J.E.4
Latek, R.R.5
Erdjument-Bromage, H.6
-
23
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
PMID: 12150926
-
Hara K., Maruki Y., Long X., Yoshino K., Oshiro N., Hidayat S., et al. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 2002, 110:177-189. PMID: 12150926.
-
(2002)
Cell
, vol.110
, pp. 177-189
-
-
Hara, K.1
Maruki, Y.2
Long, X.3
Yoshino, K.4
Oshiro, N.5
Hidayat, S.6
-
24
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
PMID: 15467718
-
Jacinto E., Loewith R., Schmidt A., Lin S., Ruegg M.A., Hall A., et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 2004, 6:1122-1128. PMID: 15467718.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 1122-1128
-
-
Jacinto, E.1
Loewith, R.2
Schmidt, A.3
Lin, S.4
Ruegg, M.A.5
Hall, A.6
-
25
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
PMID: 15268862
-
Sarbassov D.D., Ali S.M., Kim D.H., Guertin D.A., Latek R.R., Erdjument-Bromage H., et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004, 14:1296-1302. PMID: 15268862.
-
(2004)
Curr Biol
, vol.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
Ali, S.M.2
Kim, D.H.3
Guertin, D.A.4
Latek, R.R.5
Erdjument-Bromage, H.6
-
26
-
-
0037623417
-
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
-
PMID: 12718876
-
Kim D.H., Sarbassov dos D., Ali S.M., Latek R.R., Guntur K.V., Erdjument-Bromage H., et al. GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell 2003, 11:895-904. PMID: 12718876.
-
(2003)
Mol Cell
, vol.11
, pp. 895-904
-
-
Kim, D.H.1
Sarbassov dos, D.2
Ali, S.M.3
Latek, R.R.4
Guntur, K.V.5
Erdjument-Bromage, H.6
-
27
-
-
33947264077
-
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
-
PMID: 17386266
-
Sancak Y., Thoreen C.C., Peterson T.R., Lindquist R.A., Kang S.A., Spooner E., et al. PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell 2007, 25:903-915. PMID: 17386266.
-
(2007)
Mol Cell
, vol.25
, pp. 903-915
-
-
Sancak, Y.1
Thoreen, C.C.2
Peterson, T.R.3
Lindquist, R.A.4
Kang, S.A.5
Spooner, E.6
-
28
-
-
33847397874
-
Insulin signaling to mTOR mediated by the AKT/PKB substrate PRAS40
-
PMID: 17277771
-
van der Haar E., Lee S.I., Bandhakavi S., Griffin T.J., Kim D.H. Insulin signaling to mTOR mediated by the AKT/PKB substrate PRAS40. Nat Cell Biol 2007, 9:316-323. PMID: 17277771.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 316-323
-
-
van der Haar, E.1
Lee, S.I.2
Bandhakavi, S.3
Griffin, T.J.4
Kim, D.H.5
-
29
-
-
67349241955
-
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
-
PMID: 19446321
-
Peterson T.R., Laplante M., Thoreen C.C., Sancak Y., Kang S.A., Kuehl W.M., et al. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 2009, 137:873-886. PMID: 19446321.
-
(2009)
Cell
, vol.137
, pp. 873-886
-
-
Peterson, T.R.1
Laplante, M.2
Thoreen, C.C.3
Sancak, Y.4
Kang, S.A.5
Kuehl, W.M.6
-
30
-
-
0037117409
-
Identification of a conserved motif required for mTOR signaling
-
PMID: 11967149
-
Schalm S.S., Blenis J. Identification of a conserved motif required for mTOR signaling. Curr Biol 2002, 12:632-639. PMID: 11967149.
-
(2002)
Curr Biol
, vol.12
, pp. 632-639
-
-
Schalm, S.S.1
Blenis, J.2
-
31
-
-
0037718389
-
TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
-
PMID: 12747827
-
Schalm S.S., Fingar D.C., Sabatini D.M., Blenis J. TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Curr Biol 2003, 13:797-806. PMID: 12747827.
-
(2003)
Curr Biol
, vol.13
, pp. 797-806
-
-
Schalm, S.S.1
Fingar, D.C.2
Sabatini, D.M.3
Blenis, J.4
-
32
-
-
33751348056
-
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
-
PMID: 17141160
-
Guertin D.A., Stevens D.M., Thoreen C.C., Burds A.A., Kalaany N.Y., Moffat J., et al. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell 2006, 11:859-871. PMID: 17141160.
-
(2006)
Dev Cell
, vol.11
, pp. 859-871
-
-
Guertin, D.A.1
Stevens, D.M.2
Thoreen, C.C.3
Burds, A.A.4
Kalaany, N.Y.5
Moffat, J.6
-
33
-
-
6344245674
-
Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development
-
PMID: 15485918
-
Gangloff Y.G., Mueller M., Dann S.G., Svoboda P., Sticker M., Spetz J.F., et al. Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol 2004, 24:9508-9516. PMID: 15485918.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 9508-9516
-
-
Gangloff, Y.G.1
Mueller, M.2
Dann, S.G.3
Svoboda, P.4
Sticker, M.5
Spetz, J.F.6
-
34
-
-
34547099855
-
PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding
-
PMID: 17510057
-
Wang L., Harris T.E., Roth R.A., Lawrence J.C. PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding. J Biol Chem 2007, 282:20036-20044. PMID: 17510057.
-
(2007)
J Biol Chem
, vol.282
, pp. 20036-20044
-
-
Wang, L.1
Harris, T.E.2
Roth, R.A.3
Lawrence, J.C.4
-
35
-
-
33748471980
-
MSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
-
PMID: 16919458
-
Frias M.A., Thoreen C.C., Jaffe J.D., Schroder W., Sculley T., Carr S.A., et al. mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Curr Biol 2006, 16:1865-1870. PMID: 16919458.
-
(2006)
Curr Biol
, vol.16
, pp. 1865-1870
-
-
Frias, M.A.1
Thoreen, C.C.2
Jaffe, J.D.3
Schroder, W.4
Sculley, T.5
Carr, S.A.6
-
36
-
-
33751079895
-
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
-
PMID: 17043309
-
Yang Q., Inoki K., Ikenoue T., Guan K.L. Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev 2006, 20:2820-2832. PMID: 17043309.
-
(2006)
Genes Dev
, vol.20
, pp. 2820-2832
-
-
Yang, Q.1
Inoki, K.2
Ikenoue, T.3
Guan, K.L.4
-
37
-
-
34347210090
-
Identification of Protor as a novel Rictor-binding component of mTOR complex-2
-
PMID: 17461779
-
Pearce L.R., Huang X., Boudeau J., Pawlowski R., Wullschleger S., Deak M., et al. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem J 2007, 405:513-522. PMID: 17461779.
-
(2007)
Biochem J
, vol.405
, pp. 513-522
-
-
Pearce, L.R.1
Huang, X.2
Boudeau, J.3
Pawlowski, R.4
Wullschleger, S.5
Deak, M.6
-
38
-
-
33750044112
-
Stress and mTORture signaling
-
PMID: 17041623
-
Reiling J.H., Sabatini D.M. Stress and mTORture signaling. Oncogene 2006, 25:6373-6383. PMID: 17041623.
-
(2006)
Oncogene
, vol.25
, pp. 6373-6383
-
-
Reiling, J.H.1
Sabatini, D.M.2
-
39
-
-
84055178474
-
Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks
-
PMID: 22168436
-
Magnuson B., Ekim B., Fingar D.C. Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks. Biochem J 2012, 441:1-21. PMID: 22168436.
-
(2012)
Biochem J
, vol.441
, pp. 1-21
-
-
Magnuson, B.1
Ekim, B.2
Fingar, D.C.3
-
40
-
-
79958696336
-
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
-
PMID: 21659605
-
Yu Y., Yoon S.O., Poulogiannis G., Yang Q., Ma X.M., Villen J., et al. Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 2011, 332:1322-1326. PMID: 21659605.
-
(2011)
Science
, vol.332
, pp. 1322-1326
-
-
Yu, Y.1
Yoon, S.O.2
Poulogiannis, G.3
Yang, Q.4
Ma, X.M.5
Villen, J.6
-
41
-
-
79958696694
-
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling
-
PMID: 21659604
-
Hsu P.P., Kang S.A., Rameseder J., Zhang Y., Ottina K.A., Lim D., et al. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 2011, 332:1317-1322. PMID: 21659604.
