-
1
-
-
0036753494
-
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
-
DOI 10.1016/S1097-2765(02)00636-6
-
Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., Oppliger, W., Jenoe, P., and Hall, M. N. (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell 10, 457-468 (Pubitemid 35284167)
-
(2002)
Molecular Cell
, vol.10
, Issue.3
, pp. 457-468
-
-
Loewith, R.1
Jacinto, E.2
Wullschleger, S.3
Lorberg, A.4
Crespo, J.L.5
Bonenfant, D.6
Oppliger, W.7
Jenoe, P.8
Hall, M.N.9
-
2
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
DOI 10.1038/ncb1183
-
Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Rüegg, M. A, Hall, A., and Hall, M. N. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6, 1122-1128 (Pubitemid 39468014)
-
(2004)
Nature Cell Biology
, vol.6
, Issue.11
, pp. 1122-1128
-
-
Jacinto, E.1
Loewith, R.2
Schmidt, A.3
Lin, S.4
Ruegg, M.A.5
Hall, A.6
Hall, M.N.7
-
3
-
-
39749100492
-
TOR regulation of AGC kinases in yeast and mammals
-
DOI 10.1042/BJ20071518
-
Jacinto, E., and Lorberg, A. (2008) TOR regulation ofAGCkinases in yeast and mammals. Biochem. J. 410, 19-37 (Pubitemid 351300322)
-
(2008)
Biochemical Journal
, vol.410
, Issue.1
, pp. 19-37
-
-
Jacinto, E.1
Lorberg, A.2
-
4
-
-
79959409830
-
Amino acid signaling in TOR activation
-
Kim, J., and Guan, K. L. (2011) Amino acid signaling in TOR activation. Annu. Rev. Biochem. 80, 1001-1032
-
(2011)
Annu. Rev. Biochem.
, vol.80
, pp. 1001-1032
-
-
Kim, J.1
Guan, K.L.2
-
5
-
-
0042701991
-
Tuberous Sclerosis Complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
-
DOI 10.1016/S0960-9822(03)00506-2
-
Tee, A. R., Manning, B. D., Roux, P. P., Cantley, L. C., and Blenis, J. (2003) Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr. Biol. 13, 1259-1268 (Pubitemid 36953298)
-
(2003)
Current Biology
, vol.13
, Issue.15
, pp. 1259-1268
-
-
Tee, A.R.1
Manning, B.D.2
Roux, P.P.3
Cantley, L.C.4
Blenis, J.5
-
6
-
-
0043127125
-
Rheb GTpase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
DOI 10.1101/gad.1110003
-
Inoki, K., Li, Y., Xu, T., and Guan, K. L. (2003) Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 17, 1829-1834 (Pubitemid 36944560)
-
(2003)
Genes and Development
, vol.17
, Issue.15
, pp. 1829-1834
-
-
Inoki, K.1
Li, Y.2
Xu, T.3
Guan, K.-L.4
-
7
-
-
69749113579
-
The Vam6 GEF controls TORC1 by activating the EGO complex
-
Binda, M., Péli-Gulli, M. P., Bonfils, G., Panchaud, N., Urban, J., Sturgill, T. W., Loewith, R., and De Virgilio, C. (2009) The Vam6 GEF controls TORC1 by activating the EGO complex. Mol. Cell 35, 563-573
-
(2009)
Mol. Cell
, vol.35
, pp. 563-573
-
-
Binda, M.1
Péli-Gulli, M.P.2
Bonfils, G.3
Panchaud, N.4
Urban, J.5
Sturgill, T.W.6
Loewith, R.7
De Virgilio, C.8
-
8
-
-
48649085816
-
Regulation of TORC1 by Rag GTPases in nutrient response
-
Kim, E., Goraksha-Hicks, P., Li, L., Neufeld, T. P., and Guan, K. L. (2008) Regulation of TORC1 by Rag GTPases in nutrient response. Nat. Cell Biol. 10, 935-945
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 935-945
