메뉴 건너뛰기




Volumn 287, Issue 25, 2012, Pages 20913-20921

Rab5 proteins regulate activation and localization of target of rapamycin complex 1

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEX 1; MAMMALIAN CELLS; TARGET OF RAPAMYCIN;

EID: 84862275111     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.334060     Document Type: Article
Times cited : (51)

References (48)
  • 1
    • 0036753494 scopus 로고    scopus 로고
    • Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
    • DOI 10.1016/S1097-2765(02)00636-6
    • Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., Oppliger, W., Jenoe, P., and Hall, M. N. (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell 10, 457-468 (Pubitemid 35284167)
    • (2002) Molecular Cell , vol.10 , Issue.3 , pp. 457-468
    • Loewith, R.1    Jacinto, E.2    Wullschleger, S.3    Lorberg, A.4    Crespo, J.L.5    Bonenfant, D.6    Oppliger, W.7    Jenoe, P.8    Hall, M.N.9
  • 2
    • 7944235758 scopus 로고    scopus 로고
    • Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    • DOI 10.1038/ncb1183
    • Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Rüegg, M. A, Hall, A., and Hall, M. N. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6, 1122-1128 (Pubitemid 39468014)
    • (2004) Nature Cell Biology , vol.6 , Issue.11 , pp. 1122-1128
    • Jacinto, E.1    Loewith, R.2    Schmidt, A.3    Lin, S.4    Ruegg, M.A.5    Hall, A.6    Hall, M.N.7
  • 3
    • 39749100492 scopus 로고    scopus 로고
    • TOR regulation of AGC kinases in yeast and mammals
    • DOI 10.1042/BJ20071518
    • Jacinto, E., and Lorberg, A. (2008) TOR regulation ofAGCkinases in yeast and mammals. Biochem. J. 410, 19-37 (Pubitemid 351300322)
    • (2008) Biochemical Journal , vol.410 , Issue.1 , pp. 19-37
    • Jacinto, E.1    Lorberg, A.2
  • 4
    • 79959409830 scopus 로고    scopus 로고
    • Amino acid signaling in TOR activation
    • Kim, J., and Guan, K. L. (2011) Amino acid signaling in TOR activation. Annu. Rev. Biochem. 80, 1001-1032
    • (2011) Annu. Rev. Biochem. , vol.80 , pp. 1001-1032
    • Kim, J.1    Guan, K.L.2
  • 5
    • 0042701991 scopus 로고    scopus 로고
    • Tuberous Sclerosis Complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
    • DOI 10.1016/S0960-9822(03)00506-2
    • Tee, A. R., Manning, B. D., Roux, P. P., Cantley, L. C., and Blenis, J. (2003) Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr. Biol. 13, 1259-1268 (Pubitemid 36953298)
    • (2003) Current Biology , vol.13 , Issue.15 , pp. 1259-1268
    • Tee, A.R.1    Manning, B.D.2    Roux, P.P.3    Cantley, L.C.4    Blenis, J.5
  • 6
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTpase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • DOI 10.1101/gad.1110003
    • Inoki, K., Li, Y., Xu, T., and Guan, K. L. (2003) Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 17, 1829-1834 (Pubitemid 36944560)
    • (2003) Genes and Development , vol.17 , Issue.15 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.-L.4
  • 9
    • 45849105156 scopus 로고    scopus 로고
    • The rag GTPases bind raptor and mediate amino acid signaling to mTORC1
    • DOI 10.1126/science.1157535
    • Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., and Sabatini, D. M. (2008) The Rag GTPases bind Raptor and mediate amino acid signaling to mTORC1. Science 320, 1496-1501 (Pubitemid 351929429)
    • (2008) Science , vol.320 , Issue.5882 , pp. 1496-1501
    • Sancak, Y.1    Peterson, T.R.2    Shaul, Y.D.3    Lindquist, R.A.4    Thoreen, C.C.5    Bar-Peled, L.6    Sabatini, D.M.7
  • 10
    • 77951768486 scopus 로고    scopus 로고
    • Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
    • Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., and Sabatini, D. M. (2010) Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141, 290-303
    • (2010) Cell , vol.141 , pp. 290-303
    • Sancak, Y.1    Bar-Peled, L.2    Zoncu, R.3    Markhard, A.L.4    Nada, S.5    Sabatini, D.M.6