-
(2011)
Science
, vol.332
, pp. 1317-1322
-
-
Hsu, P.P.1
Kang, S.A.2
Rameseder, J.3
Zhang, Y.4
Ottina, K.A.5
Lim, D.6
-
42
-
-
34250788809
-
AKT/PKB signaling: navigating downstream
-
PMID: 17604717
-
Manning B.D., Cantley L.C. AKT/PKB signaling: navigating downstream. Cell 2007, 129:1261-1274. PMID: 17604717.
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
43
-
-
79960470913
-
MTOR complex 2 signaling and functions
-
PMID: 21670596
-
Oh W.J., Jacinto E. mTOR complex 2 signaling and functions. Cell Cycle 2011, 10:2305-2316. PMID: 21670596.
-
(2011)
Cell Cycle
, vol.10
, pp. 2305-2316
-
-
Oh, W.J.1
Jacinto, E.2
-
44
-
-
79953298958
-
Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy
-
PMID: 21490404
-
Wander S.A., Hennessy B.T., Slingerland J.M. Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy. J Clin Invest 2011, 121:1231-1241. PMID: 21490404.
-
(2011)
J Clin Invest
, vol.121
, pp. 1231-1241
-
-
Wander, S.A.1
Hennessy, B.T.2
Slingerland, J.M.3
-
45
-
-
79958026380
-
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
-
PMID: 21531565
-
Mendoza M.C., Er E.E., Blenis J. The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation. Trends Biochem Sci 2011, 36:320-328. PMID: 21531565.
-
(2011)
Trends Biochem Sci
, vol.36
, pp. 320-328
-
-
Mendoza, M.C.1
Er, E.E.2
Blenis, J.3
-
46
-
-
84865371057
-
TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1
-
PMID: 22795129
-
Dibble C.C., Elis W., Menon S., Qin W., Klekota J., Asara J.M., et al. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Mol Cell 2012, 47:535-546. PMID: 22795129.
-
(2012)
Mol Cell
, vol.47
, pp. 535-546
-
-
Dibble, C.C.1
Elis, W.2
Menon, S.3
Qin, W.4
Klekota, J.5
Asara, J.M.6
-
47
-
-
44449161481
-
The TSC1-TSC2 complex: a molecular switchboard controlling cell growth
-
PMID: 18466115
-
Huang J., Manning B.D. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J 2008, 412:179-190. PMID: 18466115.
-
(2008)
Biochem J
, vol.412
, pp. 179-190
-
-
Huang, J.1
Manning, B.D.2
-
48
-
-
0029924856
-
Insulin signal transduction and the IRS proteins
-
PMID: 8725404
-
Myers M.G., White M.F. Insulin signal transduction and the IRS proteins. Annu Rev Pharmacol Toxicol 1996, 36:615-658. PMID: 8725404.
-
(1996)
Annu Rev Pharmacol Toxicol
, vol.36
, pp. 615-658
-
-
Myers, M.G.1
White, M.F.2
-
49
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
PMID: 8978681
-
Alessi D.R., Andjelkovic M., Caudwell B., Cron P., Morrice N., Cohen P., et al. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 1996, 15:6541-6551. PMID: 8978681.
-
(1996)
EMBO J
, vol.15
, pp. 6541-6551
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, B.3
Cron, P.4
Morrice, N.5
Cohen, P.6
-
50
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
PMID: 15718470
-
Sarbassov D.D., Guertin D.A., Ali S.M., Sabatini D.M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005, 307:1098-1101. PMID: 15718470.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
51
-
-
0036342294
-
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
-
PMID: 12150915
-
Manning B.D., Tee A.R., Logsdon M.N., Blenis J., Cantley L.C. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell 2002, 10:151-162. PMID: 12150915.
-
(2002)
Mol Cell
, vol.10
, pp. 151-162
-
-
Manning, B.D.1
Tee, A.R.2
Logsdon, M.N.3
Blenis, J.4
Cantley, L.C.5
-
52
-
-
0037108750
-
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
-
PMID: 12271141
-
Tee A.R., Fingar D.C., Manning B.D., Kwiatkowski D.J., Cantley L.C., Blenis J. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci U S A 2002, 99:13571-13576. PMID: 12271141.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 13571-13576
-
-
Tee, A.R.1
Fingar, D.C.2
Manning, B.D.3
Kwiatkowski, D.J.4
Cantley, L.C.5
Blenis, J.6
-
53
-
-
18044381192
-
Rheb binds and regulates the mTOR kinase
-
PMID: 15854902
-
Long X., Lin Y., Ortiz-Vega S., Yonezawa K., Avruch J. Rheb binds and regulates the mTOR kinase. Curr Biol 2005, 15:702-713. PMID: 15854902.
-
(2005)
Curr Biol
, vol.15
, pp. 702-713
-
-
Long, X.1
Lin, Y.2
Ortiz-Vega, S.3
Yonezawa, K.4
Avruch, J.5
-
54
-
-
47049127002
-
Regulation of proline-rich Akt substrate of 40kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation
-
PMID: 18372248
-
Wang L., Harris T.E., Lawrence J.C. Regulation of proline-rich Akt substrate of 40kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation. J Biol Chem 2008, 283:15619-15627. PMID: 18372248.
-
(2008)
J Biol Chem
, vol.283
, pp. 15619-15627
-
-
Wang, L.1
Harris, T.E.2
Lawrence, J.C.3
-
55
-
-
67649344456
-
Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR
-
PMID: 19346248
-
Wang L., Lawrence J.C., Sturgill T.W., Harris T.E. Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR. J Biol Chem 2009, 284:14693-14697. PMID: 19346248.
-
(2009)
J Biol Chem
, vol.284
, pp. 14693-14697
-
-
Wang, L.1
Lawrence, J.C.2
Sturgill, T.W.3
Harris, T.E.4
-
56
-
-
73649098283
-
Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation
-
PMID: 19864431
-
Foster K.G., Acosta-Jaquez H.A., Romeo Y., Ekim B., Soliman G.A., Carriere A., et al. Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation. J Biol Chem 2010, 285:80-94. PMID: 19864431.
-
(2010)
J Biol Chem
, vol.285
, pp. 80-94
-
-
Foster, K.G.1
Acosta-Jaquez, H.A.2
Romeo, Y.3
Ekim, B.4
Soliman, G.A.5
Carriere, A.6
-
57
-
-
67651210833
-
Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth
-
PMID: 19487463
-
Acosta-Jaquez H.A., Keller J.A., Foster K.G., Ekim B., Soliman G.A., Feener E.P., et al. Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth. Mol Cell Biol 2009, 29:4308-4324. PMID: 19487463.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 4308-4324
-
-
Acosta-Jaquez, H.A.1
Keller, J.A.2
Foster, K.G.3
Ekim, B.4
Soliman, G.A.5
Feener, E.P.6
-
58
-
-
79960349522
-
MTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression
-
PMID: 21576368
-
Ekim B., Magnuson B., Acosta-Jaquez H.A., Keller J.A., Feener E.P., Fingar D.C. mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression. Mol Cell Biol 2011, 31:2787-2801. PMID: 21576368.
-
(2011)
Mol Cell Biol
, vol.31
, pp. 2787-2801
-
-
Ekim, B.1
Magnuson, B.2
Acosta-Jaquez, H.A.3
Keller, J.A.4
Feener, E.P.5
Fingar, D.C.6
-
59
-
-
84912107811
-
Akt-dependent activation of mTORC1 involves phosphorylation of mTOR by IKKa
-
PMID: 24990947
-
Dan H.C., Ebbs A., Pasparakis M., Van Dyke T., Basseres D.S., Baldwin A.S. Akt-dependent activation of mTORC1 involves phosphorylation of mTOR by IKKa. J Biol Chem 2014, PMID: 24990947.
-
(2014)
J Biol Chem
-
-
Dan, H.C.1
Ebbs, A.2
Pasparakis, M.3
Van Dyke, T.4
Basseres, D.S.5
Baldwin, A.S.6
-
60
-
-
84874093507
-
Toward a comprehensive characterization of a human cancer cell phosphoproteome
-
PMID: 23186163
-
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., et al. Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 2013, 12:260-271. PMID: 23186163.