-
-
Kim, E.1
Goraksha-Hicks, P.2
Li, L.3
Neufeld, T.P.4
Guan, K.L.5
-
9
-
-
45849105156
-
The rag GTPases bind raptor and mediate amino acid signaling to mTORC1
-
DOI 10.1126/science.1157535
-
Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., and Sabatini, D. M. (2008) The Rag GTPases bind Raptor and mediate amino acid signaling to mTORC1. Science 320, 1496-1501 (Pubitemid 351929429)
-
(2008)
Science
, vol.320
, Issue.5882
, pp. 1496-1501
-
-
Sancak, Y.1
Peterson, T.R.2
Shaul, Y.D.3
Lindquist, R.A.4
Thoreen, C.C.5
Bar-Peled, L.6
Sabatini, D.M.7
-
10
-
-
77951768486
-
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
-
Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., and Sabatini, D. M. (2010) Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141, 290-303
-
(2010)
Cell
, vol.141
, pp. 290-303
-
-
Sancak, Y.1
Bar-Peled, L.2
Zoncu, R.3
Markhard, A.L.4
Nada, S.5
Sabatini, D.M.6
-
11
-
-
42949139481
-
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
-
DOI 10.1016/j.molcel.2008.03.003, PII S109727650800169X
-
Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., and Shaw, R. J. (2008) AMPK phosphorylation of Raptor mediates a metabolic checkpoint. Mol. Cell 30, 214-226 (Pubitemid 351626684)
-
(2008)
Molecular Cell
, vol.30
, Issue.2
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
12
-
-
0345167800
-
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
-
DOI 10.1016/S0092-8674(03)00929-2
-
Inoki, K., Zhu, T., and Guan, K. L. (2003) TSC2 mediates cellular energy response to control cell growth and survival. Cell 115, 577-590 (Pubitemid 37506046)
-
(2003)
Cell
, vol.115
, Issue.5
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.-L.3
-
13
-
-
51349091876
-
Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5
-
Lodhi, I. J., Bridges, D., Chiang, S. H., Zhang, Y., Cheng, A., Geletka, L. M., Weisman, L. S., and Saltiel, A. R. (2008) Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5. Mol. Biol. Cell 19, 2718-2728
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 2718-2728
-
-
Lodhi, I.J.1
Bridges, D.2
Chiang, S.H.3
Zhang, Y.4
Cheng, A.5
Geletka, L.M.6
Weisman, L.S.7
Saltiel, A.R.8
-
14
-
-
0035818483
-
Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein
-
DOI 10.1073/pnas.241368698
-
Huang, J., Imamura, T., and Olefsky, J. M. (2001) Insulin can regulate GLUT4internalization by signaling to Rab5 and the motor protein dynein. Proc. Natl. Acad. Sci. U.S.A. 98, 13084-13089 (Pubitemid 33051321)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.23
, pp. 13084-13089
-
-
Huang, J.1
Imamura, T.2
Olefsky, J.M.3
-
15
-
-
77649140362
-
The late endosome is essential for mTORC1 signaling
-
Flinn, R. J., Yan, Y., Goswami, S., Parker, P. J., and Backer, J. M. (2010) The late endosome is essential for mTORC1 signaling. Mol. Biol. Cell 21, 833-841
-
(2010)
Mol. Biol. Cell
, vol.21
, pp. 833-841
-
-
Flinn, R.J.1
Yan, Y.2
Goswami, S.3
Parker, P.J.4
Backer, J.M.5
-
16
-
-
77953801358
-