  • 12
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
    • DOI 10.1016/S0092-8674(03)00929-2
    • Inoki, K., Zhu, T., and Guan, K. L. (2003) TSC2 mediates cellular energy response to control cell growth and survival. Cell 115, 577-590 (Pubitemid 37506046)
    • (2003) Cell , vol.115 , Issue.5 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.-L.3
  • 19
    • 33845572827 scopus 로고    scopus 로고
    • Gapex-5, a Rab31 Guanine Nucleotide Exchange Factor that Regulates Glut4 Trafficking in Adipocytes
    • DOI 10.1016/j.cmet.2006.12.006, PII S1550413106004025
    • Lodhi, I. J., Chiang, S. H., Chang, L., Vollenweider, D., Watson, R. T., Inoue, M., Pessin, J. E., and Saltiel, A. R. (2007) Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes. Cell Metab. 5, 59-72 (Pubitemid 44933113)
    • (2007) Cell Metabolism , vol.5 , Issue.1 , pp. 59-72
    • Lodhi, I.J.1    Chiang, S.-H.2    Chang, L.3    Vollenweider, D.4    Watson, R.T.5    Inoue, M.6    Pessin, J.E.7    Saltiel, A.R.8
  • 21
    • 0345616428 scopus 로고    scopus 로고
    • A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain
    • DOI 10.1093/emboj/cdg140
    • Shih, S. C., Prag, G., Francis, S. A, Sutanto, M. A., Hurley, J. H., and Hicke, L. (2003) A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain. EMBO J. 22, 1273-1281 (Pubitemid 36362691)
    • (2003) EMBO Journal , vol.22 , Issue.6 , pp. 1273-1281
    • Shih, S.C.1    Prag, G.2    Francis, S.A.3    Sutanto, M.A.4    Hurley, J.H.5    Hicke, L.6
  • 24
    • 0028181704 scopus 로고
    • Role of three rab5-like GTPases, Ypt51p, Ypt52p, and Ypt53p, in the endocytic and vacuolar protein sorting pathways of yeast
    • Singer-Krüger, B., Stenmark, H., Düsterhöft, A., Philippsen, P., Yoo, J. S., Gallwitz, D., and Zerial, M. (1994) Role of three rab5-like GTPases, Ypt51p, Ypt52p, and Ypt53p, in the endocytic and vacuolar protein sorting pathways of yeast. J. Cell Biol. 125, 283-298
    • (1994) J. Cell Biol. , vol.125 , pp. 283-298
    • Singer-Krüger, B.1    Stenmark, H.2    Düsterhöft, A.3    Philippsen, P.4    Yoo, J.S.5    Gallwitz, D.6    Zerial, M.7
  • 25
    • 32144445482 scopus 로고    scopus 로고
    • TC10 and insulin-stimulated glucose transport
    • DOI 10.1016/S0076-6879(06)06055-1, PII S0076687906060551, 55, Regulators and Effectors of Small GTPases: Rho Family
    • Chiang, S. H., Chang, L., and Saltiel, A. R. (2006) TC10 and insulin-stimulated glucose transport. Methods Enzymol. 406, 701-714 (Pubitemid 43207480)
    • (2006) Methods in Enzymology , vol.406 , pp. 701-714
    • Chiang, S.1    Chang, L.2    Saltiel, A.R.3
  • 26
    • 0037128929 scopus 로고    scopus 로고
    • Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p
    • DOI 10.1083/jcb.200201002
    • Bonangelino, C. J., Nau, J. J., Duex, J. E., Brinkman, M., Wurmser, A. E., Gary, J. D., Emr, S. D., and Weisman, L. S. (2002) Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p. J. Cell Biol. 156, 1015-1028 (Pubitemid 34839851)
    • (2002) Journal of Cell Biology , vol.156 , Issue.6 , pp. 1015-1028
    • Bonangelino, C.J.1    Nau, J.J.2    Duex, J.E.3    Brinkman, M.4    Wurmser, A.E.5    Gary, J.D.6    Emr, S.D.7    Weisman, L.S.8
  • 28
    • 84863304598 scopus 로고    scopus 로고
    • R Development Core Team R. Foundation for Statistical Computing, Vienna, Austria
    • R Development Core Team (2011) R: A Language and Environment Statistical Computing, R. Foundation for Statistical Computing, Vienna, Austria
    • (2011) R: A Language and Environment Statistical Computing
  • 29
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini, Y., and Hochberg, Y. (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Statistical Soc. Ser. B 57, 289-300
    • (1995) J. R. Statistical Soc. Ser. B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 30
    • 0035172107 scopus 로고    scopus 로고
    • Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology
    • Foti, M., Audhya, A., and Emr, S. D. (2001) Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology. Mol. Biol. Cell 12, 2396-2411 (Pubitemid 33051964)
    • (2001) Molecular Biology of the Cell , vol.12 , Issue.8 , pp. 2396-2411
    • Foti, M.1    Audhya, A.2    Emr, S.D.3
  • 31
    • 0033977744 scopus 로고    scopus 로고
    • SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases
    • DOI 10.1074/jbc.275.2.801
    • Hughes, W. E., Woscholski, R., Cooke, F. T., Patrick, R. S., Dove, S. K., McDonald, N. Q., and Parker, P. J. (2000) SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases. J. Biol. Chem. 275, 801-808 (Pubitemid 30051118)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.2 , pp. 801-808
    • Hughes, W.E.1    Woscholski, R.2    Cooke, F.T.3    Patrick, R.S.4    Dove, S.K.5    McDonald, N.Q.6    Parker, P.J.7
  • 32
    • 0033532062 scopus 로고    scopus 로고
    • SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases
    • Guo, S., Stolz, L. E., Lemrow, S. M., and York, J. D. (1999) SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases. J. Biol. Chem. 274, 12990-12995
    • (1999) J. Biol. Chem. , vol.274 , pp. 12990-12995
    • Guo, S.1    Stolz, L.E.2    Lemrow, S.M.3    York, J.D.4
  • 33
    • 0035809160 scopus 로고    scopus 로고
    • Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase y sorting in Saccharomyces cerevisiae
    • Kihara, A., Noda, T., Ishihara, N., and Ohsumi, Y. (2001) Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J. Cell Biol. 152, 519-530 (Pubitemid 34280235)
    • (2001) Journal of Cell Biology , vol.153 , Issue.3 , pp. 519-530
    • Kihara, A.1    Noda, T.2    Ishihara, N.3    Ohsumi, Y.4
  • 34
    • 0027991899 scopus 로고
    • Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase
    • Welsh, G. I., Foulstone, E. J., Young, S. W., Tavaré, J. M., and Proud, C. G. (1994) Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase. Biochem. J. 303, 15-20 (Pubitemid 24302892)
    • (1994) Biochemical Journal , vol.303 , Issue.1 , pp. 15-20
    • Welsh, G.I.1    Foulstone, E.J.2    Young, S.W.3    Tavare, J.M.4    Proud, C.G.5
  • 35
    • 0028939115 scopus 로고
    • Multiple independent inputs are required for activation of the p70 S6 kinase
    • Weng, Q. P., Andrabi, K., Kozlowski, M. T., Grove, J. R., and Avruch, J. (1995) Multiple independent inputs are required for activation of the p70 S6 kinase. Mol. Cell. Biol. 15, 2333-2340
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 2333-2340
    • Weng, Q.P.1    Andrabi, K.2    Kozlowski, M.T.3    Grove, J.R.4    Avruch, J.5
  • 36
    • 0141733228 scopus 로고    scopus 로고
    • Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin
    • DOI 10.1074/jbc.M303257200
    • Tee, A. R., Anjum, R., and Blenis, J. (2003) Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin. J. Biol. Chem. 278, 37288-37296 (Pubitemid 37175245)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.39 , pp. 37288-37296
    • Tee, A.R.1    Anjum, R.2    Blenis, J.3
  • 38
    • 42949092018 scopus 로고    scopus 로고
    • The Endosomal Protein Appl1 Mediates Akt Substrate Specificity and Cell Survival in Vertebrate Development
    • DOI 10.1016/j.cell.2008.02.044, PII S0092867408003942
    • Schenck, A., Goto-Silva, L., Collinet, C., Rhinn, M., Giner, A., Habermann, B., Brand, M., and Zerial, M. (2008) The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development. Cell 133, 486-497 (Pubitemid 351608689)
    • (2008) Cell , vol.133 , Issue.3 , pp. 486-497
    • Schenck, A.1    Goto-Silva, L.2    Collinet, C.3    Rhinn, M.4    Giner, A.5    Habermann, B.6    Brand, M.7    Zerial, M.8
  • 39
    • 36148932174 scopus 로고    scopus 로고
    • The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation
    • DOI 10.1074/jbc.M704150200