-
(2013)
J Proteome Res
, vol.12
, pp. 260-271
-
-
Zhou, H.1
Di Palma, S.2
Preisinger, C.3
Peng, M.4
Polat, A.N.5
Heck, A.J.6
-
61
-
-
17444431201
-
Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis
-
PMID: 15851026
-
Ma L., Chen Z., Erdjument-Bromage H., Tempst P., Pandolfi P.P. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 2005, 121:179-193. PMID: 15851026.
-
(2005)
Cell
, vol.121
, pp. 179-193
-
-
Ma, L.1
Chen, Z.2
Erdjument-Bromage, H.3
Tempst, P.4
Pandolfi, P.P.5
-
62
-
-
4544384577
-
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
-
PMID: 15342917
-
Roux P.P., Ballif B.A., Anjum R., Gygi S.P., Blenis J. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci U S A 2004, 101:13489-13494. PMID: 15342917.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 13489-13494
-
-
Roux, P.P.1
Ballif, B.A.2
Anjum, R.3
Gygi, S.P.4
Blenis, J.5
-
63
-
-
51049083138
-
Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation
-
PMID: 18722121
-
Carriere A., Cargnello M., Julien L.A., Gao H., Bonneil E., Thibault P., et al. Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation. Curr Biol 2008, 18:1269-1277. PMID: 18722121.
-
(2008)
Curr Biol
, vol.18
, pp. 1269-1277
-
-
Carriere, A.1
Cargnello, M.2
Julien, L.A.3
Gao, H.4
Bonneil, E.5
Thibault, P.6
-
64
-
-
78650943298
-
ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1)
-
PMID: 21071439
-
Carriere A., Romeo Y., Acosta-Jaquez H.A., Moreau J., Bonneil E., Thibault P., et al. ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1). J Biol Chem 2011, 286:567-577. PMID: 21071439.
-
(2011)
J Biol Chem
, vol.286
, pp. 567-577
-
-
Carriere, A.1
Romeo, Y.2
Acosta-Jaquez, H.A.3
Moreau, J.4
Bonneil, E.5
Thibault, P.6
-
65
-
-
58649092475
-
MTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
-
PMID: 18925875
-
Garcia-Martinez J.M., Alessi D.R. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem J 2008, 416:375-385. PMID: 18925875.
-
(2008)
Biochem J
, vol.416
, pp. 375-385
-
-
Garcia-Martinez, J.M.1
Alessi, D.R.2
-
66
-
-
44949215822
-
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
-
PMID: 18411301
-
Huang J., Dibble C.C., Matsuzaki M., Manning B.D. The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol 2008, 28:4104-4115. PMID: 18411301.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 4104-4115
-
-
Huang, J.1
Dibble, C.C.2
Matsuzaki, M.3
Manning, B.D.4
-
67
-
-
79953307234
-
Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size
-
PMID: 21474067
-
Saci A., Cantley L.C., Carpenter C.L. Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size. Mol Cell 2011, 42:50-61. PMID: 21474067.
-
(2011)
Mol Cell
, vol.42
, pp. 50-61
-
-
Saci, A.1
Cantley, L.C.2
Carpenter, C.L.3
-
68
-
-
33749076673
-
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
-
PMID: 16962653
-
Jacinto E., Facchinetti V., Liu D., Soto N., Wei S., Jung S.Y., et al. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 2006, 127:125-137. PMID: 16962653.
-
(2006)
Cell
, vol.127
, pp. 125-137
-
-
Jacinto, E.1
Facchinetti, V.2
Liu, D.3
Soto, N.4
Wei, S.5
Jung, S.Y.6
-
69
-
-
78649712949
-
MTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
-
PMID: 21045808
-
Oh W.J., Wu C.C., Kim S.J., Facchinetti V., Julien L.A., Finlan M., et al. mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J 2010, 29:3939-3951. PMID: 21045808.
-
(2010)
EMBO J
, vol.29
, pp. 3939-3951
-
-
Oh, W.J.1
Wu, C.C.2
Kim, S.J.3
Facchinetti, V.4
Julien, L.A.5
Finlan, M.6
-
70
-
-
79952293503
-
Activation of mTORC2 by association with the ribosome
-
PMID: 21376236
-
Zinzalla V., Stracka D., Oppliger W., Hall M.N. Activation of mTORC2 by association with the ribosome. Cell 2011, 144:757-768. PMID: 21376236.
-
(2011)
Cell
, vol.144
, pp. 757-768
-
-
Zinzalla, V.1
Stracka, D.2
Oppliger, W.3
Hall, M.N.4
-
71
-
-
47949125486
-
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
-
PMID: 18566586
-
Facchinetti V., Ouyang W., Wei H., Soto N., Lazorchak A., Gould C., et al. The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J 2008, 27:1932-1943. PMID: 18566586.
-
(2008)
EMBO J
, vol.27
, pp. 1932-1943
-
-
Facchinetti, V.1
Ouyang, W.2
Wei, H.3
Soto, N.4
Lazorchak, A.5
Gould, C.6
-
72
-
-
47949104258
-
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
-
PMID: 18566587
-
Ikenoue T., Inoki K., Yang Q., Zhou X., Guan K.L. Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J 2008, 27:1919-1931. PMID: 18566587.
-
(2008)
EMBO J
, vol.27
, pp. 1919-1931
-
-
Ikenoue, T.1
Inoki, K.2
Yang, Q.3
Zhou, X.4
Guan, K.L.5
-
73
-
-
84881098989
-
Feature article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology
-
PMID: 23852728
-
Betz C., Stracka D., Prescianotto-Baschong C., Frieden M., Demaurex N., Hall M.N. Feature article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology. Proc Natl Acad Sci U S A 2013, 110:12526-12534. PMID: 23852728.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 12526-12534
-
-
Betz, C.1
Stracka, D.2
Prescianotto-Baschong, C.3
Frieden, M.4
Demaurex, N.5
Hall, M.N.6
-
74
-
-
4544343980
-
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
-
PMID: 15380067
-
Shah O.J., Wang Z., Hunter T. Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr Biol 2004, 14:1650-1656. PMID: 15380067.
-
(2004)
Curr Biol
, vol.14
, pp. 1650-1656
-
-
Shah, O.J.1
Wang, Z.2
Hunter, T.3
-
75
-
-
3342958797
-
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
-
PMID: 15249583
-
Harrington L.S., Findlay G.M., Gray A., Tolkacheva T., Wigfield S., Rebholz H., et al. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol 2004, 166:213-223. PMID: 15249583.
-
(2004)
J Cell Biol
, vol.166
, pp. 213-223
-
-
Harrington, L.S.1
Findlay, G.M.2
Gray, A.3
Tolkacheva, T.4
Wigfield, S.5
Rebholz, H.6
-
76
-
-
84871703377
-
MTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8
-
PMID: 23142081
-
Kim S.J., DeStefano M.A., Oh W.J., Wu C.C., Vega-Cotto N.M., Finlan M., et al. mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8. Mol Cell 2012, 48:875-887. PMID: 23142081.
-
(2012)
Mol Cell
, vol.48
, pp. 875-887
-
-
Kim, S.J.1
DeStefano, M.A.2
Oh, W.J.3
Wu, C.C.4
Vega-Cotto, N.M.5
Finlan, M.6
-
77
-
-
77953763269
-
Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2
-
PMID: 20501647
-
Boulbes D., Chen C.H., Shaikenov T., Agarwal N.K., Peterson T.R., Addona T.A., et al. Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2. Mol Cancer Res 2010, 8:896-906. PMID: 20501647.
-
(2010)
Mol Cancer Res
, vol.8
, pp. 896-906
-
-
Boulbes, D.1
Chen, C.H.2
Shaikenov, T.3
Agarwal, N.K.4
Peterson, T.R.5
Addona, T.A.6
-
78
-
-
70350545722
-
Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1
-
PMID: 19720745
-
Dibble C.C., Asara J.M., Manning B.D. Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Mol Cell Biol 2009, 29:5657-5670. PMID: 19720745.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 5657-5670
-
-
Dibble, C.C.1
Asara, J.M.2
Manning, B.D.3
-
79
-
-
75749105049
-
MTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling
-
PMID: 19995915
-
Julien L.A., Carriere A., Moreau J., Roux P.P. mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. Mol Cell Biol 2010, 30:908-921. PMID: 19995915.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 908-921
-
-
Julien, L.A.1
Carriere, A.2
Moreau, J.3
Roux, P.P.4
-
80
-
-
77149163803
-
Rictor is a novel target of p70 S6 kinase-1
-
PMID: 19935711
-
Treins C., Warne P.H., Magnuson M.A., Pende M., Downward J. Rictor is a novel target of p70 S6 kinase-1. Oncogene 2010, 29:1003-1016. PMID: 19935711.