Regulation of mTORC1 by the Rab and Arf GTPases
-
Li, L., Kim, E., Yuan, H., Inoki, K., Goraksha-Hicks, P., Schiesher, R. L., Neufeld, T. P., and Guan, K. L. (2010) Regulation of mTORC1 by the Rab and Arf GTPases. J. Biol. Chem. 285, 19705-19709
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 19705-19709
-
-
Li, L.1
Kim, E.2
Yuan, H.3
Inoki, K.4
Goraksha-Hicks, P.5
Schiesher, R.L.6
Neufeld, T.P.7
Guan, K.L.8
-
17
-
-
0033174034
-
Phosphatidylinositol-3-OH kinases are Rab5 effectors
-
Christoforidis, S., Miaczynska, M., Ashman, K., Wilm, M., Zhao, L., Yip, S. C., Waterfield, M. D., Backer, J. M., and Zerial, M. (1999) Phosphatidylinositol- 3-OH kinases are Rab5 effectors. Nat. Cell Biol. 1, 249-252 (Pubitemid 129500945)
-
(1999)
Nature Cell Biology
, vol.1
, Issue.4
, pp. 249-252
-
-
Christoforidis, S.1
Miaczynska, M.2
Ashman, K.3
Wilm, M.4
Zhao, L.5
Yip, S.-C.6
Waterfield, M.D.7
Backer, J.M.8
Zerial, M.9
-
18
-
-
23944437499
-
An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway
-
DOI 10.1083/jcb.200505128
-
Shin, H. W., Hayashi, M., Christoforidis, S., Lacas-Gervais, S., Hoepfner, S., Wenk, M. R., Modregger, J., Uttenweiler-Joseph, S., Wilm, M., Nystuen, A., Frankel, W. N., Solimena, M., De Camilli, P., and Zerial, M. (2005) An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway. J. Cell Biol. 170, 607-618 (Pubitemid 41186935)
-
(2005)
Journal of Cell Biology
, vol.170
, Issue.4
, pp. 607-618
-
-
Shin, H.-W.1
Hayashi, M.2
Christoforidis, S.3
Lacas-Gervais, S.4
Hoepfner, S.5
Wenk, M.R.6
Modregger, J.7
Uttenweiler-Joseph, S.8
Wilm, M.9
Nystuen, A.10
Frankel, W.N.11
Solimena, M.12
De Camilli, P.13
Zerial, M.14
-
19
-
-
33845572827
-
Gapex-5, a Rab31 Guanine Nucleotide Exchange Factor that Regulates Glut4 Trafficking in Adipocytes
-
DOI 10.1016/j.cmet.2006.12.006, PII S1550413106004025
-
Lodhi, I. J., Chiang, S. H., Chang, L., Vollenweider, D., Watson, R. T., Inoue, M., Pessin, J. E., and Saltiel, A. R. (2007) Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes. Cell Metab. 5, 59-72 (Pubitemid 44933113)
-
(2007)
Cell Metabolism
, vol.5
, Issue.1
, pp. 59-72
-
-
Lodhi, I.J.1
Chiang, S.-H.2
Chang, L.3
Vollenweider, D.4
Watson, R.T.5
Inoue, M.6
Pessin, J.E.7
Saltiel, A.R.8
-
20
-
-
38349160161
-
The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis
-
Gitler, A. D., Bevis, B. J., Shorter, J., Strathearn, K. E., Hamamichi, S., Su, L. J., Caldwell, K. A., Caldwell, G. A., Rochet, J. C., McCaffery, J. M., Barlowe, C., and Lindquist, S. (2008) The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis. Proc. Natl. Acad. Sci. U.S.A. 105, 145-150
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 145-150
-
-
Gitler, A.D.1
Bevis, B.J.2
Shorter, J.3
Strathearn, K.E.4
Hamamichi, S.5
Su, L.J.6
Caldwell, K.A.7
Caldwell, G.A.8
Rochet, J.C.9
McCaffery, J.M.10
Barlowe, C.11
Lindquist, S.12
-
21
-
-
0345616428
-
A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain
-
DOI 10.1093/emboj/cdg140
-