    • Saito, T., Jones, C. C., Huang, S., Czech, M. P., and Pilch, P. F. (2007) The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation. J. Biol. Chem. 282, 32280-32287 (Pubitemid 350106472)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.44 , pp. 32280-32287
    • Saito, T.1    Jones, C.C.2    Huang, S.3    Czech, M.P.4    Pilch, P.F.5
  • 40
    • 34548421080 scopus 로고    scopus 로고
    • Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae
    • DOI 10.1534/genetics.107.072835
    • Zurita-Martinez, S. A., Puria, R., Pan, X., Boeke, J. D., and Cardenas, M. E. (2007) Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae. Genetics 176, 2139-2150 (Pubitemid 47360648)
    • (2007) Genetics , vol.176 , Issue.4 , pp. 2139-2150
    • Zurita-Martinez, S.A.1    Puria, R.2    Pan, X.3    Boeke, J.D.4    Cardenas, M.E.5
  • 42
    • 0347473810 scopus 로고    scopus 로고
    • Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways
    • DOI 10.1038/nbt919
    • Parsons, A. B., Brost, R. L., Ding, H., Li, Z., Zhang, C., Sheikh, B., Brown, G. W., Kane, P. M., Hughes, T. R., and Boone, C. (2004) Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nat. Biotechnol. 22, 62-69 (Pubitemid 38057958)
    • (2004) Nature Biotechnology , vol.22 , Issue.1 , pp. 62-69
    • Parsons, A.B.1    Brost, R.L.2    Ding, H.3    Li, Z.4    Zhang, C.5    Sheikh, B.6    Brown, G.W.7    Kane, P.M.8    Hughes, T.R.9    Boone, C.10
  • 43
    • 77950865682 scopus 로고    scopus 로고
    • Genomic analysis of severe hypersensitivity to hygromycin B reveals linkage to vacuolar defects and new vacuolar gene functions in Saccharomyces cerevisiae
    • Banuelos, M. G., Moreno, D. E., Olson, D. K., Nguyen, Q., Ricarte, F., Aguilera-Sandoval, C. R., and Gharakhanian, E. (2010) Genomic analysis of severe hypersensitivity to hygromycin B reveals linkage to vacuolar defects and new vacuolar gene functions in Saccharomyces cerevisiae. Curr. Genet. 56, 121-137
    • (2010) Curr. Genet. , vol.56 , pp. 121-137
    • Banuelos, M.G.1    Moreno, D.E.2    Olson, D.K.3    Nguyen, Q.4    Ricarte, F.5    Aguilera-Sandoval, C.R.6    Gharakhanian, E.7
  • 44
    • 69249240179 scopus 로고    scopus 로고
    • Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis
    • Huber, A., Bodenmiller, B., Uotila, A., Stahl, M., Wanka, S., Gerrits, B., Aebersold, R., and Loewith, R. (2009) Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis. Genes Dev. 23, 1929-1943
    • (2009) Genes Dev. , vol.23 , pp. 1929-1943
    • Huber, A.1    Bodenmiller, B.2    Uotila, A.3    Stahl, M.4    Wanka, S.5    Gerrits, B.6    Aebersold, R.7    Loewith, R.8
  • 45
    • 25444457577 scopus 로고    scopus 로고
    • hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
    • DOI 10.1074/jbc.M507201200
    • Byfield, M. P., Murray, J. T., and Backer, J. M. (2005) hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J. Biol. Chem. 280, 33076-33082 (Pubitemid 41368357)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.38 , pp. 33076-33082
    • Byfield, M.P.1    Murray, J.T.2    Backer, J.M.3
  • 47
    • 84855731134 scopus 로고    scopus 로고
    • Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway
    • Yoon, M. S., Du, G., Backer, J. M., Frohman, M. A., and Chen, J. (2011) Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway. J. Cell Biol. 195, 435-447
    • (2011) J. Cell Biol. , vol.195 , pp. 435-447
    • Yoon, M.S.1    Du, G.2    Backer, J.M.3    Frohman, M.A.4    Chen, J.5
  • 48
    • 79960387847 scopus 로고    scopus 로고
    • Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1)
    • Xu, L., Salloum, D., Medlin, P. S., Saqcena, M., Yellen, P., Perrella, B., and Foster, D. A. (2011) Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1). J. Biol. Chem. 286, 25477-25486
    • (2011) J. Biol. Chem. , vol.286 , pp. 25477-25486
    • Xu, L.1    Salloum, D.2    Medlin, P.S.3    Saqcena, M.4    Yellen, P.5    Perrella, B.6    Foster, D.A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.