-
(2010)
Oncogene
, vol.29
, pp. 1003-1016
-
-
Treins, C.1
Warne, P.H.2
Magnuson, M.A.3
Pende, M.4
Downward, J.5
-
81
-
-
0030021524
-
TOR controls translation initiation and early G1 progression in yeast
-
PMID: 8741837
-
Barbet N.C., Schneider U., Helliwell S.B., Stansfield I., Tuite M.F., Hall M.N. TOR controls translation initiation and early G1 progression in yeast. Mol Biol Cell 1996, 7:25-42. PMID: 8741837.
-
(1996)
Mol Biol Cell
, vol.7
, pp. 25-42
-
-
Barbet, N.C.1
Schneider, U.2
Helliwell, S.B.3
Stansfield, I.4
Tuite, M.F.5
Hall, M.N.6
-
82
-
-
0032486268
-
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
-
PMID: 9603962
-
Hara K., Yonezawa K., Weng Q.P., Kozlowski M.T., Belham C., Avruch J. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem 1998, 273:14484-14494. PMID: 9603962.
-
(1998)
J Biol Chem
, vol.273
, pp. 14484-14494
-
-
Hara, K.1
Yonezawa, K.2
Weng, Q.P.3
Kozlowski, M.T.4
Belham, C.5
Avruch, J.6
-
83
-
-
45849105156
-
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
-
PMID: 18497260
-
Sancak Y., Peterson T.R., Shaul Y.D., Lindquist R.A., Thoreen C.C., Bar-Peled L., et al. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 2008, 320:1496-1501. PMID: 18497260.
-
(2008)
Science
, vol.320
, pp. 1496-1501
-
-
Sancak, Y.1
Peterson, T.R.2
Shaul, Y.D.3
Lindquist, R.A.4
Thoreen, C.C.5
Bar-Peled, L.6
-
84
-
-
48649085816
-
Regulation of TORC1 by Rag GTPases in nutrient response
-
PMID: 18604198
-
Kim E., Goraksha-Hicks P., Li L., Neufeld T.P., Guan K.L. Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol 2008, 10:935-945. PMID: 18604198.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 935-945
-
-
Kim, E.1
Goraksha-Hicks, P.2
Li, L.3
Neufeld, T.P.4
Guan, K.L.5
-
85
-
-
77951768486
-
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
-
PMID: 20381137
-
Sancak Y., Bar-Peled L., Zoncu R., Markhard A.L., Nada S., Sabatini D.M. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 2010, 141:290-303. PMID: 20381137.
-
(2010)
Cell
, vol.141
, pp. 290-303
-
-
Sancak, Y.1
Bar-Peled, L.2
Zoncu, R.3
Markhard, A.L.4
Nada, S.5
Sabatini, D.M.6
-
86
-
-
84866431363
-
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1
-
PMID: 22980980
-
Bar-Peled L., Schweitzer L.D., Zoncu R., Sabatini D.M. Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell 2012, 150:1196-1208. PMID: 22980980.
-
(2012)
Cell
, vol.150
, pp. 1196-1208
-
-
Bar-Peled, L.1
Schweitzer, L.D.2
Zoncu, R.3
Sabatini, D.M.4
-
87
-
-
84878357685
-
A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1
-
PMID: 23723238
-
Bar-Peled L., Chantranupong L., Cherniack A.D., Chen W.W., Ottina K.A., Grabiner B.C., et al. A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science 2013, 340:1100-1106. PMID: 23723238.
-
(2013)
Science
, vol.340
, pp. 1100-1106
-
-
Bar-Peled, L.1
Chantranupong, L.2
Cherniack, A.D.3
Chen, W.W.4
Ottina, K.A.5
Grabiner, B.C.6
-
88
-
-
84886871016
-
Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases
-
PMID: 24081491
-
Petit C.S., Roczniak-Ferguson A., Ferguson S.M. Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases. J Cell Biol 2013, 202:1107-1122. PMID: 24081491.
-
(2013)
J Cell Biol
, vol.202
, pp. 1107-1122
-
-
Petit, C.S.1
Roczniak-Ferguson, A.2
Ferguson, S.M.3
-
89
-
-
84888200442
-
The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1
-
PMID: 24095279
-
Tsun Z.Y., Bar-Peled L., Chantranupong L., Zoncu R., Wang T., Kim C., et al. The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell 2013, 52:495-505. PMID: 24095279.
-
(2013)
Mol Cell
, vol.52
, pp. 495-505
-
-
Tsun, Z.Y.1
Bar-Peled, L.2
Chantranupong, L.3
Zoncu, R.4
Wang, T.5
Kim, C.6
-
90
-
-
80555143078
-
MTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase
-
PMID: 22053050
-
Zoncu R., Bar-Peled L., Efeyan A., Wang S., Sancak Y., Sabatini D.M. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science 2011, 334:678-683. PMID: 22053050.
-
(2011)
Science
, vol.334
, pp. 678-683
-
-
Zoncu, R.1
Bar-Peled, L.2
Efeyan, A.3
Wang, S.4
Sancak, Y.5
Sabatini, D.M.6
-
91
-
-
25444457577
-
HVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
-
PMID: 16049009
-
Byfield M.P., Murray J.T., Backer J.M. hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J Biol Chem 2005, 280:33076-33082. PMID: 16049009.
-
(2005)
J Biol Chem
, vol.280
, pp. 33076-33082
-
-
Byfield, M.P.1
Murray, J.T.2
Backer, J.M.3
-
92
-
-
26444575415
-
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
-
PMID: 16176982
-
Nobukuni T., Joaquin M., Roccio M., Dann S.G., Kim S.Y., Gulati P., et al. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci U S A 2005, 102:14238-14243. PMID: 16176982.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 14238-14243
-
-
Nobukuni, T.1
Joaquin, M.2
Roccio, M.3
Dann, S.G.4
Kim, S.Y.5
Gulati, P.6
-
93
-
-
84855731134
-
Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway
-
PMID: 22024166
-
Yoon M.S., Du G., Backer J.M., Frohman M.A., Chen J. Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway. J Cell Biol 2011, 195:435-447. PMID: 22024166.
-
(2011)
J Cell Biol
, vol.195
, pp. 435-447
-
-
Yoon, M.S.1
Du, G.2
Backer, J.M.3
Frohman, M.A.4
Chen, J.5
-
94
-
-
58049216316
-
RalA functions as an indispensable signal mediator for the nutrient-sensing system
-
PMID: 18948269
-
Maehama T., Tanaka M., Nishina H., Murakami M., Kanaho Y., Hanada K. RalA functions as an indispensable signal mediator for the nutrient-sensing system. J Biol Chem 2008, 283:35053-35059. PMID: 18948269.
-
(2008)
J Biol Chem
, vol.283
, pp. 35053-35059
-
-
Maehama, T.1
Tanaka, M.2
Nishina, H.3
Murakami, M.4
Kanaho, Y.5
Hanada, K.6
-
95
-
-
79551565620
-
Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase
-
PMID: 21284988
-
Kim S., Kim S.F., Maag D., Maxwell M.J., Resnick A.C., Juluri K.R., et al. Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase. Cell Metab 2011, 13:215-221. PMID: 21284988.
-
(2011)
Cell Metab
, vol.13
, pp. 215-221
-
-
Kim, S.1
Kim, S.F.2
Maag, D.3
Maxwell, M.J.4
Resnick, A.C.5
Juluri, K.R.6
-
96
-
-
84862777407
-
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
-
PMID: 22424946
-
Han J.M., Jeong S.J., Park M.C., Kim G., Kwon N.H., Kim H.K., et al. Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 2012, 149:410-424. PMID: 22424946.
-
(2012)
Cell
, vol.149
, pp. 410-424
-
-
Han, J.M.1
Jeong, S.J.2
Park, M.C.3
Kim, G.4
Kwon, N.H.5
Kim, H.K.6
-
97
-
-
84859704385
-
Leucyl-tRNA synthetase controls TORC1 via the EGO complex
-
PMID: 22424774
-
Bonfils G., Jaquenoud M., Bontron S., Ostrowicz C., Ungermann C., De Virgilio C. Leucyl-tRNA synthetase controls TORC1 via the EGO complex. Mol Cell 2012, 46:105-110. PMID: 22424774.