Shih, S. C., Prag, G., Francis, S. A, Sutanto, M. A., Hurley, J. H., and Hicke, L. (2003) A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain. EMBO J. 22, 1273-1281 (Pubitemid 36362691)
-
(2003)
EMBO Journal
, vol.22
, Issue.6
, pp. 1273-1281
-
-
Shih, S.C.1
Prag, G.2
Francis, S.A.3
Sutanto, M.A.4
Hurley, J.H.5
Hicke, L.6
-
22
-
-
0347988005
-
Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR
-
DOI 10.1172/JCI200317222
-
Zhang, H., Cicchetti, G., Onda, H., Koon, H. B., Asrican, K., Bajraszewski, N., Vazquez, F., Carpenter, C. L., and Kwiatkowski, D. J. (2003) Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through down-regulation of PDGFR. J. Clin. Invest. 112, 1223-1233 (Pubitemid 38056299)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.8
, pp. 1223-1233
-
-
Zhang, H.1
Cicchetti, G.2
Onda, H.3
Koon, H.B.4
Asrican, K.5
Bajraszewski, N.6
Vazquez, F.7
Carpenter, C.L.8
Kwiatkowski, D.J.9
-
23
-
-
0033529707
-
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis
-
DOI 10.1126/science.285.5429.901
-
Winzeler, E. A., Shoemaker, D. D., Astromoff, A., Liang, H., Anderson, K., Andre, B., Bangham, R., Benito, R., Boeke, J. D., Bussey, H., Chu, A. M., Connelly, C., Davis, K., Dietrich, F., Dow, S. W., El Bakkoury, M., Foury, F., Friend, S. H., Gentalen, E., Giaever, G., Hegemann, J. H., Jones, T., Laub, M., Liao, H., Liebundguth, N., Lockhart, D. J., Lucau-Danila, A., Lussier, M., M'Rabet, N., Menard, P., Mittmann, M., Pai, C., Rebischung, C., Revuelta, J. L., Riles, L., Roberts, C. J., Ross-MacDonald, P., Scherens, B., Snyder, M., Sookhai-Mahadeo, S., Storms, R. K., Véronneau, S., Voet, M., Volckaert, G., Ward, T. R., Wysocki, R., Yen, G. S., Yu, K., Zimmermann, K., Philippsen, P., and Johnston, M. (1999) Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 285, 901-906 (Pubitemid 29381993)
-
(1999)
Science
, vol.285
, Issue.5429
, pp. 901-906
-
-
Winzeler, E.A.1
Shoemaker, D.D.2
Astromoff, A.3
Liang, H.4
Anderson, K.5
Andre, B.6
Bangham, R.7
Benito, R.8
Boeke, J.D.9
Bussey, H.10
Chu, A.M.11
Connelly, C.12
Davis, K.13
Dietrich, F.14
Dow, S.W.15
El, B.M.16
Foury, F.17
Friend, S.H.18
Gentalen, E.19
Giaever, G.20
Hegemann, J.H.21
Jones, T.22
Laub, M.23
Liao, H.24
Liebundguth, N.25
Lockhart, D.J.26
Lucau-Danila, A.27
Lussier, M.28
M'Rabet, N.29
Menard, P.30
Mittmann, M.31
Pai, C.32
Rebischung, C.33
Revuelta, J.L.34
Riles, L.35
Roberts, C.J.36
Ross-MacDonald, P.37
Scherens, B.38
Snyder, M.39
Sookhai-Mahadeo, S.40
Storms, R.K.41
Veronneau, S.42
Voet, M.43
Volckaert, G.44
Ward, T.R.45
Wysocki, R.46
Yen, G.S.47
Yu, K.48
Zimmermann, K.49
Philippsen, P.50
Johnston, M.51
Davis, R.W.52
more..
-
24
-
-
0028181704
-
Role of three rab5-like GTPases, Ypt51p, Ypt52p, and Ypt53p, in the endocytic and vacuolar protein sorting pathways of yeast
-
Singer-Krüger, B., Stenmark, H., Düsterhöft, A., Philippsen, P., Yoo, J. S., Gallwitz, D., and Zerial, M. (1994) Role of three rab5-like GTPases, Ypt51p, Ypt52p, and Ypt53p, in the endocytic and vacuolar protein sorting pathways of yeast. J. Cell Biol. 125, 283-298
-
(1994)
