Regulation of cellular growth by the Drosophila target of rapamycin dTOR

Genes and Development

Volumn 14, Issue 21, 2000, Pages 2712-2724

  Zhang, Hongbing ^a,c   Stallock, James P ^b   Ng, Joyce C ^b   Reinhard, Christoph ^a   Neufeld, Thomas P ^b  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY OF MINNESOTA   (United States)

^c Xenogen Corporation   (United States)

Author keywords

Cell cycle; Cell growth; Drosophila; Rapamycin; TOR FRAP

Indexed keywords

AMINO ACID; CYCLIN E; GROWTH FACTOR; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; PROTEIN KINASE TOR; S6 KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE S PHASE; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DROSOPHILA; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FAT BODY; GROWTH REGULATION; IN VITRO STUDY; LIPID VESICLE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALIA; ARACHNIDA; DROSOPHILA; HEXAPODA; MAMMALIA;

EID: 0034312315     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.835000     Document Type: Article

References (70)

1. The genome sequence of Drosophila melanogaster
2. Identification and characterization of a yeast nucleolar protein that is similar to a rat liver nucleolar protein
3. TOR controls translation initiation and early G1 progression in yeast
4. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
5. Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4
6. Environmental control of the cell cycle in Drosophila: Nutrition activates mitotic and endoreplicative cells by distinct mechanisms
7. A signaling pathway to translational control
8. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
9. Adipose tissue of Drosophila melanogaster. I. An experimental study of larval fat body
10. The TOR signaling cascade regulates gene expression in response to nutrients
11. Structural and functional analysis of pp70S6k
12. TOR signaling regulates microtubule structure and function
13. The 70 kDa S6 kinase: Regulation of a kinase with multiple roles in mitogenic signalling
14. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
15. Do growth and cell division rates determine cell size in multicellular organisms?
16. Size control in animal development
17. Target of rapamycin (TOR): Balancing the opposing forces of protein synthesis and degradation
18. Nucleolar function and size in cancer cells
19. E2F-induced S phase requires cyclin E
20. Amino acids stimulate phosphorylation of p70S6k and organization of rat adipocytes into multicellular clusters
21. Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways
22. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
23. Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins
24. The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene
25. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
26. Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation
27. Drosophila myc regulates cellular growth during development
28. PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints
29. Regulation of translation initiation in mammalian cells by amino acids
30. Glucose and amino acids modulate translation factor activation by growth factors in PC12 cells
31. Functional interaction between RAFT1/FRAP/mTOR and protein kinase cdelta in the regulation of cap-dependent initiation of translation
32. Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase
33. Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
34. Modulation of transcription of rRNA genes by rapamycin
35. Drosophila S6 kinase: A regulator of cell size
36. Minutes: Mutants of Drosophila autonomously affecting cell division rate
37. 14-3-3Tau associates with a translational control factor FKBP12-rapamycin-associated protein in T-cells after stimulation by pervanadate
38. Variation of nucleolar area in fat tissue of Drosophila mulleri during development
39. Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
40. Connections between growth and the cell cycle
41. Coordination of growth and cell division in the Drosophila wing
42. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
43. Mammalian TOR controls one of two kinase pathways acting upon nPKCdelta and nPKCepsilon
44. FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions
45. Induction of Drosophila eye development by decapentaplegic
46. 1 cyclin CLN3 in yeast
47. Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae
48. Ras promotes cellular growth in the Drosophila wing
49. A Drosophila G1-specific cyclin E homolog exhibits different modes of expression during embryogenesis
50. Ectopic cyclin E expression induces premature entry into S phase and disrupts pattern formation in the Drosophila eye imaginal disc
51. Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling
52. TOR2 is required for organization of the actin cytoskeleton in yeast
53. Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway
54. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells
55. The conserved phosphoinositide 3-kinase pathway determines heart size in mice
56. The Drosophila p70s6k homolog exhibits conserved regulatory elements and rapamycin sensitivity
57. Postprandial stimulation of muscle protein synthesis is independent of changes in insulin
58. Protein kinases as mediators of phosphoinositide 3-kinase signaling
59. Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB
60. The FKBP12-rapamycin-binding domain is required for FKBP12-rapamycin-associated protein kinase activity and G1 progression
61. Amino acid availability regulates p70 S6 kinase and multiple translation factors
62. Regulation of imaginal disc cell size, cell number and organ size by drosophila class I(A) phosphoinositide 3-kinase and its adaptor
63. Multiple independent inputs are required for activation of the p70 S6 kinase
64. Insulin mediates glucose-stimulated phosphorylation of PHAS-I by pancreatic beta cells. An insulin-receptor mechanism for autoregulation of protein synthesis by translation
65. Analysis of genetic mosaics in developing and adult Drosophila tissues
66. Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR
67. Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway
68. TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin
69. Suppression of food intake and growth by amino acids in Drosophila: The role of pumpless, a fat body expressed gene with homology to vertebrate glycine cleavage system