-
(2012)
Mol Cell
, vol.46
, pp. 105-110
-
-
Bonfils, G.1
Jaquenoud, M.2
Bontron, S.3
Ostrowicz, C.4
Ungermann, C.5
De Virgilio, C.6
-
98
-
-
80053586265
-
P62 is a key regulator of nutrient sensing in the mTORC1 pathway
-
PMID: 21981924
-
Duran A., Amanchy R., Linares J.F., Joshi J., Abu-Baker S., Porollo A., et al. p62 is a key regulator of nutrient sensing in the mTORC1 pathway. Mol Cell 2011, 44:134-146. PMID: 21981924.
-
(2011)
Mol Cell
, vol.44
, pp. 134-146
-
-
Duran, A.1
Amanchy, R.2
Linares, J.F.3
Joshi, J.4
Abu-Baker, S.5
Porollo, A.6
-
99
-
-
84881553725
-
K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells
-
PMID: 23911927
-
Linares J.F., Duran A., Yajima T., Pasparakis M., Moscat J., Diaz-Meco M.T. K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells. Mol Cell 2013, 51:283-296. PMID: 23911927.
-
(2013)
Mol Cell
, vol.51
, pp. 283-296
-
-
Linares, J.F.1
Duran, A.2
Yajima, T.3
Pasparakis, M.4
Moscat, J.5
Diaz-Meco, M.T.6
-
100
-
-
34147141941
-
A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling
-
PMID: 17253963
-
Findlay G.M., Yan L., Procter J., Mieulet V., Lamb R.F. A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling. Biochem J 2007, 403:13-20. PMID: 17253963.
-
(2007)
Biochem J
, vol.403
, pp. 13-20
-
-
Findlay, G.M.1
Yan, L.2
Procter, J.3
Mieulet, V.4
Lamb, R.F.5
-
101
-
-
77955055166
-
MAP4K3 regulates body size and metabolism in Drosophila
-
PMID: 20457147
-
Bryk B., Hahn K., Cohen S.M., Teleman A.A. MAP4K3 regulates body size and metabolism in Drosophila. Dev Biol 2010, 344:150-157. PMID: 20457147.
-
(2010)
Dev Biol
, vol.344
, pp. 150-157
-
-
Bryk, B.1
Hahn, K.2
Cohen, S.M.3
Teleman, A.A.4
-
102
-
-
77649269312
-
PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR
-
PMID: 20227368
-
Yan L., Mieulet V., Burgess D., Findlay G.M., Sully K., Procter J., et al. PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR. Mol Cell 2010, 37:633-642. PMID: 20227368.
-
(2010)
Mol Cell
, vol.37
, pp. 633-642
-
-
Yan, L.1
Mieulet, V.2
Burgess, D.3
Findlay, G.M.4
Sully, K.5
Procter, J.6
-
103
-
-
84863009605
-
SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling
-
PMID: 22575674
-
Kim Y.M., Stone M., Hwang T.H., Kim Y.G., Dunlevy J.R., Griffin T.J., et al. SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling. Mol Cell 2012, 46:833-846. PMID: 22575674.
-
(2012)
Mol Cell
, vol.46
, pp. 833-846
-
-
Kim, Y.M.1
Stone, M.2
Hwang, T.H.3
Kim, Y.G.4
Dunlevy, J.R.5
Griffin, T.J.6
-
104
-
-
59049087460
-
Bidirectional transport of amino acids regulates mTOR and autophagy
-
PMID: 19203585
-
Nicklin P., Bergman P., Zhang B., Triantafellow E., Wang H., Nyfeler B., et al. Bidirectional transport of amino acids regulates mTOR and autophagy. Cell 2009, 136:521-534. PMID: 19203585.
-
(2009)
Cell
, vol.136
, pp. 521-534
-
-
Nicklin, P.1
Bergman, P.2
Zhang, B.3
Triantafellow, E.4
Wang, H.5
Nyfeler, B.6
-
105
-
-
84864931233
-
Glutaminolysis activates Rag-mTORC1 signaling
-
PMID: 22749528
-
Duran R.V., Oppliger W., Robitaille A.M., Heiserich L., Skendaj R., Gottlieb E., et al. Glutaminolysis activates Rag-mTORC1 signaling. Mol Cell 2012, 47:349-358. PMID: 22749528.
-
(2012)
Mol Cell
, vol.47
, pp. 349-358
-
-
Duran, R.V.1
Oppliger, W.2
Robitaille, A.M.3
Heiserich, L.4
Skendaj, R.5
Gottlieb, E.6
-
106
-
-
84877720366
-
The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4
-
PMID: 23663782
-
Csibi A., Fendt S.M., Li C., Poulogiannis G., Choo A.Y., Chapski D.J., et al. The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell 2013, 153:840-854. PMID: 23663782.
-
(2013)
Cell
, vol.153
, pp. 840-854
-
-
Csibi, A.1
Fendt, S.M.2
Li, C.3
Poulogiannis, G.4
Choo, A.Y.5
Chapski, D.J.6
-
107
-
-
21244480367
-
The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses
-
PMID: 15772076
-
Smith E.M., Finn S.G., Tee A.R., Browne G.J., Proud C.G. The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. J Biol Chem 2005, 280:18717-18727. PMID: 15772076.
-
(2005)
J Biol Chem
, vol.280
, pp. 18717-18727
-
-
Smith, E.M.1
Finn, S.G.2
Tee, A.R.3
Browne, G.J.4
Proud, C.G.5
-
108
-
-
32244435285
-
Regulation of the small GTPase Rheb by amino acids
-
PMID: 16170341
-
Roccio M., Bos J.L., Zwartkruis F.J. Regulation of the small GTPase Rheb by amino acids. Oncogene 2006, 25:657-664. PMID: 16170341.
-
(2006)
Oncogene
, vol.25
, pp. 657-664
-
-
Roccio, M.1
Bos, J.L.2
Zwartkruis, F.J.3
-
109
-
-
0036712905
-
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
-
PMID: 12172555
-
Gao X., Zhang Y., Arrazola P., Hino O., Kobayashi T., Yeung R.S., et al. Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat Cell Biol 2002, 4:699-704. PMID: 12172555.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 699-704
-
-
Gao, X.1
Zhang, Y.2
Arrazola, P.3
Hino, O.4
Kobayashi, T.5
Yeung, R.S.6
-
110
-
-
84894212463
-
Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2
-
PMID: 24529380
-
Demetriades C., Doumpas N., Teleman A.A. Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2. Cell 2014, 156:786-799. PMID: 24529380.
-
(2014)
Cell
, vol.156
, pp. 786-799
-
-
Demetriades, C.1
Doumpas, N.2
Teleman, A.A.3
-
111
-
-
84894114029
-
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome
-
PMID: 24529379
-
Menon S., Dibble C.C., Talbott G., Hoxhaj G., Valvezan A.J., Takahashi H., et al. Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Cell 2014, 156:771-785. PMID: 24529379.
-
(2014)
Cell
, vol.156
, pp. 771-785
-
-
Menon, S.1
Dibble, C.C.2
Talbott, G.3
Hoxhaj, G.4
Valvezan, A.J.5
Takahashi, H.6
-
112
-
-
46149098447
-
Phospholipase D1 is an effector of Rheb in the mTOR pathway
-
PMID: 18550814
-
Sun Y., Fang Y., Yoon M.S., Zhang C., Roccio M., Zwartkruis F.J., et al. Phospholipase D1 is an effector of Rheb in the mTOR pathway. Proc Natl Acad Sci U S A 2008, 105:8286-8291. PMID: 18550814.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 8286-8291
-
-
Sun, Y.1
Fang, Y.2
Yoon, M.S.3
Zhang, C.4
Roccio, M.5
Zwartkruis, F.J.6
-
113
-
-
0035976615
-
Phosphatidic acid-mediated mitogenic activation of mTOR signaling
-
PMID: 11729323
-
Fang Y., Vilella-Bach M., Bachmann R., Flanigan A., Chen J. Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science 2001, 294:1942-1945. PMID: 11729323.