J. Cell Biol.
, vol.125
, pp. 283-298
-
-
Singer-Krüger, B.1
Stenmark, H.2
Düsterhöft, A.3
Philippsen, P.4
Yoo, J.S.5
Gallwitz, D.6
Zerial, M.7
-
25
-
-
32144445482
-
TC10 and insulin-stimulated glucose transport
-
DOI 10.1016/S0076-6879(06)06055-1, PII S0076687906060551, 55, Regulators and Effectors of Small GTPases: Rho Family
-
Chiang, S. H., Chang, L., and Saltiel, A. R. (2006) TC10 and insulin-stimulated glucose transport. Methods Enzymol. 406, 701-714 (Pubitemid 43207480)
-
(2006)
Methods in Enzymology
, vol.406
, pp. 701-714
-
-
Chiang, S.1
Chang, L.2
Saltiel, A.R.3
-
26
-
-
0037128929
-
Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p
-
DOI 10.1083/jcb.200201002
-
Bonangelino, C. J., Nau, J. J., Duex, J. E., Brinkman, M., Wurmser, A. E., Gary, J. D., Emr, S. D., and Weisman, L. S. (2002) Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p. J. Cell Biol. 156, 1015-1028 (Pubitemid 34839851)
-
(2002)
Journal of Cell Biology
, vol.156
, Issue.6
, pp. 1015-1028
-
-
Bonangelino, C.J.1
Nau, J.J.2
Duex, J.E.3
Brinkman, M.4
Wurmser, A.E.5
Gary, J.D.6
Emr, S.D.7
Weisman, L.S.8
-
27
-
-
36349018627
-
Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice
-
DOI 10.1073/pnas.0702275104
-
Zhang, Y., Zolov, S. N., Chow, C. Y., Slutsky, S. G., Richardson, S. C., Piper, R. C., Yang, B., Nau, J. J., Westrick, R. J., Morrison, S. J., Meisler, M. H., and Weisman, L. S. (2007) Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. Proc. Natl. Acad. Sci. U.S.A. 104, 17518-17523 (Pubitemid 350219870)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.44
, pp. 17518-17523
-
-
Zhang, Y.1
Zolov, S.N.2
Chow, C.Y.3
Slutsky, S.G.4
Richardson, S.C.5
Piper, R.C.6
Yang, B.7
Nau, J.J.8
Westrick, R.J.9
Morrison, S.J.10
Meisler, M.H.11
Weisman, L.S.12
-
28
-
-
84863304598
-
-
R Development Core Team R. Foundation for Statistical Computing, Vienna, Austria
-
R Development Core Team (2011) R: A Language and Environment Statistical Computing, R. Foundation for Statistical Computing, Vienna, Austria
-
(2011)
R: A Language and Environment Statistical Computing
-
-
-
29
-
-
0001677717
-
Controlling the false discovery rate: A practical and powerful approach to multiple testing
-
Benjamini, Y., and Hochberg, Y. (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Statistical Soc. Ser. B 57, 289-300
-
(1995)
J. R. Statistical Soc. Ser. B
, vol.57
, pp. 289-300
-
-
Benjamini, Y.1
Hochberg, Y.2
-
30
-
-
0035172107
-
Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology
-
Foti, M., Audhya, A., and Emr, S. D. (2001) Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology. Mol. Biol. Cell 12, 2396-2411 (Pubitemid 33051964)
-
(2001)
Molecular Biology of the Cell
, vol.12
, Issue.8
, pp. 2396-2411
-
-
Foti, M.1
Audhya, A.2
Emr, S.D.3
-
31
-
-
0033977744
-
SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases
-
DOI 10.1074/jbc.275.2.801
-
Hughes, W. E., Woscholski, R., Cooke, F. T., Patrick, R. S., Dove, S. K., McDonald, N. Q., and Parker, P. J. (2000) SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases. J. Biol. Chem. 275, 801-808 (Pubitemid 30051118)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.2
, pp. 801-808
-
-
Hughes, W.E.1
Woscholski, R.2
Cooke, F.T.3
Patrick, R.S.4
Dove, S.K.5
McDonald, N.Q.6
Parker, P.J.7
-
32
-
-
0033532062
-
SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases
-
Guo, S., Stolz, L. E., Lemrow, S. M., and York, J. D. (1999) SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases. J. Biol. Chem. 274, 12990-12995
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 12990-12995
-
-
Guo, S.1
Stolz, L.E.2
Lemrow, S.M.3
York, J.D.4
-
33
-
-
0035809160
-
Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase y sorting in Saccharomyces cerevisiae
-
Kihara, A., Noda, T., Ishihara, N., and Ohsumi, Y. (2001) Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J. Cell Biol. 152, 519-530 (Pubitemid 34280235)
-
(2001)
Journal of Cell Biology
, vol.153
, Issue.3
, pp. 519-530
-
-
Kihara, A.1
Noda, T.2
Ishihara, N.3
Ohsumi, Y.4
-
34
-
-
0027991899
-
Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase
-