-
(2001)
Science
, vol.294
, pp. 1942-1945
-
-
Fang, Y.1
Vilella-Bach, M.2
Bachmann, R.3
Flanigan, A.4
Chen, J.5
-
114
-
-
33846438568
-
Regulation of mTOR by phosphatidic acid?
-
PMID: 17210675
-
Foster D.A. Regulation of mTOR by phosphatidic acid?. Cancer Res 2007, 67:1-4. PMID: 17210675.
-
(2007)
Cancer Res
, vol.67
, pp. 1-4
-
-
Foster, D.A.1
-
115
-
-
54149107123
-
MTOR signaling: PLD takes center stage
-
PMID: 18927511
-
Sun Y., Chen J. mTOR signaling: PLD takes center stage. Cell Cycle 2008, 7:3118-3123. PMID: 18927511.
-
(2008)
Cell Cycle
, vol.7
, pp. 3118-3123
-
-
Sun, Y.1
Chen, J.2
-
116
-
-
80051917141
-
Phosphatidic acid activates mammalian target of rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an allosteric effect
-
PMID: 21737445
-
Yoon M.S., Sun Y., Arauz E., Jiang Y., Chen J. Phosphatidic acid activates mammalian target of rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an allosteric effect. J Biol Chem 2011, 286:29568-29574. PMID: 21737445.
-
(2011)
J Biol Chem
, vol.286
, pp. 29568-29574
-
-
Yoon, M.S.1
Sun, Y.2
Arauz, E.3
Jiang, Y.4
Chen, J.5
-
117
-
-
84905967489
-
Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mTOR
-
PMID: 24990952
-
Foster D.A., Salloum D., Menon D., Frias M. Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mTOR. J Biol Chem 2014, 289:22583-22588. PMID: 24990952.
-
(2014)
J Biol Chem
, vol.289
, pp. 22583-22588
-
-
Foster, D.A.1
Salloum, D.2
Menon, D.3
Frias, M.4
-
118
-
-
84876812269
-
Signals from the lysosome: a control centre for cellular clearance and energy metabolism
-
PMID: 23609508
-
Settembre C., Fraldi A., Medina D.L., Ballabio A. Signals from the lysosome: a control centre for cellular clearance and energy metabolism. Nat Rev Mol Cell Biol 2013, 14:283-296. PMID: 23609508.
-
(2013)
Nat Rev Mol Cell Biol
, vol.14
, pp. 283-296
-
-
Settembre, C.1
Fraldi, A.2
Medina, D.L.3
Ballabio, A.4
-
119
-
-
84857997408
-
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
-
PMID: 22343943
-
Settembre C., Zoncu R., Medina D.L., Vetrini F., Erdin S., Erdin S., et al. A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J 2012, 31:1095-1108. PMID: 22343943.
-
(2012)
EMBO J
, vol.31
, pp. 1095-1108
-
-
Settembre, C.1
Zoncu, R.2
Medina, D.L.3
Vetrini, F.4
Erdin, S.5
Erdin, S.6
-
120
-
-
84862539692
-
The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis
-
PMID: 22692423
-
Roczniak-Ferguson A., Petit C.S., Froehlich F., Qian S., Ky J., Angarola B., et al. The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis. Sci Signal 2012, 5:ra42. PMID: 22692423.
-
(2012)
Sci Signal
, vol.5
, pp. ra42
-
-
Roczniak-Ferguson, A.1
Petit, C.S.2
Froehlich, F.3
Qian, S.4
Ky, J.5
Angarola, B.6
-
121
-
-
84874352229
-
Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes
-
PMID: 23401004
-
Martina J.A., Puertollano R. Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes. J Cell Biol 2013, 200:475-491. PMID: 23401004.
-
(2013)
J Cell Biol
, vol.200
, pp. 475-491
-
-
Martina, J.A.1
Puertollano, R.2
-
122
-
-
84885105969
-
A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS
-
PMID: 23955302
-
Zhang J., Kim J., Alexander A., Cai S., Tripathi D.N., Dere R., et al. A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nat Cell Biol 2013, 15:1186-1196. PMID: 23955302.
-
(2013)
Nat Cell Biol
, vol.15
, pp. 1186-1196
-
-
Zhang, J.1
Kim, J.2
Alexander, A.3
Cai, S.4
Tripathi, D.N.5
Dere, R.6
-
123
-
-
84885138286
-
TSC on the peroxisome controls mTORC1
-
PMID: 24084861
-
Benjamin D., Hall M.N. TSC on the peroxisome controls mTORC1. Nat Cell Biol 2013, 15:1135-1136. PMID: 24084861.
-
(2013)
Nat Cell Biol
, vol.15
, pp. 1135-1136
-
-
Benjamin, D.1
Hall, M.N.2
-
124
-
-
84864751451
-
Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1
-
PMID: 22696681
-
Bridges D., Ma J.T., Park S., Inoki K., Weisman L.S., Saltiel A.R. Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1. Mol Biol Cell 2012, 23:2955-2962. PMID: 22696681.
-
(2012)
Mol Biol Cell
, vol.23
, pp. 2955-2962
-
-
Bridges, D.1
Ma, J.T.2
Park, S.3
Inoki, K.4
Weisman, L.S.5
Saltiel, A.R.6
-
125
-
-
84898726041
-
Roles for PI(3,5)P2 in nutrient sensing through TORC1
-
PMID: 24478451
-
Jin N., Mao K., Jin Y., Tevzadze G., Kauffman E.J., Park S., et al. Roles for PI(3,5)P2 in nutrient sensing through TORC1. Mol Biol Cell 2014, 25:1171-1185. PMID: 24478451.
-
(2014)
Mol Biol Cell
, vol.25
, pp. 1171-1185
-
-
Jin, N.1
Mao, K.2
Jin, Y.3
Tevzadze, G.4
Kauffman, E.J.5
Park, S.6
-
126
-
-
77649140362
-
The late endosome is essential for mTORC1 signaling
-
PMID: 20053679
-
Flinn R.J., Yan Y., Goswami S., Parker P.J., Backer J.M. The late endosome is essential for mTORC1 signaling. Mol Biol Cell 2010, 21:833-841. PMID: 20053679.
-
(2010)
Mol Biol Cell
, vol.21
, pp. 833-841
-
-
Flinn, R.J.1
Yan, Y.2
Goswami, S.3
Parker, P.J.4
Backer, J.M.5
-
127
-
-
84862275111
-
Rab5 proteins regulate activation and localization of target of rapamycin complex 1
-
PMID: 22547071
-
Bridges D., Fisher K., Zolov S.N., Xiong T., Inoki K., Weisman L.S., et al. Rab5 proteins regulate activation and localization of target of rapamycin complex 1. J Biol Chem 2012, 287:20913-20921. PMID: 22547071.
-
(2012)
J Biol Chem
, vol.287
, pp. 20913-20921
-
-
Bridges, D.1
Fisher, K.2
Zolov, S.N.3
Xiong, T.4
Inoki, K.5
Weisman, L.S.6
-
128
-
-
84858782079
-
AMPK: a nutrient and energy sensor that maintains energy homeostasis
-
PMID: 22436748
-
Hardie D.G., Ross F.A., Hawley S.A. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 2012, 13:251-262. PMID: 22436748.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 251-262
-
-
Hardie, D.G.1
Ross, F.A.2
Hawley, S.A.3
-
129
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
PMID: 14651849
-
Inoki K., Zhu T., Guan K.L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003, 115:577-590. PMID: 14651849.
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
130
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
PMID: 18439900
-
Gwinn D.M., Shackelford D.B., Egan D.F., Mihaylova M.M., Mery A., Vasquez D.S., et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 2008, 30:214-226. PMID: 18439900.
-
(2008)
Mol Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
-
131
-
-
80052511813
-
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
-
PMID: 21892142
-
Mihaylova M.M., Shaw R.J. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 2011, 13:1016-1023. PMID: 21892142.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 1016-1023
-
-
Mihaylova, M.M.1
Shaw, R.J.2
-
132
-
-
0036118562
-
Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis
-
PMID: 11884613
-
Shoshani T., Faerman A., Mett I., Zelin E., Tenne T., Gorodin S., et al. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol Cell Biol 2002, 22:2283-2293. PMID: 11884613.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 2283-2293
-
-
Shoshani, T.1
Faerman, A.2
Mett, I.3
Zelin, E.4
Tenne, T.5
Gorodin, S.6
-
133
-
-
10044276784
-
The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila
-
PMID: 15545626
-
Reiling J.H., Hafen E. The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. Genes Dev 2004, 18:2879-2892. PMID: 15545626.
-
(2004)
Genes Dev
, vol.18
, pp. 2879-2892
-
-
Reiling, J.H.1
Hafen, E.2
-
134
-
-
84861845402
-
The updated biology of hypoxia-inducible factor
-
PMID: 22562152
-
Greer S.N., Metcalf J.L., Wang Y., Ohh M. The updated biology of hypoxia-inducible factor. EMBO J 2012, 31:2448-2460. PMID: 22562152.
-
(2012)
EMBO J
, vol.31
, pp. 2448-2460
-
-
Greer, S.N.1
Metcalf, J.L.2
Wang, Y.3
Ohh, M.4
-
135
-
-
10044276783
-
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
-
PMID: 15545625
-
Brugarolas J., Lei K., Hurley R.L., Manning B.D., Reiling J.H., Hafen E., et al. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev 2004, 18:2893-2904. PMID: 15545625.
-
(2004)
Genes Dev
, vol.18
, pp. 2893-2904
-
-
Brugarolas, J.1
Lei, K.2
Hurley, R.L.3
Manning, B.D.4
Reiling, J.H.5
Hafen, E.6
-
136
-
-
38349056675
-
Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
-
PMID: 18198340
-
DeYoung M.P., Horak P., Sofer A., Sgroi D., Ellisen L.W. Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev 2008, 22:239-251. PMID: 18198340.
-
(2008)
Genes Dev
, vol.22
, pp. 239-251
-
-
DeYoung, M.P.1
Horak, P.2
Sofer, A.3
Sgroi, D.4
Ellisen, L.W.5
-
137
-
-
84883387793
-
Targeting the unfolded protein response in disease
-
PMID: 23989796
-
Hetz C., Chevet E., Harding H.P. Targeting the unfolded protein response in disease. Nat Rev Drug Discov 2013, 12:703-719. PMID: 23989796.
-
(2013)
Nat Rev Drug Discov
, vol.12
, pp. 703-719
-
-
Hetz, C.1
Chevet, E.2
Harding, H.P.3
-
138
-
-
58149524838
-
ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression
-
PMID: 19114033
-
Whitney M.L., Jefferson L.S., Kimball S.R. ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression. Biochem Biophys Res Commun 2009, 379:451-455. PMID: 19114033.
-
(2009)
Biochem Biophys Res Commun
, vol.379
, pp. 451-455
-
-
Whitney, M.L.1
Jefferson, L.S.2
Kimball, S.R.3
-
139
-
-
63049095364
-
Activating transcription factor 4 and CCAAT/enhancer-binding protein-beta negatively regulate the mammalian target of rapamycin via Redd1 expression in response to oxidative and endoplasmic reticulum stress
-
PMID: 19439225
-
Jin H.O., Seo S.K., Woo S.H., Kim E.S., Lee H.C., Yoo D.H., et al. Activating transcription factor 4 and CCAAT/enhancer-binding protein-beta negatively regulate the mammalian target of rapamycin via Redd1 expression in response to oxidative and endoplasmic reticulum stress. Free Radic Biol Med 2009, 46:1158-1167. PMID: 19439225.
-
(2009)
Free Radic Biol Med
, vol.46
, pp. 1158-1167
-
-
Jin, H.O.1
Seo, S.K.2
Woo, S.H.3
Kim, E.S.4
Lee, H.C.5
Yoo, D.H.6
-
140
-
-
40649104735
-
Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis
-
PMID: 18342602
-
Ozcan U., Ozcan L., Yilmaz E., Duvel K., Sahin M., Manning B.D., et al. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell 2008, 29:541-551. PMID: 18342602.
-
(2008)
Mol Cell
, vol.29
, pp. 541-551
-
-
Ozcan, U.1
Ozcan, L.2
Yilmaz, E.3
Duvel, K.4
Sahin, M.5
Manning, B.D.6
-
141
-
-
48449101433
-
P53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
-
PMID: 18692468
-
Budanov A.V., Karin M. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 2008, 134:451-460. PMID: 18692468.
-
(2008)
Cell
, vol.134
, pp. 451-460
-
-
Budanov, A.V.1
Karin, M.2
-
142
-
-
79959764729
-
Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1
-
PMID: 21540236
-
Ben Sahra I., Regazzetti C., Robert G., Laurent K., Le Marchand-Brustel Y., Auberger P., et al. Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1. Cancer Res 2011, 71:4366-4372. PMID: 21540236.
-
(2011)
Cancer Res
, vol.71
, pp. 4366-4372
-
-
Ben Sahra, I.1
Regazzetti, C.2
Robert, G.3
Laurent, K.4
Le Marchand-Brustel, Y.5
Auberger, P.6
-
143
-
-
0034312315
-
Regulation of cellular growth by the Drosophila target of rapamycin dTOR
-
PMID: 11069888
-
Zhang H., Stallock J.P., Ng J.C., Reinhard C., Neufeld T.P. Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev 2000, 14:2712-2724. PMID: 11069888.
-
(2000)
Genes Dev
, vol.14
, pp. 2712-2724
-
-
Zhang, H.1
Stallock, J.P.2
Ng, J.C.3
Reinhard, C.4
Neufeld, T.P.5
-
144
-
-
0034312279
-
Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
-
PMID: 11069885
-
Oldham S., Montagne J., Radimerski T., Thomas G., Hafen E. Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev 2000, 14:2689-2694. PMID: 11069885.
-
(2000)
Genes Dev
, vol.14
, pp. 2689-2694
-
-
Oldham, S.1
Montagne, J.2
Radimerski, T.3
Thomas, G.4
Hafen, E.5
-
145
-
-
0037097863
-
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
-
PMID: 12080086
-
Fingar D.C., Salama S., Tsou C., Harlow E., Blenis J. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev 2002, 16:1472-1487. PMID: 12080086.
-
(2002)
Genes Dev
, vol.16
, pp. 1472-1487
-
-
Fingar, D.C.1
Salama, S.2
Tsou, C.3
Harlow, E.4
Blenis, J.5
-
146
-
-
0345732640
-
MTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
-
PMID: 14673156
-
Fingar D.C., Richardson C.J., Tee A.R., Cheatham L., Tsou C., Blenis J. mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol 2004, 24:200-216. PMID: 14673156.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 200-216
-
-
Fingar, D.C.1
Richardson, C.J.2
Tee, A.R.3
Cheatham, L.4
Tsou, C.5
Blenis, J.6
-
147
-
-
77952967459
-
MTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs
-
PMID: 20508131
-
Dowling R.J., Topisirovic I., Alain T., Bidinosti M., Fonseca B.D., Petroulakis E., et al. mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science 2010, 328:1172-1176. PMID: 20508131.
-
(2010)
Science
, vol.328
, pp. 1172-1176
-
-
Dowling, R.J.1
Topisirovic, I.2
Alain, T.3
Bidinosti, M.4
Fonseca, B.D.5
Petroulakis, E.6
-
148
-
-
0035498939
-
Hierarchical phosphorylation of the translation inhibitor 4E-BP1
-
PMID: 11691836
-
Gingras A.C., Raught B., Gygi S.P., Niedzwiecka A., Miron M., Burley S.K., et al. Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev 2001, 15:2852-2864. PMID: 11691836.
-
(2001)
Genes Dev
, vol.15
, pp. 2852-2864
-
-
Gingras, A.C.1
Raught, B.2
Gygi, S.P.3
Niedzwiecka, A.4
Miron, M.5
Burley, S.K.6
-
149
-
-
67349217986
-
Molecular mechanisms of mTOR-mediated translational control
-
PMID: 19339977
-
Ma X.M., Blenis J. Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol 2009, 10:307-318. PMID: 19339977.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 307-318
-
-
Ma, X.M.1
Blenis, J.2
-
150
-
-
0028207001
-
Rapamycin selectively represses translation of the polypyrimidine tract nRNA family
-
PMID: 8183928
-
Jefferies H.B.J., Reinhard C., Kozma S.C., Thomas G. Rapamycin selectively represses translation of the polypyrimidine tract nRNA family. Proc Natl Acad Sci U S A 1994, 91:4441-4445. PMID: 8183928.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 4441-4445
-
-
Jefferies, H.B.J.1
Reinhard, C.2
Kozma, S.C.3
Thomas, G.4
-
151
-
-
0033761629
-
Synthesis of the translational apparatus is regulated at the translational level
-
PMID: 11029573
-
Meyuhas O. Synthesis of the translational apparatus is regulated at the translational level. Eur J Biochem 2000, 267:6321-6330. PMID: 11029573.