Welsh, G. I., Foulstone, E. J., Young, S. W., Tavaré, J. M., and Proud, C. G. (1994) Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase. Biochem. J. 303, 15-20 (Pubitemid 24302892)
-
(1994)
Biochemical Journal
, vol.303
, Issue.1
, pp. 15-20
-
-
Welsh, G.I.1
Foulstone, E.J.2
Young, S.W.3
Tavare, J.M.4
Proud, C.G.5
-
35
-
-
0028939115
-
Multiple independent inputs are required for activation of the p70 S6 kinase
-
Weng, Q. P., Andrabi, K., Kozlowski, M. T., Grove, J. R., and Avruch, J. (1995) Multiple independent inputs are required for activation of the p70 S6 kinase. Mol. Cell. Biol. 15, 2333-2340
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 2333-2340
-
-
Weng, Q.P.1
Andrabi, K.2
Kozlowski, M.T.3
Grove, J.R.4
Avruch, J.5
-
36
-
-
0141733228
-
Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin
-
DOI 10.1074/jbc.M303257200
-
Tee, A. R., Anjum, R., and Blenis, J. (2003) Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin. J. Biol. Chem. 278, 37288-37296 (Pubitemid 37175245)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.39
, pp. 37288-37296
-
-
Tee, A.R.1
Anjum, R.2
Blenis, J.3
-
38
-
-
42949092018
-
The Endosomal Protein Appl1 Mediates Akt Substrate Specificity and Cell Survival in Vertebrate Development
-
DOI 10.1016/j.cell.2008.02.044, PII S0092867408003942
-
Schenck, A., Goto-Silva, L., Collinet, C., Rhinn, M., Giner, A., Habermann, B., Brand, M., and Zerial, M. (2008) The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development. Cell 133, 486-497 (Pubitemid 351608689)
-
(2008)
Cell
, vol.133
, Issue.3
, pp. 486-497
-
-
Schenck, A.1
Goto-Silva, L.2
Collinet, C.3
Rhinn, M.4
Giner, A.5
Habermann, B.6
Brand, M.7
Zerial, M.8
-
39
-
-
36148932174
-
The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation
-
DOI 10.1074/jbc.M704150200
-
Saito, T., Jones, C. C., Huang, S., Czech, M. P., and Pilch, P. F. (2007) The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation. J. Biol. Chem. 282, 32280-32287 (Pubitemid 350106472)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.44
, pp. 32280-32287
-
-
Saito, T.1
Jones, C.C.2
Huang, S.3
Czech, M.P.4
Pilch, P.F.5
-
40
-
-
34548421080
-
Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae
-
DOI 10.1534/genetics.107.072835
-
Zurita-Martinez, S. A., Puria, R., Pan, X., Boeke, J. D., and Cardenas, M. E. (2007) Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae. Genetics 176, 2139-2150 (Pubitemid 47360648)
-
(2007)
Genetics
, vol.176
, Issue.4
, pp. 2139-2150
-
-
Zurita-Martinez, S.A.1
Puria, R.2
Pan, X.3
Boeke, J.D.4
Cardenas, M.E.5
-
41
-
-
18844446425
-
Insights into TOR function and rapamycin response: Chemical genomic profiling by using a high-density cell array method
-
DOI 10.1073/pnas.0500297102
-
Xie, M. W., Jin, F., Hwang, H., Hwang, S., Anand, V., Duncan, M. C., and Huang, J. (2005) Insights into TOR function and rapamycin response: chemical genomic profiling by using a high-density cell array method. Proc. Natl. Acad. Sci. U.S.A. 102, 7215-7220 (Pubitemid 40696359)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.20
, pp. 7215-7220
-
-
Xie, M.W.1
Jin, F.2
Hwang, H.3
Hwang, S.4
Anand, V.5
Duncan, M.C.6
Huang, J.7
-
42
-
-
0347473810
-
Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways
-
DOI 10.1038/nbt919
-
Parsons, A. B., Brost, R. L., Ding, H., Li, Z., Zhang, C., Sheikh, B., Brown, G. W., Kane, P. M., Hughes, T. R., and Boone, C. (2004) Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nat. Biotechnol. 22, 62-69 (Pubitemid 38057958)
-
(2004)
Nature Biotechnology
, vol.22
, Issue.1
, pp. 62-69
-
-
Parsons, A.B.1
Brost, R.L.2
Ding, H.3
Li, Z.4
Zhang, C.5
Sheikh, B.6
Brown, G.W.7
Kane, P.M.8
Hughes, T.R.9
Boone, C.10
-
43
-
-
77950865682
-
Genomic analysis of severe hypersensitivity to hygromycin B reveals linkage to vacuolar defects and new vacuolar gene functions in Saccharomyces cerevisiae
-
Banuelos, M. G., Moreno, D. E., Olson, D. K., Nguyen, Q., Ricarte, F., Aguilera-Sandoval, C. R., and Gharakhanian, E. (2010) Genomic analysis of severe hypersensitivity to hygromycin B reveals linkage to vacuolar defects and new vacuolar gene functions in Saccharomyces cerevisiae. Curr. Genet. 56, 121-137
-
(2010)
Curr. Genet.