-
(2000)
Eur J Biochem
, vol.267
, pp. 6321-6330
-
-
Meyuhas, O.1
-
152
-
-
84860527756
-
A unifying model for mTORC1-mediated regulation of mRNA translation
-
PMID: 22552098
-
Thoreen C.C., Chantranupong L., Keys H.R., Wang T., Gray N.S., Sabatini D.M. A unifying model for mTORC1-mediated regulation of mRNA translation. Nature 2012, 485:109-113. PMID: 22552098.
-
(2012)
Nature
, vol.485
, pp. 109-113
-
-
Thoreen, C.C.1
Chantranupong, L.2
Keys, H.R.3
Wang, T.4
Gray, N.S.5
Sabatini, D.M.6
-
153
-
-
84901700198
-
Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner
-
PMID: 24627160
-
Miloslavski R., Cohen E., Avraham A., Iluz Y., Hayouka Z., Kasir J., et al. Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner. J Mol Cell Biol 2014, 6:255-266. PMID: 24627160.
-
(2014)
J Mol Cell Biol
, vol.6
, pp. 255-266
-
-
Miloslavski, R.1
Cohen, E.2
Avraham, A.3
Iluz, Y.4
Hayouka, Z.5
Kasir, J.6
-
154
-
-
84893912480
-
Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation
-
PMID: 24532714
-
Tcherkezian J., Cargnello M., Romeo Y., Huttlin E.L., Lavoie G., Gygi S.P., et al. Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation. Genes Dev 2014, 28:357-371. PMID: 24532714.
-
(2014)
Genes Dev
, vol.28
, pp. 357-371
-
-
Tcherkezian, J.1
Cargnello, M.2
Romeo, Y.3
Huttlin, E.L.4
Lavoie, G.5
Gygi, S.P.6
-
155
-
-
0032539664
-
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
-
PMID: 9465032
-
Burnett P.E., Barrow R.K., Cohen N.A., Snyder S.H., Sabatini D.M. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc Natl Acad Sci U S A 1998, 95:1432-1437. PMID: 9465032.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 1432-1437
-
-
Burnett, P.E.1
Barrow, R.K.2
Cohen, N.A.3
Snyder, S.H.4
Sabatini, D.M.5
-
156
-
-
0033607531
-
Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro
-
PMID: 10567431
-
Isotani S., Hara K., Tokunaga C., Inoue H., Avruch J., Yonezawa K. Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro. J Biol Chem 1999, 274:34493-34498. PMID: 10567431.
-
(1999)
J Biol Chem
, vol.274
, pp. 34493-34498
-
-
Isotani, S.1
Hara, K.2
Tokunaga, C.3
Inoue, H.4
Avruch, J.5
Yonezawa, K.6
-
157
-
-
84896629473
-
Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program
-
PMID: 23318442
-
Chauvin C., Koka V., Nouschi A., Mieulet V., Hoareau-Aveilla C., Dreazen A., et al. Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program. Oncogene 2014, 33:474-483. PMID: 23318442.
-
(2014)
Oncogene
, vol.33
, pp. 474-483
-
-
Chauvin, C.1
Koka, V.2
Nouschi, A.3
Mieulet, V.4
Hoareau-Aveilla, C.5
Dreazen, A.6
-
158
-
-
84874655800
-
The multifaceted role of mTORC1 in the control of lipid metabolism
-
PMID: 23399656
-
Ricoult S.J., Manning B.D. The multifaceted role of mTORC1 in the control of lipid metabolism. EMBO Rep 2013, 14:242-251. PMID: 23399656.
-
(2013)
EMBO Rep
, vol.14
, pp. 242-251
-
-
Ricoult, S.J.1
Manning, B.D.2
-
159
-
-
50049116472
-
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
-
PMID: 18762023
-
Porstmann T., Santos C.R., Griffiths B., Cully M., Wu M., Leevers S., et al. SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab 2008, 8:224-236. PMID: 18762023.
-
(2008)
Cell Metab
, vol.8
, pp. 224-236
-
-
Porstmann, T.1
Santos, C.R.2
Griffiths, B.3
Cully, M.4
Wu, M.5
Leevers, S.6
-
160
-
-
77955483125
-
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
-
PMID: 20670887
-
Duvel K., Yecies J.L., Menon S., Raman P., Lipovsky A.I., Souza A.L., et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell 2010, 39:171-183. PMID: 20670887.
-
(2010)
Mol Cell
, vol.39
, pp. 171-183
-
-
Duvel, K.1
Yecies, J.L.2
Menon, S.3
Raman, P.4
Lipovsky, A.I.5
Souza, A.L.6
-
161
-
-
79961165137
-
Sabatini DM: mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway
-
PMID: 21816276
-
Peterson T.R., Sengupta S.S., Harris T.E., Carmack A.E., Kang S.A., Balderas E., et al. Sabatini DM: mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell 2011, 146:408-420. PMID: 21816276.
-
(2011)
Cell
, vol.146
, pp. 408-420
-
-
Peterson, T.R.1
Sengupta, S.S.2
Harris, T.E.3
Carmack, A.E.4
Kang, S.A.5
Balderas, E.6
-
162
-
-
84874961313
-
Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis
-
PMID: 23429704
-
Robitaille A.M., Christen S., Shimobayashi M., Cornu M., Fava L.L., Moes S., et al. Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science 2013, 339:1320-1323. PMID: 23429704.
-
(2013)
Science
, vol.339
, pp. 1320-1323
-
-
Robitaille, A.M.1
Christen, S.2
Shimobayashi, M.3
Cornu, M.4
Fava, L.L.5
Moes, S.6
-
163
-
-
79551598347
-
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
-
PMID: 21258367
-
Kim J., Kundu M., Viollet B., Guan K.L. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 2011, 13:132-141. PMID: 21258367.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 132-141
-
-
Kim, J.1
Kundu, M.2
Viollet, B.3
Guan, K.L.4
-
164
-
-
80053476420
-
The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR
-
PMID: 21460621
-
Egan D., Kim J., Shaw R.J., Guan K.L. The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR. Autophagy 2011, 7:643-644. PMID: 21460621.
-
(2011)
Autophagy
, vol.7
, pp. 643-644
-
-
Egan, D.1
Kim, J.2
Shaw, R.J.3
Guan, K.L.4
-
165
-
-
84876488191
-
MTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6
-
PMID: 23524951
-
Nazio F., Strappazzon F., Antonioli M., Bielli P., Cianfanelli V., Bordi M., et al. mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6. Nat Cell Biol 2013, 15:406-416. PMID: 23524951.
-
(2013)
Nat Cell Biol
, vol.15
, pp. 406-416
-
-
Nazio, F.1
Strappazzon, F.2
Antonioli, M.3
Bielli, P.4
Cianfanelli, V.5
Bordi, M.6
-
166
-
-
84883235992
-
MTOR, AMBRA1, and autophagy: an intricate relationship
-
PMID: 23907135
-
Nazio F., Cecconi F. mTOR, AMBRA1, and autophagy: an intricate relationship. Cell Cycle 2013, 12:2524-2525. PMID: 23907135.
-
(2013)
Cell Cycle
, vol.12
, pp. 2524-2525
-
-
Nazio, F.1
Cecconi, F.2
-
167
-
-
84894170193
-
MTORC1: turning off is just as important as turning on
-
PMID: 24529368
-
Benjamin D., Hall M.N. mTORC1: turning off is just as important as turning on. Cell 2014, 156:627-628. PMID: 24529368.
-
(2014)
Cell
, vol.156
, pp. 627-628
-
-
Benjamin, D.1
Hall, M.N.2
-
168
-
-
84894523716
-
Making new contacts: the mTOR network in metabolism and signalling crosstalk
-
PMID: 24556838
-
Shimobayashi M., Hall M.N. Making new contacts: the mTOR network in metabolism and signalling crosstalk. Nat Rev Mol Cell Biol 2014, 15:155-162. PMID: 24556838.
-
(2014)
Nat Rev Mol Cell Biol
, vol.15
, pp. 155-162
-
-
Shimobayashi, M.1
Hall, M.N.2
|