, vol.56
, pp. 121-137
-
-
Banuelos, M.G.1
Moreno, D.E.2
Olson, D.K.3
Nguyen, Q.4
Ricarte, F.5
Aguilera-Sandoval, C.R.6
Gharakhanian, E.7
-
44
-
-
69249240179
-
Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis
-
Huber, A., Bodenmiller, B., Uotila, A., Stahl, M., Wanka, S., Gerrits, B., Aebersold, R., and Loewith, R. (2009) Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis. Genes Dev. 23, 1929-1943
-
(2009)
Genes Dev.
, vol.23
, pp. 1929-1943
-
-
Huber, A.1
Bodenmiller, B.2
Uotila, A.3
Stahl, M.4
Wanka, S.5
Gerrits, B.6
Aebersold, R.7
Loewith, R.8
-
45
-
-
25444457577
-
hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
-
DOI 10.1074/jbc.M507201200
-
Byfield, M. P., Murray, J. T., and Backer, J. M. (2005) hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J. Biol. Chem. 280, 33076-33082 (Pubitemid 41368357)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.38
, pp. 33076-33082
-
-
Byfield, M.P.1
Murray, J.T.2
Backer, J.M.3
-
46
-
-
26444575415
-
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
-
DOI 10.1073/pnas.0506925102
-
Nobukuni, T., Joaquin, M., Roccio, M., Dann, S. G., Kim, S. Y., Gulati, P., Byfield, M. P., Backer, J. M., Natt, F., Bos, J. L., Zwartkruis, F. J., and Thomas, G. (2005) Amino acids mediate mTOR/Raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc. Natl. Acad. Sci. U.S.A. 102, 14238-14243 (Pubitemid 41429682)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.40
, pp. 14238-14243
-
-
Nobukuni, T.1
Joaquin, M.2
Roccio, M.3
Dann, S.G.4
Kim, S.Y.5
Gulati, P.6
Byfield, M.P.7
Backer, J.M.8
Natt, F.9
Bos, J.L.10
Zwartkruis, F.J.T.11
Thomas, G.12
-
47
-
-
84855731134
-
Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway
-
Yoon, M. S., Du, G., Backer, J. M., Frohman, M. A., and Chen, J. (2011) Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway. J. Cell Biol. 195, 435-447
-
(2011)
J. Cell Biol.
, vol.195
, pp. 435-447
-
-
Yoon, M.S.1
Du, G.2
Backer, J.M.3
Frohman, M.A.4
Chen, J.5
-
48
-
-
79960387847
-
Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1)
-
Xu, L., Salloum, D., Medlin, P. S., Saqcena, M., Yellen, P., Perrella, B., and Foster, D. A. (2011) Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1). J. Biol. Chem. 286, 25477-25486
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 25477-25486
-
-
Xu, L.1
Salloum, D.2
Medlin, P.S.3
Saqcena, M.4
Yellen, P.5
Perrella, B.6
Foster, D.A.7
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